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Volumn 209, Issue 5, 2014, Pages 676-685

DNA prime and virus-like particle boost from a single H5N1 strain elicits broadly neutralizing antibody responses against head region of H5 hemagglutinin

Author keywords

HPAI H5N1; neutralizing antibody responses; vaccination

Indexed keywords

HPAI H5N1; NEUTRALIZING ANTIBODY RESPONSES; VACCINATION;

EID: 84894233437     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit414     Document Type: Conference Paper
Times cited : (13)

References (50)
  • 1
    • 84894249175 scopus 로고    scopus 로고
    • United Nations Food and Agriculture Organization Food and Agriculture Organization. New York.
    • United Nations Food and Agriculture Organization. FAO ECTAD HPAI situation update. No.562. Food and Agriculture Organization. New York. 2013.
    • (2013) FAO ECTAD HPAI Situation Update , pp. 562
  • 3
    • 79958053312 scopus 로고    scopus 로고
    • Acquisition of humantype receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt
    • Watanabe Y, Ibrahim MS, Ellakany HF, et al. Acquisition of humantype receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt. PLoS Pathog 2011; 7: e1002068.
    • (2011) PLoS Pathog , vol.7
    • Watanabe, Y.1    Ibrahim, M.S.2    Ellakany, H.F.3
  • 4
    • 84862618108 scopus 로고    scopus 로고
    • Airborne transmission of influenza A/H5N1 virus between ferrets
    • Herfst S, Schrauwen EJ, Linster M, et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science 2012; 336:1534-41.
    • (2012) Science , vol.336 , pp. 1534-1541
    • Herfst, S.1    Schrauwen, E.J.2    Linster, M.3
  • 5
    • 84861394598 scopus 로고    scopus 로고
    • Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
    • Imai M, Watanabe T, Hatta M, et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 2012; 486:420-8.
    • (2012) Nature , vol.486 , pp. 420-428
    • Imai, M.1    Watanabe, T.2    Hatta, M.3
  • 7
    • 83555173308 scopus 로고    scopus 로고
    • Continued evolution of highly pathogenic avian influenza A (H5N1): Updated nomenclature
    • WHO/OIE/FAO H5N1 Evolution Working Group
    • WHO/OIE/FAO H5N1 Evolution Working Group. Continued evolution of highly pathogenic avian influenza A (H5N1): updated nomenclature. Influenza Other Respi Viruses 2012; 6:1-5.
    • (2012) Influenza Other Respi Viruses , vol.6 , pp. 1-5
  • 9
    • 42949157327 scopus 로고    scopus 로고
    • Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle
    • Bright RA, Carter DM, Crevar CJ, et al. Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle. PLoS One 2008; 3:e1501.
    • (2008) PLoS One , vol.3
    • Bright, R.A.1    Carter, D.M.2    Crevar, C.J.3
  • 10
    • 56349088371 scopus 로고    scopus 로고
    • Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine
    • Crevar CJ, Ross TM. Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine. Virol J 2008; 5:131.
    • (2008) Virol J , vol.5 , pp. 131
    • Crevar, C.J.1    Ross, T.M.2
  • 11
    • 49149087366 scopus 로고    scopus 로고
    • Multivalent HA DNA vaccination protects against highly pathogenic H5N1 avian influenza infection in chickens and mice
    • Rao S, Kong WP, Wei CJ, et al. Multivalent HA DNA vaccination protects against highly pathogenic H5N1 avian influenza infection in chickens and mice. PLoS One 2008; 3:e2432.
    • (2008) PLoS One , vol.3
    • Rao, S.1    Kong, W.P.2    Wei, C.J.3
  • 13
    • 67849086592 scopus 로고    scopus 로고
    • Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice
    • Tao P, Luo M, Zhu D, et al. Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice. Viral Immunol 2009; 22:273-81.
