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Volumn 8, Issue 11, 2013, Pages

Targeting TNF-α and NF-κB activation by bee venom: Role in suppressing adjuvant induced arthritis and methotrexate hepatotoxicity in rats

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ARTHRITIS, EXPERIMENTAL; BEE VENOMS; LIVER; MALE; METHOTREXATE; NF-KAPPA B; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84894237586     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079284     Document Type: Article
Times cited : (77)

References (63)
  • 1
    • 60549116190 scopus 로고    scopus 로고
    • Developments in the clinical understanding of rheumatoid arthritis
    • Smolen JS, Aletaha D (2009) Developments in the clinical understanding of rheumatoid arthritis. Arthritis Res Ther 11: 204.
    • (2009) Arthritis Res Ther , vol.11 , pp. 204
    • Smolen, J.S.1    Aletaha, D.2
  • 2
    • 79960319731 scopus 로고    scopus 로고
    • Morus bombycis Koidzumi extract suppresses collagen-induced arthritis by inhibiting the activation of nuclear factor-kappaB and activator protein-1 in mice
    • Kim HS, Kim AR, Park HJ, Park DK, Kim do K, et al. (2011) Morus bombycis Koidzumi extract suppresses collagen-induced arthritis by inhibiting the activation of nuclear factor-kappaB and activator protein-1 in mice. J Ethnopharmacol 136: 392-398.
    • (2011) J Ethnopharmacol , vol.136 , pp. 392-398
    • Kim, H.S.1    Kim, A.R.2    Park, H.J.3    Park, D.K.4    Kim Do, K.5
  • 3
    • 78651296775 scopus 로고    scopus 로고
    • Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis
    • Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, et al. (2011) Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. J Cell Biochem 112: 107-117.
    • (2011) J Cell Biochem , vol.112 , pp. 107-117
    • Vaillancourt, F.1    Silva, P.2    Shi, Q.3    Fahmi, H.4    Fernandes, J.C.5
  • 4
    • 33746480903 scopus 로고    scopus 로고
    • NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
    • DOI 10.1016/j.joca.2006.04.008, PII S1063458406001105
    • Roman-Blas JA, Jimenez SA (2006) NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis Cartilage 14: 839-848. (Pubitemid 44138675)
    • (2006) Osteoarthritis and Cartilage , vol.14 , Issue.9 , pp. 839-848
    • Roman-Blas, J.A.1    Jimenez, S.A.2
  • 5
    • 2642517290 scopus 로고    scopus 로고
    • Increased synovial tissue NF-kappaB1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis
    • DOI 10.1002/art.20260
    • Benito MJ, Murphy E, Murphy EP, van den Berg WB, FitzGerald O, et al. (2004) Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum 50: 1781-1787. (Pubitemid 38725090)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.6 , pp. 1781-1787
    • Benito, M.J.1    Murphy, E.2    Murphy, E.P.3    Van Den, B.W.B.4    FitzGerald, O.5    Bresnihan, B.6
  • 6
    • 0026091413 scopus 로고
    • Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis
    • Chu CQ, Field M, Feldmann M, Maini RN (1991) Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum 34: 1125-1132.
    • (1991) Arthritis Rheum , vol.34 , pp. 1125-1132
    • Chu, C.Q.1    Field, M.2    Feldmann, M.3    Maini, R.N.4
  • 7
    • 79958121207 scopus 로고    scopus 로고
    • Methotrexate: Mainstay of rheumatoid arthritis treatment
    • Jacobs JW, Bijlsma JW (2009) [Methotrexate: mainstay of rheumatoid arthritis treatment]. Ned Tijdschr Geneeskd 153: A879.
    • (2009) Ned Tijdschr Geneeskd , vol.153
    • Jacobs, J.W.1    Bijlsma, J.W.2
  • 8
    • 0026576192 scopus 로고
    • Clinical liver disease in patients with rheumatoid arthritis taking methotrexate
    • Phillips CA, Cera PJ, Mangan TF, Newman ED (1992) Clinical liver disease in patients with rheumatoid arthritis taking methotrexate. J Rheumatol 19: 229-233.
