Bone disease in adult patients with β-thalassaemia major: A case-control study

Internal and Emergency Medicine

Volumn 9, Issue 1, 2014, Pages 59-63

  Baldini, Marina ^a   Forti, Stella ^a   Orsatti, Alessandra ^b   Ulivieri, Fabio Massimo ^a   Airaghi, Lorena ^a   Zanaboni, Laura ^a   Cappellini, Maria Domenica ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Endocrinopathy; Hypogonadism; Hypoparathyroidism; Osteoporosis; Thalassemia

Indexed keywords

SOMATOMEDIN C;

ADULT; BETA-THALASSEMIA; BONE DENSITY; CASE CONTROL STUDY; FEMALE; HUMAN; HYPOPARATHYROIDISM; MALE; OSTEOPOROSIS;

ADULT; BETA-THALASSEMIA; BONE DENSITY; CASE-CONTROL STUDIES; FEMALE; HUMANS; HYPOPARATHYROIDISM; INSULIN-LIKE GROWTH FACTOR I; MALE; OSTEOPOROSIS;

EID: 84895060325     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-011-0745-x     Document Type: Article

References (23)

1. Voskaridou E, Terpos E (2008) Pathogenesis and management of osteoporosis in thalassemia. Pediatr Endocrinol Rev 6(Suppl 1): 86-93.
2. Gaudio A, Morabito N, Xourafa A, Macri I, Meo A, Morgante S, Trifiletti A, Lasco A, Frisina N (2008) Bisphosphonates in the treatment of thalassemia-associated osteoporosis. J Endocrinol Invest 31(2): 181-184 pii: 4467.
3. Chern JP, Lin KH, Tsai WY, Wang SC, Lu MY, Lin DT, Lin KS, Lo SH (2003) Hypogonadotropic hypogonadism and hematologic phenotype in patients with transfusion-dependent beta-thalassemia. J Pediatr Hematol Oncol 25(11): 880-884.
4. Pratelli L, Verri E, Fortini M, Marconi S, Zolezzi C, Fornasari PM, Gamberini MR, De Sanctis V (2006) Chelation therapy and bone metabolism markers in thalassemia major. J Pediatr Endocrinol Metab 19(11): 1335-1342.
5. Angelopoulos NG, Goula A, Rombopoulos G, Kaltzidou V, Katounda E, Kaltsas D, Tolis G (2006) Hypoparathyroidism in transfusion-dependent patients with beta-thalassemia. J Bone Miner Metab 24(2): 138-145. doi: 10. 1007/s00774-005-0660-1.
6. Karimi M, Ghiam AF, Hashemi A, Alinejad S, Soweid M, Kashef S (2007) Bone mineral density in beta-thalassemia major and intermedia. Indian Pediatr 44(1): 29-32.
7. Carmina E, Di Fede G, Napoli N, Renda G, Vitale G, Lo Pinto C, Bruno D, Malizia R, Rini GB (2004) Hypogonadism and hormone replacement therapy on bone mass of adult women with thalassemia major. Calcif Tissue Int 74(1): 68-71. doi: 10. 1007/s00223-002-1044-3.
8. Origa R, Fiumana E, Gamberini MR, Armari S, Mottes M, Sangalli A, Paglietti E, Galanello R, Borgna-Pignatti C (2005) Osteoporosis in beta-thalassemia: clinical and genetic aspects. Ann NY Acad Sci 1054: 451-456. doi: 10. 1196/annals. 1345. 051.
9. Scacchi M, Danesi L, Cattaneo A, Valassi E, Pecori Giraldi F, Argento C, D'Angelo E, Mirra N, Carnelli V, Zanaboni L, Cappellini MD, Cavagnini F (2007) Growth hormone deficiency (GHD) in adult thalassaemic patients. Clin Endocrinol (Oxf) 67(5): 790-795. doi: 10. 1111/j. 1365-2265. 2007. 02965. x.
10. Jensen CE, Tuck SM, Agnew JE, Koneru S, Morris RW, Yardumian A, Prescott E, Hoffbrand AV, Wonke B (1998) High prevalence of low bone mass in thalassaemia major. Br J Haematol 103(4): 911-915.
11. Vogiatzi MG, Macklin EA, Fung EB, Vichinsky E, Olivieri N, Kwiatkowski J, Cohen A, Neufeld E, Giardina PJ (2006) Prevalence of fractures among the Thalassemia syndromes in North America. Bone 38(4): 571-575. doi: 10. 1016/j. bone. 2005. 10. 001.
12. Toumba M, Skordis N (2010) Osteoporosis syndrome in thalassaemia major: an overview. J Osteoporos 2010: 537673. doi: 10. 4061/2010/537673.
13. Borgna-Pignatti C, Marsella M, Zanforlin N (2010) The natural history of thalassemia intermedia. Ann NY Acad Sci 1202: 214-220. doi: 10. 1111/j. 1749-6632. 2010. 05550. x.
14. Marsella M, Pepe A, Borgna-Pignatti C (2010) Better survival and less cardiac morbidity in female patients with thalassemia major: a review of the literature. Ann NY Acad Sci 1202: 129-133. doi: 10. 1111/j. 1749-6632. 2010. 05588. x.
15. Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle-cells disease patients. Blood 106: 1460-1465.
16. Baldini M, Forti S, Marcon A, Ulivieri FM, Orsatti A, Tampieri B, Airaghi L, Zanaboni L, Cappellini MD (2010) Endocrine and bone disease in appropriately treated adult patients with beta-thalassemia major. Ann Hematol 89(12): 1207-1213. doi: 10. 1007/s00277-010-1007-0.
17. Vogiatzi MG, Macklin EA, Trachtenberg FL, Fung EB, Cheung AM, Vichinsky E, Olivieri N, Kirby M, Kwiatkowski JL, Cunningham M, Holm IA, Fleisher M, Grady RW, Peterson CM, Giardina PJ (2009) Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America. Br J Haematol 146(5): 546-556. doi: 10. 1111/j. 1365-2141. 2009. 07793. x.
18. Meczekalski B, Podfigurna-Stopa A, Genazzani AR (2010) Hypoestrogenism in young women and its influence on bone mass density. Gynecol Endocrinol 26(9): 652-657. doi: 10. 3109/09513590. 2010. 486452.
19. Yin A, Swerdloff R (2010) Treating hypogonadism in younger males. Expert Opin Pharmacother 11(9): 1529-1540. doi: 10. 1517/14656561003742947.
20. Suda T, Ueno Y, Fujii K, Shinki T (2003) Vitamin D and bone. J Cell Biochem 88(2): 259-266. doi: 10. 1002/jcb. 10331.
21. Skordis N, Efstathiou E, Kyriakou A, Toumba M (2008) Hormonal dysregulation and bones in thalassaemia-an overview. Pediatr Endocrinol Rev 6(Suppl 1): 107-115.
22. Scacchi M, Danesi L, Cattaneo A, Valassi E, Pecori Giraldi F, Argento C, D'Angelo E, Mirra N, Carnelli V, Zanaboni L, Tampieri B, Cappellini MD, Cavagnini F (2008) Bone demineralization in adult thalassaemic patients: contribution of GH and IGF-I at different skeletal sites. Clin Endocrinol (Oxf) 69(2): 202-207. doi: 10. 1111/j. 1365-2265. 2008. 03191. x.
23. Vestergaard P (2009) Bone metabolism in type 2 diabetes and role of thiazolidinediones. Curr Opin Endocrinol Diabetes Obes 16(2): 125-131. doi: 10. 1097/MED. 0b013e328325d155.