Long-acting beneficial effect of percutaneously intramyocardially delivered secretome of apoptotic peripheral blood cells on porcine chronic ischemic left ventricular dysfunction

Biomaterials

Volumn 35, Issue 11, 2014, Pages 3541-3550

  Pavo, Noemi ^a   Zimmermann, Matthias ^a   Pils, Dietmar ^b   Mildner, Michael ^c   Petrási, Zsolt ^d   Petneházy, Örs ^d   Fuzik, János ^a   Jakab, András ^a   Gabriel, Christian ^e   Sipos, Wolfgang ^f   Maurer, Gerald ^a   Gyöngyösi, Mariann ^a   Ankersmit, Hendrik Jan ^a,g  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIV KLIN FÜR FRAUENHEILKUNDE   (Austria)

^c Universitatsklinik fur Dermatologie   (Austria)

^d SZENT ISTVÁN UNIVERSITY   (Hungary)

^e Red Cross Transfusion Service for Upper Austria   (Austria)

^f UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^g INSTITUTE FOR MICROELECTRONICS   (Austria)

Author keywords

Animal model; Cell free regeneration therapy; Gene expression; Immunomodulation; Myocardial infarction; Remodeling

Indexed keywords

ANIMAL MODEL; CELL-FREE REGENERATION THERAPY; GENE EXPRESSION; IMMUNOMODULATION; MYOCARDIAL INFARCTION; REMODELING;

ADMINISTRATION, CUTANEOUS; ANIMALS; APOPTOSIS; BLOOD PROTEINS; CHRONIC DISEASE; GENE EXPRESSION REGULATION; HEMODYNAMICS; LEUKOCYTES, MONONUCLEAR; MAGNETIC RESONANCE IMAGING; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-KIT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUS SCROFA; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84894910858     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.12.071     Document Type: Article

References (31)

