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Volumn 108, Issue 2, 2014, Pages 202-211

The effects of eslicarbazepine on persistent Na+ current and the role of the Na+ channel β subunits

Author keywords

Carbamazepine; Epilepsy; Eslicarbazepine; INaP; Persistent sodium current; Sodium channel beta subunits

Indexed keywords

CARBAMAZEPINE; EPILEPSY; ESLICARBAZEPINE; I(NAP); PERSISTENT SODIUM CURRENT; SODIUM CHANNEL BETA SUBUNITS;

EID: 84895076823     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2013.11.022     Document Type: Article
Times cited : (22)

References (50)
  • 3
    • 74049163222 scopus 로고    scopus 로고
    • Key factors in the discovery and development of new antiepileptic drugs
    • Bialer M., White H.S. Key factors in the discovery and development of new antiepileptic drugs. Nat. Rev. Drug Discov. 2010, 9:68-82.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 68-82
    • Bialer, M.1    White, H.S.2
  • 4
    • 84861792459 scopus 로고    scopus 로고
    • Pharmacokinetics and drug interactions of eslicarbazepine acetate
    • Bialer M., Soares-da-Silva P. Pharmacokinetics and drug interactions of eslicarbazepine acetate. Epilepsia 2012, 53:935-946.
    • (2012) Epilepsia , vol.53 , pp. 935-946
    • Bialer, M.1    Soares-da-Silva, P.2
  • 5
    • 0035013202 scopus 로고    scopus 로고
    • Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: comparison with carbamazepine
    • Bonifácio M.J., Sheridan R.D., Parada A., Cunha R.A., Patmore L., Soares-da-Silva P. Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: comparison with carbamazepine. Epilepsia 2001, 42:600-608.
    • (2001) Epilepsia , vol.42 , pp. 600-608
    • Bonifácio, M.J.1    Sheridan, R.D.2    Parada, A.3    Cunha, R.A.4    Patmore, L.5    Soares-da-Silva, P.6
  • 6
    • 51549096558 scopus 로고    scopus 로고
    • + channels: potential for beta subunits as therapeutic targets
    • + channels: potential for beta subunits as therapeutic targets. Expert Opin. Ther. Targets 2008, 12:1191-1203.
    • (2008) Expert Opin. Ther. Targets , vol.12 , pp. 1191-1203
    • Brackenbury, W.J.1    Isom, L.L.2
  • 7
    • 84857211318 scopus 로고    scopus 로고
    • Na channel β subunits: overachievers of the ion channel family
    • Brackenbury W.J., Isom L.L. Na channel β subunits: overachievers of the ion channel family. Front. Pharmacol. 2011, 2:53.
    • (2011) Front. Pharmacol. , vol.2 , pp. 53
    • Brackenbury, W.J.1    Isom, L.L.2
  • 8
    • 0033694833 scopus 로고    scopus 로고
    • From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels
    • Catterall W.A. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 2000, 26:13-25.
    • (2000) Neuron , vol.26 , pp. 13-25
    • Catterall, W.A.1
  • 9
    • 29844438166 scopus 로고    scopus 로고
    • International Union of Pharmacology XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels
    • Catterall W.A., Goldin A.L., Waxman S.G. International Union of Pharmacology XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol. Rev. 2005, 57:397-409.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 397-409
    • Catterall, W.A.1    Goldin, A.L.2    Waxman, S.G.3
  • 11
    • 0037168659 scopus 로고    scopus 로고
    • Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits
    • Chen C., Bharucha V., Chen Y., Westenbroek R.E., Brown A., Malhotra J.D., et al. Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:17072-17077.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 17072-17077
    • Chen, C.1    Bharucha, V.2    Chen, Y.3    Westenbroek, R.E.4    Brown, A.5    Malhotra, J.D.6
  • 12
    • 11144354817 scopus 로고    scopus 로고
    • Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture
    • Chen C., Westenbroek R.E., Xu X., Edwards C.A., Sorenson D.R., Chen Y., et al. Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J. Neurosci. Off. J. Soc. Neurosci. 2004, 24:4030-4042.
