Effects of duramycin on cardiac voltage-gated ion channels

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 377, Issue 1, 2008, Pages 87-100

  Zebedin, Eva ^a   Koenig, Xaver ^a   Radenkovic, Miroslav ^a   Pankevych, Halyna ^a   Todt, Hannes ^a   Freissmuth, Michael ^a   Hilber, Karlheinz ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cardiac arrhythmias; Cystic fibrosis; Drug induced QT prolongation; Duramycin; Voltage gated ion channels

Indexed keywords

CALCIUM CHANNEL; DURAMYCIN; ION CHANNEL; PEPTIDE; POTASSIUM CHANNEL HERG; SODIUM CHANNEL;

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; CELL MEMBRANE; CHANNEL GATING; CLINICAL ARTICLE; CONCENTRATION RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG PROTEIN BINDING; EMBRYO; HEART ARRHYTHMIA; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; KINETICS; MOUSE; NEWBORN; NONHUMAN; PATCH CLAMP; PROTEIN FUNCTION; SODIUM CURRENT;

ANIMALS; ANIMALS, NEWBORN; ANTI-BACTERIAL AGENTS; BACTERIOCINS; CALCIUM CHANNELS; CELL LINE, TUMOR; CYSTIC FIBROSIS; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MICE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PEPTIDES; SODIUM CHANNELS; TRANSFECTION;

EID: 39149133628     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-007-0248-5     Document Type: Article

References (40)

