Adult c-kitpos cardiac stem cells fulfill koch's postulates as causal agents for cardiac regeneration

Circulation Research

Volumn 114, Issue 4, 2014, Pages

  Torella, Daniele ^a   Ellison, Georgina M ^b   Nadal Ginard, Bernardo ^b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT STEM CELL; ANIMAL; CYTOLOGY; HEART FAILURE; HEART MUSCLE CELL; HUMAN; MALE; NOTE; TRANSPLANTATION;

ADULT STEM CELLS; ANIMALS; HEART FAILURE; HUMANS; MALE; MYOCYTES, CARDIAC;

EID: 84894438118     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.303313     Document Type: Letter

References (10)

1. Molkentin JD, Houser SR. Are resident c-Kit+ cardiac stem cells really all that are needed to mend a broken heart? Circ Res. 2013;113:1037-1039
2. Ellison GM, Vicinanza C, Smith AJ, et al. Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. Cell. 2013;154:827-842
3. Brown MS, Goldstein JL. Koch's postulates for cholesterol. Cell. 1992;71:187-188
4. Akashi YJ, Goldstein DS, Barbaro G, Ueyama T. Takotsubo cardiomyopathy: A new form of acute, reversible heart failure. Circulation. 2008;118:2754-2762
5. Ellison GM, Torella D, Karakikes I, Purushothaman S, Curcio A, Gasparri C, Indolfi C, Cable NT, Goldspink DF, Nadal-Ginard B. Acute beta-Adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells. J Biol Chem. 2007;282:11397-11409
6. Cairns LA, Moroni E, Levantini E, Giorgetti A, Klinger FG, Ronzoni S, Tatangelo L, Tiveron C, De Felici M, Dolci S, Magli MC, Giglioni B, Ottolenghi S. Kit regulatory elements required for expression in developing hematopoietic and germ cell lineages. Blood. 2003;102:3954-3962
7. Bernex F, De Sepulveda P, Kress C, Elbaz C, Delouis C, Panthier JJ. Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos. Development. 1996;122:3023-3033
8. Schmidt-Supprian M, Rajewsky K. Vagaries of conditional gene targeting. Nat Immunol. 2007;8:665-668
9. Long MA, Rossi FM. Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells. PLoS One. 2009;4:e5435
10. Uchida S, De Gaspari P, Kostin S, Jenniches K, Kilic A, Izumiya Y, Shiojima I, Grosse Kreymborg K, Renz H, Walsh K, Braun T. Sca1-derived cells are a source of myocardial renewal in the murine adult heart. Stem Cell Reports. 2013;1:397-410