Natural Folates from Biofortified Tomato and Synthetic 5-methyl-tetrahydrofolate Display Equivalent Bioavailability in a Murine Model

Plant Foods for Human Nutrition

Volumn 69, Issue 1, 2014, Pages 57-64

  Castorena Torres, Fabiola ^a,b   Ramos Parra, Perla A ^a   Hernández Méndez, Rogelio V ^a,b   Vargas García, Andrés ^a,b   García Rivas, Gerardo ^a,b   Díaz de la Garza, Rocío I ^a  

^a SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

^b ESCUELA DE MEDICINA Y CIENCIAS DE LA SALUD   (Mexico)

Author keywords

Biofortification; Biofortified tomato; Folate bioavailability; Rat model; Vitamin

Indexed keywords

5,6,7,8-TETRAHYDROFOLIC ACID; FOLIC ACID; TETRAHYDROFOLIC ACID; TETRAHYDROFOLIC ACID DERIVATIVE; VITAMIN B COMPLEX;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; CHEMISTRY; DIET SUPPLEMENTATION; DIET THERAPY; FOLIC ACID DEFICIENCY; FRUIT; HUMAN; INTESTINE ABSORPTION; MALE; RAT; TOMATO; WISTAR RAT;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DIETARY SUPPLEMENTS; FOLIC ACID; FOLIC ACID DEFICIENCY; FOOD, FORTIFIED; FRUIT; HUMANS; INTESTINAL ABSORPTION; LYCOPERSICON ESCULENTUM; MALE; RATS; RATS, WISTAR; TETRAHYDROFOLATES; VITAMIN B COMPLEX;

EID: 84894354022     PISSN: 09219668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11130-013-0402-9     Document Type: Article

References (33)

1. Zimmerman S (2011) Fifteen years of fortifying with folic acid: birth defects are reduced and healthcare expenses are averted. Sight and Life 25(3): 54-59, 978-3-906412-66-5.
2. Rush D (2000) Nutrition and maternal mortality in the developing world. Am J Clin Nutr 72(1Suppl): 212S-240S.
3. Qin X, Huo Y, Xie D et al (2013) Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: a meta-analysis of randomized controlled trials. Clin Nutr 32(5): 722-727.
4. Kim Y-I (2004) Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev 13(4): 511-519.
5. Wald DS, Kasturiratne A, Simmonds M (2011) Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants. Alzheimers Dement 7(4): 412-417.
6. Nestel P, Bouis HE, Meenakshi JV, Pfeiffer W (2006) Biofortification of staple food crops. J Nutr 136(4): 1064-1067.
7. Czarnowska M, Gujska E (2012) Effect of freezing technology and storage conditions on folate content in selected vegetables. Plant Foods Hum Nutr 67(4): 401-406.
8. Gujska E, Michalak J, Klepacka J (2009) Folates stability in two types of rye breads during processing and frozen storage. Plant Foods Hum Nutr 64(2): 129-134.
9. Gujska E, Majewska K (2005) Effect of baking process on added folic acid and endogenous folates stability in wheat and rye breads. Plant Foods Hum Nutr 60(2): 37-42.
10. Mayer JE, Pfeiffer WH, Beyer P (2008) Biofortified crops to alleviate micronutrient malnutrition. Curr Opin Plant Biol 11(2): 166-170.
11. Lucock M, Yates Z (2009) Folic acid fortification: a double-edged sword. Curr Opin Clin Nutr Metab Care 12(6): 555-564.
12. Tibbetts AS, Appling DR (2010) Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr 30(1): 57-81.
13. Wei M, Gregory J (1998) Organic acids in selected foods inhibit intestinal brush border pteroylpolyglutamate hydrolase in vitro: potential mechanism affecting the bioavailability of dietary polyglutamyl folate. J Agric Food Chem 46(1): 211-219.
14. Diaz de la Garza RI, Gregory JF, Hanson AD (2007) Folate biofortification of tomato fruit. Proc Natl Acad Sci USA 104(10): 4218-4222.
15. Pietrzik K, Bailey L, Shane B (2010) Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet 49(8): 535-548.
16. Ramos-Parra PA, Urrea-López R, Díaz-De La Garza RI (2013) Folate analysis in complex food matrices: use of a recombinant arabidopsis γ-glutamyl hydrolase for folate deglutamylation. Food Res Int 54(1): 177-185.
17. Waller JC, Akhtar TA, Lara-Núñez A et al (2010) Developmental and feedforward control of the expression of folate biosynthesis genes in tomato fruit. Mol Plant 3(1): 66-77.
18. Clifford AJ, Heid MK, Peerson JM, Bills ND (1991) Bioavailability of food folates and evaluation of food matrix effects with a rat bioassay. J Nutr 121(4): 445-453.
19. O'Leary K, Sheehy PJA (2001) Effects of preparation and cooking of folic acid-fortified foods on the availability of folic acid in a folate depletion/repletion rat model. J Agric Food Chem 49(9): 4508-4512.
20. Huang RF, Hsu YC, Lin HL, Yang FL (2001) Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J Nutr 131(1): 33-38.
21. Castenmiller JJ, van de Poll CJ, West CE et al (2000) Bioavailability of folate from processed spinach in humans. Ann Nutr Metab 44(4): 163-169.
22. Dev S, Ahmad Wani N, Kaur J (2011) Regulatory mechanisms of intestinal folate uptake in a rat model of folate oversupplementation. Br J Nutr 105(6): 827-835.
23. Willems FF, Boers GHJ, Blom HJ et al (2004) Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease. Br J Pharmacol 141(5): 825-830.
24. Pentieva K, McNulty H, Reichert R et al (2004) The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men. J Nutr 134(3): 580-585.
25. Pérez-Conesa D, Haro-Vicente JF, Braquehais FR, Ros G (2009) [6S]-5-Methyltetrahydrofolate enhances folate status in rats fed growing-up milk. Eur J Nutr 48(6): 365-371.
26. Abad AR, Gregory JF III (1988) Assessment of folate bioavailability in the rat using extrinsic dietary enrichment with radiolabeled folates. J Agric Food Chem 36(1): 97-104.
27. Winkels RM, Brouwer IA, Siebelink E et al (2007) Bioavailability of food folates is 80% of that of folic acid. Am J Clin Nutr 85(2): 465-473.
28. McKillop DJ, McNulty H, Scott JM et al (2006) The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation. Am J Clin Nutr 84(1): 167-173.
29. Wang TT, Reisenauer AM, Halsted CH (1985) Comparison of folate conjugase activities in human, pig, rat and monkey intestine. J Nutr 115(6): 814-819.
30. Jägerstad M, Lindstrand K, Westesson AK (1972) Hydrolysis of conjugated folic acid by pancreatic "conjugase". Scand J Gastroenterol 7(2): 593-597.
31. Honein MA, Paulozzi LJ, Mathews TJ et al (2001) Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 285(23): 2981-2986.
32. Storozhenko S, De Brouwer V, Volckaert M et al (2007) Folate fortification of rice by metabolic engineering. Nat Biotechnol 25(11): 1277-1279.
33. Naqvi S, Zhu C, Farre G et al (2009) Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Proc Natl Acad Sci USA 106(19): 7762-7767.