Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression

Journal of Neuroscience

Volumn 34, Issue 9, 2014, Pages 3402-3412

  Mathews, Emily S ^a   Mawdsley, David J ^b,c   Walker, Macie ^a   Hines, Jacob H ^a   Pozzoli, Marina ^a   Appel, Bruce ^a  

^a Children's Hospital Colorado   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

Author keywords

Cholesterol; Isoprenoid; Myelin; Prenylation; Zebrafish

Indexed keywords

ATORVASTATIN; ENZYME INHIBITOR; GERANYLGERANIOL; GGTI 2133; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; ISOPRENOID; LONAFARNIB; MYELIN; RO 48 8071; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LARVA; MALE; MIGRATION INHIBITION; MUTATION; MYELINATION; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; PRIORITY JOURNAL; PROTEIN PRENYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME LAPSE IMAGING; ZEBRA FISH;

CHOLESTEROL; ISOPRENOID; MYELIN; PRENYLATION; ZEBRAFISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; BODY PATTERNING; CELL MOVEMENT; CHOLESTEROL; EMBRYO, NONMAMMALIAN; ENZYME INHIBITORS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; MUTATION; MYELIN SHEATH; OLIGODENDROGLIA; SPINAL CORD; STEM CELLS; TIME-LAPSE IMAGING; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84894440490     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4587-13.2014     Document Type: Article

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