Double-edged role of the CXCL12/CXCR4 axis in experimental myocardial infarction

Journal of the American College of Cardiology

Volumn 58, Issue 23, 2011, Pages 2415-2423

  Liehn, Elisa A ^a   Tuchscheerer, Nancy ^a   Kanzler, Isabella ^a   Drechsler, Maik ^a,b   Fraemohs, Line ^a   Schuh, Alexander ^a   Koenen, Rory R ^a,b   Zander, Simone ^d   Soehnlein, Oliver ^a,b   Hristov, Mihail ^a,b   Grigorescu, Gabriela ^e   Urs, Andreea O ^f   Leabu, Mircea ^f   Bucur, Ilie ^g   Merx, Marc W ^d   Zernecke, Alma ^h   Ehling, Josef ^a   Gremse, Felix ^a   Lammers, Twan ^a   Kiessling, Fabian ^a   Bernhagen, Jrgen ^a   Schober, Andreas ^a   Weber, Christian ^b,c,i   more..

^a RWTH AACHEN UNIVERSITY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Munich Heart Alliance   (Germany)

^d UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^e INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

^f VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY   (Romania)

^g Applied Systems   (Romania)

^h UNIVERSITY OF WÜRZBURG   (Germany)

ⁱ MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

angiogenesis; chemokine receptor; inflammation; myocardial infarction; myocardial remodeling

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; LIPID; LIPOFUSCIN; PHOSPHATIDYLSERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS RELATED GENE; ARTICLE; BLOOD VESSEL DENSITY; BLOOD VESSEL PARAMETERS; BONE MARROW; CELL COUNT; CELL HYPOXIA; CELL INFILTRATION; CELL STRESS; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; EXPERIMENTAL MODEL; FLOW CYTOMETRY; GENE; GENE EXPRESSION; HEART BLOOD VESSEL; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART PERFUSION; HEART PROTECTION; HEART VENTRICLE REMODELING; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATORY CELL; LIPID ANALYSIS; LIPID STORAGE; MONOCYTE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL; VASCULAR ENDOTHELIAL GROWTH FACTOR GENE; WILD TYPE;

ANIMALS; APOPTOSIS; CHEMOKINE CXCL12; DISEASE MODELS, ANIMAL; DNA; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 81855225283     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.08.033     Document Type: Article

References (33)

