Preliminary evidence of an association between a functional interleukin-6 polymorphism and fatigue and sleep disturbance in oncology patients and their family caregivers

Journal of Pain and Symptom Management

Volumn 40, Issue 4, 2010, Pages 531-544

  Miaskowski, Christine ^a   Dodd, Marylin ^a   Lee, Kathryn ^a   West, Claudia ^a   Paul, Steven M ^a   Cooper, Bruce A ^a   Wara, William ^b   Swift, Patrick S ^c   Dunn, Laura B ^b   Aouizerat, Bradley E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Alta Bates Comprehensive Cancer Center   (United States)

Author keywords

cancer; cytokines; family caregiver; Fatigue; genetics; interleukin 6; radiation therapy; sickness behavior; sleep disturbance

Indexed keywords

CYTOKINE; INTERLEUKIN 6;

ADULT; ALLELE; ARTICLE; CANCER PATIENT; CAREGIVER; CONTROLLED STUDY; DISEASE SEVERITY; FAMILY RELATION; FATIGUE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROTEIN POLYMORPHISM; SCORING SYSTEM; SLEEP DISORDER;

AGE FACTORS; AGED; ALLELES; CAREGIVERS; FATIGUE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; INTERLEUKIN-6; LINEAR MODELS; MALE; MIDDLE AGED; NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX; SEX FACTORS; SLEEP DISORDERS;

EID: 77957763039     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2009.12.006     Document Type: Article

References (57)

