Predicting nonlinear pharmacokinetics of omeprazole enantiomers and racemic drug using physiologically based pharmacokinetic modeling and simulation: Application to predict drug/genetic interactions

Pharmaceutical Research

Volumn 31, Issue 8, 2014, Pages 1919-1929

  Wu, Fang ^a   Gaohua, Lu ^b   Zhao, Ping ^a   Jamei, Masoud ^b   Huang, Shiew Mei ^a   Bashaw, Edward D ^a   Lee, Sue Chih ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CERTARA UK LIMITED   (United Kingdom)

Author keywords

esomeprazole; nonlinear pharmacokinetics; omeprazole; physiologically based pharmacokinetic (PBPK) model; racemic drug

Indexed keywords

CYP2C19 PROTEIN, HUMAN; CYTOCHROME P450 2C19; OMEPRAZOLE;

CHEMISTRY; DRUG DESIGN; FORECASTING; HUMAN; METABOLISM; NONLINEAR SYSTEM; PHARMACOGENETICS; PROCEDURES; STEREOISOMERISM;

CYTOCHROME P-450 CYP2C19; DRUG DESIGN; FORECASTING; HUMANS; NONLINEAR DYNAMICS; OMEPRAZOLE; PHARMACOGENETICS; STEREOISOMERISM;

EID: 84894526589     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1293-z     Document Type: Article

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