    • (2004) J. Neurosci. Off. J. Soc. Neurosci. , vol.24 , pp. 4030-4042
    • Chen, C.1    Westenbroek, R.E.2    Xu, X.3    Edwards, C.A.4    Sorenson, D.R.5    Chen, Y.6
  • 13
    • 78651429319 scopus 로고    scopus 로고
    • An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus
    • Chen S., Su H., Yue C., Remy S., Royeck M., Sochivko D., et al. An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. J. Neurophysiol. 2011, 105:117-129.
    • (2011) J. Neurophysiol. , vol.105 , pp. 117-129
    • Chen, S.1    Su, H.2    Yue, C.3    Remy, S.4    Royeck, M.5    Sochivko, D.6
  • 14
    • 33847611166 scopus 로고    scopus 로고
    • Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures
    • Elger C., Bialer M., Cramer J.A., Maia J., Almeida L., Soares-da-Silva P. Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures. Epilepsia 2007, 48:497-504.
    • (2007) Epilepsia , vol.48 , pp. 497-504
    • Elger, C.1    Bialer, M.2    Cramer, J.A.3    Maia, J.4    Almeida, L.5    Soares-da-Silva, P.6
  • 15
    • 61849168486 scopus 로고    scopus 로고
    • Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study
    • Elger C., Halász P., Maia J., Almeida L., Soares-da-Silva P. Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study. Epilepsia 2009, 50:454-463.
    • (2009) Epilepsia , vol.50 , pp. 454-463
    • Elger, C.1    Halász, P.2    Maia, J.3    Almeida, L.4    Soares-da-Silva, P.5
  • 16
    • 0037725036 scopus 로고    scopus 로고
    • Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells
    • Ellerkmann R.K., Remy S., Chen J., Sochivko D., Elger C.E., Urban B.W., et al. Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience 2003, 119:323-333.
    • (2003) Neuroscience , vol.119 , pp. 323-333
    • Ellerkmann, R.K.1    Remy, S.2    Chen, J.3    Sochivko, D.4    Elger, C.E.5    Urban, B.W.6
  • 17
    • 37349071555 scopus 로고    scopus 로고
    • The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels
    • Errington A.C., Stöhr T., Heers C., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol. Pharmacol. 2008, 73:157-169.
    • (2008) Mol. Pharmacol. , vol.73 , pp. 157-169
    • Errington, A.C.1    Stöhr, T.2    Heers, C.3    Lees, G.4
  • 18
    • 70349972675 scopus 로고    scopus 로고
    • Efficacy and safety of 800 and 1200mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures
    • Gil-Nagel A., Lopes-Lima J., Almeida L., Maia J., Soares-da-Silva P. Efficacy and safety of 800 and 1200mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures. Acta Neurol. Scand. 2009, 120:281-287.
    • (2009) Acta Neurol. Scand. , vol.120 , pp. 281-287
    • Gil-Nagel, A.1    Lopes-Lima, J.2    Almeida, L.3    Maia, J.4    Soares-da-Silva, P.5
  • 19
    • 84872077912 scopus 로고    scopus 로고
    • Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: integrated analysis of pooled data from double-blind phase III clinical studies
    • Gil-Nagel A., Elger C., Ben-Menachem E., Halász P., Lopes-Lima J., Gabbai A.A., et al. Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: integrated analysis of pooled data from double-blind phase III clinical studies. Epilepsia 2013, 54:98-107.
    • (2013) Epilepsia , vol.54 , pp. 98-107
    • Gil-Nagel, A.1    Elger, C.2    Ben-Menachem, E.3    Halász, P.4    Lopes-Lima, J.5    Gabbai, A.A.6
  • 21
    • 0035050571 scopus 로고    scopus 로고
    • Resurgence of sodium channel research
    • Goldin A.L. Resurgence of sodium channel research. Annu. Rev. Physiol. 2001, 63:871-894.
    • (2001) Annu. Rev. Physiol. , vol.63 , pp. 871-894
    • Goldin, A.L.1
  • 22
    • 78649248897 scopus 로고    scopus 로고
    • Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy
    • Halász P., Cramer J.A., Hodoba D., Członkowska A., Guekht A., Maia J., et al. Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy. Epilepsia 2010, 51:1963-1969.
