SitA contributes to the virulence of Klebsiella pneumoniae in a mouse infection model

Microbes and Infection

Volumn 16, Issue 2, 2014, Pages 161-170

  Sun, Wei Sheng W ^a,b   Syu, Wan Jr ^a,b   Ho, Wen Li ^a   Lin, Ching Nan ^a   Tsai, Shih Feng ^c   Wang, Shao Hung ^d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b ACADEMIA SINICA   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d NATIONAL CHIAYI UNIVERSITY   (Taiwan)

Author keywords

Klebsiella pneumoniae; Mouse intraperitoneal infection; SitA; Vaccination; Virulence determinant

Indexed keywords

KLEBSIELLA PNEUMONIAE; MOUSE INTRAPERITONEAL INFECTION; SITA; VACCINATION; VIRULENCE DETERMINANT;

ANIMALS; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; GENE DELETION; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICE; MICE, INBRED BALB C; SURVIVAL ANALYSIS; VIRULENCE FACTORS;

EID: 84894999839     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2013.10.019     Document Type: Article

References (49)

1. Podschun R., Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin. Microbiol. Rev. 1998, 11:589-603.
2. Ho J.Y., Lin T.L., Li C.Y., Lee A., Cheng A.N., Chen M.C., Wu S.H., Wang J.T., Li T.L., Tsai M.D. Functions of some capsular polysaccharide biosynthetic genes in Klebsiella pneumoniae NTUH K-2044. PLoS One 2011, 6:e21664.
3. Lin Y.T., Liu C.J., Fung C.P., Tzeng C.H. Nosocomial Klebsiella pneumoniae bacteraemia in adult cancer patients - characteristics of neutropenic and non-neutropenic patients. Scand. J. Infect Dis. 2011, 43:603-608.
4. Bryan C.S., Reynolds K.L., Brenner E.R. Analysis of 1,186 episodes of gram-negative bacteremia in non-university hospitals: the effects of antimicrobial therapy. Rev. Infect Dis. 1983, 5:629-638.
5. Young L.S. Nosocomial infections in the immunocompromised adult. Am. J. Med. 1981, 70:398-404.
6. Selden R., Lee S., Wang W.L., Bennett J.V., Eickhoff T.C. Nosocomial Klebsiella infections: intestinal colonization as a reservoir. Ann. Intern. Med. 1971, 74:657-664.
7. Casewell M.W., Phillips I. Epidemiological patterns of Klebsiella colonization and infection in an intensive care ward. J. Hyg. (Lond.) 1978, 80:295-300.
8. Kumarasamy K.K., Toleman M.A., Walsh T.R., Bagaria J., Butt F., Balakrishnan R., Chaudhary U., Doumith M., Giske C.G., Irfan S., Krishnan P., Kumar A.V., Maharjan S., Mushtaq S., Noorie T., Paterson D.L., Pearson A., Perry C., Pike R., Rao B., Ray U., Sarma J.B., Sharma M., Sheridan E., Thirunarayan M.A., Turton J., Upadhyay S., Warner M., Welfare W., Livermore D.M., Woodford N. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 2010, 10:597-602.
9. Yan J.J., Wu J.J., Ko W.C., Tsai S.H., Chuang C.L., Wu H.M., Lu Y.J., Li J.D. Plasmid-mediated 16S rRNA methylases conferring high-level aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae isolates from two Taiwanese hospitals. J. Antimicrob. Chemother. 2004, 54:1007-1012.
10. Lawlor M.S., O'Connor C., Miller V.L. Yersiniabactin is a virulence factor for Klebsiella pneumoniae during pulmonary infection. Infect. Immun. 2007, 75:1463-1472.
11. Ma L.C., Fang C.T., Lee C.Z., Shun C.T., Wang J.T. Genomic heterogeneity in Klebsiella pneumoniae strains is associated with primary pyogenic liver abscess and metastatic infection. J. Infect. Dis. 2005, 192:117-128.
12. Lin C.T., Wu C.C., Chen Y.S., Lai Y.C., Chi C., Lin J.C., Chen Y., Peng H.L. Fur regulation of the capsular polysaccharide biosynthesis and iron-acquisition systems in Klebsiella pneumoniae CG43. Microbiology 2011, 157:419-429.
13. Bachman M.A., Oyler J.E., Burns S.H., Caza M., Lepine F., Dozois C.M., Weiser J.N. Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2. Infect. Immun. 2011, 79:3309-3316.
