Polymorphisms of Interleukin-1 Beta and Interleukin-17Alpha Genes Are Associated With Restless Legs Syndrome

Biological Research for Nursing

Volumn 16, Issue 2, 2014, Pages 143-151

  Hennessy, Mary Dawn ^a   Zak, Rochelle S ^b   Gay, Caryl L ^b   Pullinger, Clive R ^b   Lee, Kathryn A ^b   Aouizerat, Bradley E ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

genes; HIV AIDS; inflammation; restless legs syndrome

Indexed keywords

BIOLOGICAL MARKER; IL17A PROTEIN, HUMAN; INTERLEUKIN 17; INTERLEUKIN 1BETA;

ADULT; ARTICLE; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HIV/AIDS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; MALE; METABOLISM; MIDDLE AGED; RESTLESS LEGS SYNDROME;

GENES; HIV/AIDS; INFLAMMATION; RESTLESS LEGS SYNDROME;

ADULT; BIOLOGICAL MARKERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HIV INFECTIONS; HUMANS; INTERLEUKIN-17; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RESTLESS LEGS SYNDROME;

EID: 84894548921     PISSN: 10998004     EISSN: 15524175     Source Type: Journal    
DOI: 10.1177/1099800413478827     Document Type: Article

References (54)

1. Aguilar-Valles A.,Flores C.,Luheshi G. N.Prenatal inflammation-induced hypoferremia alters dopamine function in the adult offspring in rat: Relevance for schizophrenia.PloS One. 2010;5:e10967.
2. Ajioka R. S.,Levy J. E.,Andrews N. C.,Kushner J. P.Regulation of iron absorption in Hfe mutant mice.Blood. 2002;100:1465-1469.
3. Allen R. P.Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome.American Journal of Medicine. 2007;120:S13-S21.
4. Allen R. P.,Walters A. S.,Montplaisir J.,Hening W.,Myers A.,Bell T. J.,Ferini-Strambi L.Restless legs syndrome prevalence and impact: REST general population study.Archives of Internal Medicine. 2005;165:1286-1292.
5. Aouizerat B. E.,Dodd M.,Lee K.,West C.,Paul S. M.,Cooper B. A.Miaskowski C.Preliminary evidence of a genetic association between tumor necrosis factor alpha and the severity of sleep disturbance and morning fatigue.Biological Research for Nursing. 2009;11:27-41.
6. Baynes R. D.Assessment of iron status.Clinical Biochemistry. 1996;29:209-215.
7. Bjorvatn B.,Leissner L.,Ulfberg J.,Gyring J.,Karlsborg M.,Regeur L.Pallesen S.Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries.Sleep Medicine. 2005;6:307-312.
8. Bonati M. T.,Ferini-Strambi L.,Aridon P.,Oldani A.,Zucconi M.,Casari G.Autosomal dominant restless legs syndrome maps on chromosome 14q.Brain: A Journal of Neurology. 2003;126:1485-1492.
9. Cardoso F.HIV-related movement disorders: Epidemiology, pathogenesis and management.CNS Drugs. 2002;16:663-668.
10. Chokroverty S.Sleep disorders medicine: Basic science, technical considerations, and clinical aspects. 2009). Sleep disorders medicine: Basic science, technical considerations, and clinical aspects (3rd ed.). Philadelphia, PA: Saunders/Elsevier.Philadelphia, PA: Saunders/Elsevier; 2009:.
11. Conde L.,Vaquerizas J. M.,Dopazo H.,Arbiza L.,Reumers J.,Rousseau F.Dopazo J.PupaSuite: Finding functional single nucleotide polymorphisms for large-scale genotyping purposes.Nucleic Acids Research. 2006;34:W621-W625.
12. Connor J. R.,Ponnuru P.,Wang X. S.,Patton S. M.,Allen R. P.,Earley C. J.Profile of altered brain iron acquisition in restless legs syndrome.Brain: A Journal of Neurology. 2011;134:959-968.
13. Desautels A.,Turecki G.,Montplaisir J.,Sequeira A.,Verner A.,Rouleau G. A.Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q.American Journal of Human Genetics. 2001;69:1266-1270.
14. di Patti M. C.,Persichini T.,Mazzone V.,Polticelli F.,Colasanti M.,Musci G.Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis.Neuroscience Letters. 2004;363:182-186.