    • (1992) J Rheumatol , vol.19 , pp. 229-233
    • Phillips, C.A.1    Cera, P.J.2    Mangan, T.F.3    Newman, E.D.4
  • 9
    • 0025789613 scopus 로고
    • Hepatotoxicity in a rat model caused by orally administered methotrexate
    • Hall PD, Jenner MA, Ahern MJ (1991) Hepatotoxicity in a rat model caused by orally administered methotrexate. Hepatology 14: 906-910.
    • (1991) Hepatology , vol.14 , pp. 906-910
    • Hall, P.D.1    Jenner, M.A.2    Ahern, M.J.3
  • 10
    • 76649093275 scopus 로고    scopus 로고
    • Complementary and alternative medicine in rheumatoid arthritis: No longer the last resort!
    • Efthimiou P, Kukar M, Mackenzie CR (2010) Complementary and alternative medicine in rheumatoid arthritis: no longer the last resort! HSS J 6: 108-111.
    • (2010) HSS J , vol.6 , pp. 108-111
    • Efthimiou, P.1    Kukar, M.2    Mackenzie, C.R.3
  • 12
    • 1542470588 scopus 로고    scopus 로고
    • Advances in the study of bee venom and its clinical uses
    • Liu H, Tong F (2003) [Advances in the study of bee venom and its clinical uses]. Zhong Yao Cai 26: 456-458.
    • (2003) Zhong Yao Cai , vol.26 , pp. 456-458
    • Liu, H.1    Tong, F.2
  • 13
    • 55349119473 scopus 로고    scopus 로고
    • Effects of bee venom on the maturation of murine dendritic cells stimulated by LPS
    • Lee HS, Chung SH, Song MY, Kim SS, Shin HD, et al. (2008) Effects of bee venom on the maturation of murine dendritic cells stimulated by LPS. J Ethnopharmacol 120: 215-219.
    • (2008) J Ethnopharmacol , vol.120 , pp. 215-219
    • Lee, H.S.1    Chung, S.H.2    Song, M.Y.3    Kim, S.S.4    Shin, H.D.5
  • 14
    • 3042521436 scopus 로고    scopus 로고
    • Inhibition of COX-2 activity and proinflammatory cytokines (TNF-alpha and IL-1beta) production by water-soluble sub-fractionated parts from bee (Apis mellifera) venom
    • Nam KW, Je KH, Lee JH, Han HJ, Lee HJ, et al. (2003) Inhibition of COX-2 activity and proinflammatory cytokines (TNF-alpha and IL-1beta) production by water-soluble sub-fractionated parts from bee (Apis mellifera) venom. Arch Pharm Res 26: 383-388.
    • (2003) Arch Pharm Res , vol.26 , pp. 383-388
    • Nam, K.W.1    Je, K.H.2    Lee, J.H.3    Han, H.J.4    Lee, H.J.5
  • 15
    • 8444239358 scopus 로고    scopus 로고
    • Antiarthritic effect of bee venom: Inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit
    • Park HJ, Lee SH, Son DJ, Oh KW, Kim KH, et al. (2004) Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit. Arthritis Rheum 50: 3504-3515.
    • (2004) Arthritis Rheum , vol.50 , pp. 3504-3515
    • Park, H.J.1    Lee, S.H.2    Son, D.J.3    Oh, K.W.4    Kim, K.H.5
  • 16
    • 54449091802 scopus 로고    scopus 로고
    • Clinical randomized study of bee-sting therapy for rheumatoid arthritis
    • Liu XD, Zhang JL, Zheng HG, Liu FY, Chen Y (2008) [Clinical randomized study of bee-sting therapy for rheumatoid arthritis]. Zhen Ci Yan Jiu 33: 197-200.
    • (2008) Zhen Ci Yan Jiu , vol.33 , pp. 197-200
    • Liu, X.D.1    Zhang, J.L.2    Zheng, H.G.3    Liu, F.Y.4    Chen, Y.5
  • 18
    • 34547109974 scopus 로고    scopus 로고
    • Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis
    • Paulos CM, Varghese B, Widmer WR, Breur GJ, Vlashi E, et al. (2006) Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis Res Ther 8: R77.
