Detection of enterovirus in the islet cells of patients with type 1 diabetes: What do we learn from immunohistochemistry?

Diabetologia

Volumn 57, Issue 3, 2014, Pages 645-646

  Hansson, Sara F ^a   Korsgren, Stella ^b   Pontén, Fredrik ^b   Korsgren, Olle ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Enterovirus; Immunohistochemistry; Type 1 diabetes; VP 1

Indexed keywords

CAPSID PROTEIN; MONOCLONAL ANTIBODY; OLIGOPEPTIDE;

ENTEROVIRUS; ENTEROVIRUS INFECTION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METABOLISM; PANCREAS; PROCEDURES;

ANTIBODIES, MONOCLONAL; CAPSID PROTEINS; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS; ENTEROVIRUS INFECTIONS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; OLIGOPEPTIDES; PANCREAS;

EID: 84894580581     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3138-z     Document Type: Letter

References (15)

1. Richardson SJ, Leete P, Dhayal S et al (2013) Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia. doi: 10.1007/s00125-013-3094-7
2. Hansson SF, Korsgren S, Ponten F, Korsgren O (2013) Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins. J Pathol 229:719-728
3. Dako (2003) Specification sheet for clone 5-D8/1, code no. M 7064. Available from www.dako.com/uk/download.pdf?objectid=104286003, accessed 29 November 2013
4. Flodstrom M, Maday A, Balakrishna D, Cleary MM, Yoshimura A, Sarvetnick N (2002) Target cell defense prevents the development of diabetes after viral infection. Nat Immunol 3:373-382
5. Flodstrom-Tullberg M, Hultcrantz M, Stotland A et al (2005) RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection. J Immunol 174:1171-1177
6. Aida K, Nishida Y, Tanaka S et al (2011) RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes. Diabetes 60:884-889
7. Drescher KM, Kono K, Bopegamage S, Carson SD, Tracy S (2004) Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection. Virology 329:381-394
8. Kobayashi T, Nishida Y, Tanaka S, Aida K (2011) Pathological changes in the pancreas of fulminant type 1 diabetes and slowly progressive insulin-dependent diabetes mellitus (SPIDDM): innate immunity in fulminant type 1 diabetes and SPIDDM. Diabetes Metab Res Rev 27:965-970
9. Bopegamage S, Kovacova J, Vargova A et al (2005) Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection. J Gen Virol 86:3271-3280
10. Oikarinen M, Tauriainen S, Honkanen T et al (2008) Analysis of pancreas tissue in a child positive for islet cell antibodies. Diabetologia 51:1796-1802
11. Dotta F, Censini S, van Halteren AG et al (2007) Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A 104:5115-5120
12. Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013) Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia 56:185-193
13. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52:1143-1151
14. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011) Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia 54:2417-2420
15. Roivainen M, Klingel K (2009) Role of enteroviruses in the pathogenesis of type 1 diabetes. Diabetologia 52:995-996