Untargeted profiling of pesticide metabolites by LC-HRMS: An exposomics tool for human exposure evaluation

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 4, 2014, Pages 1149-1161

  Jamin, Emilien L ^a   Bonvallot, Nathalie ^a,b,c   Tremblay Franco, Marie ^a   Cravedi, Jean Pierre ^a   Chevrier, Cécile ^b,d   Cordier, Sylvaine ^b,d   Debrauwer, Laurent ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c EHESP   (France)

^d UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Epidemiology; Exposure; Mass spectrometry; Metabolites; Pesticides

Indexed keywords

PESTICIDE;

ADULT; ANIMAL; ARTICLE; COHORT ANALYSIS; ENVIRONMENTAL EXPOSURE; EVALUATION STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PREGNANCY; RAT; URINE; WISTAR RAT;

ADULT; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COHORT STUDIES; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; MASS SPECTROMETRY; PESTICIDES; PREGNANCY; RATS; RATS, WISTAR;

EID: 84894902321     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7136-2     Document Type: Article

References (56)

1. US-EPA (2011) Pesticides industry sales and usage. http://www.epa.gov/ opp00001/pestsales/07pestsales/market-estimates2007.pdf. 2013
2. UIPP (2011-2012) Rapport d'activité (Acitivity report). http://asp.zone-secure.net/v2/indexPop.jsp?id=4419/5741/25126&lng=fr. 2013
3. Mnif W, Hassine AIH, Bouaziz A, Bartegi A, Thomas O, Roig B (2011) Effect of endocrine disruptor pesticides: a review. Int J Environ Res Public Health 8:2265-2303
4. Kamel F, Enge LS, Gladen BC, Hoppin JA, Alavanja MCR, Sandler DP (2007) Neurologic symptoms in licensed pesticide applicators in the Agricultural Health Study. Hum Exp Toxicol 26:243-250
5. Kamel F, Tanner CM, Umbach DM, Hoppin JA, Alavanja MCR, Blair A, Comyns K, Goldman SM, Korell M, Langston JW, Ross GW, Sandler DP (2007) Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am J Epidemiol 165:364-374
6. Blanc-Lapierre A, Bouvier G, Garrigou A, Canal-Raffin M, Raherison C, Brochard P, Baldi I (2012) Effets chroniques des pesticides sur le système nerveux central: état des connaissances épidémiologiques (Chronic effects of pesticides on the central nervous system: current epidemiological knowledge). Rev Epidemiol Santé Publique 60:389-400
7. Sever LE, Arbuckle TE, Sweeney A (1997) Reproductive and developmental effects of occupational pesticide exposure: the epidemiologic evidence. Occup Med State Art Rev 12:305-325
8. Bretveld RW, Thomas CMG, Scheepers PTJ, Zielhuis GA, Roeleveld N (2006) Pesticide exposure: the hormonal function of the female reproductive system disrupted? Reprod Biol Endocrinol 4:1-14
9. Bretveld R, Brouwers M, Ebisch I, Roeleveld N (2007) Influence of pesticides on male fertility. Scand J Work Environ Health 33:13-28
10. Weselak M, Arbuckle TE, Foster W (2007) Pesticide exposures and developmental outcomes: the epidemiological evidence. J Toxicol Environ Health B Crit Rev 10:41-80
11. Dich J, Zahm SH, Hanberg A, Adami HO (1997) Pesticides and cancer. Cancer Causes Control 8:420-443
12. Zahm SH, Ward MH, Blair A (1997) Pesticides and cancer. Occup Med State Art Rev 12:269-289
13. Merhi M, Raynal H, Cahuzac E, Vinson F, Cravedi JP, Gamet-Payrastre L (2007) Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case-control studies. Cancer Causes Control 18:1209-1226
14. Weichenthal S, Moase C, Chan P (2010) A review of pesticide exposure and cancer incidence in the Agricultural Health Study Cohort. Environ Health Perspect 118:1117-1125
15. ANSES (2010) Exposition de la population générale aux résidus de pesticides en France: Synthèse et recommandations du comité d'orientation et de prospective scientifique de l'observatoire des résidus de pesticides, ORP (Exposure of the general population to pesticide residues in France: Summary and recommendations of the steering and the scientific prospective committee of the pesticide residues observatory, PRO). Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail. http://www.observatoire-pesticides.gouv.fr/ upload/bibliotheque/171959218396043870616875052847/exposition-population- generale-pesticides-2010-vdef.pdf. 2013
