Hypogonadotropic Hypogonadism and Hematologic Phenotype in Patients with Transfusion-Dependent Beta-Thalassemia

Journal of Pediatric Hematology/Oncology

Volumn 25, Issue 11, 2003, Pages 880-884

  Chern, Jimmy P S ^b   Lin, Kai Hsin ^a   Tsai, Wen Yu ^a   Wang, Shih Chung ^b   Lu, Meng Yao ^a   Lin, Dong Tsamn ^a   Lin, Kuo Sin ^a   Lo, Su Heuy ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NONE

Author keywords

Hematologic genotype; Hematologic phenotype; Hypogonadotropic hypogonadism; Thalassemia

Indexed keywords

ADULT; ALLELE; ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; CLINICAL ARTICLE; CODON; FEMALE; GENETIC DIFFERENCE; GONADORELIN TEST; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; LOGISTIC REGRESSION ANALYSIS; MALE; MENSTRUAL IRREGULARITY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SECONDARY AMENORRHEA;

ADOLESCENT; ADULT; BETA-THALASSEMIA; BLOOD TRANSFUSION; FEMALE; GENOTYPE; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; HUMANS; HYPOGONADISM; MALE; PHENOTYPE; RISK FACTORS;

EID: 0242609135     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-200311000-00011     Document Type: Article

References (19)

1. Ko TM, Hsu PM, Chen CJ, et al. Incidence study of heterozygous β-thalassemia in northern Taiwan. J Formos Med Assoc. 1989;88:678-681.
2. Lin KH, Lin LL, Su S, et al. The incidence of β-thalassemia trait in Taiwan. Int J Pediatr Hematol Oncol. 1994;1:383-388.
3. Ko TM, Xu X. Molecular study and prenatal diagnosis of α- and β-thalassemia in Chinese. J Formos Med Assoc. 1998;97:5-15.
4. Tiosano D, Hochberg Z. Endocrine complications of thalassemia. J Endocrinol Invest. 2001;24:716-723.
5. Low LCK. Growth, puberty and endocrine function in beta- thalassemia major. J Pediatr Endocrinol Metab. 1997;10:175-184.
6. Kwan EYW, Lee ACW, Li AMC, et al. A cross-sectional study of growth, puberty and endocrine function in patients with thalassemia major in Hong-Kong. J Paediatr Child Health. 1995;31:83-87.
7. Rodda CP, Reid ED, Johnson S, et al. Short stature in homozygous β-thalassemia is due to disproportionate truncal shortening. Clin Endocrinol. 1995;42:587-592.
8. Italian Working Group on Endocrine Complications in Non-endocrine Diseases. Multicentre study on prevalence of endocrine complications in thalassemia major. Clin Endocrinol. 1995;42:581-586.
9. Wang C, Tso SC, Todd D. Hypogonadotropic hypogonadism in severe β-thalassemia: effect of chelation and pulsatile gonadotropin-releasing hormone therapy. J Clin Endocrinol Metab. 1989;68:511-516.
10. Bergeon C, Kovacs K. Pituitary siderosis: a histologic, immunocytologic, and ultrastructural study. Am J Pathol. 1978;9:295-309.
11. Bronspiegel-Weintrob N, Olivieri NF, Tyler B, et al. Effect of age at the start of iron chelation therapy on gonadal function in β-thalassemia major. N Engl J Med. 1990;323:713-719.
12. Olivieri NF, Nathan DJ, MacMillan JH, et al. Survival in medically treated patients with homozygous β-thalassemia. N Engl J Med. 1994; 331:574-578.
13. Olivieri NF. The β-thalassemias. N Engl J Med. 1999; 341:99-109.
14. Chatterjee R, Katz M, Cox TF, et al. Prospective study of the hypothalamic-pituitary axis in thalassemic patients who developed secondary amenorrhea. Clin Endocrinol (Oxf). 1993;39:287-296.
15. Maggio C, Giuffre M, Cuccia L, et al. Pattern of spontaneous and post-stimulation FSH and LH in male adolescents with thalassemia. Minerva Pediatr. 1998;50:147-150.
16. Berkovitch M, Bistritzer T, Milone SD, et al. Iron deposition in the anterior pituitary in homozygous beta-thalassemia: MRI evaluation and correlation with gonadal function. J Pediatr Endocrinol Metab. 2000; 13: 179-184.
17. Filosa A, Di Maio S, Vocca S, et al. Longitudinal monitoring of bone mineral density in thalassemic patients. Genetic structure and osteoporosis. Acta Paediatr. 1997;86:342-346.
18. Ho PJ, Hall GW, Luo LY, et al. Beta-thalassaemia intermedia: is it possible consistently to predict phenotype from genotype? Br J Haematol. 1998;100:70-78.
19. Winichagoon P, Fucharoen S, Chen P, et al. Genetic factors affecting clinical severity in beta-thalassemia syndromes. J Pediatr Hematol Oncol. 2000;22:573-580.