Discrepancies regarding the quality of life of patients with alzheimer's disease: A three-year longitudinal study

Journal of Alzheimer's Disease

Volumn 39, Issue 3, 2014, Pages 511-525

  Conde Sala, Josep L ^a   Turró Garriga, Oriol ^b,c   Garre Olmo, Josep ^b,d   Vilalta Franch, Joan ^b   Lopez Pousa, Secundino ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Hospital de Santa Caterina   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d UNIVERSITY OF GIRONA   (Spain)

Author keywords

Alzheimer's disease; anosognosia; caregiver burden; caregivers; disabilities; longitudinal study; mental health; neuropsychiatric symptoms; patients; quality of life

Indexed keywords

AGED; ALZHEIMER DISEASE; ANOSOGNOSIA; ARTICLE; CAREGIVER; CAREGIVER BURDEN; COHORT ANALYSIS; DEMENTIA; DISABILITY; FEMALE; HUMAN; INTERVIEW; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; QUESTIONNAIRE; SYMPTOM;

ALZHEIMER'S DISEASE; ANOSOGNOSIA; CAREGIVER BURDEN; CAREGIVERS; DISABILITIES; LONGITUDINAL STUDY; MENTAL HEALTH; NEUROPSYCHIATRIC SYMPTOMS; PATIENTS; QUALITY OF LIFE;

ADULT; AGED; AGED, 80 AND OVER; AGNOSIA; ALZHEIMER DISEASE; BEHAVIORAL SYMPTOMS; CAREGIVERS; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; QUALITY OF LIFE; QUESTIONNAIRES; TIME FACTORS;

EID: 84894202628     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-131286     Document Type: Article

References (49)