    • (2009) Viral Immunol , vol.22 , pp. 273-281
    • Tao, P.1    Luo, M.2    Zhu, D.3
  • 14
    • 51649100250 scopus 로고    scopus 로고
    • A consensus-hemagglutininbased DNA vaccine that protects mice against divergent H5N1 influenza viruses
    • Chen MW, Cheng TJ, Huang Y, et al. A consensus-hemagglutininbased DNA vaccine that protects mice against divergent H5N1 influenza viruses. Proc Natl Acad Sci USA 2008; 105:13538-43.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13538-13543
    • Chen, M.W.1    Cheng, T.J.2    Huang, Y.3
  • 15
    • 78651097861 scopus 로고    scopus 로고
    • Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine development
    • Ducatez MF, Bahl J, Griffin Y, et al. Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine development. Proc Natl Acad Sci USA 2011; 108:349-54.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 349-354
    • Ducatez, M.F.1    Bahl, J.2    Griffin, Y.3
  • 16
    • 0037189323 scopus 로고    scopus 로고
    • Diversity considerations in HIV-1 vaccine selection
    • Gaschen B, Taylor J, Yusim K, et al. Diversity considerations in HIV-1 vaccine selection. Science 2002; 296:2354-60.
    • (2002) Science , vol.296 , pp. 2354-2360
    • Gaschen, B.1    Taylor, J.2    Yusim, K.3
  • 17
    • 84863229743 scopus 로고    scopus 로고
    • A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses
    • Hu H, Voss J, Zhang G, et al. A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses. J Virol 2012; 86:2978-89.
    • (2012) J Virol , vol.86 , pp. 2978-2989
    • Hu, H.1    Voss, J.2    Zhang, G.3
  • 18
    • 84863994618 scopus 로고    scopus 로고
    • A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses
    • Zhou F, Wang G, Buchy P, et al. A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses. J Virol 2012; 86:6970-8.
    • (2012) J Virol , vol.86 , pp. 6970-6978
    • Zhou, F.1    Wang, G.2    Buchy, P.3
  • 19
    • 77955011794 scopus 로고    scopus 로고
    • An antibody against a novel and conserved epitope in the hemagglutinin 1 subunit neutralizes numerous H5N1 influenza viruses
    • Oh HL, Akerstrom S, Shen S, et al. An antibody against a novel and conserved epitope in the hemagglutinin 1 subunit neutralizes numerous H5N1 influenza viruses. J Virol 2010; 84:8275-86.
    • (2010) J Virol , vol.84 , pp. 8275-8286
    • Oh, H.L.1    Akerstrom, S.2    Shen, S.3
  • 20
    • 77956119219 scopus 로고    scopus 로고
    • Induction of broadly neutralizing H1N1 influenza antibodies by vaccination
    • Wei CJ, Boyington JC, McTamney PM, et al. Induction of broadly neutralizing H1N1 influenza antibodies by vaccination. Science 2010; 329:1060-4.
    • (2010) Science , vol.329 , pp. 1060-1064
    • Wei, C.J.1    Boyington, J.C.2    McTamney, P.M.3
  • 21
    • 81855182191 scopus 로고    scopus 로고
    • DNA priming and influenza vaccine immunogenicity: Two phase 1 open label randomised clinical trials
    • Ledgerwood JE, Wei CJ, Hu Z, et al. DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials. Lancet Infect Dis 2011; 11:916-24.
    • (2011) Lancet Infect Dis , vol.11 , pp. 916-924
    • Ledgerwood, J.E.1    Wei, C.J.2    Hu, Z.3
  • 22
    • 79551516478 scopus 로고    scopus 로고
    • Superior neutralizing antibody response and protection in mice vaccinated with heterologous DNA prime and virus like particle boost against HPAI H5N1 virus
    • Ding H, Tsai C, Gutierrez RA, et al. Superior neutralizing antibody response and protection in mice vaccinated with heterologous DNA prime and virus like particle boost against HPAI H5N1 virus. PLoS One 2011; 6:e16563.
