Intracellular gene transcription factor protein-guided MRI by DNA aptamers in vivo

FASEB Journal

Volumn 28, Issue 1, 2014, Pages 464-473

  Liu, Christina H ^a,b   Ren, Jiaqian ^a   Liu, Charng Ming ^a   Liu, Philip K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

AP1 knockout; Attention; Monoamine oxidase A; Stress; Transgenic mice

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; AMPHETAMINE; APTAMER; CONTRAST MEDIUM; DNA BINDING PROTEIN; FLUORESCEIN; GOLD NANOPARTICLE; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TRANSCRIPTION FACTOR AP 1; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A;

ANIMAL EXPERIMENT; ARTICLE; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; GENETIC TRANSCRIPTION; IMAGING; IN VIVO STUDY; INTRACELLULAR PROTEIN GUIDED IMAGING; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; AP1 KNOCKOUT; ATTENTION; C57BL MOUSE; CHEMISTRY; METABOLISM; METHODOLOGY; STRESS;

AP1 KNOCKOUT; ATTENTION; MONOAMINE OXIDASE A; STRESS; TRANSGENIC MICE;

ANIMALS; APTAMERS, NUCLEOTIDE; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MONOAMINE OXIDASE;

EID: 84894560878     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-234229     Document Type: Article

References (30)

