Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis)

Microbes and Infection

Volumn 16, Issue 2, 2014, Pages 171-174

  Kager, Liesbeth M ^a   Wiersinga, W Joost ^a   Roelofs, Joris J T H ^a   Van 't Veer, Cornelis ^a   Van der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Lung inflammation; Melioidosis; Pneumonia; Protease activated receptor 1; Sepsis

Indexed keywords

LUNG INFLAMMATION; MELIOIDOSIS; PNEUMONIA; PROTEASE-ACTIVATED RECEPTOR-1; SEPSIS;

ANIMALS; BURKHOLDERIA PSEUDOMALLEI; DISEASE MODELS, ANIMAL; HOST-PATHOGEN INTERACTIONS; MALE; MELIOIDOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, PAR-1; SEPSIS; SURVIVAL ANALYSIS;

EID: 84895012271     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2013.11.001     Document Type: Article

References (23)

1. Cheng A.C., Currie B.J. Melioidosis: epidemiology, pathophysiology, and management. Clin. Microbiol. Rev. 2005, 18:383-416.
2. Wiersinga W.J., Currie B.J., Peacock S.J. Melioidosis. N. Engl. J. Med. 2012, 367:1035-1044.
3. Wiersinga W.J., van der Poll T., White N.J., Day N.P., Peacock S.J. Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat. Rev. Microbiol. 2006, 4:272-282.
4. Butler D. Viral research faces clampdown. Nature 2012, 490:456.
5. Sokolova E., Reiser G. A novel therapeutic target in various lung diseases: airway proteases and protease-activated receptors. Pharmacol. Ther. 2007, 115:70-83.
6. Coughlin S.R. Protease-activated receptors in vascular biology. Thromb. Haemostasis 2001, 86:298-307.
7. Bae J.S., Yang L., Manithody C., Rezaie A.R. The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood 2007, 110:3909-3916.
8. Mosnier L.O., Zlokovic B.V., Griffin J.H. The cytoprotective protein C pathway. Blood 2007, 109:3161-3172.
9. Schuepbach R.A., Madon J., Ender M., Galli P., Riewald M. Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. J. Thromb. Haemostasis 2012, 10:1675-1684.
10. Ludeman M.J., Kataoka H., Srinivasan Y., Esmon N.L., Esmon C.T., Coughlin S.R. PAR1 cleavage and signaling in response to activated protein C and thrombin. J. Biol. Chem. 2005, 280:13122-13128.
11. Wiersinga W.J., Meijers J.C., Levi M., Van 't Veer C., Day N.P., Peacock S.J., Van der Poll T. Activation of coagulation with concurrent impairment of anticoagulant mechanisms correlates with a poor outcome in severe melioidosis. J. Thromb. Haemostasis 2008, 6:32-39.
12. Connolly A.J., Ishihara H., Kahn M.L., Farese R.V., Coughlin S.R. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996, 381:516-519.
13. Kager L.M., Wiersinga W.J., Roelofs J.J., Meijers J.C., Levi M., van't Veer C., van der Poll T. Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis). J. Thromb. Haemostasis 2011, 9:2020-2028.
14. Kager L.M., Wiersinga W.J., Roelofs J.J., Meijers J.C., Zeerleder S.S., Esmon C.T., Van 't Veer C., Van der Poll T. Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis). J. Thromb. Haemostasis 2013, 11:282-292.
15. Schouten M., van't Veer C., Roelofs J.J., Levi M., van der Poll T. Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study. Crit. Care 2012, 16:R238.
16. Khoufache K., Berri F., Nacken W., Vogel A.B., Delenne M., Camerer E., Coughlin S.R., Carmeliet P., Lina B., Rimmelzwaan G.F., Planz O., Ludwig S., Riteau B. PAR1 contributes to influenza A virus pathogenicity in mice. J. Clin. Invest. 2013, 123:206-214.
17. Niessen F., Schaffner F., Furlan-Freguia C., Pawlinski R., Bhattacharjee G., Chun J., Derian C.K., Andrade-Gordon P., Rosen H., Ruf W. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 2008, 452:654-658.
18. Camerer E., Cornelissen I., Kataoka H., Duong D.N., Zheng Y.W., Coughlin S.R. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood 2006, 107:3912-3921.
19. Pawlinski R., Mackman N. Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis. Crit. Care Med. 2004, 32:S293-S297.
20. Kaneider N.C., Leger A.J., Agarwal A., Nguyen N., Perides G., Derian C., Covic L., Kuliopulos A. 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage. Nat. Immunol. 2007, 8:1303-1312.
21. Howell D.C., Johns R.H., Lasky J.A., Shan B., Scotton C.J., Laurent G.J., Chambers R.C. Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am. J. Pathol. 2005, 166:1353-1365.
22. Antoniak S., Owens A.P., Baunacke M., Williams J.C., Lee R.D., Weithauser A., Sheridan P.A., Malz R., Luyendyk J.P., Esserman D.A., Trejo J., Kirchhofer D., Blaxall B.C., Pawlinski R., Beck M.A., Rauch U., Mackman N. PAR-1 contributes to the innate immune response during viral infection. J. Clin. Invest. 2013, 123:1310-1322.
23. Peters T., Henry P.J. Protease-activated receptors and prostaglandins in inflammatory lung disease. Br. J. Pharmacol. 2009, 158:1017-1033.