    • (2011) PLoS One , vol.6
    • Ding, H.1    Tsai, C.2    Gutierrez, R.A.3
  • 23
    • 78049495617 scopus 로고    scopus 로고
    • Neutralizing epitopes of influenza virus hemagglutinin: Target for the development of a universal vaccine against H5N1 lineages
    • Prabakaran M, He F, Meng T, et al. Neutralizing epitopes of influenza virus hemagglutinin: target for the development of a universal vaccine against H5N1 lineages. J Virol 2010; 84:11822-30.
    • (2010) J Virol , vol.84 , pp. 11822-11830
    • Prabakaran, M.1    He, F.2    Meng, T.3
  • 24
    • 84875808678 scopus 로고    scopus 로고
    • Cross-protective efficacy of bivalent recombinant baculoviral vaccine against heterologous influenza H5N1 challenge
    • Prabakaran M, Kolpe AB, He F, Kwang J. Cross-protective efficacy of bivalent recombinant baculoviral vaccine against heterologous influenza H5N1 challenge. Vaccine 2013; 31:1385-92.
    • (2013) Vaccine , vol.31 , pp. 1385-1392
    • Prabakaran, M.1    Kolpe, A.B.2    He, F.3    Kwang, J.4
  • 25
    • 0027471177 scopus 로고
    • A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains
    • Okuno Y, Isegawa Y, Sasao F, Ueda S. A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains. J Virol 1993; 67:2552-8.
    • (1993) J Virol , vol.67 , pp. 2552-2558
    • Okuno, Y.1    Isegawa, Y.2    Sasao, F.3    Ueda, S.4
  • 26
    • 58049198443 scopus 로고    scopus 로고
    • Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells
    • Throsby M, van den Brink E, Jongeneelen M, et al. Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One 2008; 3:e3942.
    • (2008) PLoS One , vol.3
    • Throsby, M.1    Van Den Brink, E.2    Jongeneelen, M.3
  • 27
    • 64849114224 scopus 로고    scopus 로고
    • Antibody recognition of a highly conserved influenza virus epitope
    • Ekiert DC, Bhabha G, Elsliger MA, et al. Antibody recognition of a highly conserved influenza virus epitope. Science 2009; 324:246-51.
    • (2009) Science , vol.324 , pp. 246-251
    • Ekiert, D.C.1    Bhabha, G.2    Elsliger, M.A.3
  • 28
    • 62049083943 scopus 로고    scopus 로고
    • Structural and functional bases for broad-spectrum neutralization of avian and human influenza Aviruses
    • Sui J, Hwang WC, Perez S, et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza Aviruses. Nat Struct Mol Biol 2009; 16:265-73.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 265-273
    • Sui, J.1    Hwang, W.C.2    Perez, S.3
  • 29
    • 80051670323 scopus 로고    scopus 로고
    • A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
    • Corti D, Voss J, Gamblin SJ, et al. A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science 2011; 333:850-6.
    • (2011) Science , vol.333 , pp. 850-856
    • Corti, D.1    Voss, J.2    Gamblin, S.J.3
  • 30
    • 84866122029 scopus 로고    scopus 로고
    • Highly conserved protective epitopes on influenza B viruses
    • Dreyfus C, Laursen NS, Kwaks T, et al. Highly conserved protective epitopes on influenza B viruses. Science 2012; 337:1314-8.
    • (2012) Science , vol.337 , pp. 1314-1318
    • Dreyfus, C.1    Laursen, N.S.2    Kwaks, T.3
  • 31
    • 77649242815 scopus 로고    scopus 로고
    • Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins
    • Wang TT, Tan GS, Hai R, et al. Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog 2010; 6:e1000796.
    • (2010) PLoS Pathog , vol.6
    • Wang, T.T.1    Tan, G.S.2    Hai, R.3
  • 32
    • 80051635697 scopus 로고    scopus 로고
    • A highly conserved neutralizing epitope on group 2 influenza Aviruses
    • Ekiert DC, Friesen RH, Bhabha G, et al. A highly conserved neutralizing epitope on group 2 influenza Aviruses. Science 2011; 333:843-50.