    • (2006) Arthritis Res Ther , vol.8
    • Paulos, C.M.1    Varghese, B.2    Widmer, W.R.3    Breur, G.J.4    Vlashi, E.5
  • 19
    • 0027491671 scopus 로고
    • 1-acid glycoprotein (AGP) gene induction following honey bee venom administration to adjuvant arthritic (AA) rats; possible role of AGP on AA development
    • Yiangou M, Konidaris C, Victoratos P, Hadjipetrou-Kourounakis L (1993) Modulation of alpha 1-acid glycoprotein (AGP) gene induction following honey bee venom administration to adjuvant arthritic (AA) rats; possible role of AGP on AA development. Clin Exp Immunol 94: 156-162. (Pubitemid 23308382)
    • (1993) Clinical and Experimental Immunology , vol.94 , Issue.1 , pp. 156-162
    • Yiangou, M.1    Konidaris, C.2    Victoratos, P.3    Hadjipetrou-Kourounakis, L.4
  • 20
    • 0035864885 scopus 로고    scopus 로고
    • Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses
    • Kwon YB, Lee JD, Lee HJ, Han HJ, Mar WC, et al. (2001) Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. Pain 90: 271-280.
    • (2001) Pain , vol.90 , pp. 271-280
    • Kwon, Y.B.1    Lee, J.D.2    Lee, H.J.3    Han, H.J.4    Mar, W.C.5
  • 21
    • 55349127899 scopus 로고    scopus 로고
    • Suppressive effects of bee venom on the immune responses in collagen-induced arthritis in rats
    • Kim KW, Shin YS, Kim KS, Chang YC, Park KK, et al. (2008) Suppressive effects of bee venom on the immune responses in collagen-induced arthritis in rats. Phytomedicine 15: 1099-1107.
    • (2008) Phytomedicine , vol.15 , pp. 1099-1107
    • Kim, K.W.1    Shin, Y.S.2    Kim, K.S.3    Chang, Y.C.4    Park, K.K.5
  • 22
    • 33746080019 scopus 로고    scopus 로고
    • Therapeutic effects of Semecarpus anacardium Linn. nut milk extract on the changes associated with collagen and glycosaminoglycan metabolism in adjuvant arthritic Wistar rats
    • DOI 10.1016/j.cbi.2006.05.003, PII S0009279706001098
    • Ramprasath VR, Shanthi P, Sachdanandam P (2006) Therapeutic effects of Semecarpus anacardium Linn. nut milk extract on the changes associated with collagen and glycosaminoglycan metabolism in adjuvant arthritic Wistar rats. Chem Biol Interact 162: 43-52. (Pubitemid 44080165)
    • (2006) Chemico-Biological Interactions , vol.162 , Issue.1 , pp. 43-52
    • Ramprasath, V.R.1    Shanthi, P.2    Sachdanandam, P.3
  • 23
    • 33644871177 scopus 로고    scopus 로고
    • Anti-inflammatory effects of contralateral administration of the kappa-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis
    • DOI 10.1093/rheumatology/kei156
    • Bileviciute-Ljungar I, Saxne T, Spetea M (2006) Anti-inflammatory effects of contralateral administration of the kappa-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis. Rheumatology (Oxford) 45: 295-302. (Pubitemid 43372844)
    • (2006) Rheumatology , vol.45 , Issue.3 , pp. 295-302
    • Bileviciute-Ljungar, I.1    Saxne, T.2    Spetea, M.3
  • 24
    • 0034799876 scopus 로고    scopus 로고
    • The kappa-opioid agonist, asimadoline, alters cytokine gene expression in adjuvant arthritis
    • Oxford
    • Bush KA, Kirkham BW, Walker JS (2001) The kappa-opioid agonist, asimadoline, alters cytokine gene expression in adjuvant arthritis. Rheumatology (Oxford) 40: 1013-1021.
    • (2001) Rheumatology , vol.40 , pp. 1013-1021
    • Bush, K.A.1    Kirkham, B.W.2    Walker, J.S.3
  • 25
    • 84984548871 scopus 로고    scopus 로고
    • Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice
    • DOI 10.1016/j.brainres.2007.07.086, PII S0006899307016642
    • Savegnago L, Jesse CR, Pinto LG, Rocha JB, Nogueira CW (2007) Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice. Brain Res 1175: 54-59. (Pubitemid 47513005)
    • (2007) Brain Research , vol.1175 , Issue.1 , pp. 54-59
    • Savegnago, L.1    Jesse, C.R.2    Pinto, L.G.3    Rocha, J.B.T.4    Nogueira, C.W.5
  • 27
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
    • Reitman S, Frankel S (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28: 56-63.
