Alpha-synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures

Molecular Neurobiology

Volumn 49, Issue 1, 2014, Pages 399-412

  Xu, Bin ^a   Wang, Fei ^a   Wu, Sheng Wen ^a   Deng, Yu ^a   Liu, Wei ^a   Feng, Shu ^a   Yang, Tian Yao ^a   Xu, Zhao Fa ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Alpha synuclein; Endoplasmic reticulum stress; Manganese; Neurotoxicity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA SYNUCLEIN; CASPASE 12; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; LENTIVIRUS VECTOR; MANGANESE; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN IRE1; PROTEIN P90; PROTEIN PERK; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; BRAIN SLICE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; REVIEW; RNA INTERFERENCE; RNA SPLICING; SIGNAL TRANSDUCTION;

ALPHA-SYNUCLEIN; ANIMALS; ANIMALS, NEWBORN; BRAIN; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; MANGANESE; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 84894308144     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8527-2     Document Type: Review

References (29)

1. Roels HA, Bowler RM, Kim Y, Henn BC, Mergler D, Hoet P, Gocheva VV, Bellinger DC, Wright RO, Harris MG, Chang Y, Bouchard MF, Riojas-Rodriguez H, Menezes-Filho JA, Tellez-Rojo MM (2012) Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity. Neurotoxicology 33(4):872-880. doi: 10.1016/j.neuro.2012.03.009
2. Criswell SR, Perlmutter JS, Huang JL, Golchin N, Flores HP, Hobson A, Aschner M, Erikson KM, Checkoway H, Racette BA (2012) Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup Environ Med 69(6):437-443. doi: 10.1136/oemed-2011-100119
3. Guilarte TR (2010) Manganese and Parkinson's disease: a critical review and new findings. Environ Health Perspect 118(8):1071-1080. doi: 10.1289/ehp.0901748
4. Milatovic D, Zaja-Milatovic S, Gupta RC, Yu Y, Aschner M (2009) Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol 240(2):219-225. doi: 10.1016/j.taap.2009.07.004
5. Yoon H, Kim DS, Lee GH, Kim KW, Kim HR, Chae HJ (2011) Apoptosis induced by manganese on neuronal SK-N-MC cell line: endoplasmic reticulum (ER) stress and mitochondria dysfunction. Environ Health Toxicol 26:e2011017. doi: 10.5620/eht.2011.26.e2011017
6. Matus S, Castillo K, Hetz C (2012) Hormesis: protecting neurons against cellular stress in Parkinson disease. Autophagy 8(6):997-1001. doi: 10.4161/auto.20748
7. Lind KR, Ball KK, Cruz NF, Dienel GA (2013) The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes. Neurochem Int 62(5):784-795. doi: 10.1016/j.neuint.2013. 02.009
8. Roussel BD, Kruppa AJ, Miranda E, Crowther DC, Lomas DA, Marciniak SJ (2013) Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurol 12(1):105-118. doi: 10.1016/S1474-4422(12)70238-7
9. Krasnoslobodtsev AV, Peng J, Asiago JM, Hindupur J, Rochet JC, Lyubchenko YL (2012) Effect of spermidine on misfolding and interactions of alpha-synuclein. PLoS One 7(5):e38099. doi: 10.1371/journal.pone.0038099
10. Hoozemans JJ, van Haastert ES, Eikelenboom P, de Vos RA, Rozemuller JM, Scheper W (2007) Activation of the unfolded protein response in Parkinson's disease. Biochem Biophys Res Commun 354(3):707-711. doi: 10.1016/j.bbrc.2007.01. 043
11. Xu B, Wu SW, Lu CW, Deng Y, Liu W, Wei YG, Yang TY, Xu ZF (2013) Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures. Toxicology 305:71-78. doi: 10.1016/j.tox.2013.01.006
