An up-date on the molecular biomarkers as potential therapeutic targets in human testicular germ cell tumors

Open Andrology Journal

Volumn 5, Issue 1, 2013, Pages 6-9

  Chieffi, Paolo ^a   Chieffi, Sergio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Aurora B; Gonocytes; GPR30; HMGA; PATZ1; Seminomas; Teratoma; Testicular cancer; Testicular germ cells tumors; Testis

Indexed keywords

ALPHA FETOPROTEIN; AURORA B KINASE; BIOLOGICAL MARKER; CCDC6; CHORIONIC GONADOTROPIN; G PROTEIN COUPLED RECEPTOR 30; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP B PROTEIN; MICRORNA; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR SOX; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ALPHA FETOPROTEIN BLOOD LEVEL; ARTICLE; AT HOOK MOTIF; GERM CELL TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; LACTATE DEHYDROGENASE BLOOD LEVEL; NON SEMINOMATOUS GERMINOMA; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; SEMINOMA;

EID: 84894781888     PISSN: None     EISSN: 1876827X     Source Type: Journal    
DOI: 10.2174/1876827X01305010006     Document Type: Article

References (47)

1. Oosterhuis JW, Looijenga LH. Testicular germ-cell tumors in a broader perspective. Nat Rev Cancer 2005; 5: 210-22.
2. Chieffi P, Chieffi S, Franco R, Sinisi A. Recent advances in the biology of germ cell tumors: implications for the diagnosis and treatment. J Endocrinol Invest 2012; 35: 1015-20
3. Chaganti RS, Houldsworth J. Genetics and biology of adult human male germ cell tumors. Cancer Res 2000; 60: 1474-82.
4. Ulbright TM. Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Modern Pathol 2005; 18: S61-S79.
5. Chieffi P, Franco R, Portella G. Molecular and cell biology of testicular germ cell tumors. Int Rev Cell Mol Biol 2009; 278: 277-308.
6. Jones RH, Vasey PA. Part II: testicular cancer-management of advanced disease. Lancet Oncol 2003; 4:738-47.
7. Skakkebaek NE. Possible carcinoma-in-situ of the testis. Lancet 1972; 2:516-7.
8. Rajpert-De Meyts E, Skakkebaek NE. Pathogenesis of testicular carcinoma in situ and germ cell cancer: still more questions than answers. Int J Androl 2011; 34: e2-6.
9. Skakkebaek NE, Berthelsen JG, Giwercman A, Muller J. Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 1987; 10:19-28.
10. von Eyben FE. Laboratory markers and germ cell tumors. Crit Rev Clin Lab Sci 2003; 40: 377-427.
11. Chieffi P, Battista S, Barchi M et al. HMGA1 and HMGA2 protein expression in mouse spermatogenesis. Oncogene 2002; 21: 3644-50.
12. Franco R, Esposito F, Fedele M, et al. Detection of high mobility group proteins A1 and A2 represents a valid diagnostic marker in post-puberal testicular germ cell tumours. J Pathol 2008; 214: 58-64.
13. Pero R, Lembo F, Di Vizio D, et al. RNF4 is a growth inhibitor expressed in germ cells and lost in human testicular tumours. Am J Pathol 2001; 159: 1225-30.
14. Pero R, Lembo F, Chieffi P, et al. Translational regulation of a novel testis-specific RNF4 transcript. Mol Reprod Dev 2003; 66: 1-7.
15. Fedele M, Franco R, Salvatore G, et al. PATZ1 gene has a critical role in the spermatogenesis and testicular tumours. J Pathol 2008; 215: 39-47.
16. Esposito F, Boscia F, Franco R, et al. Down-regulation of estrogen receptor-β associates with transcriptional coregulator PATZ1 delocalization in human testicular seminomas. J Pathol 2011; 224: 110-20.
17. Esposito F, Boscia F, Gigantino V, et al. The high mobility group A1-oestrogen receptor β nuclear interaction is impaired in human testicular seminomas J Cell Physiol 2012; 227: 3749-55.
18. Chieffi P, Troncone G, Caleo A, et al. Aurora B expression in normal testis and seminomas. J Endocrinol 2004; 181: 263-70.
19. Esposito F, Libertini S, Franco R, et al. Aurora B expression in post-puberal testicular germ cell tumours. J Cell Physiol 2009; 221: 435-9.
20. Portella G, Passaro C, Chieffi P. Aurora B: a new prognostic marker and therapeutic target in cancer. Curr Med Chem 2011; 18: 482-96.
