Cognitive decline and depressive symptoms in late-life are associated with statin use: Evidence from a population-based study of Sardinian old people living in their own home

Neurological Research

Volumn 36, Issue 3, 2014, Pages 247-254

  Mandas, Antonella ^a   Congiu, Maria G ^a   Abete, Claudia ^a   Dessí, Sandra ^a   Manconi, Paolo E ^a   Musio, Monica ^a   Columbu, Silvia ^a   Racugno, Walter ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Cholesterol; Cognitive impairment; Depression; Elderly; Statins

Indexed keywords

CHOLESTEROL,; COGNITIVE IMPAIRMENT,; DEPRESSION,; ELDERLY,; STATINS;

AGED; AGED, 80 AND OVER; COGNITION DISORDERS; DEPRESSION; DYSLIPIDEMIAS; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; ITALY; MALE; RISK FACTORS;

EID: 84894376233     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132813Y.0000000287     Document Type: Article

References (42)

1. Kalmijn S, van Boxtel MP, Ocké M, Verschuren WM, Kromhout D, Launer LJ. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology. 2004;62:275-80.
2. Wu CW, Liao PC, Lin C, Kuo CJ, Chen ST, Chen HI, et al. Brain region-dependent increases in beta-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits. J Neural Transm. 2003;110:641-9.
3. Shie FS, Jin LW, Cook DG, Leverenz JB, LeBoeuf RC. Dietinduced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. Neuroreport. 2002;13:455-9.
4. Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology. 1995;45:1092-6.
5. Sparks DL. Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? Ann NY Acad Sci. 1997;826:128-46.
6. Kivipelto M, Helkala E-L, Hanninen T, Laakso MP, Hallikainen M, Alhainen K, et al. Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study. Neurology. 2001;56:1683-9.
7. van Exel E, de Craen AJM, Gussekloo J, Houx P, Bootsma-van der Wiel A, Macfarlane PW, et al. Association between high density lipoprotein and cognitive impairment in the oldest old. Ann Neurol. 2002;51:716-21.
8. Frears ER, Stephens DJ, Walters CE, Davies H, Austen BM. The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport. 1999;10:1699-705.
9. Yaffe K, Barrett-Connor E, Lin F, Grady D. Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol. 2002;59(3):378-84.
10. Singh-Manoux A, Gimeno D, Kivimaki M, Brunner E, Marmot MG. Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study. Arterioscler Throm Vasc Biol. 2008;28:1556-62.
11. Elias PK, Elias MF, D'Agostino RB, Sullivan LM, Wolf PA. Serum cholesterol and cognitive performance in the Framingham Heart Study. Psychosom Med. 2005;67:24-30.
12. Crouch MA. Effective use of statins to prevent coronary heart disease. Am Fam Physician. 2001;63:309-20.
13. van Vliet P. van de Water W, de Craen AJ, Westendorp RG. The influence of age on the association between cholesterol and cognitive function. Exp Gerontol. 2009;44:112-22.
14. Carlsson CM, Gleason CE, Hess TM, Moreland KA, Blazel HM, Koscik RL, et al. Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease. J Alzheimers Dis. 2008;13:187-97.
15. Goveas JS, Espeland MA, Woods NF, Wassertheil-Smoller S, Kotchen JM. Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2011;59:57-66.
16. Savaskan E. The emotional memory in the elderly and depression. Praxis (Bern 1994). 2010;99:1565-8.
17. Mandas A, Congiu MG, Balestrieri C, et al. Nutritional status and oxidative stress in an elderly Sardinian population. Med J Nutrition Metab. 2008;1:99-107
18. Pani A, Mandas A, Diaz G, Abete C, Cocco PL, Angius F, et al. Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of disease. BMC Med. 2009;7:66.
19. Bucks RS, Ashworth DL, Wilcock GK, Siegfried K. Assessment of activities of daily living in dementia: development of the Bristol activities of daily living scale. Age Ageing. 1996;25:113-20.
20. Lawton MP, Brody EM. Assessment of older people; selfmaintaining and instrumental activity of daily living. Gerontologist. 1969;9:179-86.
21. Folstein MF, Folstein SE, McHigh PR. Mini mental state: a pratical method for grading the cognitive state of patients for the clinician. J Psych Res. 1975;12:189-98.
22. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1983;17:37-49.
23. Tinetti ME. Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc. 1986;119-26.
24. Reuben DB, Siu AL. An objective measure of physical function of elderly outpatients. The Physical Performance Test. J Am Geriatr Soc. 1990;38:1105-12.
25. Guigoz Y, Vellas B, Garry PJ, et al. Mini nutritional assessment: a practical assessment tool for grading the nutritional state of elderly patients. Facts Res Gerontol 1994; 4: 15-59.
26. Greenacre MJ. Correspondence analysis in practice, 2nd edn. London: Chapman & Hall/CRC; 2007.
27. McCullagh P, Nelder JA. Generalized linear models, 2nd edn. Boca Raton, Florida: Chapman & Hall/CRC; 1989.
28. Pappolla MA, Bryant-Thomas TK, Herbert D, Pacheco J, Fabra Garcia M, Manjon M, et al. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology. 2003;61:199-205.
29. Zambón D, Quintana M, Mata P, Alonso R, Benavent J, Cruz- Sánchez F, et al. Higher incidence of mild cognitive impairment in familial hypercholesterolemia. Am J Med. 2010;123:267-74.
30. Reitz C. Dyslipidemia and dementia: current epidemiology, genetic evidence and mechanisms behind the associations. J Alzheimers Dis. 2012;30:S127-45.
31. Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Arch Neurol. 2011;68:1385-92.
32. Rojas-Fernandez CH, Cameron JC. Is statin-associated cognitive impairment clinically relevant? A narrative review and clinical recommendations. Ann Pharmacother. 2012;46:549-57.
33. Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol. 2005;19:117-25.
34. Wood WG, Eckert GP, Igbavboa U, Müller WE. Statins and neuroprotection: a prescription to move the field forward. Ann N Y Acad Sci. 2010;1199:69-76.
35. Heart Protection Study Collaborative Group. MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360:7-22.
36. Thelen KM, Rentsch KM, Gutteck U, Heverin M, Olin M, Andersson U, et al. Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. J Pharmacol Exp Ther. 2006;316:1146-52.
37. Johnson-Anuna LN, Eckert GP, Keller JH, Igbavboa U, Franke C, Fechner T, et al. Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J Pharmacol Exp Ther. 2005;312:786-93.
38. Anchisi L, Dessí S, Pani A, et al. Neutral lipid determination in peripheral blood mononuclear cells: a useful tool for diagnostic and therapeutic interventions in dementia. J Mol Biomarkers Diagn. 2012;3:6.
39. Anchisi L, Dessí S, Pani A, Mandas A. Cholesterol homeostasis: a key to prevent or slow down neurodegeneration. Front Physiol. 2013;3:486.
40. Dietschy JM, Turley SD. Cholesterol metabolism in the brain. Curr Opin Lipidol. 2001;12:105-12.
41. Koudinov AR, Koudinova NV. Cholesterol homeostasis failure as a unifying cause of synaptic degeneration. J Neurol Sci. 2005;15:233-40.
42. Lütjohann D, von Bergmann K. 24S-hydroxycholesterol: a marker of brain cholesterol metabolism. Pharmacopsychiatry. 2003;36: S102-6.