15. Earley C. J.,Kuwabara H.,Wong D. F.,Gamaldo C.,Salas R.,Brasic J.Allen R. P.The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome.Sleep. 2011;34:341-347.
16. Ferguson B. J.,Skikne B. S.,Simpson K. M.,Baynes R. D.,Cook J. D.Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia.Journal of Laboratory Clinical Medicine. 1992;119:385-390.
17. Fulda S.,Stalla G. K.,Wetter T. C.Prevalence of the restless legs syndrome in transsexual patients: The hormonal hypothesis revisited.Journal of Neurology. 2007;254:1748-1749.
18. Gautier-Sauvigne S.,Colas D.,Parmantier P.,Clement P.,Gharib A.,Sarda N.,Cespuglio R.Nitric oxide and sleep.Sleep Medicine Reviews. 2005;9:101-113.
19. Halder I.,Shriver M.,Thomas M.,Fernandez J. R.,Frudakis T.A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: Utility and applications.Human Mutation. 2008;29:648-658.
20. Happe S.,Kundmuller L.,Reichelt D.,Husstedt I. W.,Evers S.Comorbidity of restless legs syndrome and HIV infection.Journal of Neurology. 2007;254:1401-1406.
21. Hening W. A.,Allen R. P.,Earley C. J.,Picchietti D. L.,Silber M. H.An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder.Sleep. 2004;27:560-583.
22. Hervera A.,Negrete R.,Leanez S.,Martin-Campos J. M.,Pol O.Peripheral effects of morphine and expression of mu-opioid receptors in the dorsal root ganglia during neuropathic pain: Nitric oxide signaling.Molecular Pain. 2011;7:25.
23. Hoggart C. J.,Parra E. J.,Shriver M. D.,Bonilla C.,Kittles R. A.,Clayton D. G.,McKeigue P. M.Control of confounding of genetic associations in stratified populations.American Journal of Human Genetics. 2003;72:1492-1504.
24. Kim S. W.,Kim E. S.,Moon C. M.,Park J. J.,Kim T. I.,Kim W. H.,Cheon J. H.Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease.Gut. 2011;60:1527-1536.
25. Kiss J. P.,Zsilla G.,Vizi E. S.Inhibitory effect of nitric oxide on dopamine transporters: Interneuronal communication without receptors.Neurochemistry International. 2004;45:485-489.
26. Knowles R. G.,Moncada S.Nitric oxide synthases in mammals.Biochemical Journal. 1994;298:249-258.
27. Krstic A.,Santibanez J. F.,Okic I.,Mojsilovic S.,Kocic J.,Jovcic G.Bugarski D.Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice.Acta Physiologica. 2010;199:31-41.
28. Lee K. A.,Gay C.,Portillo C. J.,Coggins T.,Davis H.,Pullinger C. R.,Aouizerat B. E.Symptom experience in HIV-infected adults: A function of demographic and clinical characteristics.Journal of Pain and Symptom Management. 2009;38:882-893.
29. Lee K. A.,Zaffke M. E.,Baratte-Beebe K.Restless legs syndrome and sleep disturbance during pregnancy: The role of folate and iron.Journal of Women's Health & Gender-Based Medicine. 2001;10:335-341.
30. Levchenko A.,Provost S.,Montplaisir J. Y.,Xiong L.,St-Onge J.,Thibodeau P.Rouleau G. A.A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13.Neurology. 2006;67:900-901.
31. Machado A.,Herrera A. J.,Venero J. L.,Santiago M.,De Pablos R. M.,Villaran R. F.Cano J.Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in Parkinson's disease incidence.Parkinson's Disease. 2011;2011:393769.
32. Manconi M.,Ferini-Strambi L.,Filippi M.,Bonanni E.,Iudice A.,Murri L.Londrillo F.Multicenter case-control study on restless legs syndrome in multiple sclerosis: The REMS study.Sleep. 2008;31:944-952.
33. Miaskowski C.,Dodd M.,Lee K.,West C.,Paul S. M.,Cooper B. A.Aouizerat B. E.Preliminary evidence of an association between a functional interleukin-6 polymorphism and fatigue and sleep disturbance in oncology patients and their family caregivers.Journal of Pain and Symptom Management. 2010;40:531-544.
34. Milligan S. A.,Chesson A. L.Restless legs syndrome in the older adult: Diagnosis and management.Drugs & Aging. 2002;19:741-751.