16. Aprea MC (2012) Environmental and biological monitoring in the estimation of absorbed doses of pesticides. Toxicol Lett 210:110-118
17. Needham LL, Calafat AM, Barr DB (2007) Uses and issues of biomonitoring. Int J Hyg Environ Health 210:229-238
18. Lu CS, Rodriguez T, Funez A, Irish RS, Fenske RA (2006) The assessment of occupational exposure to diazinon in Nicaraguan plantation workers using saliva biomonitoring. In: Mehlman MA, Soffritti M, Landrigan P, Bingham E, Belpoggi F (ed) Living in a chemical world: framing the future in light of the past, vol 1076. Annals of the New York Academy of Sciences. Blackwell Publishing, Oxford, pp 355-365
19. Porta M, Puigdomenech E, Ballester F, Selva J, Ribas-Fito N, Llop S, Lopez T (2008) Monitoring concentrations of persistent organic pollutants in the general population: the international experience. Environ Int 34:546-561
20. Esteban M, Castano A (2009) Non-invasive matrices in human biomonitoring: a review. Environ Int 35:438-449
21. Harris SA, Villeneuve PJ, Crawley CD, Mays JE, Yeary RA, Hurto KA, Meeker JD (2010) National study of exposure to pesticides among professional applicators: an investigation based on urinary biomarkers. J Agric Food Chem 58:10253-10261
22. Fujii Y, Ito Y, Harada KH, Hitomi T, Koizumi A, Haraguchi K (2012) Comparative survey of levels of chlorinated cyclodiene pesticides in breast milk from some cities of China, Korea and Japan. Chemosphere 89:452-457
23. Bradman A, Whyatt RM (2005) Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children's Study: a review of monitoring and measurement methodologies. Environ Health Perspect 113:1092-1099
24. Ueyama J, Saito I, Kamijima M (2010) Analysis and evaluation of pyrethroid exposure in human population based on biological monitoring of urinary pyrethroid metabolites. J Pestic Sci 35:87-98
25. Sleeuwenhoek A, Cocker J, Jones K, Cherrie JW (2007) Biological monitoring of pesticide exposures. Research Report TM/07/02. IOM. http://www.iom-world.org/research/report-list.php?pageNum-listReports= 1&totalRows-listReports=469. 2011
26. Bouvier G, Seta N, Vigouroux-Villard A, Blanchard O, Momas I (2005) Insecticide urinary metabolites in nonoccupationally exposed populations. J Toxicol Environ Health B Crit Rev 8:485-512
27. Aprea C, Colosio C, Mammone T, Minoia C, Maroni M (2002) Biological monitoring of pesticide exposure: a review of analytical methods. J Chromatogr B 769:191-219
28. Barr DB, Needham LL (2002) Analytical methods for biological monitoring of exposure to pesticides: a review. J Chromatogr B 778:5-29
29. Margariti MG, Tsakalof AK, Tsatsakis AM (2007) Analytical methods of biological monitoring for exposure to pesticides: recent update. Ther Drug Monit 29:150-163
30. Le Bizec B, Pinel G, Antignac JP (2009) Options for veterinary drug analysis using mass spectrometry. J Chromatogr A 1216:8016-8034
31. Bicker W, Lammerhofer M, Genser D, Kiss H, Lindner W (2005) A case study of acute human chlorpyrifos poisoning: novel aspects on metabolism and toxicokinetics derived from liquid chromatography-tandem mass spectrometry analysis of urine samples. Toxicol Lett 159:235-251
32. Ahn KC, Watanabe T, Gee SJ, Hammock BD (2004) Hapten and antibody production for a sensitive immunoassay determining a human urinary metabolite of the pyrethroid insecticide permethrin. J Agric Food Chem 52:4583-4594
33. Shim WB, Yakovleva ME, Kim KY, Nam BR, Vylegzhanina ES, Komarov AA, Eremin SA, Chung DH (2009) Development of fluorescence polarization immunoassay for the rapid detection of 6-chloronicotinic acid: main metabolite of neonicotinoid insecticides. J Agric Food Chem 57:791-796
34. Colume A, Cardenas S, Gallego M, Valcarcel M (2001) A solid phase extraction method for the screening and determination of pyrethroid metabolites and organochlorine pesticides in human urine. Rapid Commun Mass Spectrom 15:2007-2013
35. Maurer HH (2007) Current role of liquid chromatography-mass spectrometry in clinical and forensic toxicology. Anal Bioanal Chem 388:1315-1325