    • (2010) Epilepsia , vol.51 , pp. 1963-1969
    • Halász, P.1    Cramer, J.A.2    Hodoba, D.3    Członkowska, A.4    Guekht, A.5    Maia, J.6
  • 23
    • 84872063845 scopus 로고    scopus 로고
    • Inhibitory effects of eslicarbazepine acetate and its metabolites against neuronal voltage-gated sodium channels
    • Hebeisen S., Brady K., Konrad D., Soares-da-Silva P. Inhibitory effects of eslicarbazepine acetate and its metabolites against neuronal voltage-gated sodium channels. Epilepsia 2011, 52(Suppl. 6):257-258.
    • (2011) Epilepsia , vol.52 , Issue.SUPPL. 6 , pp. 257-258
    • Hebeisen, S.1    Brady, K.2    Konrad, D.3    Soares-da-Silva, P.4
  • 24
    • 84873081426 scopus 로고    scopus 로고
    • Long-term safety and efficacy of eslicarbazepine acetate as adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy: results of a 1-year open-label extension study
    • Hufnagel A., Ben-Menachem E., Gabbai A.A., Falcão A., Almeida L., Soares-da-Silva P. Long-term safety and efficacy of eslicarbazepine acetate as adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy: results of a 1-year open-label extension study. Epilepsy Res. 2013, 103:262-269.
    • (2013) Epilepsy Res. , vol.103 , pp. 262-269
    • Hufnagel, A.1    Ben-Menachem, E.2    Gabbai, A.A.3    Falcão, A.4    Almeida, L.5    Soares-da-Silva, P.6
  • 25
    • 0028263694 scopus 로고
    • Auxiliary subunits of voltage-gated ion channels
    • Isom L.L., De Jongh K.S., Catterall W.A. Auxiliary subunits of voltage-gated ion channels. Neuron 1994, 12:1183-1194.
    • (1994) Neuron , vol.12 , pp. 1183-1194
    • Isom, L.L.1    De Jongh, K.S.2    Catterall, W.A.3
  • 26
    • 77951460956 scopus 로고    scopus 로고
    • Long-term treatment of partial epilepsy with eslicarbazepine acetate (ESL): results of a one-year open-label extension of study BIA-2093-303
    • Lopes-Lima J., Gil-Nagel A., Maia J., Almeida L., Soares-da-Silva P. Long-term treatment of partial epilepsy with eslicarbazepine acetate (ESL): results of a one-year open-label extension of study BIA-2093-303. Epilepsia 2008, 49(Suppl. 7):441-442.
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 7 , pp. 441-442
    • Lopes-Lima, J.1    Gil-Nagel, A.2    Maia, J.3    Almeida, L.4    Soares-da-Silva, P.5
  • 27
    • 58249130592 scopus 로고    scopus 로고
    • A catalog of SCN1A variants
    • Lossin C. A catalog of SCN1A variants. Brain Dev. 2009, 31:114-130.
    • (2009) Brain Dev. , vol.31 , pp. 114-130
    • Lossin, C.1
  • 28
    • 20744457438 scopus 로고    scopus 로고
    • An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin
    • Lucas P.T., Meadows L.S., Nicholls J., Ragsdale D.S. An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin. Epilepsy Res. 2005, 64:77-84.
    • (2005) Epilepsy Res. , vol.64 , pp. 77-84
    • Lucas, P.T.1    Meadows, L.S.2    Nicholls, J.3    Ragsdale, D.S.4
  • 29
    • 0032843750 scopus 로고    scopus 로고
    • Biophysical properties and slow voltage-dependent inactivation of a sustained sodium current in entorhinal cortex layer-II principal neurons: a whole-cell and single-channel study
    • Magistretti J., Alonso A. Biophysical properties and slow voltage-dependent inactivation of a sustained sodium current in entorhinal cortex layer-II principal neurons: a whole-cell and single-channel study. J. Gen. Physiol. 1999, 114:491-509.