    • (1957) Am J Clin Pathol , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.2
  • 28
    • 31144448702 scopus 로고    scopus 로고
    • Smokeless tobacco impairs the antioxidant defense in liver, lung, and kidney of rats
    • DOI 10.1093/toxsci/kfj041
    • Avti PK, Kumar S, Pathak CM, Vaiphei K, Khanduja KL (2006) Smokeless Tobacco Impairs the Antioxidant Defense in Liver, Lung, and Kidney of Rats. Toxicol Sci 89: 547-553. (Pubitemid 43126014)
    • (2006) Toxicological Sciences , vol.89 , Issue.2 , pp. 547-553
    • Avti, P.K.1    Kumar, S.2    Pathak, C.M.3    Vaiphei, K.4    Khanduja, K.L.5
  • 29
    • 35649023211 scopus 로고    scopus 로고
    • Pharmacokinetics of intravenous methotrexate in mutant nagase analbuminemic rats
    • DOI 10.1002/bdd.565
    • Choi YH, Bae SK, Oh JM, Kim SO, Lee MG (2007) Pharmacokinetics of intravenous methotrexate in mutant Nagase analbuminemic rats. Biopharm Drug Dispos 28: 385-392. (Pubitemid 350020229)
    • (2007) Biopharmaceutics and Drug Disposition , vol.28 , Issue.7 , pp. 385-392
    • Choi, Y.H.1    Bae, S.K.2    Oh, J.M.3    Kim, S.-O.4    Lee, M.G.5
  • 30
    • 79953196092 scopus 로고    scopus 로고
    • Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis
    • Mendes MT, Murari-do-Nascimento S, Torrigo IR, Alponti RF, Yamasaki SC, et al. (2011) Basic aminopeptidase activity is an emerging biomarker in collagen-induced rheumatoid arthritis. Regul Pept 167: 215-221.
    • (2011) Regul Pept , vol.167 , pp. 215-221
    • Mendes, M.T.1    Murari-Do-Nascimento, S.2    Torrigo, I.R.3    Alponti, R.F.4    Yamasaki, S.C.5
  • 31
    • 84948781689 scopus 로고    scopus 로고
    • High-Performance Liquid Chromatography Determination of Methotrexate in Plasma
    • Moghbel A, Zand-Moghaddam A, Rezaee S, Pedram M (2003) High-Performance Liquid Chromatography Determination of Methotrexate in Plasma. Iran J Pharm Res2: 149-152.
    • (2003) Iran J Pharm Res , vol.2 , pp. 149-152
    • Moghbel, A.1    Zand-Moghaddam, A.2    Rezaee, S.3    Pedram, M.4
  • 32
    • 0025147457 scopus 로고
    • Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue
    • Wolfrom C, Hepp R, Hartmann R, Breithaupt H, Henze G (1990) Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue. Eur J Clin Pharmacol 39: 377-383. (Pubitemid 20362350)
    • (1990) European Journal of Clinical Pharmacology , vol.39 , Issue.4 , pp. 377-383
    • Wolfrom, C.1    Hepp, R.2    Hartmann, R.3    Breithaupt, H.4    Henze, G.5
  • 33
    • 38649095612 scopus 로고    scopus 로고
    • Therapeutic effects and mechanisms of total flavonoids of Turpinia Arguta Seen on adjuvant arthritis in rats
    • Zhang L, Li J, Yu SC, Jin Y, Lv XW, et al. (2008) Therapeutic effects and mechanisms of total flavonoids of Turpinia Arguta Seen on adjuvant arthritis in rats. J Ethnopharmacol 116: 167-172.
