Fluorescence-guided surgery of malignant gliomas based on 5-aminolevulinic acid: Paradigm shifts but not a panacea

Nature Reviews Cancer

Volumn 14, Issue 2, 2014, Pages 146-

  Moiyadi, Aliasgar ^a   Syed, Parvez ^b   Srivastava, Sanjeeva ^b  

^a TATA MEMORIAL HOSPITAL   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HUMANS; MOLECULAR IMAGING; NEOPLASM, RESIDUAL; NEOPLASMS; OPTICAL IMAGING;

EID: 84894538840     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3566-c1     Document Type: Letter

References (8)

1. Nguyen, Q. T. & Tsien, R. Y. Fluorescence-guided surgery with live molecular navigation-a new cutting edge. Nature Rev. Cancer 13, 653-662 (2013).
2. Stummer, W. et al. Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients. J. Neurosurg. 93, 1003-1013 (2000).
3. Stummer, W. et al. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 7, 392-401 (2006).
4. Colditz, M. J., Leyen, K. & Jeffree, R. L. Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. J. Clin. Neurosci. 19, 1611-1616 (2012).
5. Rodriguez, L. et al. Study of the mechanisms of uptake of 5-aminolevulinic acid derivatives by PEPT1 and PEPT2 transporters as a tool to improve photodynamic therapy of tumours. Int. J. Biochem. Cell Biol. 38, 1530-1539 (2006).
6. Xiang, J. et al. PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 1122, 18-23 (2006).
7. Sanai, N. et al. Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas. J. Neurosurg. 115, 740-748 (2011).
8. Nabavi, A. et al. Five-aminolevulinic acid for fluorescence-guided resection of recurrent malignant gliomas: a phase II study. Neurosurgery 65, 1070-1076 (2009).