1. Boxerman, J. L., Hamberg, L. M., Rosen, B. R., and Weisskoff, R. M. (1995) MR contrast due to intravascular magnetic susceptibility perturbations. Magn. Reson. Med. 34, 555-566
2. Sorensen, A. G., Wray, S. H., Weisskoff, R. M., Boxerman, J. L., Davis, T. L., Caramia, F., Kwong, K. K., Stern, C. E., Baker, J. R., Breiter, H., Gazit, I. E., Belliveau, J. W., Brady, T. J., and Rosen, B. R. (1995) Functional MR of brain activity and perfusion in patients with chronic cortical stroke. Am. J. Neuroradiol. 16, 1753-1762
3. Bulte, J. W., Arbab, A. S., Douglas, T., and Frank, J. A. (2004) Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging. Methods Enzymol. 386, 275-299
4. Högemann, D., Josephson, L., Weissleder, R., and Basilion, J. P. (2000) Improvement of MRI probes to allow efficient detection of gene expression. Bioconjug. Chem. 11, 941-946
5. Zimmer, C., Weissleder, R., O'Connor, D., LaPointe, L., Brady, T. J., and Enochs, W. S. (1995) Cerebral iron oxide distribution: in vivo mapping with MR imaging. Radiology 196, 521-527
6. Berman, S. C., Galpoththawela, C., Gilad, A. A., Bulte, J. W., and Walczak, P. (2011) Long-term MR cell tracking of neural stem cells grafted in immunocompetent versus immunodeficient mice reveals distinct differences in contrast between live and dead cells. Magn. Res. Med. 65, 564-574
7. Lind, K., Kresse, M., Debus, N. P., and Müller, R. H. (2002) A novel formulation for superparamagnetic iron oxide (SPIO) particles enhancing MR lymphography: comparison of physicochemical properties and the in vivo behaviour. J. Drug Target. 10, 221-230
8. Ichikawa, T., Högemann, D., Saeki, Y., Tyminski, E., Terada, K., Weissleder, R., Chiocca, E. A., and Basilion, J. P. (2002) MRI of transgene expression: correlation to therapeutic gene expression. Neoplasia 4, 523-530
9. Liu, C. H., Yang, J., Ren, J. Q., Liu, C. M., You, Z., and Liu, P. K. (2013) MRI reveals differential effects of amphetamine exposure on neuroglia in vivo. FASEB J. 27, 712-724
10. Paletzki, R. F., Myakishev, M. V., Polesskaya, O., Orosz, A., Hyman, S. E, and Vinson, C. (2008) Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. Neuroscience 152, 1040-1053
11. Bonovich, M., Olive, M., Reed, E., O'Connell, B., and Vinson, C. (2002) Adenoviral delivery of A-FOS, an AP-1 dominant negative, selectively inhibits drug resistance in two human cancer cell lines. Cancer Gene Ther. 9, 62-70
12. Liu, P. K., Salminen, A., He, Y. Y., Jiang, M. H., Xue, J. J., Liu, J. S., and Hsu, C. Y. (1994) Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA. Ann. Neurol. 36, 566-576
13. Liu, C. H., Kim, Y. R., Ren, J. Q., Eichler, F., Rosen, B. R., and Liu, P. K. (2007) Imaging cerebral gene transcripts in live animals. J. Neurosci. 27, 713-722
14. Wahlestedt, C., Golanov, E., Yamamoto, S., Yee, F., Ericson, H., Yoo, H., Inturrisi, C. E., and Reis, D. J. (1993) Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature 363, 260-263
15. Liu, C. H., Ren, J. Q., Yang, J., Liu, C. M., Mandeville, J. B., Rosen, B. R., Bhide, P. G., Yanagawa, Y., Liu, P. K. (2009) DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains. J. Neurosci. 29, 10663-10670
16. Strome, E. M., Wheler, G. H., Higley, J. D., Loriaux, D. L., Suomi, S. J., and Doudet, D. J. (2002) Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates. Proc. Natl. Acad. Sci. U. S. A. 99, 15749-15754
17. Liu, C. H., You, Z., Ren, J., Kim, Y. R., Eikermann-Haerter, K., and Liu, P. K. (2008) Noninvasive delivery of gene targeting probes to live brains for transcription MRI. FASEB J. 22, 1193-1203
18. Liu, C. H., Ren, J. Q., You, Z., Yang, J., Liu, C. M., Uppal, R., and Liu, P. K. (2012) Noninvasive detection of neural progenitor cells in living brains by MRI. FASEB J. 26, 1652-1662
19. Fitzgerald, M. L., Xavier, R., Haley, K. J., Welti, R., Goss, J. L., Brown, C. E., Zhuang, D. Z., Bell, S. A., Lu, N., McKee, M., Seed, B., and Freeman, M. W. (2007) ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J. Lipid Res. 48, 621-632
20. Liu, C. H., D'Arceuil, H. E., and de Crespigny, A. J. (2004) Direct CSF injection of MnCl(2) for dynamic manganeseenhanced MRI. Magn. Res. Med. 51, 978-987
21. Muldoon, L. L., Nilaver, G., Kroll, R. A., Pagel, M. A., Breakefield, X. O., Chiocca, E. A., Davidson, B. L., Weissleder, R., and Neuwelt, E. A. (1995) Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. Am. J. Pathol. 147, 1840-1851
22. Beltinger, C., Saragovi, H. U., Smith, R. M., LeSauteur, L., Shah, N., DeDionisio, L., Christensen, L., Raible, A., Jarett, L., and Gewirtz, A. M. (1995) Binding, uptake, and intracellular trafficking of phosphorothioate- modified oligodeoxynucleotides. J. Clin. Invest. 95, 1814-1823
23. Zhu, X. M., Wang, Y. X., Leung, K. C., Lee, S. F., Zhao, F., Wang, D. W., Lai, J. M., Wan, C., Cheng, C. H., and Ahuja, A. T. (2012) Enhanced cellular uptake of aminosilane-coated superparamagnetic iron oxide nanoparticles in mammalian cell lines. Int. J. Nanomed. 7, 953-964
24. Liu, C. H., Huang, S., Cui, J., Kim, Y. R., Farrar, C. T., Moskowitz, M. A., Rosen, B. R., and Liu, P. K. (2007) MR contrast probes that trace gene transcripts for cerebral ischemia in live animals. FASEB J. 21, 3004-3015
25. Liu, P. K., Mandeville, J. B., Dai, G., Jenkins, B. G., Kim, Y. R., and Liu, C. H. (2007) Transcription MRI: a new view of the living brain. Neuroscientist 14, 503-520
26. Brody, S.A., Geyer, M. A., and Large, C. H. (2003) Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice. Psychopharmacol. (Berl.) 169, 240-246
27. Zhang, Z., Andersen, A., Grondin, R., Barber, T., Avison, R., Gerhardt, G., and Gash, D. (2001) Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys. Neuroimage 14, 1159-1167
28. Komatsu, T., Trindade, L. S., Chiba, T., Hayashi, H., Henmi, T., Ushiroda, Y., Mori, R., and Shimokawa, I. (2011) Acute stress response modified by modest inhibition of growth hormone axis: a potential machinery of the anti-aging effect of calorie restriction. Mech. Ageing Dev. 132, 103-109
29. Sterrenburg, L., Gaszner, B., Boerrigter, J., Santbergen, L., Bramini, M., Roubos, E. W., Peeters, B. W., and Kozicz, T. (2012) Sex-dependent and differential responses to acute restraint stress of corticotropin-releasing factor-producing neurons in the rat paraventricular nucleus, central amygdala, and bed nucleus of the stria terminalis. J. Neurosci. Res. 90, 179-192
30. Soliman, A., Udemgba, C., Fan, I., Xu, X., Miler, L., Rusjan, P., Houle, S., Wilson, A. A., Pruessner, J., Ou, X. M., and Meyer, J. H. (2012) Convergent effects of acute stress and glucocorticoid exposure upon MAO-A in humans. J. Neurosci. 32, 17120-17127