    • (2008) J Ethnopharmacol , vol.116 , pp. 167-172
    • Zhang, L.1    Li, J.2    Yu, S.C.3    Jin, Y.4    Lv, X.W.5
  • 34
    • 2342555611 scopus 로고    scopus 로고
    • Antiinflammatory and Analgesic Effects of Somatostatin Released from Capsaicin-Sensitive Sensory Nerve Terminals in a Freund's Adjuvant-Induced Chronic Arthritis Model in the Rat
    • DOI 10.1002/art.20184
    • Helyes Z, Szabó Á, Németh J, Jakab B, Pintér E, et al. (2004) Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat. Arthritis Rheum 50: 1677-1685. (Pubitemid 38608091)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.5 , pp. 1677-1685
    • Helyes, Z.1    Szabo, A.2    Nemeth, J.3    Jakab, B.4    Pinter, E.5    Banvolgyi, A.6    Kereskai, L.7    Keri, G.8    Szolcsanyi, J.9
  • 35
    • 4143053594 scopus 로고    scopus 로고
    • Anti-inflammatory effect of bee venom on type II collagen-induced arthritis
    • Lee JD, Kim SY, Kim TW, Lee SH, Yang HI, et al. (2004) Anti-inflammatory effect of bee venom on type II collagen-induced arthritis. Am J Chin Med 32: 361-367.
    • (2004) Am J Chin Med , vol.32 , pp. 361-367
    • Lee, J.D.1    Kim, S.Y.2    Kim, T.W.3    Lee, S.H.4    Yang, H.I.5
  • 36
    • 33644936572 scopus 로고    scopus 로고
    • Antinociceptive effect and the mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the rat model of collagen-induced arthritis: Mediation by alpha2-Adrenoceptors
    • Baek YH, Huh JE, Lee JD, Choi do Y, Park DS (2006) Antinociceptive effect and the mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the rat model of collagen-induced arthritis: Mediation by alpha2-Adrenoceptors. Brain Res 1073-1074: 305-310.
    • (2006) Brain Res , vol.1073-1074 , pp. 305-310
    • Baek, Y.H.1    Huh, J.E.2    Lee, J.D.3    Choi Do, Y.4    Park, D.S.5
  • 37
    • 33749567082 scopus 로고    scopus 로고
    • Effects of bee venom on protease activities and free radical damages in synovial fluid from type II collagen-induced rheumatoid arthritis rats
    • Suh SJ, Kim KS, Kim MJ, Chang YC, Lee SD, et al. (2006) Effects of bee venom on protease activities and free radical damages in synovial fluid from type II collagen-induced rheumatoid arthritis rats. Toxicol In Vitro 20: 1465-1471.
    • (2006) Toxicol in Vitro , vol.20 , pp. 1465-1471
    • Suh, S.J.1    Kim, K.S.2    Kim, M.J.3    Chang, Y.C.4    Lee, S.D.5
  • 38
    • 40949154817 scopus 로고    scopus 로고
    • Bee venom acupuncture for musculoskeletal pain: A review
    • Lee MS, Pittler MH, Shin BC, Kong JC, Ernst E (2008) Bee venom acupuncture for musculoskeletal pain: a review. J Pain 9: 289-297.
    • (2008) J Pain , vol.9 , pp. 289-297
    • Lee, M.S.1    Pittler, M.H.2    Shin, B.C.3    Kong, J.C.4    Ernst, E.5
  • 39
    • 22944470530 scopus 로고    scopus 로고
    • Low-dose methotrexate: A mainstay in the treatment of rheumatoid arthritis
    • Cronstein BN (2005) Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol Rev 57: 163-172.
    • (2005) Pharmacol Rev , vol.57 , pp. 163-172
    • Cronstein, B.N.1
  • 40
    • 34447312502 scopus 로고    scopus 로고
    • Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds
    • DOI 10.1016/j.pharmthera.2007.04.004, PII S0163725807000782
    • Son DJ, Lee JW, Lee YH, Song HS, Lee CK, et al. (2007) Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol Ther 115: 246-270. (Pubitemid 47053894)
    • (2007) Pharmacology and Therapeutics , vol.115 , Issue.2 , pp. 246-270
    • Son, D.J.1    Lee, J.W.2    Lee, Y.H.3    Song, H.S.4    Lee, C.K.5    Hong, J.T.6
  • 41
    • 0023640577 scopus 로고
    • Characterization of bee venom and its main components by high-performance liquid chromatography
    • DOI 10.1016/S0021-9673(01)81820-3
    • Rader K, Wildfeuer A, Wintersberger F, Bossinger P, Mucke HW (1987) Characterization of bee venom and its main components by high-performance liquid chromatography. J Chromatogr 408: 341-348. (Pubitemid 17159034)
    • (1987) Journal of Chromatography , vol.408 , pp. 341-348
    • Rader, K.1    Wildfeuer, A.2    Wintersberger, F.3    Bossinger, P.4    Mucke, H.-W.5
  • 42
    • 78650217588 scopus 로고    scopus 로고
    • Characterization of honeybee venom by MALDI-TOF and nanoESI-QqTOF mass spectrometry
    • Matysiak J, Schmelzer CE, Neubert RH, Kokot ZJ (2011) Characterization of honeybee venom by MALDI-TOF and nanoESI-QqTOF mass spectrometry. J Pharm Biomed Anal 54: 273-278.
