Protein Kinase Profiling in Miscarriage: Implications for the Pathogenesis of Trisomic Pregnancy

Journal of Obstetrics and Gynaecology Canada

Volumn 34, Issue 12, 2012, Pages 1141-1148

  Yong, Paul J ^a,b   McFadden, Deborah E ^a,b   Robinson, Wendy P ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Expression profiling; Miscarriage; Protein kinase; Trisomy

Indexed keywords

CASEIN KINASE IEPSILON; CYCLIC GMP DEPENDENT PROTEIN KINASE 1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE 9; DNA DEPENDENT PROTEIN KINASE; I KAPPA B KINASE ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN KINASE; PROTEIN KINASE C BETA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ZETA; PROTEIN TYROSINE KINASE; S6 KINASE;

ARTICLE; CHORION VILLUS; CHROMOSOME 16; CONTROLLED STUDY; FIRST TRIMESTER PREGNANCY; GENE DOSAGE; GENETIC VARIATION; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEX; SPONTANEOUS ABORTION; TRISOMY; TRISOMY 15; TRISOMY 16; WESTERN BLOTTING; CHROMOSOME 15; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENETICS; MOSAICISM; PATHOLOGY; PHYSIOLOGY; PREGNANCY;

ABORTION, SPONTANEOUS; CHORIONIC VILLI; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 16; FEMALE; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION PROFILING; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MOSAICISM; PREGNANCY; PROTEIN KINASES; TRISOMY;

EID: 84894482138     PISSN: 17012163     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1701-2163(16)35461-5     Document Type: Article

References (38)

