Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells

Journal of Molecular Neuroscience

Volumn 52, Issue 3, 2014, Pages 378-383

  Deslauriers, Jessica ^a   Desmarais, Christian ^a   Sarret, Philippe ^a   Grignon, Sylvain ^a,b  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

Author keywords

Antipsychotics; Dopamine D2 receptor; ERK; Lipoic acid; SH SY5Y

Indexed keywords

ANTIPSYCHOTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; HALOPERIDOL; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NEUROPROTECTIVE AGENTS; RECEPTORS, DOPAMINE D2; RNA, MESSENGER; SULPIRIDE; THIOCTIC ACID; UP-REGULATION;

EID: 84894364228     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0158-6     Document Type: Article

References (26)

1. Beaulieu JM, Gainetdinov RR, Caron MG (2009) Akt/GSK3 signaling in the action of psychotropic drugs. Annu Rev Pharmacol Toxicol 49:327-347
2. Bertran-Gonzalez J, Bosch C, Maroteaux M, Matamales M, Herve D, Valjent E, Girault JA (2008) Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J Neurosci 28:5671-5685
3. Deslauriers J, Lefrancois M, Larouche A, Sarret P, Grignon S (2011) Antipsychotic-induced DRD2 upregulation and its prevention by alpha-lipoic acid in SH-SY5Y neuroblastoma cells. Synapse 65:321-331
4. Deslauriers J, Desmarais C, Sarret P, Grignon S (2013) alpha-Lipoic acid interaction with dopamine D2 receptor-dependent activation of the Akt/GSK-3beta signaling pathway induced by antipsychotics: potential relevance for the treatment of schizophrenia. J Mol Neurosci 50:134-145
5. Ha JS, Lim HM, Park SS (2010) Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity. Brain Res 1359:291-297
6. Hakansson K, Pozzi L, Usiello A, Haycock J, Borrelli E, Fisone G (2004) Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol. Eur J Neurosci 20:1108-1112
7. Harrison PJ (1999) The neuropathological effects of antipsychotic drugs. Schizophr Res 40:87-99
8. Hwang SL, Jeong YT, Li X, Kim YD, Yue L, Chang YC, Lee IK, Chang HW (2013) Inhibitory Cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Br J Pharmacol 169:69-81
9. Jenner P, Rupniak NM, Marsden CD (1985) Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats. Psychopharmacology Suppl 2:174-181
10. Jeste DV, Lacro JP, Palmer B, Rockwell E, Harris MJ, Caligiuri MP (1999) Incidence of tardive dyskinesia in early stages of low-dose treatment with typical neuroleptics in older patients. Am J Psychiatry 156:309-311
11. Kim MJ, Park IJ, Yun H, Kang I, Choe W, Kim SS, Ha J (2010) AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma. J Biol Chem 285:14617-14627
12. Kropp S, Kern V, Lange K, Degner D, Hajak G, Kornhuber J, Ruther E, Emrich HM, Schneider U, Bleich S (2005) Oxidative stress during treatment with first- and second-generation antipsychotics. J Neuropsychiatry Clin Neurosci 17:227-231
13. Kwon SH, Kim JA, Hong SI, Jung YH, Kim HC, Lee SY, Jang CG (2011) Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells. Neurochem Int 58:533-541
14. Lee WJ, Lee IK, Kim HS, Kim YM, Koh EH, Won JC, Han SM, Kim MS, Jo I, Oh GT, Park IS, Youn JH, Park SW, Lee KU, Park JY (2005) Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol 25:2488-2494
15. Lee WR, Kim A, Kim KS, Park YY, Park JH, Kim KH, Kim SJ, Park KK (2012) Alpha-lipoic acid attenuates atherosclerotic lesions and inhibits proliferation of vascular smooth muscle cells through targeting of the Ras/MEK/ERK signaling pathway. Mol Biol Rep 39:6857-6866
16. Liu JC, Baker RE, Sun C, Sundmark VC, Elsholtz HP (2002) Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene. J Biol Chem 277:35819-35825
17. Quan W, Kim JH, Albert PR, Choi H, Kim KM (2008) Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation. Biochem Biophys Res Commun 377:705-709
18. Richfield EK, Penney JB, Young AB (1989) Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system. Neuroscience 30:767-777
19. Santini E, Valjent E, Usiello A, Carta M, Borgkvist A, Girault JA, Herve D, Greengard P, Fisone G (2007) Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in l-DOPA-induced dyskinesia. J Neurosci 27:6995-7005
20. Silvestri S, Seeman MV, Negrete JC, Houle S, Shammi CM, Remington GJ, Kapur S, Zipursky RB, Wilson AA, Christensen BK, Seeman P (2000) Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study. Psychopharmacology (Berl) 152:174-180
21. Son Y, Cheong YK, Kim NH, Chung HT, Kang DG, Pae HO (2011) Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways? J Signal Transduct 2011:792639
22. Stanciu M, Wang Y, Kentor R, Burke N, Watkins S, Kress G, Reynolds I, Klann E, Angiolieri MR, Johnson JW, DeFranco DB (2000) Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem 275:12200-12206
23. Thaakur S, Himabindhu G (2009) Effect of alpha lipoic acid on the tardive dyskinesia and oxidative stress induced by haloperidol in rats. J Neural Transm 116:807-814
24. Tillu DV, Melemedjian OK, Asiedu MN, Qu N, De Felice M, Dussor G, Price TJ (2012) Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain. Mol Pain 8:5
25. Valjent E, Pages C, Herve D, Girault JA, Caboche J (2004) Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain. Eur J Neurosci 19:1826-1836
26. Wang HQ, Sun XB, Xu YX, Zhao H, Zhu QY, Zhu CQ (2010) Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Res 1360:159-167