Case report: Intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype

Diagnostic Pathology

Volumn 9, Issue 1, 2014, Pages

  Ahls, Maria G ^a   Niedergethmann, Marco ^a   Dinter, Dietmar ^a   Sauer, Christian ^a   Lüttges, Jutta ^b   Post, Stefan ^a   Marx, Alexander ^a   Gaiser, Timo ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Marienhospital Hamburg   (Germany)

Author keywords

Clear cell morphology; Intraductal tubulopapillary neoplasm; Pancreatic neoplasm ITPN

Indexed keywords

TUMOR MARKER;

ADULT; ARTICLE; CASE REPORT; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; PANCREAS CARCINOMA; PANCREAS TUMOR; PAPILLARY CARCINOMA; PATHOLOGY; PHENOTYPE;

ADULT; CARCINOMA, PANCREATIC DUCTAL; CARCINOMA, PAPILLARY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; PANCREATIC NEOPLASMS; PHENOTYPE; TUMOR MARKERS, BIOLOGICAL;

EID: 84894635541     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-9-11     Document Type: Article

References (24)

1. Yamaguchi H, Shimizu M, Ban S, Koyama I, Hatori T, Fujita I, Yamamoto M, Kawamura S, Kobayashi M, Ishida K, et al. Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 2009, 33:1164-1172. 10.1097/PAS.0b013e3181a162e5, 19440145.
2. Bosman F, Carneiro F, Hruban RH, Theise ND. WHO Classification of Tumours of the Digestive System 2010, 304-313. Lyon: IARC.
3. Matthaei H, Schulick RD, Hruban RH, Maitra A. Cystic precursors to invasive pancreatic cancer. Nat Rev Gastroenterol Hepatol 2011, 8:141-150. 10.1038/nrgastro.2011.2, 3236705, 21383670.
4. Chang XY, Lu ZH, Li XQ, Chen J. Intraductal tubulopapillary neoplasm of the pancreas: a clinicopathologic study of 6 cases. Zhonghua Bing Li Xue Za Zhi 2013, 42:248-251.
5. Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shimizu K, Shiratori K, Shibata N, Shimizu M, Furukawa T. The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant. J Pathol 2013, 231:335-341.
6. Tajiri T, Tate G, Matsumoto K, Hoshino H, Iwamura T, Kodaira Y, Takahashi K, Ohike N, Kunimura T, Mitsuya T, Morohoshi T. Diagnostic challenge: intraductal neoplasms of the pancreatobiliary system. Pathol Res Pract 2012, 208:691-696. 10.1016/j.prp.2012.09.002, 23057996.
7. Guan H, Gurda G, Marie Lennon A, Hruban RH, Erozan YS. Intraductal tubulopapillary neoplasm of the pancreas on fine needle aspiration: case report with differential diagnosis. Diagn Cytopathol in press.
8. Jokoji R, Tsuji H, Tsujimoto M, Shinno N, Tori M. Intraductal tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia; a case report. Pathol Int 2012, 62:339-343. 10.1111/j.1440-1827.2012.02791.x, 22524663.
9. Zen Y, Amarapurkar AD, Portmann BC. Intraductal tubulopapillary neoplasm of the bile duct: potential origin from peribiliary cysts. Hum Pathol 2012, 43:440-445. 10.1016/j.humpath.2011.03.013, 21813159.
10. Park HJ, Jang KT, Heo JS, Choi YL, Han J, Kim SH. A potential case of intraductal tubulopapillary neoplasms of the bile duct. Pathol Int 2010, 60:630-635. 10.1111/j.1440-1827.2010.02572.x, 20712650.
11. Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, et al. Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. Am J Surg Pathol 2011, 35:1812-1817. 10.1097/PAS.0b013e31822769a0, 21945955.
12. Katabi N, Torres J, Klimstra DS. Intraductal tubular neoplasms of the bile ducts. Am J Surg Pathol 2012, 36:1647-1655. 10.1097/PAS.0b013e3182684d4f, 23073323.
13. Konigsrainer I, Glatzle J, Kloppel G, Konigsrainer A, Wehrmann M. Intraductal and cystic tubulopapillary adenocarcinoma of the pancreas-a possible variant of intraductal tubular carcinoma. Pancreas 2008, 36:92-95. 10.1097/MPA.0b013e318149f536, 18192889.
14. Tajiri T, Tate G, Kunimura T, Inoue K, Mitsuya T, Yoshiba M, Morohosh T. Histologic and immunohistochemical comparison of intraductal tubular carcinoma, intraductal papillary-mucinous carcinoma, and ductal adenocarcinoma of the pancreas. Pancreas 2004, 29:116-122. 10.1097/00006676-200408000-00006, 15257103.
15. Ott C, Heinmoller E, Gaumann A, Scholmerich J, Klebl F. Intraepithelial neoplasms (PanIN) and intraductal papillary-mucinous neoplasms (IPMN) of the pancreas as precursor lesions of pancreatic carcinoma. Med Klin (Munich) 2007, 02:127-135.
16. Keogan MT, Tyler D, Clark L, Branch MS, McDermott VG, DeLong DM, Coleman RE. Diagnosis of pancreatic carcinoma: role of FDG PET. AJR Am J Roentgenol 1998, 171:1565-1570. 10.2214/ajr.171.6.9843289, 9843289.
17. Ariyama J, Suyama M, Satoh K, Wakabayashi K. Endoscopic ultrasound and intraductal ultrasound in the diagnosis of small pancreatic tumors. Abdom Imaging 1998, 23:380-386. 10.1007/s002619900365, 9663273.
18. Guan ZW, Sun L, Wang YQ, Xu BX. Solid pseudopapillary tumor of the pancreas and concomitant urogenital malformations in a young woman. Diagn Pathol 2013, 8:35. 10.1186/1746-1596-8-35, 3606420, 23445554.
19. Li P, Wang Y, Zhang Q, Liu Y, Lv Y, Wang Z. A noninvasive mucinous cystic neoplasm with intermediate-grade dysplasia of the pancreas and extensive squamous metaplasia: a case report with clinicopathological correlation. Diagn Pathol 2012, 7:89. 10.1186/1746-1596-7-89, 3487951, 22849702.
20. Nakamura A, Horinouchi M, Goto M, Nagata K, Sakoda K, Takao S, Imai K, Kim YS, Sato E, Yonezawa S. New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. J Pathol 2002, 197:201-210. 10.1002/path.1109, 12015744.
21. Luttges J, Vogel I, Menke M, Henne-Bruns D, Kremer B, Kloppel G. Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype. Histopathology 1998, 32:444-448. 10.1046/j.1365-2559.1998.00411.x, 9639120.
22. Guo G, Gui Y, Gao S, Tang A, Hu X, Huang Y, Jia W, Li Z, He M, Sun L, et al. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet 2012, 44:17-19.
23. Rohan SM, Xiao Y, Liang Y, Dudas ME, Al-Ahmadie HA, Fine SW, Gopalan A, Reuter VE, Rosenblum MK, Russo P, Tickoo SK. Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. Mod Pathol 2011, 24:1207-1220. 10.1038/modpathol.2011.80, 21602815.
24. Basturk O, Khayyata S, Klimstra DS, Hruban RH, Zamboni G, Coban I, Adsay NV. Preferential expression of MUC6 in oncocytic and pancreatobiliary types of intraductal papillary neoplasms highlights a pyloropancreatic pathway, distinct from the intestinal pathway, in pancreatic carcinogenesis. Am J Surg Pathol 2010, 34:364-370. 10.1097/PAS.0b013e3181cf8bb6, 3160822, 20139757.