Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation

OncoImmunology

Volumn 2, Issue 12, 2013, Pages

  Madsen, Daniel H ^a   Bugge, Thomas H ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Cathepsin; Collagen endocytosis; Collagenase; Endo180; In vivo imaging; Interstitial collagen degradation; Lysosome; M2 polarized macrophages; Mannose receptor; Matrix metalloproteinase; Mrc1; Mrc2; Tumor invasion; Urokinase plasminogen activator receptor associated protein

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; COLLAGEN; LYSOZYME; MANNOSE RECEPTOR;

ARTICLE; BREAST ADENOCARCINOMA; CANCER GROWTH; CELLULAR DISTRIBUTION; COLLAGEN DEGRADATION; DEGRADATION; ENDOCYTOSIS; ENDOSOME; EXTRACELLULAR MATRIX DEGRADATION; HUMAN; IN VIVO STUDY; M2 POLARIZED MACROPHAGE; MACROPHAGE; MACROPHAGE FUNCTION; NONHUMAN; PANCREAS ADENOCARCINOMA; PROTEIN EXPRESSION; TISSUE REPAIR; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; WOUND HEALING;

EID: 84894569726     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.27127     Document Type: Article

References (10)

1. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8:958-69; PMID:19029990; http://dx.doi.org/10.1038/nri2448
2. Okada A, Bellocq JP, Rouyer N, Chenard MP, Rio MC, Chambon P, Basset P. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci U S A 1995; 92:2730-4; PMID:7708715; http://dx.doi.org/10.1073/pnas.92.7.2730
3. Bugge TH, Behrendt N. Cooperation between proteolysis and endocytosis in collagen turnover. In: Parks WC, Mecham RP, eds. Extracellular matrix degradation. Heidelberg: Springer, 2011:53-74.
4. Rowe RG, Weiss SJ. Navigating ECM barriers at the invasive front: the cancer cell-stroma interface. Annu Rev Cell Dev Biol 2009; 25:567-95; PMID:19575644; http://dx.doi.org/10.1146/annurev.cellbio.24.110707.175315
5. Holmbeck K, Bianco P, Birkedal-Hansen H. MT1-mmp: a collagenase essential for tumor cell invasive growth. Cancer Cell 2003; 4:83-4; PMID:12957281; http://dx.doi.org/10.1016/S1535-6108(03)00196-X
6. Mohamed MM, Sloane BF. Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 2006; 6:764-75; PMID:16990854; http://dx.doi.org/10.1038/nrc1949
7. Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, et al. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol 2013; 202:951-66; PMID:24019537; http://dx.doi.org/10.1083/jcb.201301081
8. Leitinger B, Hohenester E. Mammalian collagen receptors. Matrix Biol 2007; 26:146-55; PMID:17141492; http://dx.doi.org/10.1016/j.matbio.2006.10.007
9. DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009; 16:91-102; PMID:19647220; http://dx.doi.org/10.1016/j.ccr.2009.06.018
10. Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL, Berman T, Joyce JA. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 2010; 24:241-55; PMID:20080943; http://dx.doi.org/10.1101/gad.1874010