21. Barbagallo F, Paronetto MP, Franco R, et al. Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas. J Pathol 2009; 217: 431-41.
22. Di Agostino S, Fedele M, Chieffi P, et al. Phosphorylation of high mobility group protein A2 by Nek kinase during the first meiotic division in mouse spermatocytes. Mol Biol Cell 2004; 15:1224-32.
23. Ledford H. Doubts raised over stem-cell marker. Nature (London) 2007; 449: 647.
24. Atlasi Y, Mowla SJ, Ziaee SA, Gokhale PJ, Andrews PW. OCT4 spliced variants are differentially expressed in human pluripotent and non-pluripotent cells. Stem Cells 2008; 26: 3068-74.
25. Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, Lovell Badge R. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 2003; 17: 126-40.
26. Yamaguchi S, Kimura H, Tada M, Nakatsuji N, Tada T. Nanog expression in mouse germ cell development. Gene Exp Patterns 2005; 5: 639-46.
27. de Jong J, Looijenga LH. Stem cell marker OCT3/4 in tumor biology and germ cell tumor diagnostics: history and future. Crit Rev Oncog 2006; 12: 171-203.
28. Hart AH, Hartley L, Parker K, et al. The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer 2005; 104: 2092-8.
29. de Jong J, Stoop H, Gillis AJ, et al. Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications. J Pathol 2008; 215: 21-30.
30. Kim I, Saunders TL, Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 2007; 130: 470-83.
31. Gashaw I, Grummer R, Klein-Hitpass L, et al. Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4. Cell Mol Life Sci 2005; 62: 2359-68.
32. Gashaw I, Dushaj O, Behr R, et al. Novel germ cell markers characterize testicular seminoma and fetal testis. Mol Hum Reprod 2007; 13: 721-7.
33. Chieffi P, Franco R, Fulgione D, Staibano S. PCNA in the testis of the frog, Rana esculenta: a molecular marker of the mitotic testicular epithelium proliferation. Gen Comp Endocrinol 2000; 119: 11-6.
34. Chieffi P, Colucci D'Amato L, Staibano S, Franco R, Tramontano D. Estradiol-induced mitogen-activated protein kinase (extracellular signal-regulated kinase 1 and 2) activity in the frog (Rana esculenta) testis. J Endocrinol 2000; 167: 77-84.
35. Chieffi P, Colucci-D'Amato GL, Guarino F, Salvatore G, Angelini F. 17FF-estradiol induces spermatogonial proliferation through mitogen-activated protein kinase (extracellular signal-regulated kinase 1) activity In the lizard (Podarcis s. sicula). Mol Reprod Dev 2002; 61: 218-25.
36. Franco R, Boscia F, Gigantino V, et al. GPR30 is over-expressed in post puberal testicular germ cell tumors. Cancer Biol Ther 2011; 11: 609-13.
37. Chieffi P, Chieffi S. Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumours: an overview. J Cell Physiol 2013; 228, 1641-6.
38. Vicini E, Loiarro M, Di Agostino S, et al. 2006 17-22-estradiol elicits genomic and non-genomic responses in mouse male germ cells. J Cell Physiol 2006: 238-245
39. Chieffi P. Molecular targets for the treatment of testicular germ cell tumors. Mini Rev Med Chem 2007; 7: 755-9.
40. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005; 307: 1625-30.
41. Meng X, de Rooij DG, Westerdahl K, Saarma M, Sariola H Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis. Cancer Res 2001; 61: 3267-71.
42. Ferranti F, Muciaccia B, Ricci G, et al. Glial cell line-derived neurotrophic factor promotes invasive behaviour in testicular seminoma cells. Int J Androl 2012; 35: 758-68.
43. Staibano S, Ilardi G, Leone V, et al. Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors. BMC Cancer 2013: 13: 433.
44. Voorhoeve PM, Le Sage C, Schrier M, et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006; 124:1169-81.
45. Maatouk DM, Loveland KL, McManus MT, Moore K, Harfe BD. Dicer1 is required for differentiation of the mouse male germline. Biol Reprod 2008; 79: 696-703.
46. Kedde M, Strasser MJ, Boldajipour B, et al. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell 2007; 131: 1273-86.
47. Linger R, Dudakia D, Huddart R, et al. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. Genes Chromosomes Cancer 2008; 47: 247-52.