12. Chun HS, Lee H, Son JH (2001) Manganese induces endoplasmic reticulum (ER) stress and activates multiple caspases in nigral dopaminergic neuronal cells, SN4741. Neurosci Lett 316(1):5-8. doi: 10.1016/S0304-3940(01)02341-2
13. Ohnishi M, Katsuki H, Unemura K, Izumi Y, Kume T, Takada-Takatori Y, Akaike A (2010) Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture. Brain Res 1347:170-178. doi: 10.1016/j.brainres.2010.05.077
14. Stoppini L, Buchs PA, Muller D (1991) A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37(2):173-182. doi: 10.1016/0165-0270(91)90128-M
15. Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N (2010) In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Mol Ther 18(8):1450-1457. doi: 10.1038/mt.2010.115
16. Xu B, Xu ZF, Deng Y (2009) Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Neurotoxicology 30(6):941-949. doi: 10.1016/j.neuro.2009.07.011
17. Villalba M, Pereira R, Martinez-Serrano A, Satrustegui J (1995) Altered cell calcium regulation in synaptosomes and brain cells of the 30-month-old rat: prominent effects in hippocampus. Neurobiol Aging 16(5):809-816. doi: 10.1016/0197-4580(95)00087-U
18. Allagnat F, Christulia F, Ortis F, Pirot P, Lortz S, Lenzen S, Eizirik DL, Cardozo AK (2010) Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis. Diabetologia 53(6):1120-1130. doi: 10.1007/s00125-010-1699-7
19. Zhang B, Wang Y, Pang X, Su Y, Ai G, Wang T (2010) ER stress induced by ionising radiation in IEC-6 cells. Int J Radiat Biol 86(6):429-435. doi: 10.3109/09553001003668014
20. Paillusson S, Tasselli M, Lebouvier T, Mahe MM, Chevalier J, Biraud M, Cario-Toumaniantz C, Neunlist M, Derkinderen P (2010) Alpha-synuclein expression is induced by depolarization and cyclic AMP in enteric neurons. J Neurochem 115(3):694-706. doi: 10.1111/j.1471-4159.2010.06962.x
21. Xu B, Xu Z, Deng Y, Liu W, Yang H, Wei YG (2013) MK-801 protects against intracellular Ca(2+) overloading and improves N-methyl-D-aspartate receptor expression in cerebral cortex of methylmercury-poisoned rats. J Mol Neurosci: MN 49(1):162-171. doi: 10.1007/s12031-012-9926-y
22. Uversky VN, Li J, Fink AL (2001) Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. J Biol Chem 276(47):44284-44296. doi: 10.1074/jbc.M105343200
23. Wan OW, Chung KK (2012) The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease. PloS One 7(6):e38545. doi: 10.1371/journal.pone.0038545
24. Hoozemans JJ, van Haastert ES, Nijholt DA, Rozemuller AJ, Scheper W (2012) Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease. Neurodegener Dis 10(1-4):212-215. doi: 10.1159/000334536
25. Wang S, Kaufman RJ (2012) The impact of the unfolded protein response on human disease. J Cell Biol 197(7):857-867. doi: 10.1083/jcb.201110131
26. Ohri SS, Maddie MA, Zhang Y, Shields CB, Hetman M, Whittemore SR (2012) Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injury. J Neurotrauma 29(3):579-588. doi: 10.1089/neu.2011.1940
27. Moserova I, Kralova J (2012) Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways. PloS One 7(3):e32972. doi: 10.1371/journal.pone.0032972
28. Yeh CH, Chiang HS, Lai TY, Chien CT (2011) Unilateral ureteral obstruction evokes renal tubular apoptosis via the enhanced oxidative stress and endoplasmic reticulum stress in the rat. Neurourol Urodyn 30(3):472-479. doi: 10.1002/nau.20855
29. Yoon H, Lee GH, Kim DS, Kim KW, Kim HR, Chae HJ (2011) The effects of 3, 4 or 5 amino salicylic acids on manganese-induced neuronal death: ER stress and mitochondrial complexes. Toxicol In Vitro 25(7):1259-1268. doi: 10.1016/j.tiv.2011.04.002