Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets

Cardiovascular Research

Volumn 99, Issue 3, 2013, Pages 452-460

  Phillips, Helen M ^a   Mahendran, Pavithra ^a   Singh, Esha ^a   Anderson, Robert H ^a   Chaudhry, Bill ^a   Henderson, Deborah J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Bicuspid aortic valve; Congenital heart disease; Mouse heart development; Neural crest cells

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; RHO KINASE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; AORTA VALVE DISEASE; ARTICLE; BICUSPID AORTIC VALVE; CELL ADHESION; CELL COMMUNICATION; CORONARY ARTERY ANOMALY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MITRAL VALVE; MOUSE; NEURAL CREST CELL; NONHUMAN; OUTFLOW CUSHION DEVELOPMENT; PRIORITY JOURNAL; PULMONARY VALVE DISEASE; THREE DIMENSIONAL IMAGING; TRANSGENIC MOUSE; VEIN BLOOD FLOW; ANIMAL; AORTA VALVE; BIOLOGICAL MODEL; CELL CULTURE; CORONARY BLOOD VESSEL; CORONARY VESSEL MALFORMATION; CYTOLOGY; DEFICIENCY; DISEASE MODEL; EMBRYOLOGY; ENDOCARDIAL CUSHION; ENDOCARDIAL CUSHION DEFECT; GENETICS; HEART VALVE DISEASES; HUMAN; METABOLISM; MORPHOGENESIS; NEURAL CREST; SIGNAL TRANSDUCTION; CONGENITAL HEART DISEASE; CONGENITAL MALFORMATION; MOUSE HEART DEVELOPMENT; NEURAL CREST CELLS; PRENATAL DEVELOPMENT; VALVULAR HEART DISEASE;

ANIMALS; AORTIC VALVE; BODY PATTERNING; CELL ADHESION; CELL COMMUNICATION; CELLS, CULTURED; CORONARY VESSEL ANOMALIES; CORONARY VESSELS; DISEASE MODELS, ANIMAL; ENDOCARDIAL CUSHION DEFECTS; ENDOCARDIAL CUSHIONS; HEART VALVE DISEASES; HUMANS; MICE; MICE, TRANSGENIC; MODELS, CARDIOVASCULAR; NEURAL CREST; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

BICUSPID AORTIC VALVE; CONGENITAL HEART DISEASE; MOUSE HEART DEVELOPMENT; NEURAL CREST CELLS;

EID: 84894448373     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt132     Document Type: Article

References (31)

