Individual and contextual factors influencing patient attrition from antiretroviral therapy care in an urban community of Lusaka, Zambia

Journal of the International AIDS Society

Volumn 15, Issue , 2012, Pages

  Musheke, Maurice ^a,b,c   Bond, Virginia ^a,d   Merten, Sonja ^b,c  

^a UNIVERSITY OF ZAMBIA   (Zambia)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Antiretroviral therapy; Attrition; Faith healing; Herbal remedies; PLHIV; Zambia

Indexed keywords

EID: 84894486143     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.15.3.17366     Document Type: Article

References (53)

1. Egger M, May M, Chene G, Phillip AN, Ledergerber B, Dabis F, et al. Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet. 2002;360: 119-29.
2. Ivers LC, Kendrick D, Doucette K. Efficacy of antiretroviral therapy programs in resource-poor settings: a meta-analysis of the published literature. Clin Infect Dis. 2005;41:217-24.
3. Coetzee D, Hildebrand K, Boulle A, Maartens G, Louis F, Labatala V, et al. Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. AIDS. 2004;18:887-95.
4. Laurent C, Ngom Gueye NF, Ndour CT, Gueye PM, Diof M, Diakhate N, et al. Long-term benefits of highly active antiretroviral therapy in Senegalese HIV-1- infected adults. J Acquir Immune Defic Syndr. 2005;38:14-7.
5. Hammond R, Harry TC. Efficacy of antiretroviral therapy in Africa: effect on immunological and virological outcome measures: a meta-analysis. Int J STD AIDS. 2008;19:291-6.
6. Joint United Nations Programme on HIV/AIDS. Global report: UNAIDS report on the global AIDS epidemic 2010. Geneva: UNAIDS; 2010.
7. Fox MP, Rosen S. Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: systematic review. Trop Med Int Health. 2010;15 Suppl 1:1-15.
8. Rosen S, Fox MP, Gill CJ. Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Med. 2007;4:e298.
9. Tassie JM, Baijal P, Vitoria MA, Alisalad A, Crowley SP, Souteyrand Y, et al. Trends in retention on antiretroviral therapy in national programs in lowincome and middle-income countries. J Acquir Immune Defic Syndr. 2010;54:437-41.
10. Babb DA, Pemba L, Seatlanyane P. Use of traditional medicine by HIVinfected individuals in South Africa in the era of antiretroviral therapy. Psychol Health Med. 2007;12(3):314-20.
11. Dahab M, Salome Charalambous S, Hamilton R. That is why I stopped the ART'': Patients' & providers' perspectives on barriers to and enablers of HIV treatment adherence in a South African workplace programme. BMC Public Health. 2008;8:63.
12. Unge C, Ragnarsson A, Ekström AM, Indalo D, Belita A, Carter J, et al. The influence of traditional medicine and religion on discontinuation of ART in an urban informal settlement in Nairobi, Kenya. AIDS Care. 2011;23(7):851-8.
13. Miller CM, Ketlhapile M, Rybasack-Smith H. Why are antiretroviral treatment patients lost to follow-up? A qualitative study from South Africa. Trop Med Int Health. 2010;15(Suppl 1):48-54.
14. Roura M, Nsigaye R, Nhandi B, Wamoyi J, Busza J, Urassa M, et al. ''Driving the devil away'': qualitative insights into miraculous cures for AIDS in a rural Tanzanian ward. BMC Public Health. 2010;10:427.
15. Wanyama J, Castelnuovo B, Wandera B, Mwebaze P, Kambungu A, Bangsberg DR, et al. Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda. AIDS. 2007;21(11):1486-7.
16. Ministry of Health/National AIDS Council. Zambia Country Report. Multisectoral AIDS response monitoring and evaluation biennial report for 2008- 2009. Submitted to the United Nations General Assembly Special Session on AIDS. Lusaka: MoH/NAC; 2010.
17. Central Statistics Office (CSO), Ministry of Health (MoH), Tropical Disease Research Centre (TDRC), University of Zambia, and Macro International Inc: Zambia Demographic and Health Survey 2007. Calverton, Maryland, USA: CSO and Macro International Inc; 2009.
18. Reid S, Mulenga LB, Folk WR. Abandonment of antiretroviral therapy: a potential barrier to scale-up in sub-Saharan Africa. S Afr Med J. 2008; 98(6):448-450.
19. Grant E, Logie D, Masura M, Gorman D, Murray SA. Factors facilitating and challenging access and adherence to antiretroviral therapy in a township in the Zambian Copperbelt: a qualitative study. AIDS Care. 2008;20(10):1155-60.
20. Murray LK, Semrau K, McCauley E, Thea DM, Scott N, Mwiya M, et al. Barriers to acceptance and adherence of antiretroviral therapy in urban Zambian women: a qualitative study. AIDS Care. 2009;21(1):78-86.
21. Joint United Nations Programme on HIV/AIDS. Sexual behavioural change for HIV: where have the theories taken us? Geneva: UNAIDS; 1999.
22. Mackian S, Bedri N, Lovel H. Up the garden path and over the edge: where might health-seeking behaviour take us? Health Policy Plan. 2004;19(3): 137-46.