    • (2011) J Pharm Biomed Anal , vol.54 , pp. 273-278
    • Matysiak, J.1    Schmelzer, C.E.2    Neubert, R.H.3    Kokot, Z.J.4
  • 43
    • 79953289027 scopus 로고    scopus 로고
    • Effects induced by Apis mellifera venom and its components in experimental models of nociceptive and inflammatory pain
    • Merlo LA, Bastos LFS, Godin AM, Rocha LTS, Nascimento Jr EB, et al. (2011) Effects induced by Apis mellifera venom and its components in experimental models of nociceptive and inflammatory pain. Toxicon 57: 764-771.
    • (2011) Toxicon , vol.57 , pp. 764-771
    • Merlo, L.A.1    Bastos, L.F.S.2    Godin, A.M.3    Rocha, L.T.S.4    Nascimento Jr., E.B.5
  • 44
    • 0034942860 scopus 로고    scopus 로고
    • NF-kappa B in rheumatoid arthritis: A pivotal regulator of inflammation, hyperplasia, and tissue destruction
    • Makarov SS (2001) NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res 3: 200-206.
    • (2001) Arthritis Res , vol.3 , pp. 200-206
    • Makarov, S.S.1
  • 45
    • 0036730319 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis: Pivotal cytokines involved in bone degradation and inflammation
    • Bingham CO, 3rd (2002) The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation. J Rheumatol Suppl 65: 3-9.
    • (2002) J Rheumatol Suppl , vol.65 , pp. 3-9
    • Bingham III, C.O.1
  • 46
    • 5644304287 scopus 로고    scopus 로고
    • Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate
    • DOI 10.1002/art.20518
    • Kane D, Gogarty M, O'Leary J, Silva I, Bermingham N, et al. (2004) Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum 50: 3286-3295. (Pubitemid 39372006)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.10 , pp. 3286-3295
    • Kane, D.1    Gogarty, M.2    O'Leary, J.3    Silva, I.4    Bermingham, N.5    Bresnihan, B.6    FitzGerald, O.7
  • 48
    • 0037247929 scopus 로고    scopus 로고
    • The Anti-Inflammatory Effect of Bee Venom Stimulation in a Mouse Air Pouch Model Is Mediated by Adrenal Medullary Activity
    • Kwon YB, Kim HW, Ham TW, Yoon SY, Roh DH, et al. (2003) The Anti-Inflammatory Effect of Bee Venom Stimulation in a Mouse Air Pouch Model Is Mediated by Adrenal Medullary Activity. J Neuroendocrinol 15: 93-96.
    • (2003) J Neuroendocrinol , vol.15 , pp. 93-96
    • Kwon, Y.B.1    Kim, H.W.2    Ham, T.W.3    Yoon, S.Y.4    Roh, D.H.5
  • 49
    • 77950801122 scopus 로고    scopus 로고
    • TNF-alpha and neuropathic pain - A review
    • Leung L, Cahill CM (2010) TNF-alpha and neuropathic pain-a review. J Neuroinflammation 7: 27.
    • (2010) J Neuroinflammation , vol.7 , pp. 27
    • Leung, L.1    Cahill, C.M.2
  • 50
    • 0033963153 scopus 로고    scopus 로고
    • Nociceptive and inflammatory effects of subcutaneous TNFalpha
    • Junger H, Sorkin LS (2000) Nociceptive and inflammatory effects of subcutaneous TNFalpha. Pain 85: 145-151.