36. Dresen S, Ferreiros N, Gnann H, Zimmermann R, Weinmann W (2010) Detection and identification of 700 drugs by multi-target screening with a 3200 Q TRAP(A (R)) LC-MS-MS system and library searching. Anal Bioanal Chem 396:2425-2434
37. Polettini A, Gottardo R, Pascali JP, Tagliaro F (2008) Implementation and performance evaluation of a database of chemical formulas for the screening of pharmaco/toxicologically relevant compounds in biological samples using electrospray ionization-time-of-flight mass spectrometry. Anal Chem 80:3050-3057
38. Pelander A, Ojanpera I, Laks S, Rasanen I, Vuori E (2003) Toxicological screening with formula-based metabolite identification by liquid chromatography/time-of-flight mass spectrometry. Anal Chem 75:5710-5718
39. Lee HK, Ho CS, Iu YPH, Lai PSJ, Shek CC, Lo YC, Klinke HB, Wood M (2009) Development of a broad toxicological screening technique for urine using ultra-performance liquid chromatography and time-of-flight mass spectrometry. Anal Chim Acta 649:80-90
40. Broecker S, Herre S, Wust B, Zweigenbaum J, Pragst F (2011) Development and practical application of a library of CID accurate mass spectra of more than 2,500 toxic compounds for systematic toxicological analysis by LC-QTOF-MS with data-dependent acquisition. Anal Bioanal Chem 400:101-117
41. Peters RJB, Stolker AAM, Mol JGJ, Lommen A, Lyris E, Angelis Y, Vonaparti A, Stamou M, Georgakopoulos C, Nielen MWF (2010) Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry. Trends Anal Chem 29:1250-1268
42. Petit C, Blangiardo M, Richardson S, Coquet F, Chevrier C, Cordier S (2002) Association of environmental insecticide exposure and fetal growth with a Bayesian model including multiple exposure sources. Am J Epidemiol 175:1182-1190
43. Agreste (2000) Recensement agricole (Agricultural census). Ministere de l'agriculture, de l'agroalimentaire et de la forêt. http://agreste. agriculture.gouv.fr/enquetes/recensement-agricole/. 2011
44. Wold S, Antti H, Lindgren F, Ohman J (1998) Orthogonal signal correction of near-infrared spectra. Chemometr Intell Lab Syst 44:175-185
45. Dettmer K, Aronov PA, Hammock BD (2007) Mass spectrometry-based metabolomics. Mass Spectrom Rev 26:51-78
46. COREP Bretagne (2011) Liste des études suivies par la COREP (List of studies undertaken by COREP). Ministere de l'agriculture, de l'agroalimentaire et de la forêt. http://draf.bretagne.agriculture.gouv. fr/corpep/spip.php?article166. 2011
47. Association de Coordination Technique Agricole ACTA, Couteux A, Lejeune V (2004) Index phytosanitaire 2004. ACTA, 149 rue de Bercy, Paris, France
48. IPCS INCHEM (2011) Pesticides data sheets and environmental health criteria. http://www.inchem.org/pages/pds.html. 2011
49. European Food Safety Authority (2010) 2008 annual report on pesticide residues. EFSA J 8:1646-2088
50. University of Hertfordshire (2011) PPDB: Pesticide Properties DataBase. http://sitem.herts.ac.uk/aeru/footprint/en/index.htm. 2011
51. Roberts TR (1999) Metabolic pathways of agrochemicals: part 2: insecticides and fungicides. Royal Society of Chemistry, Cambridge
52. Roberts TR, Hutson DH (1998) Metabolic pathways of agrochemicals: part 1: herbicides and plant growth regulators. Royal Society of Chemistry, Cambridge
53. Ueyama J, Saito I, Kondo T, Taki T, Kimata A, Saito S, Ito Y, Murata K, Iwata T, Gotoh M, Shibata E, Wakusawa S, Kamijima M (2012) Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers. Chemosphere 87:1403-1409
54. Sumner LW, Amberg A, Barrett D, Beale MH, Beger R, Daykin CA, Fan TWM, Fiehn O, Goodacre R, Griffin JL, Hankemeier T, Hardy N, Harnly J, Higashi R, Kopka J, Lane AN, Lindon JC, Marriott P, Nicholls AW, Reily MD, Thaden JJ, Viant MR (2007) Proposed minimum reporting standards for chemical analysis. Metabolomics 3:211-221
55. Krieger RI, Chen L, Ginevan M, Watkins D, Cochran RC, Driver JH, Ross JH (2012) Implications of estimates of residential organophosphate exposure from dialkylphosphates (DAPs) and their relevance to risk. Regul Toxicol Pharmacol 64:263-266
56. Hays SM, Aylward LL, Driver J, Ross J, Kirman C (2012) 2,4-D exposure and risk assessment: comparison of external dose and biomonitoring based approaches. Regul Toxicol Pharmacol 64:481-489