Inhibition of melanin content by punicalagins in the super fruit pomegranate (Punica granatum)

Journal of Cosmetic Science

Volumn 64, Issue 6, 2013, Pages 445-453

  Rana, Jatinder ^a   Diwakar, Ganesh ^a   Saito, Lisa ^b   Scholten, Jeffrey D ^a   Mulder, Timothy ^a  

^a Amway Corporation   (United States)

^b Nutrilite   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEPIGMENTING AGENT; ELLAGIC ACID; MELANIN; MONOPHENOL MONOOXYGENASE; PLANT EXTRACT; PUNICALAGIN; TANNIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; ISOLATION AND PURIFICATION; LYTHRACEAE; MELANOCYTE; METABOLISM; MOUSE; SKIN; SKIN PIGMENTATION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; ELLAGIC ACID; HUMANS; HYDROLYZABLE TANNINS; MELANINS; MELANOCYTES; MICE; MONOPHENOL MONOOXYGENASE; PLANT EXTRACTS; PUNICACEAE; SKIN; SKIN LIGHTENING PREPARATIONS; SKIN PIGMENTATION;

EID: 84894411617     PISSN: 15257886     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. A. Slominski, D. J. Tobin, S. Shibahara, and J. Wortsman, Melanin pigmentation in mammalian skin and its hormonal regulation, Physiol. Rev., 84, 1155–1228 (2004).
2. E. Raynaud, C. Cellier, and J. L. Perret, Depigmentation for cosmetic purposes: Prevalence and side-effects in a female population in Senegal, Ann. Dermatol. Venereol., 128, 720–724 (2001).
3. M. Nakagawa, K. Kawai, and K. Kawai, Contact allergy to kojic acid in skin care products, Contact Dermatitis, 32, 9–13 (1995).
4. N. Smit, J. Vicanova, and S. Pavel, The hunt for natural skin whitening agents, Int. J. Mol. Sci., 10, 5326–5349 (2009).
5. V. A. Evreinoff, Le grenadier, Fruits d’Outre-Mer, 4, 161–170 (1949).
6. R. F. Wang, W. D. Xie, Z. Zhang. D. M. Xing, Y. Ding, W. Wang, and L. J. Du, Bioactive compounds from the seeds of Punica granatum (Pomegranate), J. Nat. Prod., 67, 2096–2098 (2004).
7. T. B. Machado, I. C. R. Leal, A. C. F. Amaral, K. R. N. Dos Santos, G. Marlei, M. G. da Silva, and R. M. Kuster, Antimicrobial ellagitannin of Punica granatum fruits, J. Brazilian Chem. Soc., 13, 606–610 (2002).
8. M. Aviram, L. Dornfeld, M. Rosenblat, N. Volkova, M. Kaplan, R. Coleman, T. Hayek, D. Presser, and B. Fuheman, Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: Studies in humans and in atherosclerotic apolipoprotein E-deficient mice, Am. J. Clin. Nutr., 71, 1062–1076 (2000).
9. B. Fuhrman, N. Volkova, and M. Aviram, Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages, J. Nutr. Biochem., 16, 570–576 (2005).
10. M. Larrosa, F. A. Tomás-Barberán, and J. C. Espin, The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway, J. Nutr. Biochem., 17, 611–625 (2006).
11. T. M. Li, G. W. Chen, C. C. Su, J. G. Lin, C. C. Yeh, J. G. Chung, and K. C. Cheng, Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells, Anticancer Res., 25, 971–979 (2005).
12. H. Shimogaki, Y. Tanaka, H. Tamai, and M. Masuda, In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition, Int. J. Cosmet. Sci., 22, 291–303 (2000).
13. I. Ertam, B. Mutlu, I. Unal, S. Alper, B. Kivcak, and O. Ozer, Efficiency of ellagic acid and arbutin in melasma: A randomized, prospective, open-label study. J. Dermatol., 35, 570–574 (2008).
14. N. Akhtar, R. Parveeen, B. A. Khan, M. Jamshaid, and H. Khan, Development of skin-friendly dermatological water-in-oil emulsion of pomegranate juice, Proc. Pak. Acad. Sci., 49, 269–278 (2012).
15. M. Yoshimura, Y. Watanabe, K. Kasai, J. Yamakoshi, and T. Koga, Inhibitory effect of an ellagic acid-rich pomegranate extract on tyrosinase activity and ultraviolet-induced pigmentation, Biosci. Biotechnol. Biochem., 69, 2368–2373 (2005).
16. S. Rout and R. Banerjee, Free radical scavenging, anti-glycation and tyrosinase inhibition properties of a polysaccharide fraction isolated from the rind from Punica granatum, Bioresour. Technol., 98, 3159–3163 (2007).
17. G. Diwakar, J. Rana, and J. D. Scholten, Inhibition of melanin production by a combination of Siberian larch and pomegranate fruit extracts, Fitoterapia, 83, 989–995 (2012).
18. D. C. Bennett, P. J. Cooper, and I. R. Hart, A line of non-tumerogenic melanocytes, syngeneic with B16 melanoma and requiring a tumor promoter for growth, Int. J. Cancer, 39, 414–418 (1987).
19. L. Ni-Komatsu, J. K. Leung, D. Williams, J. Min, S. M. Khersonsky, Y. T. Chang, and S. J. Orlow, Triazine-based tyrosinase inhibitors identified by chemical genetic screening, Pigment Cell Res., 18, 447–453 (2005).
20. N. P. Seeram, L. S. Adams, S. M. Henning, Y. Niu, Y. Zhang, M. G. Nair, and D. Heber, In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice, J. Nutr. Biochem., 16, 360–367 (2005).
21. V. M. Virador, N. Kobayashi, J. Matsunaga, and V. J. Hearing, A standardized protocol for assessing regulators of pigmentation, Anal. Biochem., 270, 207–219 (1999).
22. B. Cerdá, R. Llorach, J. J. Cerón, J. C. Espín, and F. A. Tomás-Barberán, Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice, Eur. J. Nutr., 42, 18–28 (2003).
23. D. Heber, “Pomegranate Ellagitannins,” in Herbal Medicine: Biomolecular and Clinical Aspects, F. F. Benzie and S. Wachtel-Galor. Eds. (CRC Press, Boca Raton, FL, 2011), Chapter 10.
24. S. Parvez, M. Kang, H. S. Chung, C. Cho, M. C. Hong, M. K. Shin, and H. Bae, Survey and mechanism of skin depigmenting and lightening agents, Phytother. Res., 20, 921–934 (2006).
25. J. Rana and G. Diwakar, Topical composition with skin lightening effect, US patent 7897184 B1 (2012).
26. J. Rana and G. Diwakar, Topical composition with skin lightening effect, US patent 8202556 B2 (2012).