35. Nakano K.,Yamaoka K.,Hanami K.,Saito K.,Sasaguri Y.,Yanagihara N.Tanaka Y.Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model.Journal of Immunology. 2011;186:3745-3752.
36. Nemeth E.,Ganz T.Regulation of iron metabolism by hepcidin.Annual Review of Nutrition. 2006;26:323-342.
37. Okada H.,Inoue T.,Hashimoto K.,Suzuki H.,Matsushita S.D1-like receptor antagonist inhibits IL-17 expression and attenuates crescent formation in nephrotoxic serum nephritis.American Journal of Nephrology. 2009;30:274-279.
38. Patrick L. R.Restless legs syndrome: Pathophysiology and the role of iron and folate.Alternative Medicine Review: A Journal of Clinical Therapeutics. 2007;12:101-112.
39. Persichini T.,Maio N.,di Patti M. C.,Rizzo G.,Colasanti M.,Musci G.Interleukin-1beta induces ceruloplasmin and ferroportin-1 gene expression via MAP kinases and C/EBPbeta, AP-1, and NF-kappaB activation.Neuroscience Letters. 2010;484:133-138.
40. Plazzi G.,Ferri R.,Antelmi E.,Bayard S.,Franceschini C.,Cosentino F. I.Dauvilliers Y.Restless legs syndrome is frequent in narcolepsy with cataplexy patients.Sleep. 2010;33:689-694.
41. Price A. L.,Patterson N. J.,Plenge R. M.,Weinblatt M. E.,Shadick N. A.,Reich D.Principal components analysis corrects for stratification in genome-wide association studies.Nature Genetics. 2006;38:904-909.
42. Rothman K. J.No adjustments are needed for multiple comparisons.Epidemiology. 1990;1:43-46.
43. Salih A. M.,Gray R. E.,Mills K. R.,Webley M.A clinical, serological and neurophysiological study of restless legs syndrome in rheumatoid arthritis.British Journal of Rheumatology. 1994;33:60-63.
44. Salmela E.,Lappalainen T.,Fransson I.,Andersen P. M.,Dahlman-Wright K.,Fiebig A.Lahermo P.Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe.PloS One. 2008;3:e3519.
45. Schormair B.,Plag J.,Kaffe M.,Gross N.,Czamara D.,Samtleben W.Winkelmann J.MEIS1 and BTBD9: Genetic association with restless leg syndrome in end stage renal disease.Journal of Medical Genetics. 2011;48:462-466.
46. Siddiqui F.,Strus J.,Sun Y. J.,Walters A. S.No significant difference in cytokine levels in patients with restless legs syndrome versus controls-preliminary data.Sleep Medicine. 2007;8:98-99.
47. Tian C.,Gregersen P. K.,Seldin M. F.Accounting for ancestry: Population substructure and genome-wide association studies.Human Molecular Genetics. 2008;17:R143-R150.
48. Weinstock L. B.,Bosworth B. P.,Scherl E. J.,Li E.,Iroku U.,Munsell M. A.Walters A. S.Crohn's disease is associated with restless legs syndrome.Inflammatory Bowel Diseases. 2010;16:275-279.
49. Weinstock L. B.,Walters A. S.Restless legs syndrome is associated with irritable bowel syndrome and small intestinal bacterial overgrowth.Sleep Medicine. 2011;12:610-613.
50. Weinstock L. B.,Walters A. S.,Mullin G. E.,Duntley S. P.Celiac disease is associated with restless legs syndrome.Digestive Diseases and Sciences. 2010;55:1667-1673.
51. Weinstock L. B.,Walters A. S.,Paueksakon P.Restless legs syndrome-Theoretical roles of inflammatory and immune mechanisms.Sleep Medicine Reviews. 2012;16:341-354.
52. Winkelmann J.,Lichtner P.,Schormair B.,Uhr M.,Hauk S.,Stiasny-Kolster K.Muller-Myhsok B.Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome.Movement Disorders: Official Journal of the Movement Disorder Society. 2008;23:350-358.
53. Winkelmann J.,Muller-Myhsok B.,Wittchen H. U.,Hock B.,Prager M.,Pfister H.Trenkwalder C.Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families.Annals of Neurology. 2002;52:297-302.
54. Winkelmann J.,Schormair B.,Lichtner P.,Ripke S.,Xiong L.,Jalilzadeh S.Meitinger T.Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.Nature Genetics. 2007;39:1000-1006.