1. Yusuf R.Z., Naeem R. Cytogenetic abnormalities in products of conception: a relationship revisited. Am J Reprod Immunol 2004, 52:88-96.
2. Yong P.J., Langlois S., von Dadelszen P., Robinson W.P. The association between preeclampsia and placental trisomy 16 mosaicism. Prenat Diagn 2006, 26:956-961.
3. Epstein C.J. The consequences of chromosome imbalance. Am J Med Genet Suppl 1990, 7:31-37.
4. Vilardell M., Rasche A., Thormann A., Maschke-Dutz M., Perez-Jurado L.A., Lehrach H., et al. Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes. BMC Genomics 2011, 12:229. Available at:, Accessed November 2, 2012. http://www.biomedcentral.com/1471-2164/12/229.
5. Shapiro B.L. Down Syndrome-a disruption of hemostasis. Am J Med Genet 1983, 14:241-269.
6. Pritchard M.A., Kola I. The "gene dosage effect" hypothesis versus the "amplified developmental instability" hypothesis in Down Syndrome. J Neural Transm Suppl 1999, 25:293-303.
7. Katznelson M.B., Bejerano M., Yakovenko K., Kobyliansky E. Relationship between genetic anomalies of different levels and deviations in dermatoglyphic traits. Part 4: Dermatoglyphic peculiarities of males and females with Down Syndrome. Family Study. Anthropol Anz 1999, 57:193-255.
8. Reeves R.H., Baxter L.L., Richtsmeier J.T. Too much of a good thing: mechanisms of gene action in Down Syndrome. Trends Genet 2001, 17:83-88.
9. Caniggia I, Taylor CV, Ritchie JW, Lye SJ, Letarte M. Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explants. Endocrinology 138:4977-88.
10. Yong P.J., McFadden D.E., Robinson W.P. Developmental origin of chorionic villus cultures from spontaneous abortion and chorionic villus sampling. J Obstet Gynaecol Can 2011, 33:449-452.
11. Robinson W.P., Barrett I.J., Bernard L., Telenius A., Bernasconi F., Wilson R.D., et al. Meiotic origin of trisomy in confined placental mosaicism is correlated with presence of fetal uniparental disomy, high levels of trisomy in trophoblast, and increased risk of fetal intrauterine growth restriction. Am J Hum Genet 1997, 60:917-927.
12. Blaschitz A., Weiss U., Dohr G., Desoye G. Antibody reaction patterns in first trimester placenta: implications for trophoblast isolation and purity screening. Placenta 2000, 21:733-741.
13. Kinexus [website]. 2012, Available at:, Note: ERK6 was not available at the time our experiments were conducted. http://www.kinexus.ca/ourServices/immunoblotting/kinase_profilmg/kmase_profiling.html.
14. Pelech S., Sutter C., Zhang H. Kinetworks protein kinase multiblot analysis. Methods Mol Biol 2003, 218:99-111.
15. Zar J.H. Biostatistical analysis 1996, Prentice Hall College Div, Upper Saddle River, NJ. 3rd ed.
16. Roux P.P., Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004, 68:320-344.
17. Cheon M.S., Kim S.H., Yaspo M.L., Blasi F., Aoki Y., Melen K., et al. Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain: challenging the gene dosage effect hypothesis (Part I). Amino Acids 2003, 24:111-117.
18. Cheon M.S., Bajo M., Kim S.H., Claudio J.O., Stewart A.K., Patterson D., et al. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part II). Amino Acids 2003, 24:119-125.
19. Cheon M.S., Kim S.H., Ovod V., Kopitar Jerala N., Morgan J.I., Hatefi Y., et al. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part III). Amino Acids 2003, 24:127-134.
20. Birchler J.A. Reflections on studies of gene expression in aneuploids. Biochem J 2010, 426:119-123.
21. Engidawork E., Lubec G. Molecular changes in the fetal Down syndrome brain. J Neurochem 2003, 84:895-904.
22. Shah O.J., Kimball S.R., Jefferson L.S. Among translational effectors, p70S6K is uniquely sensitive to inhibition by glucocorticoids. Biochem J 2000, 347:389-397.
23. Berven L.A., Willard F.S., Crouch M.F. Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. Exp Cell Res 2004, 296:183-195.
24. Friedl M., Gluesserian T., Lubec G., Fountoulakis M., Lubec B. Deterioration of the transcriptional, splicing, and elongation machinery in brain of fetal Down syndrome. J Neural Transm Suppl 2001, 61:47-57.
25. Saran N.G., Pletcher M.T., Natale J.E., Cheng Y., Reeves R.H. Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum Mol Genet 2003, 12:2013-2019.
26. Chou C.Y., Liu L.Y., Chen C.Y., Tsai C.H., Hwa H.L., Chang L.Y., et al. Gene expression variation increase in trisomy 21 tissues. Mamm Genome 2008, 19:398-405.
27. Mao R., Zielke C.L., Zielke H.R., Pevsner J. Global up-regulation of chromosome 21 gene expression in developing Down syndrome brain. Genomics 2003, 81:457-467.
28. Deitz S.L., Roper R.J. Trisomic and allelic differences influence phenotypic variability during development of Down syndrome mice. Genetics 2011, 189:1487-1495.
29. Cho C.K.J., Diamandis E.P. Application of proteomics to prenatal screening and diagnosis for aneuploidies. Clin Chem Lab Med 2011, 49:33-41.
30. Reddy C.S.K., Holzgreve W., Hahn S. Detection of new screening markers for fetal aneuploidies in maternal plasma: a proteomic approach. Methods Mol Biol 2008, 444:311-326.
31. Busch A., Michel S., Hoppe C., Driesch D., Claussen U., von Eggeling F. Proteome analysis of maternal serum samples for trisomy 21 pregnancies using ProteinChip arrays and bioinformatics. J Histochem Cytochem 2005, 341-343.
32. Gardiner K. Predicting pathway perturbations in Down syndrome. J Neural Transm Suppl 2003, 67:21-37.
33. Vaillancourt C., Lanoix D., Le Belleg F., Daoud G., Lafondi J. Involvement of MAPK signalling in human villous trophoblast differentiation. Mini Rev Med Chem 2009, 9:962-973.
34. Moon K.C., Park J.S., Norwitz E.R., Kim D.I., Oh K.J., Park C.W., et al. Expression of extracellular signal-regulated kinase 1/2 and p38 mitogen- activated protein kinase in the invasive trophoblasts at the human placental bed. Placenta 2008, 29:391-395.
35. Prast J., Saleh L., Husslein H., Sonderegger S., Helmer H., Knofler M. Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulted kinase and AKT signaling. Endocrinology 2008, 149:979-987.
36. Murphy M., Stinnakre M.G., Senamaud-Beaufort C., Winston N.J., Sweeny C., Kubelka M., et al. Delayed embryonic lethality following disruption of the murine cyclin A2 gene. Nat Genet 1997, 15:83-86.
37. Eckert J.J., McCallum A., Mears A., Rumsby M.G., Cameron I.T., Fleming T.P. PKC signalling regulates tight junction membrane assembly in the pre-implantation mouse embryo. Reproduction 2004, 127:653-667.
38. Rachidi M., Lopes C. Mental retardation in Down Syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci Res 2007, 59:349-369.