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Volumn 31, Issue 9, 2014, Pages 2287-2296

A mechanism enhancing macromolecule transport through paracellular spaces induced by poly-L-arginine: Poly-L-arginine induces the internalization of tight junction proteins via clathrin-mediated endocytosis

Author keywords

absorption enhancer; drug delivery; hydrophilic macromolecules; poly L arginine; tight junction

Indexed keywords


EID: 84894550577     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1324-4     Document Type: Article
Times cited : (24)

References (27)
  • 1
    • 0027202375 scopus 로고
    • Altering the blood-brain barrier in the rat by intracarotid infusion of polycations: A comparison between protamine, poly-L-lysine and poly-L-arginine
    • 8237428 1:CAS:528:DyaK2cXls1Sl
    • Westergren I, Johansson BB. Altering the blood-brain barrier in the rat by intracarotid infusion of polycations: a comparison between protamine, poly-L-lysine and poly-L-arginine. Acta Physiol Scand. 1993;149(1):99-104.
    • (1993) Acta Physiol Scand , vol.149 , Issue.1 , pp. 99-104
    • Westergren, I.1    Johansson, B.B.2
  • 2
    • 0345055299 scopus 로고    scopus 로고
    • Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
    • 9685902
    • Kotze AF, Luessen HL, de Leeuw BJ, deBoer AG, Verhoef JC, Junginger HE. Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Control Release. 1998;51(1):35-46.
    • (1998) J Control Release , vol.51 , Issue.1 , pp. 35-46
    • Kotze, A.F.1    Luessen, H.L.2    De Leeuw, B.J.3    Deboer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 3
    • 33750171316 scopus 로고    scopus 로고
    • Histological evaluzation of buccal penetration enhancement properties of chitosan and trimethyl chitosan
    • 17034655 1:CAS:528:DC%2BD2sXksVKmt7c%3D
    • Sandri G, Poggi P, Bonferoni MC, Rossi S, Ferrari F, Caramella C. Histological evaluzation of buccal penetration enhancement properties of chitosan and trimethyl chitosan. J Pharm Pharmacol. 2006;58(10):1327-36.
    • (2006) J Pharm Pharmacol , vol.58 , Issue.10 , pp. 1327-1336
    • Sandri, G.1    Poggi, P.2    Bonferoni, M.C.3    Rossi, S.4    Ferrari, F.5    Caramella, C.6
  • 4
    • 0027285513 scopus 로고
    • Polycation-induced enhancement of epithelial paracellular permeability is independent of tight junctional characteristics
    • 8499468 1:CAS:528:DyaK3sXkt1Ggu70%3D
    • McEwan G, Jepson M, Hirst BH, Simmons NL. Polycation-induced enhancement of epithelial paracellular permeability is independent of tight junctional characteristics. Biochim Biophys Acta. 1993;1148(1):51-60.
    • (1993) Biochim Biophys Acta , vol.1148 , Issue.1 , pp. 51-60
    • McEwan, G.1    Jepson, M.2    Hirst, B.H.3    Simmons, N.L.4
  • 5
    • 0028071051 scopus 로고
    • Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
    • 7816770 1:CAS:528:DyaK2cXls12ltbg%3D
    • Artursson P, Lindmark T, Davis SS, Illum L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res. 1994;11(9):1358-61.
    • (1994) Pharm Res , vol.11 , Issue.9 , pp. 1358-1361
    • Artursson, P.1    Lindmark, T.2    Davis, S.S.3    Illum, L.4
  • 6
    • 0032810369 scopus 로고    scopus 로고
    • Screening of cationic compounds as an absorption enhancer for nasal drug delivery
    • 10425360 1:CAS:528:DyaK1MXks1Cqurw%3D
    • Natsume H, Iwata S, Ohtake K, Miyamoto M, Yamaguchi M, Hosoya K, et al. Screening of cationic compounds as an absorption enhancer for nasal drug delivery. Int J Pharm. 1999;185(1):1-12.
    • (1999) Int J Pharm , vol.185 , Issue.1 , pp. 1-12
    • Natsume, H.1    Iwata, S.2    Ohtake, K.3    Miyamoto, M.4    Yamaguchi, M.5    Hosoya, K.6
  • 7
    • 0344514889 scopus 로고    scopus 로고
    • Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium
    • 14661930 1:CAS:528:DC%2BD3sXptVChur4%3D
    • Ohtake K, Maeno T, Ueda H, Ogihara M, Natsume H, Morimoto Y. Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium. Pharm Res. 2003;20(11):1838-45.
    • (2003) Pharm Res , vol.20 , Issue.11 , pp. 1838-1845
    • Ohtake, K.1    Maeno, T.2    Ueda, H.3    Ogihara, M.4    Natsume, H.5    Morimoto, Y.6
  • 8
    • 0028110309 scopus 로고
    • Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
    • 7798316 1:CAS:528:DyaK2cXmvFOmu7g%3D
    • Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S, et al. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol. 1994;127(6 Pt 1):1617-26.
    • (1994) J Cell Biol , vol.127 , Issue.6 PT 1 , pp. 1617-1626
    • Furuse, M.1    Itoh, M.2    Hirase, T.3    Nagafuchi, A.4    Yonemura, S.5    Tsukita, S.6
  • 9
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • 9647647 1:CAS:528:DyaK1cXksFWjur8%3D 2132999
    • Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998;141(7):1539-50.
    • (1998) J Cell Biol , vol.141 , Issue.7 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 10
    • 0032547833 scopus 로고    scopus 로고
    • A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
    • 9786950 1:CAS:528:DyaK1cXmsl2gtLY%3D 2132845
    • Furuse M, Sasaki H, Fujimono K, Tsukita S. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol. 1998;143(2):391-401.
    • (1998) J Cell Biol , vol.143 , Issue.2 , pp. 391-401
    • Furuse, M.1    Sasaki, H.2    Fujimono, K.3    Tsukita, S.4
  • 12
    • 79957938610 scopus 로고    scopus 로고
    • Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
    • 21415414 1:CAS:528:DC%2BC3MXot1Cnsbo%3D 3119114
    • Al-Sadi R, Khatib K, Guo S, Youssef M, Ma T. Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2011;300(6):G1054-64.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , Issue.6 , pp. 1054-G1064
    • Al-Sadi, R.1    Khatib, K.2    Guo, S.3    Youssef, M.4    Ma, T.5
  • 13
    • 29144533473 scopus 로고    scopus 로고
    • Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    • 16365161 1:CAS:528:DC%2BD2MXhtlequ7fP 2171318
    • Ikenouchi J, Furuse M, Furuse K, Sasaki H, Tsukita S, Tsukita S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol. 2005;171(6):939-45.
    • (2005) J Cell Biol , vol.171 , Issue.6 , pp. 939-945
    • Ikenouchi, J.1    Furuse, M.2    Furuse, K.3    Sasaki, H.4    Tsukita, S.5    Tsukita, S.6
  • 14
    • 84875499547 scopus 로고    scopus 로고
    • Poly-L-arginine-induced internalization of tight junction proteins increases the paracellular permeability of the Caco-2 cell monolayer to hydrophilic macromolecules
    • 23257957 1:CAS:528:DC%2BC3sXntVCltrg%3D
    • Yamaki T, Ohtake K, Ichikawa K, Uchida M, Uchida H, Ohshima S, et al. Poly-L-arginine-induced internalization of tight junction proteins increases the paracellular permeability of the Caco-2 cell monolayer to hydrophilic macromolecules. Biol Pharm Bull. 2013;36(3):432-41.
    • (2013) Biol Pharm Bull , vol.36 , Issue.3 , pp. 432-441
    • Yamaki, T.1    Ohtake, K.2    Ichikawa, K.3    Uchida, M.4    Uchida, H.5    Ohshima, S.6
  • 15
    • 68949129005 scopus 로고    scopus 로고
    • Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability
    • 19478092 1:CAS:528:DC%2BD1MXovFWrtbY%3D 2742868
    • Murakami T, Felinski EA, Antonetti DA. Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem. 2009;284(31):21036-46.
    • (2009) J Biol Chem , vol.284 , Issue.31 , pp. 21036-21046
    • Murakami, T.1    Felinski, E.A.2    Antonetti, D.A.3
  • 16
    • 0347360336 scopus 로고    scopus 로고
    • Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment
    • 14528017 1:CAS:528:DC%2BD2cXlsFSnug%3D%3D 307538
    • Ivanov AL, Nusrat A, Parkos CA. Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell. 2004;15(1):176-88.
    • (2004) Mol Biol Cell , vol.15 , Issue.1 , pp. 176-188
    • Ivanov, A.L.1    Nusrat, A.2    Parkos, C.A.3
  • 17
    • 67650511699 scopus 로고    scopus 로고
    • Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells
    • 19423710 1:CAS:528:DC%2BD1MXotVKnt7o%3D 2707189
    • Stamatovic SM, Keep RF, Wang MM, Jankovic I, Andjelkovic AV. Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J Biol Chem. 2009;284(28):19053-66.
    • (2009) J Biol Chem , vol.284 , Issue.28 , pp. 19053-19066
    • Stamatovic, S.M.1    Keep, R.F.2    Wang, M.M.3    Jankovic, I.4    Andjelkovic, A.V.5
  • 18
    • 20444481707 scopus 로고    scopus 로고
    • Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
    • 1:CAS:528:DC%2BD2MXkvVCrtLk%3D
    • Bruewer M, Utech M, Ivanov AL, Hopkins AM, Parkos CA, Nusrat A. Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB. 2005;19(8):923-33.
    • (2005) FASEB , vol.19 , Issue.8 , pp. 923-933