1. Burnashev NA, Undrovinas AI, Fleidervish IA, Makielski JC, Rosenshtraukh LV (1991) Modulation of cardiac sodium channel gating by lysophosphatidylcholine. J Mol Cell Cardiol 1(23 Suppl):23-30
2. Burnashev NA, Undrovinas AI, Fleidervish IA, Rosenshtraukh LV (1989) Ischemic poison lysophosphatidylcholine modifies heart sodium channels gating inducing long-lasting bursts of openings. Pflugers Arch 415:124-126
3. Clarkson CW, Ten Eick RE (1983) On the mechanism of lysophosphatidylcholine-induced depolarization of cat ventricular myocardium. Circ Res 52:543-556
4. Cloutier MM, Guernsey L, Mattes P, Koeppen B (1990) Duramycin enhances chloride secretion in airway epithelium. Am J Physiol 259:C450-C454
5. Cloutier MM, Guernsey L, Sha 'afi RI (1993) Duramycin increases intracellular calcium in airway epithelium. Membr Biochem 10:107-118
6. DaTorre SD, Creer MH, Pogwizd SM, Corr PB (1991) Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart. J Mol Cell Cardiol 1(23 Suppl):11-22
7. De Paola AA, Horowitz LN, Morganroth J, Senior S, Spielman SR, Greenspan AM, Kay HR (1987) Influence of left ventricular dysfunction on flecainide therapy. J Am Coll Cardiol 9:163-168
8. Denac H, Mevissen M, Scholtysik G (2000) Structure, function and pharmacology of voltage-gated sodium channels. Naunyn-Schmiedeberg's Arch Pharmacol 362:453-479
9. Gilmour RF Jr, Zipes DP (1985) Slow inward current and cardiac arrhythmias. Am J Cardiol 55:89B-101B
10. Grasemann H, Stehling F, Brunar H, Widmann R, Laliberte TW, Molina L, Doring G, Ratjen F (2007) Inhalation of Moli1901 in patients with cystic fibrosis. Chest 131:1461-1466
11. Herre JM, Titus C, Oeff M, Eldar M, Franz MR, Griffin JC, Scheinman MM (1990) Inefficacy and proarrhythmic effects of flecainide and encainide for sustained ventricular tachycardia and ventricular fibrillation. Ann Intern Med 113:671-676
12. Hirsh JK, Quandt FN (1996) Down-regulation of Na channel expression by A23187 in N1E-115 Neuroblastoma Cells. Brain Res 706:343-346
13. Hoffman BF, Rosen MR (1981) Cellular mechanisms for cardiac arrhythmias. Circ Res 49:1-15
14. Iwamoto K, Hayakawa T, Murate M, Makino A, Ito K, Fujisawa T, Kobayashi T (2007) Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin. Biophys J 93:1608-1619
15. Kannankeril PJ, Roden DM (2007) Drug-induced long QT and torsade de pointes: recent advances. Curr Opin Cardiol 22:39-43
16. Kester MB, Sokolove PM (1990) The effect of adriamycin and duramycin on calcium translocation in liposome systems modeled on the inner mitochondrial membrane. Arch Biochem Biophys 280:405-411
17. Kirsch GE, Trepakova ES, Brimecombe JC, Sidach SS, Erickson HD, Kochan MC, Shyjka LM, Lacerda AE, Brown AM (2004) Variability in the measurement of HERG potassium channel inhibition: effects of temperature and stimulus pattern. J Pharmacol Toxicol Methods 50:93-101
18. Marki F, Hanni E, Fredenhagen A, van Oostrum J (1991) Mode of action of the lanthionine-containing peptide antibiotics duramycin, duramycin B and C, and cinnamycin as indirect inhibitors of phospholipase A2. Biochem Pharmacol 42:2027-2035
19. McNulty MJ, Hutabarat RH, Findlay JW, Devereux K, Knick VC, Harvey RJ, Molina L (2003) Pharmacokinetics and tissue distribution of the nonadecapeptide Moli1901 in rats and mice. Xenobiotica 33:197-210
20. Minardo JD, Heger JJ, Miles WM, Zipes DP, Prystowsky EN (1988) Clinical characteristics of patients with ventricular fibrillation during antiarrhythmic drug therapy. N Engl J Med 319:257-262
21. Navarro J, Chabot J, Sherrill K, Aneja R, Zahler SA, Racker E (1985) Interaction of duramycin with artificial and natural membranes. Biochemistry 24:4645-4650
22. Nuss HB, Marban E (1994) Electrophysiological properties of neonatal mouse cardiac myocytes in primary culture. J Physiol 479.2:265-279
23. Ratjen F, Doring G (2003) Cystic fibrosis. Lancet 361:681-689
24. Reuter H (1979) Properties of two inward membrane currents in the heart. Annu Rev Physiol 41:413-424
25. Roberts M, Hladky SB, Pickles RJ, Cuthbert AW (1991) Stimulation of sodium transport by duramycin in cultured human colonic epithelia. J Pharmacol Exp Ther 259:1050-1058
26. Rosen MR, Wit AL (1987) Arrhythmogenic actions of antiarrhythmic drugs. Am J Cardiol 59:10E-18E
27. Sato T, Kiyosue T, Arita M (1992) Inhibitory effects of palmitoylcarnitine and lysophosphatidylcholine on the sodium current of cardiac ventricular cells. Pflugers Arch 420:94-100
28. Sato T, Arita M, Kiyosue T (1993) Differential mechanism of block of palmitoyl lysophosphatidylcholine and of palmitoylcarnitine on inward rectifier K+ channels of guinea-pig ventricular myocytes. Cardiovasc Drugs Ther 7(Suppl 3):575-584
29. Schlepper M (1989) Cardiodepressive effects of antiarrhythmic drugs. Eur Heart J 10(Suppl E):73-80
30. Shander GS, Undrovinas AI, Makielski JC (1996) Rapid onset of lysophosphatidylcholine-induced modification of whole cell cardiac sodium current kinetics. J Mol Cell Cardiol 28:743-753
31. Sheth TR, Henderson RM, Hladky SB, Cuthbert AW (1992) Ion channel formation by duramycin. Biochim Biophys Acta 1107:179-185
32. Stork D, Timin EN, Berjukow S, Huber C, Hohaus A, Auer M, Hering S (2007) State dependent dissociation of HERG channel inhibitors. Br J Pharmacol 151:1368-1376
33. Tillman TS, Cascio M (2003) Effects of membrane lipids on ion channel structure and function. Cell Biochem Biophys 38:161-190
34. Undrovinas AI, Fleidervish IA, Makielski JC (1992) Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine. Circ Res 71:1231-1241
35. Vandenberg JI, Walker BD, Campbell TJ (2001) HERG K+ channels: friend and foe. Trends Pharmacol Sci 22:240-246
36. Wu J, Corr PB (1992) Influence of long-chain acylcarnitines on voltage-dependent calcium current in adult ventricular myocytes. Am J Physiol 263:H410-H417
37. Zebedin E, Sandtner W, Galler S, Szendroedi J, Just H, Todt H, Hilber K (2004) Fiber type conversion alters inactivation of voltage-dependent sodium currents in mouse C2C12 skeletal muscle cells. Am J Physiol Cell Physiol 287:C270-C280
38. Zebedin E, Mille M, Speiser M, Zarrabi T, Sandtner W, Latzenhofer B, Todt H, Hilber K (2007) C2C12 Skeletal muscle cells adopt cardiac-like sodium current properties in a cardiac cell environment. Am J Physiol Heart Circ Physiol 292:H439-H450
39. Zeitlin PL, Boyle MP, Guggino WB, Molina L (2004) A Phase I trial of intranasal Moli1901 for cystic fibrosis. Chest 125:143-149
40. Zimmermann N, Freund S, Fredenhagen A, Jung G (1993) Solution structures of the lantibiotics duramycin B and C. Eur J Biochem 216:419-428