Stability and cell uptake of calcium carbonate templated insulin microparticles

Acta Biomaterialia

Volumn 10, Issue 3, 2014, Pages 1423-1430

  Schmidt, S ^a,b   Uhlig, K ^a   Duschl, C ^a   Volodkin, D ^a  

^a FRAUNHOFER INSTITUTE FOR BIOMEDICAL ENGINEERING   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Biopharmaceuticals; Hard templating; Microgels; Micromechanics; Microparticles

Indexed keywords

ATOMIC FORCE MICROSCOPY; CALCITE; CONTROLLED DRUG DELIVERY; DICHROISM; INSULIN; PHYSIOLOGICAL MODELS; PRECIPITATION (CHEMICAL); PROTEINS; TARGETED DRUG DELIVERY;

BIOPHARMACEUTICALS; CELL UPTAKE; HARD TEMPLATING; ISO-ELECTRIC POINTS; MICRO PARTICLES; MICROGEL; PARTICLE PROPERTIES; PROTEIN PARTICLES; TEMPLATED; THERAPEUTIC PROTEIN;

CALCIUM CARBONATE;

CALCIUM CARBONATE; INSULIN; PROTEIN; MICROSPHERE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CIRCULAR DICHROISM; DENATURATION; DRUG DECOMPOSITION; DRUG DELIVERY SYSTEM; DRUG STABILITY; DRUG UPTAKE; IN VITRO STUDY; INSULIN RELEASE; ISOELECTRIC POINT; LUNG ALVEOLUS MACROPHAGE; MICROSCOPY; MICROTECHNOLOGY; PARTICLE SIZE; PH; PHAGOCYTOSIS; POROSITY; PRECIPITATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; STATIC ELECTRICITY; ANIMAL; BOVINE; ENDOCYTOSIS; METABOLISM; PROTEIN DENATURATION; ULTRAVIOLET SPECTROPHOTOMETRY; YOUNG MODULUS;

ANIMALS; CALCIUM CARBONATE; CATTLE; CIRCULAR DICHROISM; ELASTIC MODULUS; ENDOCYTOSIS; HYDROGEN-ION CONCENTRATION; INSULIN; MICROSPHERES; PARTICLE SIZE; PHAGOCYTOSIS; PROTEIN DENATURATION; SPECTROPHOTOMETRY, ULTRAVIOLET; STATIC ELECTRICITY;

EID: 84895067131     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.11.011     Document Type: Article

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