23. Roura M, Busza J, Wringe A, Mbata D, Urassa M, Zaba B. Barriers to sustaining antiretroviral treatment in Kisesa, Tanzania: a follow up study to understand attrition from antiretroviral programme. AIDS Patient Care STDS. 2009;23(3):203-10.
24. Stokols D. Translating social ecology theory into guidelines for community health promotion. Am J Health Promot. 1996;10(4):282-93.
25. Choi K, Yep G, Kumekawa E. HIV prevention among Asian and Pacific Islander American men who have sex with men: a critical review of theoretical models and directions for future research. AIDS Educ Prev. 1998;10 Suppl A (1):19-30.
26. Ulin PR, Robinson ET, Tolley EE. Qualitative methods in public health: a field guide for applied research. San Francisco: Jossy-Bass; 2005.
27. Latkin CA, Kowlton AR. Micro-social structural approaches to HIV prevention: a social ecological perspective. AIDS Care. 2005;17:S102-13.
28. Duff P, Kipp W, Wild TC, Rubaale T, Okech-Ojony J. Barriers to accessing highly active antiretroviral therapy by HIV-positive women attending an antenatal clinic in a regional hospital in western Uganda. J Int AIDS Soc. 2010;13:37.
29. Munro SA, Lewin SA, Smith HJ, Engel ME, Fretheim A, Volmink J. Patient adherence to Tuberculosis treatment: a systematic review of qualitative findings. PloS Med. 2007;4(7):238.
30. Parker RG, Easton D, Klein CH. Structural barriers and facilitators in HIV prevention: a review of international research. AIDS. 2000;14(Suppl 1):S22-32.
31. McLeroy KN, Bibeau D, Steckler A, Glanz K. An ecological perspective on health promotion programme. Health Educ Q. 1988;15(4):351-77.
32. Sumartojo E. Structural factors in HIV prevention: concepts, examples and implications for research. AIDS. 2000;14(Suppl 1):S3-10.
33. Ministry of Health. Adult and adolescent antiretroviral therapy protocols. 2nd ed. Lusaka: Ministry of Health; 2010.
34. Graneheim UH, Lundman B. Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. Nurse Educ Today. 2004;24:105-12.
35. Siegel K, Schrimshaw EW, Dean L. Symptom interpretation and medication adherence among late middle-age and older HIV-infected adults. J Health Psychol. 1999;4(2):247-57.
36. Lumme-Sandt K, Hervonen A, Jylha M. Interpretative repertoires of medication among the oldest-old. Soc Sci Med. 2000;50:1843-50.
37. Siegel K, Gorey E. HIV-infected women: barriers to AZT use. Soc Sci Med. 1997;45(1):15-22.
38. Stevens PE, Hilderbrandt E. Pill taking from the perspective of HIV-infected women who are vulnerable to antiretroviral treatment failure. Qual Health Res. 2009;19(5):593-604.
39. Wong WKT, Ussher J. How do subjectively constructed meanings ascribed to anti-HIV treatments affect treatment-adherent practice? Qual Health Res. 2008;18:458-68.
40. Wong WK, Ussher JM. Life with HIV and AIDS in the era of effective treatments: 'It's not just about living longer!. Soc Theory Health. 2008;6:117-31.
41. Orrell C, Bansberg DR, Badri M, Wood R. Adherence is not a barrier to successful antiretroviral therapy in South Africa. AIDS. 2003;17:1369-75.
42. Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America. J Am Med Assoc. 2006;296:679-90.
43. Merten S, Kenter E, MacKenzie O, Musheke M, Ntalasha H, Martin-Hilber A. Patient reported barriers and drivers of adherence to antiretrovirals in sub- Saharan Africa: a Meta-ethnography. Trop Med Int Health. 2010;15(Suppl 1):16-33.
44. Reda AA, Biadgilign S. Determinants of adherence to antiretroviral therapy among HIV-infected patients in Africa. AIDS Res Treat. 2012; Article ID 574656, 8 pages 2012. doi:10.1155/2012/574656.
45. United National Development Programme. Human Development Report: sustainability and equity: a better future for all. New York: UNDP; 2011.
46. Republic of Zambia. Fifth National Development Plan (2006-2010). Lusaka: Republic of Zambia; 2006.
47. Republic of Zambia. Sixth National Development Plan (2011-2015). Lusaka: Republic of Zambia; 2011.
48. Muchedzi A, Chandisarewa W, Keatinge J, Stranix-Chibanda L, Woelk G, Mbizvo E, et al. Factors associated with access to HIV care and treatment in a prevention of mother to child transmission programme in urban Zimbabwe. J Int AIDS Soc. 2010;13:38.
49. Mutale C, Bond VA. Barriers and outcomes: TB patients co-infected with HIV accessing antiretroviral therapy in rural Zambia. AIDS Care. 2010; 22(Suppl 1):51-9.
50. Tugenberg T, Ware NC, Wyatt MA. Paradoxical effects of clinician emphasis on adherence to combination antiretroviral therapy for HIV/AIDS. AIDS Patient Care STDS. 2006;20(4):269-74.
51. Tocco JU. Every disease has its cure': faith and HIV therapies in Islamic northern Nigeria. Afr J AIDS Res. 2010;9(4):385-95.
52. Berhanu Z. Holy water as an intervention for HIV/AIDS in Ethiopia. J HIV/AIDS Soc Sci. 2010;9:240-60.
53. Banda Y, Chapman V, Goldenberg RL, Stringer JS, Culhane JF, Sinkala M, et al. Use of traditional medicine among pregnant women in Lusaka, Zambia. J Altern Complement Med. 2007;13(1):123-7.