    • (1999) J. Gen. Physiol. , vol.114 , pp. 491-509
    • Magistretti, J.1    Alonso, A.2
  • 31
    • 0037115031 scopus 로고    scopus 로고
    • Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1
    • Meadows L.S., Malhotra J., Loukas A., Thyagarajan V., Kazen-Gillespie K.A., Koopman M.C., et al. Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. J. Neurosci. Off. J. Soc. Neurosci. 2002, 22:10699-10709.
    • (2002) J. Neurosci. Off. J. Soc. Neurosci. , vol.22 , pp. 10699-10709
    • Meadows, L.S.1    Malhotra, J.2    Loukas, A.3    Thyagarajan, V.4    Kazen-Gillespie, K.A.5    Koopman, M.C.6
  • 32
    • 77954514571 scopus 로고    scopus 로고
    • Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects
    • Meisler M.H., O'Brien J.E., Sharkey L.M. Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects. J. Physiol. 2010, 588:1841-1848.
    • (2010) J. Physiol. , vol.588 , pp. 1841-1848
    • Meisler, M.H.1    O'Brien, J.E.2    Sharkey, L.M.3
  • 33
    • 84869088193 scopus 로고    scopus 로고
    • Sodium channels and the neurobiology of epilepsy
    • Oliva M., Berkovic S.F., Petrou S. Sodium channels and the neurobiology of epilepsy. Epilepsia 2012, 53:1849-1859.
    • (2012) Epilepsia , vol.53 , pp. 1849-1859
    • Oliva, M.1    Berkovic, S.F.2    Petrou, S.3
  • 35
    • 78049361936 scopus 로고    scopus 로고
    • Electrophysiology and beyond multiple roles of Na+ channel β subunits in development and disease
    • Patino G.A., Isom L.L. Electrophysiology and beyond multiple roles of Na+ channel β subunits in development and disease. Neurosci. Lett. 2010, 486:53-59.
    • (2010) Neurosci. Lett. , vol.486 , pp. 53-59
    • Patino, G.A.1    Isom, L.L.2
  • 36
    • 0037669865 scopus 로고    scopus 로고
    • Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats
    • Remy S., Urban B.W., Elger C.E., Beck H. Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats. Eur. J. Neurosci. 2003, 17:2648-2658.
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 2648-2658
    • Remy, S.1    Urban, B.W.2    Elger, C.E.3    Beck, H.4
  • 37
    • 84866179907 scopus 로고    scopus 로고
    • Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies
    • Savio-Galimberti E., Gollob M.H., Darbar D. Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies. Front. Pharmacol. 2012, 3:124.
    • (2012) Front. Pharmacol. , vol.3 , pp. 124
    • Savio-Galimberti, E.1    Gollob, M.H.2    Darbar, D.3
  • 38
    • 0030943313 scopus 로고    scopus 로고
    • Generalized epilepsy with febrile seizures plus: a genetic disorder with heterogeneous clinical phenotypes
    • Scheffer I.E., Berkovic S.F. Generalized epilepsy with febrile seizures plus: a genetic disorder with heterogeneous clinical phenotypes. Brain J. Neurol. 1997, 120(Pt 3):479-490.
    • (1997) Brain J. Neurol. , vol.120 , Issue.PART 3 , pp. 479-490
    • Scheffer, I.E.1    Berkovic, S.F.2
  • 40
    • 4143079087 scopus 로고    scopus 로고
    • Estimating action potential thresholds from neuronal time-series: new metrics and evaluation of methodologies
    • Sekerli M., Del Negro C.A., Lee R.H., Butera R.J. Estimating action potential thresholds from neuronal time-series: new metrics and evaluation of methodologies. IEEE Trans. Biomed. Eng. 2004, 51:1665-1672.
    • (2004) IEEE Trans. Biomed. Eng. , vol.51 , pp. 1665-1672
    • Sekerli, M.1    Del Negro, C.A.2    Lee, R.H.3    Butera, R.J.4
  • 41
    • 45749155596 scopus 로고    scopus 로고
    • Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine
    • Sheets P.L., Heers C., Stoehr T., Cummins T.R. Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine. J. Pharmacol. Exp. Ther. 2008, 326:89-99.