14. Lee J.C., Lee E.J., Lee J.H., Jun S.H., Choi C.W., Kim S.I., Kang S.S., Hyun S. Klebsiella pneumoniae secretes outer membrane vesicles that induce the innate immune response. FEMS Microbiol. Lett. 2012, 331:17-24.
15. Bauman S.J., Kuehn M.J. Purification of outer membrane vesicles from Pseudomonas aeruginosa and their activation of an IL-8 response. Microbes Infect. 2006, 8:2400-2408.
16. Lear S., Eren E., Findlow J., Borrow R., Webster D., Jolles S. Meningococcal meningitis in two patients with primary antibody deficiency treated with replacement intravenous immunoglobulin. J. Clin. Pathol. 2006, 59:1191-1193.
17. Janakiraman A., Slauch J.M. The putative iron transport system SitABCD encoded on SPI1 is required for full virulence of Salmonella typhimurium. Mol. Microbiol. 2000, 35:1146-1155.
18. Sabri M., Leveille S., Dozois C.M. A SitABCD homologue from an avian pathogenic Escherichia coli strain mediates transport of iron and manganese and resistance to hydrogen peroxide. Microbiology 2006, 152:745-758.
19. Shu H.Y., Fung C.P., Liu Y.M., Wu K.M., Chen Y.T., Li L.H., Liu T.T., Kirby R., Tsai S.F. Genetic diversity of capsular polysaccharide biosynthesis in Klebsiella pneumoniae clinical isolates. Microbiology 2009, 155:4170-4183.
20. Chen J.W., Sun C.M., Sheng W.L., Wang Y.C., Syu W.J. Expression analysis of up-regulated genes responding to plumbagin in Escherichia coli. J. Bacteriol. 2006, 188:456-463.
21. Su M.S., Kao H.C., Lin C.N., Syu W.J. Gene l0017 encodes a second chaperone for EspA of enterohaemorrhagic Escherichia coli O157: H7. Microbiology 2008, 154:1094-1103.
22. Skorupski K., Taylor R.K. Positive selection vectors for allelic exchange. Gene 1996, 169:47-52.
23. Russo T.A., Shon A.S., Beanan J.M., Olson R., MacDonald U., Pomakov A.O., Visitacion M.P. Hypervirulent K. pneumoniae secretes more and more active iron-acquisition molecules than "classical" K. pneumoniae thereby enhancing its virulence. PLoS One 2011, 6:e26734.
24. Sabri M., Caza M., Proulx J., Lymberopoulos M.H., Bree A., Moulin-Schouleur M., Curtiss R., Dozois C.M. Contribution of the SitABCD, MntH, and FeoB metal transporters to the virulence of avian pathogenic Escherichia coli O78 strain chi7122. Infect. Immun. 2008, 76:601-611.
25. Bearden S.W., Perry R.D. The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague. Mol. Microbiol. 1999, 32:403-414.
26. Lemaitre C., Bidet P., Bingen E., Bonacorsi S. Transcriptional analysis of the Escherichia coli ColV-Ia plasmid pS88 during growth in human serum and urine. BMC Microbiol. 2012, 12:115.
27. Hsieh P.F., Lin T.L., Lee C.Z., Tsai S.F., Wang J.T. Serum-induced iron-acquisition systems and TonB contribute to virulence in Klebsiella pneumoniae causing primary pyogenic liver abscess. J. Infect. Dis. 2008, 197:1717-1727.
28. Kim Y.K., Pai H., Lee H.J., Park S.E., Choi E.H., Kim J., Kim J.H., Kim E.C. Bloodstream infections by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome. Antimicrob. Agents Chemother. 2002, 46:1481-1491.
29. Tullus K., Berglund B., Fryklund B., Kuhn I., Burman L.G. Epidemiology of fecal strains of the family Enterobacteriaceae in 22 neonatal wards and influence of antibiotic policy. J. Clin. Microbiol. 1988, 26:1166-1170.
30. Kenny B., Abe A., Stein M., Finlay B.B. Enteropathogenic Escherichia coli protein secretion is induced in response to conditions similar to those in the gastrointestinal tract. Infect. Immun. 1997, 65:2606-2612.
31. Sezonov G., Joseleau-Petit D., D'Ari R. Escherichia coli physiology in Luria-Bertani broth. J. Bacteriol. 2007, 189:8746-8749.