1. Orlic D., Kajstura J., Chimenti S., Limana F., Jakoniuk I., Quaini F., et al. Mobilized bone marrow cell repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 2001, 98:10344-10349.
2. Jeevanantham V., Butler M., Saad A., Abdel-Latif A., Zuba-Surma E.K., Dawn B. Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis. Circulation 2012, 126:551-556.
3. Martin-Rendon E., Brunskill S., Dorée C., Hyde C., Watt S., Mathur A., et al. Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev 2008, (4):CD006536.
4. Thum T., Bauersachs J., Poole-Wilson P.A., Volk H.D., Anker S.D. The dying stem cell hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. J Am Coll Cardiol 2005, 46:1799-1802.
5. Saas P., Bonnefoy F., Kury-Paulin S., Kleinclauss F., Perrche S. Mediators involved in the immunomodulatory effects of apoptotic cells. Transplantation 2007, 84(Suppl. 1):31-34.
6. Gnecchi M., Zang Z., Ni A., Dzau V.J. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008, 103:1204-1219.
7. Korf-Klingebiel M., Kempf T., Sauer T., Brinkmann E., Fischer P., Meyer G.P., et al. Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction. Eur Heart J 2008, 29:2851-2858.
8. Di Santo S., Yang Z., Wyler von Ballmoos M., Voelzmann J., Diehm N., Baumgartner I., et al. Novel cell free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantation. PLoS One 2009, 4:e5643.
9. Lichtenauer M., Mildner M., Baumgartner A., Hasun M., Werba G., Beer L., et al. Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodeling by increasing elastin expression in cardiac scar tissue after myocardial infarction. Basic Res Cardiol 2011, 106:645-655.
10. Ankersmit H.J., Hoetzenecker K., Dietl W., Soleiman A., Horvat R., Wolfsberger M., et al. Irradiated cultured apoptotic peripheral blood mononuclear cells regenerate infarcted myocardium. Eur J Clin Invest 2009, 39:445-456.
11. Lichtenauer M., Mildner M., Hoetzenecker K., Zimmermann M., Podesser B.K., Sipos W., et al. Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study. Basic Res Cardiol 2011, 106:1283-1297.
12. Hoetzenecker K., Zimmermann M., Hoetzenecker W., Schweiger T., Kollmann D., Mildner M., et al. Mononuclear cell secretome protects from experimental autoimmune myocarditis. Eur Heart J 2013 Jan 14, 10.1093/eurheartj/ehs459.
13. Freyman T., Polin G., Osman H., Crary J., Lu M., Cheng L., et al. A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J 2006, 27:1114-1122.
14. Dixon J.A., Gorman R.C., Stroud R.E., Bouges S., Hirotsugu H., Gorman J.H., et al. Mesenchymal cell transplantation and myocardial remodelling following myocardial infarction. Circulation 2009, 120(Suppl. 11):S220-S229.
15. Cheng Y., Yi G., Conditt G.B., Sheehy A., Kolodgie F.D., Tellez A., et al. Catheter based endomyocardial delivery of mesenchymal precursor cells using 3D echo guidance improves cardiac function in a chronic myocardial injury ovine model. Cell Transplant 2013, 22:2299-2309.
16. Xiang F., Shi Z., Guo X., Qiu Z., Chen X., Huang F., et al. Proteomic analysis of myocardial tissue from the border zone during early stage post-infarct remodelling in rats. Eur J Heart Fail 2011, 13:254-263.
17. Yndestad A., Neurauter C.G., Oie E., Forstrøm R.J., Vinge L.E., Eide L., et al. Up-regulation of myocardial DNA base excision repair activities in experimental heart failure. Mutat Res 2009, 666:32-38.
18. Gyöngyösi M., Dib N. Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease. Nat Rev Cardiol 2011, 8:393-404.
19. Heiberg E., Sjögren J., Ugander M., Carlsson M., Engblom H., Arheden H. Design and validation of segment - a freely available software for cardiovascular image analysis. BMC Med Imaging 2010, 10:1-13.
20. Core team R: A language and environment for statistical computing 2012, R Foundation for Statistical Computing, Vienna, Austria. http://www.R-project.org/.
21. Smyth G.K. limma: Linear Models for Microarray Data. Bioinformatics and computational biology solutions using R and bioconductor 2005, 397-420. Springer, New York. R. Gentleman, V. Carey, W. Huber, R. Irizarry, S. Dudoit (Eds.).
22. Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4:44-57.
23. Ranganath S.H., Levy O., Inamdar M.S., Karp J.M. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 2012, 10:244-258.
24. Ertel A., Tozeren A. Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality. BMC Genomics 2008, 9:628.
25. Jin H., Yang R., Awad T.A., Wang F., Li W., Williams S.P., et al. Effects of early angiotensin-converting enzyme inhibition on cardiac gene expression after acute myocardial infarction. Circulation 2001, 103:736-742.
26. Sehl P.D., Tai J.T., Hillan K.J., Brown L.A., Goddard A., Yang R., et al. Application of cDNA microarrays in determining molecular phenotype in cardiac growth, development, and response to injury. Circulation 2000, 101:1990-1999.
27. Stanton L.W., Garrard L.J., Damm D., Garrick B.L., Lam A., Kapoun A.M., et al. Altered patterns of gene expression in response to myocardial infarction. Circ Res 2000, 86:939-945.
28. Song G.Y., Wu Y.J., Yang Y.J., Li J.J., Zhang H.L., Pei H.J., et al. The accelerated post-infarction progression of cardiac remodelling is associated with genetic changes in an untreated streptozotocin-induced diabetic rat model. Eur J Heart Fail 2009, 11:911-921.
29. Prat-Vidal C., Gálvez-Montón C., Nonell L., Puigdecanet E., Astier L., Solé F., et al. Identification of temporal and region-specific myocardial gene expression patterns in response to infarction in swine. PLoS One 2013, 8:e54785.
30. Roy S., Khanna S., Kuhn D.E., Rink C., Williams W.T., Zweier J.L., et al. Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix. Physiol Genomics 2006, 25:364-374.
31. Jameel M.N., Li Q., Mansoor A., Qiang X., Sarver A., Wang X., et al. Long-term functional improvement and gene expression changes after bone marrow-derived multipotent progenitor cell transplantation in myocardial infarction. Am J Physiol Heart Circ Physiol 2010, 298:H1348-H1356.