A novel anti-tumor agent, polyoxomolybdate induces apoptotic cell death in AsPC-1 human pancreatic cancer cells

Biomedicine and Pharmacotherapy

Volumn 59, Issue 5, 2005, Pages 240-244

  Ogata, A ^a   Mitsui, S ^a   Yanagie, H ^b   Kasano, H ^c   Hisa, T ^b   Yamase, T ^a   Eriguchi, M ^b  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Polytronics Co LTD   (Japan)

Author keywords

Anti tumor; Apoptosis; Polyoxomolybdate

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; DNA FRAGMENT; HOE 33342; PM 8; POLYOXOMOLYBDATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CONTROLLED STUDY; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; NICK END LABELING; PANCREAS CANCER; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA FRAGMENTATION; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; MOLECULAR STRUCTURE; MOLYBDENUM; PANCREATIC NEOPLASMS;

EID: 20444414498     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2004.11.008     Document Type: Article

References (26)

1. S.G. Sarafianos, U. Kortz, M.T. Pope, and M.J. Modak Mechanism of polyoxo metalate-mediated inactivation of DNA polymerases: an analysis with HIV-1 reverse transcriptase indicates specificity for the DNA-binding cleft Biochem. J. 319 1996 619 626
2. 2O on human immunodeficiency virus type 1 Antiviral Res. 20 4 1993 317 331
3. Y. Inoue, Y. Fujimoto, M. Sugiyama, T. Yoshida, and T. Yamase Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity Biol. Pharm. Bull. 18 7 1995 996 1000
4. G.S. Kim, D.A. Judd, C.L. Hill, and R.F. Schinazi Synthesis, characterization, and biological activity of a new potent class of anti-HIV agents, the peroxonibium-substituted heteropolytungstates J. Med. Chem. 37 6 1994 816 820
5. K. Dan, K. Miyashita, Y. Seto, H. Fujita, and T. Yamase Mechanism of the protective effect of heteropolyoxotungstate against herpes simplex virus type 2 Pharmacology 67 2003 83 89
6. K. Dan, K. Miyashita, Y. Seto, H. Fujita, and T. Yamase The memory effect of heteropolyoxotungstate (PM-19) pretreatment on infection by herpes simplex virus at the penetration stage Pharmacol. Res. 46 4 2002 357 362
7. S. Shigeta, S. Mori, J. Watanabe, S. Soeda, K. Takahashi, and T. Yamase Synergistic anti-influenza virus A (H1N1) activity of PM-523 (polyoxometalate) and rebavirin in vitro and in vivo Antimicrob. Agents Chemother. 41 7 1997 1423 1427
8. K. Kimura, K. Ishioka, K. Hashimoto, S. Mori, T. Suzutani, and T.L. Bowlin Isolation and characterization of NMSO3-resistant mutants of respiratory syncytial virus Antiviral Res. 61 3 2004 165 171
9. N. Fukuda, T. Yamase, and Y. Tajima Inhibitory effect of polyoxotungstates on the production of penicillin-binding proteins and beta-lactamase against methicillin-resistant Staphylococcus aureus Biol. Pharm. Bull. 22 5 1999 463 470
10. T. Yamase Polyoxometalates for molecular devices: antitumor activity and luminescence Mol. Eng. 3 1993 241 262
11. T. Yamase Medical chemistry of polyoxometalates. Part 1. Potent antitumor activity of polyoxomolybdates on animal transplantable tumors and human cancer xenograft Inorg. Chim. Acta 151 1988 15 18
12. T. Yamase, and T. Ikawa Photochemical study of the alkylammonium molybdates. III. Preparation and properties Bull. Chem. Soc. Jpn. 50 3 1977 746 749
13. N.W. Roehm, G.H. Rodger, S.M. Hatfield, and A.L. Glasebrook An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT J. Immunol. Methods 142 2 1991 257 265
14. M. Eriguchi, Y. Nonaka, H. Yanagie, I. Yoshizaki, Y. Takeda, and M. Sekiguchi A molecular biological study of anti-tumor mechanisms of an anti-cancer agent Oxaliplatin against established human gastric cancer cell lines Biomed. Pharmacother. 57 2003 412 415
15. Z. Li, D.Y. Hu, Q. Chu, J.H. Wu, C. Gao, and Y.Q. Zhang Cell apoptosis and regeneration of hepatocellular carcinoma after transarterial chemoembolization World J. Gastroenterol. 10 13 2004 1876 1880
16. C. Topham, J. Glees, N.S.B. Rawson, E.M. Woods, and R.C. Coombes Randomised trial of epirubicin alone versus 5-fluorouracil, epirubicin and mitomycin C in locally advanced and metastatic carcinoma of the pancreas Br. J. Cancer 64 1991 179 181
17. D. Kelsen, C. Hudis, D. Niedzwiecki, J. Dougherty, E. Casper, and J. Botet A phase III comparison trial of streptozotocin, mitomycin, and 5-fluorouracil with cisplatin, cytosine, arabinoside, and caffeine in patients with advanced pancreatic carcinoma Cancer 68 1991 965 969
18. P. Rougier, J.J. Zarba, M. Ducreux, M. Basile, J.P. Pignon, and M. Mahjoubi Phase II study of cisplatin and 120-h continuous infusion of 5-fluorouracil in patients with advanced pancreatic adenocarcinoma Ann. Oncol. 4 1993 333 336
19. H. Nose, S. Okada, T. Okusaka, J. Furuse, M. Yoshino, and K. Ogoshi 5-Fluorouracil continuous infusion combined with cisplatin for advanced pancreatic cancer: a Japanese Cooperative Study Hepato-Gastroenterology 46 1999 3244 3248
20. C. Louvet, K. Beerblock, A. De Gramont, C. Varette, B. Demuynck, and M. Bennamoun High-dose folinic acid, 5-fluorouracil bolus and infusion in advanced pancreatic adenocarcinoma: a pilot study Eur. J. Cancer 29A 1993 1217
21. B.H. Weinerman, and R.E. MacCormick A phase II survival comparison of patients with adenocarcinoma of the pancreas treated with 5-fluorouracil and calcium leucovorin versus a matched tumor registry control population Am. J. Clin. Oncol. 17 1994 467 469
22. R. Pazdur, J.J. Ajani, J.L. Abbruzzese, R.J. Belt, S.R. Dakhil, and D. Dubovsky Phase II evaluation of fluorouracil and recombinant α-2a-interferon in previously untreated patients with pancreatic adenocarcinoma Cancer 70 1992 2073 2076
23. H. Bernhard, E. Jager-Anand, G. Bernhard, M. Heike, O. Klein, and J.F. Reimann Treatment of advanced pancreatic cancer with 5-fluorouracil, folinic acid and interferon alpha-2A: results of a phase II trial Br. J. Cancer 71 1995 102 105
24. T. Yamase Medical chemistry of polyoxometalates part 3. Electrochemical study of a 1:1 polyoxomolybdate-flavin mononucleotide complex in aqueous solutions Inorg. Chim. Acta 169 1990 147 150
25. L. Stryer Biochemistry 1975
26. T. Yamase Antitumoral and antiviral polyoxometalates (Inorganic discrete polymers of metal oxide) Polymeric Materials Encyclopedia 1 1996 365 373