1. D.P. Lawrence, B. Kupelnick, K. Miller, D. Devine, and J. Lau Evidence report on the occurrence, assessment, and treatment of fatigue in cancer patients J Natl Cancer Inst Monogr 32 2004 40 50
2. B.A. Jereczek-Fossa, H.R. Marsiglia, and R. Orecchia Radiotherapy-related fatigue Crit Rev Oncol Hematol 41 2002 317 325
3. J.T. Hickok, J.A. Roscoe, and G.R. Morrow Frequency, severity, clinical course, and correlates of fatigue in 372 patients during 5 weeks of radiotherapy for cancer Cancer 104 2005 1772 1778
4. J.E. Bower Cancer-related fatigue: links with inflammation in cancer patients and survivors Brain Behav Immun 21 2007 863 871
5. M. Hofman, J.L. Ryan, C.D. Figueroa-Moseley, P. Jean-Pierre, and G.R. Morrow Cancer-related fatigue: the scale of the problem Oncologist 12 Suppl 1 2007 4 10
6. M. Levy Cancer fatigue: a review for psychiatrists Gen Hosp Psychiatry 30 2008 233 244
7. P.C. Stone, and O. Minton Cancer-related fatigue Eur J Cancer 44 2008 1097 1104
8. G. Graci Pathogenesis and management of cancer-related insomnia J Support Oncol 3 2005 349 359
9. K. Lee, M. Cho, C. Miaskowski, and M. Dodd Impaired sleep and rhythms in persons with cancer Sleep Med Rev 8 2004 199 212
10. J. Savard, and C.M. Morin Insomnia in the context of cancer: a review of a neglected problem J Clin Oncol 19 2001 895 908
11. T.S. Lee, S.L. Kilbreath, and K.M. Refshauge Quality of life of women treated with radiotherapy for breast cancer Support Care Cancer 16 2008 399 405
12. M. Reich, A. Lesur, and C. Perdrizet-Chevallier Depression, quality of life and breast cancer: a review of the literature Breast Cancer Res Treat 110 2008 9 17
13. I. Vistad, S.D. Fossa, G.B. Kristensen, and A.A. Dahl Chronic fatigue and its correlates in long-term survivors of cervical cancer treated with radiotherapy BJOG 114 2007 1150 1158
14. B.A. Fletcher, C. Miaskowski, M.J. Dodd, and K.L. Schumacher A review of the literature on the symptom experience of family caregivers of patients with cancer Oncol Nurs Forum 35 2008 E23 E44
15. B.S. Fletcher, S.M. Paul, and M.J. Dodd Prevalence, severity, and impact of symptoms on female family caregivers of patients at the initiation of radiation therapy for prostate cancer J Clin Oncol 26 2008 599 605
16. S. Jensen, and B.A. Given Fatigue affecting family caregivers of cancer patients Cancer Nurs 14 1991 181 187
17. S.D. Passik, and K.L. Kirsh A pilot examination of the impact of cancer patients' fatigue on their spousal caregivers Palliat Support Care 3 2005 273 279
18. P.A. Carter Caregivers' descriptions of sleep changes and depressive symptoms Oncol Nurs Forum 29 2002 1277 1283
19. B.A. Fletcher, K.L. Schumacher, and M. Dodd Trajectories of fatigue in family caregivers of patients undergoing radiation therapy for prostate cancer Res Nurs Health 32 2009 125 139
20. C. Miaskowski, S.M. Paul, and B.A. Cooper Trajectories of fatigue in men with prostate cancer before, during, and after radiation therapy J Pain Symptom Manage 35 2008 632 643
21. E. Calcagni, and I. Elenkov Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases Ann N Y Acad Sci 1069 2006 62 76
22. J.K. Kiecolt-Glaser, K.J. Preacher, and R.C. MacCallum Chronic stress and age-related increases in the proinflammatory cytokine IL-6 Proc Natl Acad Sci U S A 100 2003 9090 9095
23. B.S. McEwen Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators Eur J Pharmacol 583 2008 174 185
24. A. Collado-Hidalgo, J.E. Bower, P.A. Ganz, S.W. Cole, and M.R. Irwin Inflammatory biomarkers for persistent fatigue in breast cancer survivors Clin Cancer Res 12 2006 2759 2766
25. A. Collado-Hidalgo, J.E. Bower, P.A. Ganz, M.R. Irwin, and S.W. Cole Cytokine gene polymorphisms and fatigue in breast cancer survivors: early findings Brain Behav Immun 22 2008 1197 1200
26. B.E. Aouizerat, M. Dodd, and K. Lee Preliminary evidence of a genetic association between tumor necrosis factor alpha and the severity of sleep disturbance and morning fatigue Biol Res Nurs 11 2009 27 41
27. A.J. Smith, F. D'Aiuto, and J. Palmen Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism Clin Chem 54 2008 841 850
28. I. Pantsulaia, S. Trofimov, E. Kobyliansky, and G. Livshits Genetic and environmental influences on IL-6 and TNF-alpha plasma levels in apparently healthy general population Cytokine 19 2002 138 146
29. M. Song, and J.A. Kellum Interleukin-6 Crit Care Med 33 2005 S463 S465
30. O. Olomolaiye, N.A. Wood, and J.L. Bidwell A novel NlaIII polymorphism in the human IL-6 promoter Eur J Immunogenet 25 1998 267
31. C.F. Terry, V. Loukaci, and F.R. Green Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation J Biol Chem 275 2000 18138 18144
32. D.J. Brull, H.E. Montgomery, and J. Sanders Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery Arterioscler Thromb Vasc Biol 21 2001 1458 1463
33. L. Boiardi, B. Casali, and E. Farnetti Relationship between interleukin 6 promoter polymorphism at position -174, IL-6 serum levels, and the risk of relapse/recurrence in polymyalgia rheumatica J Rheumatol 33 2006 703 708
34. G. Ravaglia, P. Forti, and F. Maioli Associations of the -174 G/C interleukin-6 gene promoter polymorphism with serum interleukin 6 and mortality in the elderly Biogerontology 6 2005 415 423
35. J. Walston, D.E. Arking, and D. Fallin IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women Exp Gerontol 40 2005 344 352
36. D. Fishman, G. Faulds, and R. Jeffery The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis J Clin Invest 102 1998 1369 1376
37. A. Malarstig, L. Wallentin, and A. Siegbahn Genetic variation in the interleukin-6 gene in relation to risk and outcomes in acute coronary syndrome Thromb Res 119 2007 467 473
38. D. Karnofsky, W.H. Abelmann, L.V. Craver, and J.H. Burchenal The use of nitrogen mustards in the palliative treatment of carcinoma Cancer 1 1948 634 656
39. K.A. Lee, and J.F. DeJoseph Sleep disturbances, vitality, and fatigue among a select group of employed childbearing women Birth 19 1992 208 213
40. K.A. Lee, C.J. Portillo, and H. Miramontes The influence of sleep and activity patterns on fatigue in women with HIV/AIDS J Assoc Nurses AIDS Care 12 Suppl 2001 19 27
41. K.A. Lee Self-reported sleep disturbances in employed women Sleep 15 1992 493 498
42. K.A. Lee, G. Hicks, and G. Nino-Murcia Validity and reliability of a scale to assess fatigue Psychiatry Res 36 1991 291 298
43. S. Raudenbush, and A. Bryk Hierarchical linear models: Applications and data analysis methods 2nd. ed 2002 Sage Publications Thousand Oaks, CA
44. S. Raudenbush, A. Bryk, Y.F. Cheong, and R. Congdon HLM6: Hierarchical linear and nonlinear modeling 2004 Scientific Software International, Inc. Lincolnwood, IL
45. I. Gomes, A. Collins, and C. Lonjou Hardy-Weinberg quality control Ann Hum Genet 63 1999 535 538
46. K.J. Rothman No adjustments are needed for multiple comparisons Epidemiology 1 1990 43 46
47. R. Dantzer, L. Capuron, and M.R. Irwin Identification and treatment of symptoms associated with inflammation in medically ill patients Psychoneuroendocrinology 33 2008 18 29
48. R. Dantzer, and K.W. Kelley Twenty years of research on cytokine-induced sickness behavior Brain Behav Immun 21 2007 153 160
49. D. Osoba Interpreting the meaningfulness of changes in health-related quality of life scores: lessons from studies in adults Int J Cancer Suppl 12 1999 132 137
50. J.A. Sloan, and A. Dueck Issues for statisticians in conducting analyses and translating results for quality of life end points in clinical trials J Biopharm Stat 14 2004 73 96
51. C. Miaskowski, B.A. Cooper, and S.M. Paul Subgroups of patients with cancer with different symptom experiences and quality-of-life outcomes: a cluster analysis Oncol Nurs Forum 33 2006 E79 E89
52. D. Pud, S. Ben Ami, and B.A. Cooper The symptom experience of oncology outpatients has a different impact on quality-of-life outcomes J Pain Symptom Manage 35 2008 162 170
53. C. Miaskowski Gender differences in pain, fatigue, and depression in patients with cancer J Natl Cancer Inst Monogr 32 2004 139 143
54. P. Servaes, C. Verhagen, and G. Bleijenberg Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions Eur J Cancer 38 2002 27 43
55. J.E. Gaugler, W.C. Given, and J. Linder Work, gender, and stress in family cancer caregiving Support Care Cancer 16 2008 347 357
56. T. Akechi, A. Kugaya, H. Okamura, S. Yamawaki, and Y. Uchitomi Fatigue and its associated factors in ambulatory cancer patients: a preliminary study J Pain Symptom Manage 17 1999 42 48
57. A.F. Husain, K. Stewart, and R. Arseneault Women experience higher levels of fatigue than men at the end of life: a longitudinal home palliative care study J Pain Symptom Manage 33 2007 389 397