32. Kehl-Fie T.E., Skaar E.P. Nutritional immunity beyond iron: a role for manganese and zinc. Curr. Opin. Chem. Biol. 2010, 14:218-224.
33. Patzer S.I., Hantke K. Dual repression by Fe(2+)-Fur and Mn(2+)-MntR of the mntH gene, encoding an NRAMP-like Mn(2+) transporter in Escherichia coli. J. Bacteriol. 2001, 183:4806-4813.
34. Kehres D.G., Zaharik M.L., Finlay B.B., Maguire M.E. The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen. Mol. Microbiol. 2000, 36:1085-1100.
35. Kehres D.G., Maguire M.E. Emerging themes in manganese transport, biochemistry and pathogenesis in bacteria. FEMS Microbiol. Rev. 2003, 27:263-290.
36. Runyen-Janecky L.J., Reeves S.A., Gonzales E.G., Payne S.M. Contribution of the Shigella flexneri Sit, Iuc, and Feo iron acquisition systems to iron acquisition invitro and in cultured cells. Infect. Immun. 2003, 71:1919-1928.
37. Oelschlaeger T.A., Tall B.D. Invasion of cultured human epithelial cells by Klebsiella pneumoniae isolated from the urinary tract. Infect. Immun. 1997, 65:2950-2958.
38. Cryz S.J., Furer E., Germanier R. Safety and immunogenicity of Klebsiella pneumoniae K1 capsular polysaccharide vaccine in humans. J. Infect. Dis. 1985, 151:665-671.
39. Rukavina T., Ticac B., Susa M., Jendrike N., Jonjic S., Lucin P., Marre R., Doric M., Trautmann M. Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection. Infect. Immun. 1997, 65:1754-1760.
40. Donta S.T., Peduzzi P., Cross A.S., Sadoff J., Haakenson C., Cryz S.J., Kauffman C., Bradley S., Gafford G., Elliston D., Beam T.R., John J.F., Ribner B., Cantey R., Welsh C.H., Ellison R.T., Young E.J., Hamill R.J., Leaf H., Schein R.M., Mulligan M., Johnson C., Abrutyn E., Griffiss J.M., Slagle D., et al. Immunoprophylaxis against Klebsiella and Pseudomonas aeruginosa infections. The federal hyperimmune immunoglobulin trial study group. J. Infect. Dis. 1996, 174:537-543.
41. Ahmad T.A., El-Sayed L.H., Haroun M.A., Hussein A.A., El Ashry E.S. Development of immunization trials against Klebsiella pneumoniae. Vaccine 2012, 30:2411-2420.
42. Byrd W., de Lorimier A., Zheng Z.R., Cassels F.J. Microencapsulated subunit vaccine approach to enterotoxigenic Escherichia coli and other mucosal pathogens. Adv. Drug Deliv. Rev. 2005, 57:1362-1380.
43. Lavender H., Jagnow J.J., Clegg S. Klebsiella pneumoniae type 3 fimbria-mediated immunity to infection in the murine model of respiratory disease. Int. J. Med. Microbiol. 2005, 295:153-159.
44. Rauly I., Goetsch L., Haeuw J.F., Tardieux C., Baussant T., Bonnefoy J.Y., Corvaia N. Carrier properties of a protein derived from outer membrane protein A of Klebsiella pneumoniae. Infect. Immun. 1999, 67:5547-5551.
45. Cryz S.J., Furer E., Germanier R. Purification and vaccine potential of Klebsiella capsular polysaccharides. Infect. Immun. 1985, 50:225-230.
46. Chhibber S., Bajaj J. Polysaccharide-iron-regulated cell surface protein conjugate vaccine: its role in protection against Klebsiella pneumoniae-induced lobar pneumonia. Vaccine 1995, 13:179-184.
47. Jarosik G.P., Sanders J.D., Cope L.D., Muller-Eberhard U., Hansen E.J. A functional tonB gene is required for both utilization of heme and virulence expression by Haemophilus influenzae type b. Infect. Immun. 1994, 62:2470-2477.
48. Kadurugamuwa J.L., Anwar H., Brown M.R., Hengstler B., Kunz S., Zak O. Influence of cephalosporins and iron on surface protein antigens of Klebsiella pneumoniae invivo. Antimicrob. Agents Chemother. 1988, 32:364-368.
49. Chibber S., Bhardwaj S.B. Protection in a mouse peritonitis model mediated by iron-regulated outer-membrane protein of Salmonella typhi coupled to its Vi antigen. J. Med. Microbiol. 2004, 53:705-709.