1. Siu SC, Silversides CK. Bicuspid aortic valve disease. J Am Coll Cardiol 2010;55: 2789-2800.
2. Tadros TM, Klein MD, Shapira OM. Ascending aortic dilatation associated with bicuspid aortic valve: pathophysiology, molecular biology, and clinical implications. Circulation 2009;119:880-890.
3. Kappetein AP, Gittenberger-de Groot AC, Zwinderman AH, Rohmer J, Poelmann RE, Huysmans HA. The neural crest as a possible pathogenetic factor in coarctation of the aorta and bicuspid aortic valve. J Thorac Cardiovasc Surg 1991;102:830-836.
4. Jain R, Engleka KA, Rentschler SL, Manderfield LJ, Li L, Yuan L et al. Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. J Clin Invest 2011;121:422-430.
5. Kirby ML, Gale TF, Stewart DE. Neural crest cells contribute to normal aorticopulmonary septation. Science 1983;220:1059-1061.
6. Porras D, Brown CB. Temporal-spatial ablation of neural crest in the mouse results in cardiovascular defects. Dev Dyn 2008;237:153-162.
7. Vallejo-Illarramendi A, Zang K, Reichardt LF. Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development. J Clin Invest 2009; 119:2218-2230.
8. Nomura-Kitabayashi A, Phoon CK, Kishigami S, Rosenthal J, Yamauchi Y, Abe K et al. Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest. Am J Physiol Heart Circ Physiol 2009;297:H1617-H628.
9. Satoh K, Fukumoto Y, Shimokawa H. Rho-kinase: important new therapeutic target in cardiovascular diseases. Am J Physiol Heart Circ Physiol 2011;301:H287-H296.
10. Thumkeo D, Shimizu Y, Sakamoto S, Yamada S, Narumiya S. ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo. Genes Cells 2005;10:825-834.
11. Thumkeo D, Keel J, Ishizaki T, Hirose M, Nonomura K, Oshima H et al. Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol 2003;23:5043-5055.
12. Wei L, RobertsW, Wang L, Yamada M, Zhang S, Zhao Z et al. Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Development 2001;128: 2953-2962.
13. Groysman M, Shoval I, Kalcheim C. A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells. Neural Dev 2008;3: 27.
14. Kobayashi K, Takahashi M, Matsushita N, Miyazaki J, Koike M, YaginumaHet al. Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rhokinase. J Neurosci 2004;24:3480-3488.
15. Phillips HM, PapoutsiT, Soenen H, Ybot-Gonzalez P, Henderson DJ, Chaudhry B. Neural crest cell survival is dependent on Rho kinase and is required for development of the mid face in mouse embryos. PLoS One 2012;7:e37685.
16. Moase CE, Trasler DG. Delayed neural crest cell emigration from Sp and Spd mouse neural tube explants. Teratology 1990;42:171-182.
17. Soufan AT, Ruijter JM, van den Hoff MJB, de Boer PAJ, Hagoort J, Moorman AFM. Threedimensional reconstruction of gene expression patterns during cardiac development. Physiol Genomics 2003;13:187-195.
18. Kramer TC. The partitioning of the truncus and conus and the formation of the membranous portion of the interventricular septum in the human heart. Am J Anat 1942; 71:343-370.
19. Xu X, Francis R, Wei CJ, Linask KL, LoCW. Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells. Development 2006;133:3629-3639.
20. Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM. Fate of themammalian cardiac neural crest. Development 2000;127:1607-1616.
21. Luna-Zurita L, Prados B, Grego-Bessa J, LuxánG, del Monte G, Benguría A et al. Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest 2010;120:3493-3507.
22. Lee TC, Zhao YD, Courtman DW, Stewart DJ. Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase. Circulation 2000;101:2345-2348.
23. Laforest B, Andelfinger G, Nemer M. Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest 2011;121:2876-2887.
24. Thomas PS, Sridurongrit S, Ruiz-Lozano P, Kaartinen V. Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. PLoS One 2012;7:e35539.
25. Sans-Coma V, Fernández B, Durán AC, Thiene G, Arqué JM, Muñoz-Chápuli R et al. Fusion of valve cushions as a key factor in the formation of congenital bicuspid aortic valves in Syrian hamsters. Anat Rec 1996;244:490-498.
26. Fernández B, Durán AC, Fernández-Gallego T, Fernández MC, Such M, Arqué JM et al. Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities. J Am Coll Cardiol 2009;54:2312-2318.
27. Higgins CB, Wexler L. Reversal of dominance of the coronary arterial system in isolated aortic stenosis and bicuspid aortic valve. Circulation 1975;52:292-296.
28. Anderson RH, Chaudhry B, Mohun TJ, Bamforth SD, Hoyland D, Phillips HM et al. Normal and abnormal development of the intrapericardial arterial trunks in humans and mice. Cardiovasc Res 2012;95:108-115.
29. Comunale F, Causeret M, Favard C, Cau J, Taulet N, Charrasse S et al. Rac1 and RhoA GTPases have antagonistic functions during N-cadherin-dependent cell-cell contact formation in C2C12 myoblasts. Biol Cell 2007;99:503-517.
30. LuoY, High FA, Epstein JA, Radice GL. N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev Biol 2006;299:517-528.
31. DeLise AM, Tuan RS. Alterations in the spatiotemporal expression pattern and function of N-cadherin inhibit cellular condensation and chondrogenesis of limb mesenchymal cells in vitro. J Cell Biochem 2002;87:342-359.