1. N.G. Frangogiannis, and M.L. Entman Chemokines in myocardial ischemia Trends Cardiovasc Med 15 2005 163 169 (Pubitemid 41297626)
2. A. Schober, E. Karshovska, A. Zernecke, and C. Weber SDF-1alpha-mediated tissue repair by stem cells: a promising tool in cardiovascular medicine? Trends Cardiovasc Med 16 2006 103 108
3. A. Zernecke, A. Schober, and I. Bot SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells Circ Res 96 2005 784 791 (Pubitemid 40559518)
4. M. Zhang, N. Mal, and M. Kiedrowski SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction FASEB J 21 2007 3197 3207 (Pubitemid 47565538)
5. J.D. Abbott, Y. Huang, and D. Liu Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury Circulation 110 2004 3300 3305 (Pubitemid 39557491)
6. A.T. Askari, S. Unzek, and Z.B. Popovic Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy Lancet 362 2003 697 703 (Pubitemid 37101067)
7. D. Zhang, G.C. Fan, and X. Zhou Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium J Mol Cell Cardiol 44 2008 281 292
8. V.F. Segers, T. Tokunou, and L.J. Higgins Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction Circulation 116 2007 1683 1692 (Pubitemid 47537842)
9. X. Hu, S. Dai, and W.J. Wu Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis Circulation 116 2007 654 663 (Pubitemid 47356350)
10. A. Saxena, J.E. Fish, and M.D. White Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction Circulation 117 2008 2224 2231
11. A. Schuh, E.A. Liehn, and A. Sasse Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model Basic Res Cardiol 103 2008 69 77 (Pubitemid 50002796)
12. C. Proulx, V. El-Helou, and H. Gosselin Antagonism of stromal cell-derived factor-1alpha reduces infarct size and improves ventricular function after myocardial infarction Pflugers Arch 455 2007 241 250 (Pubitemid 47546792)
13. S.R. Vlahakis, A. Villasis-Keever, and T. Gomez G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways J Immunol 169 2002 5546 5554 (Pubitemid 35291653)
14. E. De Clercq The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil) Biochem Pharmacol 77 2009 1655 1664
15. Q. Ma, D. Jones, and P.R. Borghesani Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice Proc Natl Acad Sci U S A 95 1998 9448 9453 (Pubitemid 28506251)
16. D.H. Walter, J. Haendeler, and J. Reinhold Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease Circ Res 97 2005 1142 1151
17. M. Nahrendorf, F.K. Swirski, and E. Aikawa The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions J Exp Med 204 2007 3037 3047 (Pubitemid 350179569)
18. G. Nalbone, E. Termine, and J. Leonardi Effect of dietary salmon oil feeding on rat heart lipid status J Nutr 118 1988 809 817
19. B. Yang, T.G. Saldeen, W.W. Nichols, and J.L. Mehta Dietary fish oil supplementation attenuates myocardial dysfunction and injury caused by global ischemia and reperfusion in isolated rat hearts J Nutr 123 1993 2067 2074 (Pubitemid 24020730)
20. K.J. Eash, J.M. Means, D.W. White, and D.C. Link CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions Blood 113 2009 4711 4719
21. S.T. Tarzami, W. Miao, and K. Mani Opposing effects mediated by the chemokine receptor CXCR2 on myocardial ischemia-reperfusion injury: recruitment of potentially damaging neutrophils and direct myocardial protection Circulation 108 2003 2387 2392 (Pubitemid 37413547)
22. A. Zernecke, I. Bot, and Y. Djalali-Talab Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis Circ Res 102 2008 209 217 (Pubitemid 351651125)
23. E. Karshovska, D. Zagorac, and A. Zernecke A small molecule CXCR4 antagonist inhibits neointima formation and smooth muscle progenitor cell mobilization after arterial injury J Thromb Haemost 6 2008 1812 1815
24. E.A. Liehn, M.W. Merx, and O. Postea Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction J Cell Mol Med 12 2008 496 506 (Pubitemid 351555130)
25. O. Soehnlein, A. Zernecke, and E.E. Eriksson Neutrophil secretion products pave the way for inflammatory monocytes Blood 112 2008 1461 1471
26. E.A. Liehn, A.M. Piccinini, and R.R. Koenen A new monocyte chemotactic protein-1/chemokine CC motif ligand-2 competitor limiting neointima formation and myocardial ischemia/reperfusion injury in mice J Am Coll Cardiol 56 2010 1847 1857
27. T. Lapidot, and I. Petit Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells Exp Hematol 30 2002 973 981 (Pubitemid 35286613)
28. R.T. Pyo, J. Sui, and A. Dhume CXCR4 modulates contractility in adult cardiac myocytes J Mol Cell Cardiol 41 2006 834 844 (Pubitemid 44635574)
29. U. Agarwal, W. Ghalayini, and F. Dong Role of cardiac myocyte CXCR4 expression in development and left ventricular remodeling after acute myocardial infarction Circ Res 107 2010 667 676
30. C.E. Hock, L.D. Beck, R.C. Bodine, and D.K. Reibel Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion Am J Physiol 259 1990 H1518 H1526
31. A.L. Hunter, J.C. Choy, and D.J. Granville Detection of apoptosis in cardiovascular diseases Methods Mol Med 112 2005 277 289
32. G.F. Baxter, and P. Ferdinandy Delayed preconditioning of myocardium: current perspectives Basic Res Cardiol 96 2001 329 344 (Pubitemid 32700570)
33. P.R. Hoffmann, J.A. Kench, and A. Vondracek Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo J Immunol 174 2005 1393 1404