    • (2000) Pain , vol.85 , pp. 145-151
    • Junger, H.1    Sorkin, L.S.2
  • 51
    • 77955300958 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
    • van de Steeg E, Wagenaar E, van der Kruijssen CM, Burggraaff JE, de Waart DR, et al. (2010) Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J Clin Invest 120: 2942-2952.
    • (2010) J Clin Invest , vol.120 , pp. 2942-2952
    • Van De Steeg, E.1    Wagenaar, E.2    Van Der Kruijssen, C.M.3    Burggraaff, J.E.4    De Waart, D.R.5
  • 52
    • 59649117206 scopus 로고    scopus 로고
    • Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1)
    • van de Steeg E, van der Kruijssen CM, Wagenaar E, Burggraaff JE, Mesman E, et al. (2009) Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1). Drug Metab Dispos 37: 277-281.
    • (2009) Drug Metab Dispos , vol.37 , pp. 277-281
    • Van De Steeg, E.1    Van Der Kruijssen, C.M.2    Wagenaar, E.3    Burggraaff, J.E.4    Mesman, E.5
  • 53
    • 16644383355 scopus 로고    scopus 로고
    • Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury
    • Ding WX, Yin XM (2004) Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. J Cell Mol Med 8: 445-454.
    • (2004) J Cell Mol Med , vol.8 , pp. 445-454
    • Ding, W.X.1    Yin, X.M.2
  • 57
    • 0034747144 scopus 로고    scopus 로고
    • Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats
    • DOI 10.1053/jhep.2001.29400
    • Uesugi T, Froh M, Arteel GE, Bradford BU, Gabele E, et al. (2001) Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats. Hepatology 34: 1149-1157. (Pubitemid 33096587)
    • (2001) Hepatology , vol.34 , Issue.6 , pp. 1149-1157
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Gbele, E.5    Wheeler, M.D.6    Thurman, R.G.7
  • 59
    • 78650377859 scopus 로고    scopus 로고
    • Resveratrol protects against methotrexate-induced hepatic injury in rats
    • Tunali-Akbay T, Sehirli O, Ercan F, Sener G (2010) Resveratrol protects against methotrexate-induced hepatic injury in rats. J Pharm Pharm Sci 13: 303-310.
    • (2010) J Pharm Pharm Sci , vol.13 , pp. 303-310
    • Tunali-Akbay, T.1    Sehirli, O.2    Ercan, F.3    Sener, G.4
  • 61
    • 77949890358 scopus 로고    scopus 로고
    • Bee venom protects hepatocytes from tumor necrosis factor-alpha and actinomycin D
    • Park JH, Kim KH, Kim SJ, Lee WR, Lee KG, et al. (2010) Bee venom protects hepatocytes from tumor necrosis factor-alpha and actinomycin D. Arch Pharm Res 33: 215-223.
    • (2010) Arch Pharm Res , vol.33 , pp. 215-223
    • Park, J.H.1    Kim, K.H.2    Kim, S.J.3    Lee, W.R.4    Lee, K.G.5
  • 62
    • 77953857517 scopus 로고    scopus 로고
    • The protective effect of bee venom against ethanol-induced hepatic injury via regulation of the mitochondria-related apoptotic pathway
    • Kim KH, Kum YS, Park YY, Park JH, Kim SJ, et al. (2010) The protective effect of bee venom against ethanol-induced hepatic injury via regulation of the mitochondria-related apoptotic pathway. Basic Clin Pharmacol Toxicol 107: 619-624.
    • (2010) Basic Clin Pharmacol Toxicol , vol.107 , pp. 619-624
    • Kim, K.H.1    Kum, Y.S.2    Park, Y.Y.3    Park, J.H.4    Kim, S.J.5
  • 63
    • 0020554087 scopus 로고
    • The pharmacology and clinical use of methotrexate
    • Jolivet J, Cowan KH, Curt GA, Clendeninn NJ, Chabner BA (1983) The pharmacology and clinical use of methotrexate. N Engl J Med 309: 1094-1104. (Pubitemid 13023161)
    • (1983) New England Journal of Medicine , vol.309 , Issue.18 , pp. 1094-1104
    • Jolivet, J.1    Cowan, K.H.2    Curt, G.A.3


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