Dynamic patterns of ventricular remodeling and apoptosis in hearts unloaded by heterotopic transplantation

Journal of Heart and Lung Transplantation

Volumn 33, Issue 2, 2014, Pages 203-210

  Brinks, Henriette ^a   Giraud, Marie Noelle ^b   Segiser, Adrian ^a   Ferrié, Celine ^a   Longnus, Sarah ^a   Ullrich, Nina D ^c   Koch, Walter J ^d   Most, Patrick ^e   Carrel, Thierry P ^a   Tevaearai, Hendrik T ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

apoptosis; atrophy; cardiac recovery; heterotopic heart transplantation; myocardial unloading

Indexed keywords

APOPTOSIS; ATROPHY; CARDIAC RECOVERY; HETEROTOPIC HEART TRANSPLANTATION; MYOCARDIAL UNLOADING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL MARKERS; CASPASE 6; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; HEART; HEART TRANSPLANTATION; MALE; MEMBRANE PROTEINS; MODELS, ANIMAL; MYOCARDIUM; PROTO-ONCOGENE PROTEINS; RATS; RATS, INBRED LEW; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; VENTRICULAR REMODELING;

EID: 84895061850     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2013.10.006     Document Type: Article

References (20)

1. E.J. Birks, R.S. George, and M. Hedger et al. Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study Circulation 123 2011 381 390
2. D. Burkhoff, S. Klotz, and D.M. Mancini LVAD-induced reverse remodeling: basic and clinical implications for myocardial recovery J Card Fail 12 2006 227 239
3. S. Klotz, A.H. Jan Danser, and D. Burkhoff Impact of left ventricular assist device (LVAD) support on the cardiac reverse remodeling process Prog Biophys Molec Biol 97 2008 479 496
4. C. Depre, G.L. Shipley, and W. Chen et al. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy Nat Med 4 1998 1269 1275
5. H. Brinks, H. Tevaearai, and C. Muhlfeld et al. Contractile function is preserved in unloaded hearts despite atrophic remodeling J Thorac Cardiovasc Surg 137 2009 742 746
6. N. deJonge, D.F. van Wichen, and J. van Kuik et al. Cardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators J Heart Lung Transplant 22 2003 1028 1036
7. R.D. Patten, D. Denofrio, and M. El-Zaru et al. Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart J Am Coll Cardiol 45 2005 1419 1424
8. C. Kassiotis, K. Ballal, and K. Wellnitz et al. Markers of autophagy are downregulated in failing human heart after mechanical unloading Circulation 120 2009 S191 S197
9. H. Muranaka, A. Marui, and M. Tsukashita et al. Prolonged mechanical unloading preserves myocardial contractility but impairs relaxation in rat heart of dilated cardiomyopathy accompanied by myocardial stiffness and apoptosis J Thorac Cardiovasc Surg 140 2010 916 922
10. S. Schena, Y. Kurimoto, and J. Fukada et al. Effects of ventricular unloading on apoptosis and atrophy of cardiac myocytes J Surg Res 120 2004 119 126
11. P. Razeghi, S. Sharma, and J. Ying et al. Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation Circulation 108 2003 2536 2541
12. P. Berthon, S. Duguez, and F.B. Favier et al. Regulation of ubiquitin-proteasome system, caspase enzyme activities, and extracellular proteinases in rat soleus muscle in response to unloading Pflugers Arch 454 2007 625 633
13. P. Razeghi, M.E. Wang, K.A. Youker, L. Golfman, S. Stepkowski, and H. Taegtmeyer Lack of nf-kappab1 (p105/p50) attenuates unloading-induced downregulation of PPARalpha and PPARalpha-regulated gene expression in rodent heart Cardiovasc Res 74 2007 133 139
14. H. Brinks, M. Boucher, and E. Gao et al. Level of g protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms Circ Res 107 2010 1140 1149
15. P. Razeghi, K.K. Baskin, and S. Sharma et al. Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart Biochem Biophys Res Commun 342 2006 361 364
16. H. Taegtmeyer, L. Golfman, S. Sharma, P. Razeghi, and M. van Arsdall Linking gene expression to function: metabolic flexibility in the normal and diseased heart Ann N Y Acad Sci 1015 2004 202 213
17. A. Rodrigue-Way, D. Burkhoff, and B.J. Geesaman et al. Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support J Heart Lung Transplant 24 2005 73 80
18. S.G. Drakos, A.G. Kfoury, and E.H. Hammond et al. Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart J Am Coll Cardiol 56 2010 382 391
19. S.I. Lok, B. Winkens, and R. Goldschmeding et al. Circulating growth differentiation factor-15 correlates with myocardial fibrosis in patients with non-ischaemic dilated cardiomyopathy and decreases rapidly after left ventricular assist device support Eur J Heart Fail 14 2012 1249 1256
20. T. Doenst, H. Bugger, S. Leippert, B. Barleon, D. Marme, and F. Beyersdorf Differential gene expression in response to ventricular unloading in rat and human myocardium Thorac Cardiovasc Surg 54 2006 381 387