    • Bruewer, M.1    Utech, M.2    Ivanov, A.L.3    Hopkins, A.M.4    Parkos, C.A.5    Nusrat, A.6
  • 19
    • 0037422066 scopus 로고    scopus 로고
    • Regulated portals of entry into the cell
    • 12621426 1:CAS:528:DC%2BD3sXhs1yit7Y%3D
    • Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature. 2003;422(6927):37-44.
    • (2003) Nature , vol.422 , Issue.6927 , pp. 37-44
    • Conner, S.D.1    Schmid, S.L.2
  • 20
    • 77949313388 scopus 로고    scopus 로고
    • Endocytosis and recycling of tight junction proteins in inflammation
    • 20011071
    • Utech M, Mennigen R, Bruewer M. Endocytosis and recycling of tight junction proteins in inflammation. J Biomed Biotechnol. 2010;2010:484987.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 484987
    • Utech, M.1    Mennigen, R.2    Bruewer, M.3
  • 21
    • 3042805201 scopus 로고    scopus 로고
    • Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism
    • 15200429 1:CAS:528:DC%2BD2cXmtVSitrk%3D
    • Liu J, Kesiry R, Periyasamy SM, Malhotra D, Xie Z, Shapiro JI. Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism. Kidney Int. 2004;66(1):227-41.
    • (2004) Kidney Int , vol.66 , Issue.1 , pp. 227-241
    • Liu, J.1    Kesiry, R.2    Periyasamy, S.M.3    Malhotra, D.4    Xie, Z.5    Shapiro, J.I.6
  • 22
    • 60849098434 scopus 로고    scopus 로고
    • Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
    • 19171760 1:CAS:528:DC%2BD1MXhs1Sjsbw%3D 2654298
    • Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, et al. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol. 2009;184(2):309-22.
    • (2009) J Cell Biol , vol.184 , Issue.2 , pp. 309-322
    • Kim, Y.1    Kugler, M.C.2    Wei, Y.3    Kim, K.K.4    Li, X.5    Brumwell, A.N.6
  • 23
    • 78249264715 scopus 로고    scopus 로고
    • Analysis of the rat skin permeation of hydrophilic compounds using the Renkin function
    • 21048322 1:CAS:528:DC%2BC3cXhs1artrrF
    • Seki T, Kiuchi T, Seto H, Kimura S, Egawa Y, Ueda H, et al. Analysis of the rat skin permeation of hydrophilic compounds using the Renkin function. Biol Pharm Bull. 2010;33(11):1915-8.
    • (2010) Biol Pharm Bull , vol.33 , Issue.11 , pp. 1915-1918
    • Seki, T.1    Kiuchi, T.2    Seto, H.3    Kimura, S.4    Egawa, Y.5    Ueda, H.6
  • 24
    • 34249668828 scopus 로고    scopus 로고
    • Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer
    • 17298946 1:CAS:528:DC%2BD2sXjvFagtLc%3D
    • Seth A, Sheth P, Elias BC, Rao R. Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer. J Biol Chem. 2007;282(15):11487-98.
    • (2007) J Biol Chem , vol.282 , Issue.15 , pp. 11487-11498
    • Seth, A.1    Sheth, P.2    Elias, B.C.3    Rao, R.4
  • 25
    • 0037016669 scopus 로고    scopus 로고
    • The chloride channel CIC-4 co-localizes with cystic fibrosis transmembrane conductance regulator and may mediate chloride flux across the apical membrane of intestinal epithelia
    • 11675385 1:CAS:528:DC%2BD38XjslGntw%3D%3D
    • Mohammad-Panah R, Ackerley C, Rommens J, Choudhury M, Wang Y, Bear CE. The chloride channel CIC-4 co-localizes with cystic fibrosis transmembrane conductance regulator and may mediate chloride flux across the apical membrane of intestinal epithelia. J Biol Chem. 2002;277(1):566-74.
    • (2002) J Biol Chem , vol.277 , Issue.1 , pp. 566-574
    • Mohammad-Panah, R.1    Ackerley, C.2    Rommens, J.3    Choudhury, M.4    Wang, Y.5    Bear, C.E.6
  • 26
    • 33947631511 scopus 로고    scopus 로고
    • IL-1beta causes an increase in intestinal epithelial tight junction permeability
    • 17372023 1:CAS:528:DC%2BD2sXjt1WksLk%3D 3724221
    • Al-Sadi RM, Ma TY. IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol. 2007;178(7):4641-9.
    • (2007) J Immunol , vol.178 , Issue.7 , pp. 4641-4649
    • Al-Sadi, R.M.1    Ma, T.Y.2
  • 27
    • 80053581738 scopus 로고    scopus 로고
    • MicroRNA regulation of intestinal epithelial tight junction permeability
    • 21763238 1:CAS:528:DC%2BC3MXht1Ois73P 3724217
    • Ye D, Guo S, Al-Sadi R, Ma TY. MicroRNA regulation of intestinal epithelial tight junction permeability. Gastroenterology. 2011;141(4):1323-33.
    • (2011) Gastroenterology , vol.141 , Issue.4 , pp. 1323-1333
    • Ye, D.1    Guo, S.2    Al-Sadi, R.3    Ma, T.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.