Automated quantification of epicardial adipose tissue using CT angiography: Evaluation of a prototype software

European Radiology

Volumn 24, Issue 2, 2014, Pages 519-526

  Spearman, James V ^a   Meinel, Felix G ^a,b   Schoepf, U Joseph ^a   Apfaltrer, Paul ^a,c   Silverman, Justin R ^a   Krazinski, Aleksander W ^a   Canstein, Christian ^d   De Cecco, Carlo Nicola ^a,e   Costello, Philip ^a   Geyer, Lucas L ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d SIEMENS CORPORATE RESEARCH   (United States)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Atherosclerosis; Cardiac computed tomography; Cardiovascular risk factor; Epicardial adipose tissue; Prototype

Indexed keywords

ADIPOSE TISSUE; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MIDDLE AGED; OBSERVER VARIATION; PERICARDIUM; RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SOFTWARE; SOFTWARE DESIGN; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84895074505     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-013-3052-2     Document Type: Article

References (31)

1. Bastarrika G, Broncano J, Schoepf UJ et al (2010) Relationship between coronary artery disease and epicardial adipose tissue quantification at cardiac CT: comparison between automatic volumetric measurement and manual bidimensional estimation. Acad Radiol 17:727-734
2. Rosito GA, Massaro JM, Hoffmann U et al (2008) Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 117:605-613
3. Taguchi R, Takasu J, Itani Y et al (2001) Pericardial fat accumulation in men as a risk factor for coronary artery disease. Atherosclerosis 157:203-209
4. Schlett CL, Ferencik M, Kriegel MF et al (2012) Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT. Atherosclerosis 222:129-134
5. Mazurek T, Zhang L, Zalewski A et al (2003) Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108:2460-2466
6. Sacks HS, Fain JN (2007) Human epicardial adipose tissue: a review. Am Heart J 153:907-917
7. Apfaltrer P, Schoepf UJ, Vliegenthart R et al (2011) Coronary computed tomography-present status and future directions. Int J Clin Pract Suppl. doi: 10.1111/j.1742-1241.2011.02784.x:3-13
8. Gruettner J, Fink C, Walter T et al (2013) Coronary computed tomography and triple rule out CT in patients with acute chest pain and an intermediate cardiac risk profile. Part 1: impact on patient management. Eur J Radiol 82:100-105
9. Moscariello A, Vliegenthart R, Schoepf UJ et al (2012) Coronary CT angiography versus conventional cardiac angiography for therapeutic decision making in patients with high likelihood of coronary artery disease. Radiology 265:385-392
10. Ebersberger U, Eilot D, Goldenberg R et al (2013) Fully automated derivation of coronary artery calcium scores and cardiovascular risk assessment from contrast medium-enhanced coronary CT angiography studies. Eur Radiol 23:650-657
11. Nichols JH, Samy B, Nasir K et al (2008) Volumetric measurement of pericardial adipose tissue from contrast-enhanced coronary computed tomography angiography: a reproducibility study. J Cardiovasc Comput Tomogr 2:288-295
12. Wheeler GL, Shi R, Beck SR et al (2005) Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families. Invest Radiol 40:97-101
13. Park MJ, Jung JI, Oh YS, Youn HJ (2010) Assessment of epicardial fat volume with threshold-based 3-dimensional segmentation in CT: comparison with the 2-dimensional short axis-based method. Korean Circ J 40:328-333
14. Iacobellis G, Bianco AC (2011) Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab 22:450-457
15. Iacobellis G, Corradi D, Sharma AM (2005) Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med 2:536-543
16. Iacobellis G, Ribaudo MC, Assael F et al (2003) Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 88:5163-5168
17. Sicari R, Sironi AM, Petz R et al (2011) Pericardial rather than epicardial fat is a cardiometabolic risk marker: an MRI vs echo study. J Am Soc Echocardiogr 24:1156-1162
18. Marwan M, Achenbach S (2013) Quantification of epicardial fat by computed tomography: why, when and how? J Cardiovasc Comput Tomogr 7:3-10
19. Dey D, Suzuki Y, Suzuki S et al (2008) Automated quantitation of pericardiac fat from noncontrast CT. Invest Radiol 43:145-153
20. Xu Y, Cheng X, Hong K, Huang C, Wan L (2012) How to interpret epicardial adipose tissue as a cause of coronary artery disease: a meta-analysis. Coron Artery Dis 23:227-233
21. Greif M, Becker A, von Ziegler F et al (2009) Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol 29:781-786
22. Tamarappoo B, Dey D, Shmilovich H et al (2010) Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT. JACC Cardiovasc Imaging 3:1104-1112
23. Mahabadi AA, Berg MH, Lehmann N et al (2013) Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: the Heinz Nixdorf Recall Study. J Am Coll Cardiol 61:1388-1395
24. Shimabukuro M, Hirata Y, Tabata M et al (2013) Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis. Arterioscler Thromb Vasc Biol 33:1077-1084
25. Cheng VY, Dey D, Tamarappoo B et al (2010) Pericardial fat burden on ECG-gated noncontrast CT in asymptomatic patients who subsequently experience adverse cardiovascular events. JACC Cardiovasc Imaging 3:352-360
26. Nakanishi R, Rajani R, Cheng VY et al (2011) Increase in epicardial fat volume is associated with greater coronary artery calcification progression in subjects at intermediate risk by coronary calcium score: a serial study using non-contrast cardiac CT. Atherosclerosis 218:363-368
27. Nakazato R, Dey D, Cheng VY et al (2012) Epicardial fat volume and concurrent presence of both myocardial ischemia and obstructive coronary artery disease. Atherosclerosis 221:422-426
28. Achenbach S, Boehmer K, Pflederer T et al (2010) Influence of slice thickness and reconstruction kernel on the computed tomographic attenuation of coronary atherosclerotic plaque. J Cardiovasc Comput Tomogr 4:110-115
29. Birnbaum BA, Hindman N, Lee J, Babb JS (2007) Multi-detector row CT attenuation measurements: assessment of intra- and interscanner variability with an anthropomorphic body CT phantom. Radiology 242:109-119
30. Baker AR, Silva NF, Quinn DW et al (2006) Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol 5:1
31. Cheng KH, Chu CS, Lee KT et al (2008) Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes (Lond) 32:268-274