    • (2008) J. Pharmacol. Exp. Ther. , vol.326 , pp. 89-99
    • Sheets, P.L.1    Heers, C.2    Stoehr, T.3    Cummins, T.R.4
  • 42
    • 84887021198 scopus 로고    scopus 로고
    • Slow and fast inactivation of voltage-gated sodium channels by eslicarbazepine and carbamazepine
    • Soares-da-Silva P., Hebeisen S. Slow and fast inactivation of voltage-gated sodium channels by eslicarbazepine and carbamazepine. Epilepsia 2012, 53(Suppl. 5):54.
    • (2012) Epilepsia , vol.53 , Issue.SUPPL. 5 , pp. 54
    • Soares-da-Silva, P.1    Hebeisen, S.2
  • 43
    • 37749029721 scopus 로고    scopus 로고
    • Persistent sodium current and its role in epilepsy
    • Stafstrom C.E. Persistent sodium current and its role in epilepsy. Epilepsy Curr. Am. Epilepsy Soc. 2007, 7:15-22.
    • (2007) Epilepsy Curr. Am. Epilepsy Soc. , vol.7 , pp. 15-22
    • Stafstrom, C.E.1
  • 44
    • 77954091119 scopus 로고    scopus 로고
    • Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents
    • Uebachs M., Opitz T., Royeck M., Dickhof G., Horstmann M.-T., Isom L.L., et al. Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J. Neurosci. Off. J. Soc. Neurosci. 2010, 30:8489-8501.
    • (2010) J. Neurosci. Off. J. Soc. Neurosci. , vol.30 , pp. 8489-8501
    • Uebachs, M.1    Opitz, T.2    Royeck, M.3    Dickhof, G.4    Horstmann, M.-T.5    Isom, L.L.6
  • 45
    • 84869097151 scopus 로고    scopus 로고
    • Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents
    • Uebachs M., Albus C., Opitz T., Isom L., Niespodziany I., Wolff C., et al. Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents. Epilepsia 2012, 53:1959-1967.
    • (2012) Epilepsia , vol.53 , pp. 1959-1967
    • Uebachs, M.1    Albus, C.2    Opitz, T.3    Isom, L.4    Niespodziany, I.5    Wolff, C.6
  • 46
    • 17344367657 scopus 로고    scopus 로고
    • Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B
    • Wallace R.H., Wang D.W., Singh R., Scheffer I.E., George A.L., Phillips H.A., et al. Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat. Genet. 1998, 19:366-370.
    • (1998) Nat. Genet. , vol.19 , pp. 366-370
    • Wallace, R.H.1    Wang, D.W.2    Singh, R.3    Scheffer, I.E.4    George, A.L.5    Phillips, H.A.6
  • 47
    • 84870831253 scopus 로고    scopus 로고
    • Pharmacoresistance and the role of surgery in difficult to treat epilepsy
    • Wiebe S., Jette N. Pharmacoresistance and the role of surgery in difficult to treat epilepsy. Nat. Rev. Neurol. 2012, 8:669-677.
    • (2012) Nat. Rev. Neurol. , vol.8 , pp. 669-677
    • Wiebe, S.1    Jette, N.2
  • 48
    • 0037264170 scopus 로고    scopus 로고
    • Overview of the voltage-gated sodium channel family
    • Yu F.H., Catterall W.A. Overview of the voltage-gated sodium channel family. Genome Biol. 2003, 4:207.
    • (2003) Genome Biol. , vol.4 , pp. 207
    • Yu, F.H.1    Catterall, W.A.2
  • 50
    • 27144464110 scopus 로고    scopus 로고
    • Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells
    • Yue C., Remy S., Su H., Beck H., Yaari Y. Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. J. Neurosci. Off. J. Soc. Neurosci. 2005, 25:9704-9720.
    • (2005) J. Neurosci. Off. J. Soc. Neurosci. , vol.25 , pp. 9704-9720
    • Yue, C.1    Remy, S.2    Su, H.3    Beck, H.4    Yaari, Y.5


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