Resveratrol-4-O-D-(2'-galloyl)-glucopyranoside isolated from Polygonum cuspidatum exhibits anti-hepatocellular carcinoma viability by inducing apoptosis via the JNK and ERK pathway

Molecules

Volumn 19, Issue 2, 2014, Pages 1592-1602

  Xie, Qichao ^a   Yang, Yupeng ^a   Wang, Zhiyi ^a   Chen, Fanglin ^a   Zhang, Anmei ^a   Liu, Chengcheng ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; ERK; Hepatocellular carcinoma; JNK; Resveratrol 4 O D (2' galloyl) glucopyranoside

Indexed keywords

GLUCURONIDE; PLANT EXTRACT; RESVERATROL 4' O GLUCURONIDE; RESVERATROL-4'-O-GLUCURONIDE; STILBENE DERIVATIVE;

ANIMAL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; PATHOLOGY; POLYGONUM CUSPIDATUM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; GLUCURONIDES; HUMANS; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; PLANT EXTRACTS; POLYGONUM CUSPIDATUM; STILBENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84894621056     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19021592     Document Type: Article

References (24)

1. Peng, W.; Qin, R.X.; Li, X.L.; Zhou, H. Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb.et Zucc: A review. J. Ethnopharmacol. 2013, 148, 729-745.
2. Editorial Board of Flora of China. Flora of China, 1st ed.; Science Publishing House: Beijing, China, 2003; pp. 277-350.
3. Peng, J.; Song, Z.F.; Ma, C. Emodin Studies on pharmacokinetics and distribution in rat liver after Polygonum cuspidatum Sieb.et Zucc extract administration. Mode Tradit. Chin. Med. Mater. Med. 2008, 10, 64-67.
4. Han, J.H.; Koh, W.; Lee, H.J.; Lee, H.J.; Lee, E.O.; Lee, S.J.; Khil, J.H.; Kim, J.T.; Jeong, S.J.; Kim, S.H. Analgesic and anti-inflammatory effects of ethyl acetate fraction of Polygonum cuspidatum in experimental animals. Immunopharmacol. Immunotoxicol. 2012, 34, 191-195.
5. Editorial Committee of Chinese Pharmacopoeia. Chinese Pharmacopoeia; Medical Science and Technology Press: Beijing, China, 2010; pp. 194-195.
6. Hegde, V.R.; Pu, H.Y.; Patel, M.; Black, T.; Soriano, A.; Zhao, W.J.; Gullo, V.P.; Chan, T.M. Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum. Bioorg. Med. Chem. Lett. 2004, 14, 2275-2277.
7. Xiao, K.; Xuan, L.J.; Xu, Y.M.; Bai, D.L.; Zhong, D.X. Constituents from Polygonum cuspidatum. Chem. Pharm. Bull. 2002, 50, 605-608.
8. Fan, P.H.; Hay, A.E.; Marston, A.; Lou, H.X.; Hostettmann, K. Chemical variability of the invasive neophytes Polygonum cuspidatum Sieb. and Zucc. and Polygonum sachalinensis F. Schmidt ex Maxim. Biochem. Syst. Ecol. 2009, 37, 24-34.
9. Yan, Y.; Gao, Y.Y.; Liu, B.Q.; Niu, X.F.; Zhuang, Y.; Wang, H.Q. Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response. BMC Cancer 2010, 10, 445.
10. Muto, A.; Hori, M.; Sasaki, Y.; Saitoh, A.; Yasuda, I.; Maekawa, T.; Uchida, T.; Asakura, K.; Nakazato, T.; Kaneda, T.; et al. Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor. Mol. Cancer Ther. 2007, 6, 987-994.
11. Van Ginkel, P.R.; Sareen, D.; Subramanian, L. Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria. Clin. Cancer Res. 2007, 13, 5162-5169.
12. Yu, C.X.; Zhang, X.Q.; Kang, L.D.; Zhang, P.J.; Chen, W.W.; Liu, W.W.; Liu, Q.W.; Zhang, J.Y. Emodin induces apoptosis in human prostate cancer cell LNCaP. Asian J. Androl. 2008, 10, 625-634.
13. Wang, C.G.; Yang, J.Q.; Liu, B.Z.; Jin, D.T.; Wang, C.; Zhong, L.; Zhu, D.; Wu, Y. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur. J. Pharmacol. 2010, 627, 33-41.
14. Kuo, T.C.; Yang, J.S.; Lin, M.W.; Hsu, S.C.; Lin, J.J.; Lin, H.J.; Hsia, T.C.; Liao, C.L.; Yang, M.D.; Fan, M.J.; et al. Emodin has cytotoxic and protective effects in rat C6 glioma cells: Roles of Mdr1a and nuclear factor kappaB in cell survival. J. Pharmacol. Exp. Ther. 2009, 330, 736-744.
15. Hsu, C.M.; Hsu, Y.A.; Tsai, Y.; Shieh, F.K.; Huang, S.H.; Wan, L.; Tsai, F.J. Emodin inhibits the growth of hepatoma cells: Finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells. Biochem. Biophys. Res. Commun. 2010, 392, 473-478.
16. Pelaia, G.; Gallelli, L.; Renda, T.; Fratto, D.; Falcone, D.; Caraglia, M.; Busceti, M.T.; Terracciano, R.; Vatrella, A.; Maselli, R.; et al. Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells. Cell Prolif. 2012, 45, 557-565.
17. Tseng, S.H.; Lin, S.M.; Chen, J.C.; Su, Y.H.; Huang, H.Y.; Chen, C.K.; Lin, P.Y.; Chen Y. Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Clin. Cancer Res. 2004, 10, 2190-2202.
18. Chang, L.; Karin, M. Mammalian MAP kinase signalling cascades. Nature 2001, 410, 37-40.
19. Pearson, G.; Robinson, F.; Gibson, B.T.; Xu, B.E.; Karandikar, M.; Berman, K.; Cobb, M.H. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr. Rev. 2001, 22, 153-183.
20. Xia, Z.; Dickens, M.; Raingeaud, J.; Davis, R.J.; Greenberg, M.E. Opposing effects of ERK and JNK-P38 MAP kinases on apop-tosis. Science 1995, 270, 1326-1331.
21. Enayat, S.; Ceyhan, M.S.; Basaran, A.A.; Gürsel, M.; Banerjee, S. Anticarcinogenic effects of the ethanolic extract of salix aegyptiaca in colon cancer cells: Involvement of Akt/PKB and MAPK pathways. Nutr. Cancer 2013, 65, 1045-1058.
22. Gao, N.; Budhraja, A.; Cheng, S.; Liu, E.H.; Huang, C.; Chen, J.; Yang, Z.; Chen, D.; Zhang, Z.; Shi, X. Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo. Apoptosis 2011, 16, 511-523.
23. Liu, H.; Zhu, Y.; Zhang, T.; Zhao, Z.; Zhao, Y.; Cheng, P.; Li, H.; Gao, H.; Su, X. Anti-tumor effects of atractylenolide I isolated from Atractylodes macrocephala in human lung carcinoma cell lines. Molecules 2013, 18, 13357-13368.
24. Ogata, A.; Mitsui, S.; Yanagie, H.; Kasano, H.; Hisa, T.; Yamase, T.; Eriguchi, M. A novel anti-tumor agent, polyoxomolybdate induces apoptotic cell death in AsPC-1 human pancreatic cancer cells. Biomed. Pharmacother. 2005, 59, 240-244.