Ghrelin alleviates neuropathic pain through GHSR-1a-mediated suppression of the p38 MAPK/NF-κB pathway in a rat chronic constriction injury model

Regional Anesthesia and Pain Medicine

Volumn 39, Issue 2, 2014, Pages 137-148

  Zhou, Cheng Hua ^a   Li, Xin ^a   Zhu, Yang Zi ^b   Huang, He ^b   Li, Jing ^b   Liu, Lu ^b   Hu, Qian ^b   Ma, Teng Fei ^a   Shao, Yong ^a   Wu, Yu Qing ^a,b  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b Jiangsu Province Key Laboratory of Anesthesiology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; CHRONIC DISEASE; CONSTRICTION, PATHOLOGIC; GHRELIN; INJECTIONS, SPINAL; MALE; NEURALGIA; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GHRELIN; SCIATIC NEUROPATHY;

EID: 84894462840     PISSN: 10987339     EISSN: 15328651     Source Type: Journal    
DOI: 10.1097/AAP.0000000000000050     Document Type: Article

References (30)

1. Treede RD, Jensen TS, Campbell JN, et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008;70:1630-1635.
2. Fornasari D. Pain mechanisms in patients with chronic pain. Clin Drug Investig. 2012;32(suppl 1):45-52.
3. Gosselin RD, Suter MR, Ji RR, Decosterd I. Glial cells and chronic pain. Neuroscientist. 2010;16:519-531.
4. Zhuo M, Wu G, Wu LJ. Neuronal and microglial mechanisms of neuropathic pain. Mol Brain. 2011;4:31.
5. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656-660.
6. Zhou X, Xue C. Ghrelin attenuates acute pancreatitis-induced lung injury and inhibits substance P expression. Am J Med Sci. 2010;339: 49-54.
7. Konturek PC, Brzozowski T, Engel M, et al. Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves. J Physiol Pharmacol. 2009;60:41-47.
8. Wang W, Bansal S, Falk S, Ljubanovic D, Schrier R. Ghrelin protects mice against endotoxemia-induced acute kidney injury. Am J Physiol Renal Physiol. 2009;297:1032-1037.
9. Huang CX, Yuan MJ, Huang H, et al. Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect. Peptides. 2009;30:2286-2291.
10. Ueberberg B, Unger N, Saeger W, Mann K, Petersenn S. Expression of ghrelin and its receptor in human tissues. Horm Metab Res. 2009;41:814-821.
11. Ferrini F, Salio C, Lossi L, Merighi A. Ghrelin in central neurons. Curr Neuropharmacol. 2009;7:37-49.
12. Furness JB, Hunne B, Matsuda N, et al. Investigation of the presence of ghrelin in the central nervous system of the rat and mouse. Neuroscience. 2011;193:1-9.
13. Erriquez J, Bernascone S, Ciarletta M, Filigheddu N, Graziani A, Distasi C. Calcium signals activated by ghrelin and D-Lys(3)-GHRP-6 ghrelin antagonist in developing dorsal root ganglion glial cells. Cell Calcium. 2009;46:197-208.
14. Theil MM, Miyake S, Mizuno M, et al. Suppression of experimental autoimmune encephalomyelitis by ghrelin. J Immunol. 2009;183: 2859-2866.
15. Moon M, Kim HG, Hwang L, et al. Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation. Neurotox Res. 2009;15:332-347.
16. Bulgarelli I, Tamiazzo L, Bresciani E, et al. Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils. J Neurosci Res. 2009;87:2718-2727.
17. Sibilia V, Lattuada N, Rapetti D, et al. Ghrelin inhibits inflammatory pain in rats: Involvement of the opioid system. Neuropharmacology. 2006;51:497-505.
18. Tander B, Atmaca A, Aliyazicioglu Y, Canturk F. Serum ghrelin levels but not GH, IGF-1 and IGFBP-3 levels are altered in patients with fibromyalgia syndrome. Joint Bone Spine. 2007;74:477-481.
19. Kawamata T, Omote K, Kawamata M, Iwasaki H, Namiki A. Antinociceptive interaction of intrathecal α2-adrenergic agonists, tizanidine and clonidine, with lidocaine in rats. Anesthesiology. 1997;87:436-448.
20. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33: 87-107.
21. Sun T, Song WG, Fu ZJ, Liu ZH, Liu YM, Yao SL. Alleviation of neuropathic pain by intrathecal injection of antisense oligonucleotides to p65 subunit of NF-κB. Brit J Anaesth. 2006;97:553-558.
22. Nanzer AM, Khalaf S, Mozid AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004;151:233-240.
23. Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000;407:908-913.
24. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature. 2001;409:194-198.
25. Zhu X, Cao Y, Voogd K, Steiner DF. On the processing of proghrelin to ghrelin. J Biol Chem. 2006;281:38867-38870.
26. Ozawa A, Cai Y, Lindberg I. Production of bioactive peptides in an in vitro system. Anal Biochem. 2007;366:182-189.
27. Zimmermann M. Pathobiology of neuropathic pain. Eur J Pharmacol. 2001;429:23-37.
28. Dixit VD, Schaffer EM, Pyle RS, et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest. 2004;114:57-66.
29. Guneli E, Kazikdas KC, Kolatan E. Ghrelin may attenuate proinflammatory cytokine-mediated neuropathic pain. Med Hypotheses. 2007;69:356-360.
30. Guneli E, Onal A, Ates M, et al. Effects of repeated administered ghrelin on chronic constriction injury of the sciatic nerve in rats. Neurosci Lett. 2010;479:226-230.