    • (2011) Science , vol.333 , pp. 843-850
    • Ekiert, D.C.1    Friesen, R.H.2    Bhabha, G.3
  • 33
    • 77956379133 scopus 로고    scopus 로고
    • Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge
    • Bommakanti G, Citron MP, Hepler RW, et al. Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge. Proc Natl Acad Sci USA 2010; 107: 13701-6.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13701-13706
    • Bommakanti, G.1    Citron, M.P.2    Hepler, R.W.3
  • 34
    • 79952140653 scopus 로고    scopus 로고
    • Influenza virus vaccine based on the conserved hemagglutinin stalk domain
    • doi:10.1128/mBio.00018-10
    • Steel J, Lowen AC, Wang TT, et al. Influenza virus vaccine based on the conserved hemagglutinin stalk domain. MBio 2010; 1. doi:10.1128/mBio.00018-10.
    • (2010) MBio , pp. 1
    • Steel, J.1    Lowen, A.C.2    Wang, T.T.3
  • 35
    • 78649953803 scopus 로고    scopus 로고
    • Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes
    • Wang TT, Tan GS, Hai R, et al. Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proc Natl Acad Sci USA 2010; 107:18979-84.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18979-18984
    • Wang, T.T.1    Tan, G.S.2    Hai, R.3
  • 36
    • 84870656355 scopus 로고    scopus 로고
    • Design of Escherichia coliexpressed stalk domain immunogens of H1N1 hemagglutinin that protect mice from lethal challenge
    • Bommakanti G, Lu X, Citron MP, et al. Design of Escherichia coliexpressed stalk domain immunogens of H1N1 hemagglutinin that protect mice from lethal challenge. J Virol 2012; 86:13434-44.
    • (2012) J Virol , vol.86 , pp. 13434-13444
    • Bommakanti, G.1    Lu, X.2    Citron, M.P.3
  • 37
    • 58749101350 scopus 로고    scopus 로고
    • Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes
    • Chen Y, Qin K, Wu WL, et al. Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes. J Infect Dis 2009; 199:49-58.
    • (2009) J Infect Dis , vol.199 , pp. 49-58
    • Chen, Y.1    Qin, K.2    Wu, W.L.3
  • 38
    • 63449125762 scopus 로고    scopus 로고
    • Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza Aviruses
    • Yoshida R, Igarashi M, Ozaki H, et al. Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza Aviruses. PLoS Pathog 2009; 5:e1000350.
    • (2009) PLoS Pathog , vol.5
    • Yoshida, R.1    Igarashi, M.2    Ozaki, H.3
  • 39
    • 80052184942 scopus 로고    scopus 로고
    • Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin
    • Whittle JR, Zhang R, Khurana S, et al. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc Natl Acad Sci USA 2011; 108:14216-21.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14216-14221
    • Whittle, J.R.1    Zhang, R.2    Khurana, S.3
  • 40
    • 84866953140 scopus 로고    scopus 로고
    • Cross-neutralization of influenza Aviruses mediated by a single antibody loop
    • Ekiert DC, Kashyap AK, Steel J, et al. Cross-neutralization of influenza Aviruses mediated by a single antibody loop. Nature 2012; 489:6.
    • (2012) Nature , vol.489 , pp. 6
    • Ekiert, D.C.1    Kashyap, A.K.2    Steel, J.3
  • 41
    • 84867641531 scopus 로고    scopus 로고
    • Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity
    • Lee PS, Yoshida R, Ekiert DC, et al. Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity. Proc Natl Acad Sci USA 2012; 109:17040-5.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 17040-17045
    • Lee, P.S.1    Yoshida, R.2    Ekiert, D.C.3
  • 42
    • 84874747938 scopus 로고    scopus 로고
    • Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin
    • Qian M, Hu H, Zuo T,Wang G, Zhang L, Zhou P. Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin. J Virol 2013; 87:3571-7.
