Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders

Clinical Epigenetics

Volumn 5, Issue 1, 2013, Pages

  Stringer, Randa L ^a   Laufer, Benjamin I ^a   Kleiber, Morgan L ^a   Singh, Shiva M ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Cannabinoid receptor 1; Epigenetics; Gene regulation; MicroRNA; Mouse; Neurodevelopment; Prenatal alcohol exposure

Indexed keywords

MICRORNA; MICRORNA 26B; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN FUNCTION; CNR1 GENE; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; FETAL ALCOHOL SYNDROME; GENE EXPRESSION REGULATION; GENE TARGETING; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR GENE; RNA BINDING; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84894857576     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/1868-7083-5-14     Document Type: Article

References (21)

1. Chudley AE, Conry J, Cook JL, Loock C, Rosales T, LeBlanc N: Public Health Agency of Canada's National Advisory Committee on Fetal Alcohol Spectrum Disorder. Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis. CMAJ 2005, 172(5 Suppl):S1-S21.
2. May PA, Gossage JP, Kalberg WO, Robinson LK, Buckley D, Manning M, Hoyme HE: Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. Dev Disabil Res Rev 2009, 15(3):176-192.
3. Bhatara V, Loudenberg R, Ellis R: Association of attention deficit hyperactivity disorder and gestational alcohol exposure: an exploratory study. J Atten Disord 2006, 9(3):515-522. (Pubitemid 43171144)
4. Hellemans KG, Verma P, Yoon E, Yu W, Weinberg J: Prenatal alcohol exposure increases vulnerability to stress and anxiety-like disorders in adulthood. Ann N Y Acad Sci 2008, 1144:154-175.
5. Kleiber ML, Mantha K, Stringer RL, Singh SM: Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure. J Neurodev Disord 2013, 5(1):6.
6. Laufer BI, Mantha K, Kleiber ML, Diehl EJ, Addison SM, Singh SM: Long lasting alterations to DNA methylation and ncRNAs may underlie the effects of fetal alcohol exposure in mice. Dis Model Mech 2013, 6(4):977-992.
7. Wang LL, Zhang Z, Li Q, Yang R, Pei X, Xu Y, Wang J, Zhou SF, Li Y: Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum Reprod 2009, 24(3):562-579.
8. Soares AR, Pereira PM, Ferreira V, Reverendo M, Simoes J, Bezerra AR, Moura GR, Santos MA: Ethanol exposure induces upregulation of specific microRNAs in zebrafish embryos. Toxicol Sci 2012, 127(1):18-28.
9. Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A: MicroRNAs can generate thresholds in target gene expression. Nat Genet 2011, 43(9):854-859.
10. Pertwee RG: The pharmacology of cannabinoid receptors and their ligands: an overview. Int J Obes (Lond) 2006, 30(Suppl 1):S13-S18.
11. Adermark L, Jonsson S, Ericson M, Soderpalm B: Intermittent ethanol consumption depresses endocannabinoid-signaling in the dorsolateral striatum of rat. Neuropharmacology 2011, 61(7):1160-1165.
12. Elphick MR, Egertova M: The neurobiology and evolution of cannabinoid signalling. Philos Trans R Soc Lond B Biol Sci 2001, 356(1407):381-408. (Pubitemid 32324674)
13. Dubreucq S, Kambire S, Conforzi M, Metna-Laurent M, Cannich A, Soria-Gomez E, Richard E, Marsicano G, Chaouloff F: Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors. Neuroscience 2012, 204:230-244.
14. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Horster F, Tenkova T, Dikranian K, Olney JW: Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 2000, 287(5455):1056-1060. (Pubitemid 30094364)
15. Wozniak DF, Hartman RE, Boyle MP, Vogt SK, Brooks AR, Tenkova T, Young C, Olney JW, Muglia LJ: Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis 2004, 17(3):403-414. (Pubitemid 39574874)
16. Friedman RC, Farh KK, Burge CB, Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009, 19(1):92-105.
17. Sowa N, Horie T, Kuwabara Y, Baba O, Watanabe S, Nishi H, Kinoshita M, Takanabe-Mori R, Wada H, Shimatsu A, Hasegawa K, Kimura T, Ono K: MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene. J Cell Biochem 2012, 113(11):3455-3465.
18. Dill H, Linder B, Fehr A, Fischer U: Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes Dev 2012, 26(1):25-30.
19. Caputo V, Sinibaldi L, Fiorentino A, Parisi C, Catalanotto C, Pasini A, Cogoni C, Pizzuti A: Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding. PLoS One 2011, 6 (12):e28656.
20. Ashton CH, Moore PB: Endocannabinoid system dysfunction in mood and related disorders. Acta Psychiatr Scand 2011, 124(4):250-261.
21. Mantha K, Kleiber M, Singh S: Neurodevelopmental timing of ethanol exposure may contribute to observed heterogeneity of behavioral deficits in a mouse model of fetal alcohol spectrum disorder (FASD). J Behav Brain Sci 2013, 3:85-99.