The small fibrinopeptide Bβ15-42 as renoprotective agent preserving the endothelial and vascular integrity in early ischemia reperfusion injury in the mouse kidney

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Urbschat, Anja ^a   Zacharowski, Kai ^a   Obermüller, Nicholas ^a   Rupprecht, Katrin ^a   Penzkofer, Daniela ^b   Jennewein, Carla ^a   Tran, Nguyen ^a   Scheller, Bertram ^a   Dimmeler, Stefanie ^b   Paulus, Patrick ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; ANIMALS; ANTIGENS, CD; APOPTOSIS; CADHERINS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; LIPOCALINS; MALE; MICE; NEUTROPHIL INFILTRATION; ONCOGENE PROTEINS; P-SELECTIN; PEPTIDE FRAGMENTS; PROTECTIVE AGENTS; RECEPTORS, CXCR4; RENAL CIRCULATION; REPERFUSION INJURY;

EID: 84894264597     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084432     Document Type: Article

References (38)

1. Bonventre JV (2010) Pathophysiology of AKI: injury and normal and abnormal repair. Contrib Nephrol 165: 9-17.
2. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, et al. (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294: 813-818. (Pubitemid 41175724)
3. Lote CJ, Harper L, Savage CO (1996) Mechanisms of acute renal failure. Br J Anaesth 77: 82-89. (Pubitemid 26229915)
4. Schrier RW, Wang W (2004) Acute renal failure and sepsis. N Engl J Med 351: 159-169.
5. Vestweber D (2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol 28: 223-232.
6. Dejana E, Spagnuolo R, Bazzoni G (2001) Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration. Thromb Haemost 86: 308-315. (Pubitemid 32663961)
7. Broman MT, Mehta D, Malik AB (2007) Cdc42 regulates the restoration of endothelial adherens junctions and permeability. Trends Cardiovasc Med 17: 151-156. (Pubitemid 46898842)
8. Dejana E, Tournier-Lasserve E, Weinstein BM (2009) The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev Cell 16: 209-221.
9. Sahni A, Arevalo MT, Sahni SK, Simpson-Haidaris PJ (2009) The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells. Int J Cancer 125: 577-584.
10. Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, et al. (2009) Bbeta15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion. Crit Care Med 37: 598-605.
11. Groger M, Pasteiner W, Ignatyev G, Matt U, Knapp S, et al. (2009) Peptide Bbeta(15-42) preserves endothelial barrier function in shock. PLoS One 4: e5391.
12. Atar D, Petzelbauer P, Schwitter J, Huber K, Rensing B, et al. (2009) Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction results of the F.I.R.E. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury) trial. J Am Coll Cardiol 53: 720-729.
13. Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA, et al. (2007) The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury. Crit Care Med 35: 1730-1735. (Pubitemid 46985877)
14. Gorlatov S, Medved L (2002) Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains. Biochemistry 41: 4107-4116. (Pubitemid 34251050)
15. Bach TL, Barsigian C, Yaen CH, Martinez J (1998) Endothelial cell VE-cadherin functions as a receptor for the beta15-42 sequence of fibrin. J Biol Chem 273: 30719-30728. (Pubitemid 28545554)
16. Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, et al. (2005) The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med 11: 298-304. (Pubitemid 40460558)
17. Paulus P, Ockelmann P, Tacke S, Karnowski N, Ellinghaus P, et al. (2012) Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat. PLoS One 7: e39265.
18. Paulus P, Holfeld J, Urbschat A, Mutlak H, Ockelmann PA, et al. (2013) Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation. PLoS One 8: e73298.
19. Bellomo R, Kellum JA, Ronco C (2012) Acute kidney injury. Lancet 380: 756-766.
20. Nguyen MT, Devarajan P (2008) Biomarkers for the early detection of acute kidney injury. Pediatr Nephrol 23: 2151-2157.
21. Obermüller N, Geiger H, Weipert C, Urbschat A (2013) Current developments in early diagnosis of acute kidney injury. Int Urol Nephrol.
22. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, et al. (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14: 2534-2543. (Pubitemid 37169339)
23. Mori K, Nakao K (2007) Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage. Kidney Int 71: 967-970. (Pubitemid 46741985)
24. Lee WL, Slutsky AS (2010) Sepsis and endothelial permeability. N Engl J Med 363: 689-691.
25. Molitoris BA, Sandoval R, Sutton TA (2002) Endothelial injury and dysfunction in ischemic acute renal failure. Crit Care Med 30: S235-240. (Pubitemid 34507997)
26. Urbschat A, Obermüller N, Haferkamp A (2011) Biomarkers of kidney injury. Biomarkers 16 Suppl 1: S22-30.
27. Harris ES, Nelson WJ (2010) VE-cadherin: at the front, center, and sides of endothelial cell organization and function. Curr Opin Cell Biol 22: 651-658.
28. Zacharowski K, Zacharowski P, Reingruber S, Petzelbauer P (2006) Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction. J Mol Med (Berl) 84: 469-477. (Pubitemid 43801325)
29. Kelly KJ, Williams WW, Jr., Colvin RB, Meehan SM, Springer TA, et al. (1996) Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest 97: 1056-1063. (Pubitemid 26070586)
30. Haller H, Dragun D, Miethke A, Park JK, Weis A, et al. (1996) Antisense oligonucleotides for ICAM-1 attenuate reperfusion injury and renal failure in the rat. Kidney Int 50: 473-480. (Pubitemid 26274374)
31. Klausner JM, Paterson IS, Goldman G, Kobzik L, Rodzen C, et al. (1989) Postischemic renal injury is mediated by neutrophils and leukotrienes. Am J Physiol 256: F794-802.
32. Eash KJ, Means JM, White DW, Link DC (2009) CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood 113: 4711-4719.
33. Paulus P, Jennewein C, Zacharowski K (2011) Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis? Biomarkers 16 Suppl 1: S11-21.
34. Singbartl K, Forlow SB, Ley K (2001) Platelet, but not endothelial, P-selectin is critical for neutrophil-mediated acute postischemic renal failure. FASEB J 15: 2337-2344. (Pubitemid 33063162)
35. Schnell D, Darmon M (2012) Renal Doppler to assess renal perfusion in the critically ill: a reappraisal. Intensive Care Med 38: 1751-1760.
36. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, et al. (2003) Differential gene expression following early renal ischemia/reperfusion. Kidney Int 63: 1714-1724. (Pubitemid 36513317)
37. Sorensen I, Rong S, Susnik N, Gueler F, Shushakova N, et al. (2011) Bbeta(15-42) attenuates the effect of ischemia-reperfusion injury in renal transplantation. J Am Soc Nephrol 22: 1887-1896.
38. Krishnamoorthy A, Ajay AK, Hoffmann D, Kim TM, Ramirez V, et al. (2011) Fibrinogen beta-derived Bbeta(15-42) peptide protects against kidney ischemia/reperfusion injury. Blood 118: 1934-1942.