    • (2013) J Virol , vol.87 , pp. 3571-3577
    • Qian, M.1    Hu, H.2    Zuo, T.3    Wang, G.4    Zhang, L.5    Zhou, P.6
  • 43
    • 34249669303 scopus 로고    scopus 로고
    • Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
    • Simmons CP, Bernasconi NL, Suguitan AL, et al. Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Med 2007; 4:e178.
    • (2007) PLoS Med , vol.4
    • Simmons, C.P.1    Bernasconi, N.L.2    Suguitan, A.L.3
  • 44
    • 80055113889 scopus 로고    scopus 로고
    • H5N1 virus-like particle vaccine elicits cross-reactive neutralizing antibodies that preferentially bind to the oligomeric form of influenza virus hemagglutinin in humans
    • Khurana S, Wu J, Verma N, et al. H5N1 virus-like particle vaccine elicits cross-reactive neutralizing antibodies that preferentially bind to the oligomeric form of influenza virus hemagglutinin in humans. J Virol 2011; 85:10945-54.
    • (2011) J Virol , vol.85 , pp. 10945-10954
    • Khurana, S.1    Wu, J.2    Verma, N.3
  • 45
    • 33846909686 scopus 로고    scopus 로고
    • A DNA vaccine for Ebola virus is safe and immunogenic in a phase i clinical trial
    • Martin JE, Sullivan NJ, Enama ME, et al. A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial. Clin Vaccine Immunol 2006; 13:1267-77.
    • (2006) Clin Vaccine Immunol , vol.13 , pp. 1267-1277
    • Martin, J.E.1    Sullivan, N.J.2    Enama, M.E.3
  • 46
    • 55749111036 scopus 로고    scopus 로고
    • A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a phase i clinical trial
    • Martin JE, Louder MK, Holman LA, et al. A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a phase I clinical trial. Vaccine 2008; 26: 6338-43.
    • (2008) Vaccine , vol.26 , pp. 6338-6343
    • Martin, J.E.1    Louder, M.K.2    Holman, L.A.3
  • 47
    • 75749141272 scopus 로고    scopus 로고
    • A phase 1/2 study of a multiclade HIV-1 DNA plasmid prime and recombinant adenovirus serotype 5 boost vaccine in HIV-uninfected East Africans (RV 172)
    • Kibuuka H, Kimutai R, Maboko L, et al. A phase 1/2 study of a multiclade HIV-1 DNA plasmid prime and recombinant adenovirus serotype 5 boost vaccine in HIV-uninfected East Africans (RV 172). J Infect Dis 2010; 201:600-7.
    • (2010) J Infect Dis , vol.201 , pp. 600-607
    • Kibuuka, H.1    Kimutai, R.2    Maboko, L.3
  • 48
    • 79955003350 scopus 로고    scopus 로고
    • AWest Nile virus DNA vaccine utilizing a modified promoter induces neutralizing antibody in younger and older healthy adults in a phase i clinical trial
    • Ledgerwood JE, Pierson TC, Hubka SA, et al. AWest Nile virus DNA vaccine utilizing a modified promoter induces neutralizing antibody in younger and older healthy adults in a phase I clinical trial. J Infect Dis 2011; 203:1396-404.
    • (2011) J Infect Dis , vol.203 , pp. 1396-1404
    • Ledgerwood, J.E.1    Pierson, T.C.2    Hubka, S.A.3
  • 49
    • 80053606312 scopus 로고    scopus 로고
    • Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico
    • Lopez-Macias C, Ferat-Osorio E, Tenorio-Calvo A, et al. Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico. Vaccine 2011; 29:7826-34.
    • (2011) Vaccine , vol.29 , pp. 7826-7834
    • Lopez-Macias, C.1    Ferat-Osorio, E.2    Tenorio-Calvo, A.3
  • 50
    • 84865118710 scopus 로고    scopus 로고
    • Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure
    • Wei CJ, Yassine HM, McTamney PM, et al. Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure. Sci Transl Med 2012; 4:147ra14.
    • (2012) Sci Transl Med , vol.4
    • Wei, C.J.1    Yassine, H.M.2    McTamney, P.M.3


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