1. Kurz A, Schulz M, Reed P, Wortmann M, Rodrigo J, von Lützau Hohlbein H, Grosssberg G (2008) Personal perspectives of persons with Alzheimer's disease and their carers: A global survey. Alzheimers Dement 4, 345-352.
2. Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, BäckmanL, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H (2013) The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress. Alzheimers Dement 9, 657-665.
3. Lyketsos CG, Miller DS; Neuropsychiatric Syndromes Professional Interest Areaofthe International Societyto Advance Alzheimer's Research and Treatment (2012) Addressing the Alzheimer's disease crisis through better understanding, treatment, and eventual prevention of associated neuropsychiatric syndromes. Alzheimers Dement 8, 60-64.
4. Katona C, Livingston G, Cooper C, Ames D, Brodaty H, Chiu E (2007) International Psychogeriatric Association consensus statement on defining and measuring treatment benefits in dementia. Int Psychogeriatr 19, 345-354.
5. Cooper C, Mukadam N, Katona C, Lyketsos CG, Ames D, Rabins P, Engedal K, de Mendonça Lima C, Blazer D, Teri L, Brodaty H, Livingston G, World Federation of Biological Psychiatry-Old Age, Taskforce (2012) Systematic review of the effectiveness of non-pharmacological interventions to improve quality of life of people with dementia. Int Psy-chogeriatr 24, 856-870.
6. Vogel A, Mortensen EL, Hasselbalch SG, Andersen BB, Waldemar G (2006) Patient versus informant reported quality of life in the earliest phases of Alzheimer's disease. Int J Geriatr Psychiatry 21, 1132-1138.
7. Ready RE, Ott BR, Grace J (2006) Insight and cognitive impairment: Effects on quality-of-life reports from mild cognitive impairment and Alzheimer's disease patients. Am J Alzheimers Dis Other Demen 21, 242-248.
8. Selwood A, Thorgrimsen L, Orrell M (2005) Quality of life in dementia-a one-year follow-up study. Int J Geriatr Psychiatry 20, 232-237.
9. Karlawish JH, Zbrozek A, Kinosian B, Gregory A, Ferguson A, Low DV, Glick HA (2008) Caregivers' assessments of preference-based quality of life in Alzheimer's disease. Alzheimers Dement 4, 203-211.
10. Jönsson L, Andreasen N, Kilander L, Soininen H, Walde-mar G, Nygaard H, Winblad B, Jönhagen ME, Hallikainen M, Wimo A (2006) Patient and proxy-reported utility in Alzheimer disease using the Euro Qo L. Alzheimer Dis Assoc Disord 20, 49-55.
11. Tatsumi H, Nakaaki S, Torii K, Shinagawa Y, Watanabe N, Murata Y, Sato J, Mimura M, Furukawa TA (2009) Neu-ropsychiatric symptoms predict change in quality of life of Alzheimer disease patients: A two-year follow-up study. Psychiatry Clin Neurosci 63, 374-384.
12. Missotten P, Ylieff M, Di Notte D, Paquay L, De Lepeleire J, Buntinx F, Fontaine O (2007) Quality of life in dementia: A 2-year follow-up study. Int J Geriatr Psychiatry 22, 1201-1207.
13. Lyketsos CG, Gonzales-Salvador T, Chin JJ, Baker A, Black B, Rabins P (2003) A follow-up study of change in quality of life among persons with dementia residing in a long-term care facility. Int J Geriatr Psychiatry 18, 275-281.
14. Vogel A, Bhattacharya S, Waldorff FB, Waldemar G (2012) Proxy-rated quality of life in Alzheimer's disease: A three-year longitudinal study. Int Psychogeriatr 24, 82-89.
15. American Psychiatric, Association (2001) Manual diagnóstico y estadístico de los trastornos mentales, 4th ed., texto revisado (DSM-IV-TR), Masson, Barcelona.
16. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosisof Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services task force on Alzheimer's disease. Neurology 34, 939-944.
17. Conde-Sala JL, Garre-Olmo J, Turró-Garriga O, López-Pousa S, Vilalta-Franch J (2009) Factors related to perceived quality of life in patients with Alzheimer's disease: The patient's perception compared with that of caregivers. Int J Geriatr Psychiatry 24, 585-594.
18. Logsdon RG, Gibbons LE, McCurry SM, Teri L (2002) Assessing quality of life in older adults with cognitive impairment. Psychosom Med 64, 510-519.
19. Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S, Goddard R (1986) CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 149, 698-709.
20. Folstein MF, Folstein SE, McHugh PR (1975) 'Mini Mental State'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
21. Gélinas I, Gauthier L, McIntyre M, Gauthier S (1999) Development of a functional measure for persons with Alzheimer's disease: The Disability Assessmentfor Dementia. Am J Occup Ther 53, 471-481.
22. Cummings JL, Mega M, Gray K, Rosemberg-Thompson S, Carusi DA, Gornbein J (1994) The neuropsychiatric inventory. Comprehensive assessment of psychopathology in dementia. Neurology 44, 2308-2314.
23. Ware JE Jr, Kosinski M, Keller SD (1996) A 12-Item Short-Form Health Survey: Construction of scales and preliminary tests of reliability and validity. Med Care 34, 220-233.
24. Zarit SH, Todd PA, Zarit JM (1986) Subjective burden of husbands and wivesascaregiver:Alongitudinal study.Geron-tologist 26, 260-266.
25. Guilford JP, Fruchter B (1973) Fundamental Statistics in Psychology and Education, 5th ed, McGraw-Hill, New York.
26. Cohen J (1973) Eta-squared and partial eta-squared in fixed factor ANOVA designs. Educ Psychol Meas 33, 107-112.
27. Cohen J (1988) Statistical Power Analysis for the Behavioral Sciences, 2nd ed. Erlbaum, Hillsdale, NJ.
28. Naglie G, Hogan DB, Krahn M, Beattie BL, Black SE, Mack-night C, Freedman M, Patterson C, Borrie M, Bergman H, Byszewski A, Streiner D, Irvine J, Ritvo P, Comrie J, Kowgier M, Tomlinson G (2011) Predictors of patient self-ratings of quality of life in alzheimer disease: Cross-sectional results from the Canadian Alzheimer's Disease Quality of Life Study. Am J Geriatr Psychiatry 19, 881-890.
29. Berwig M, Leicht H, Gertz HJ (2009) Critical evaluation of self-rated quality of life in mild cognitive impairment and Alzheimer's disease-further evidence for the impact of anosognosia and global cognitive impairment. J Nutr Health Aging 13, 226-230.
30. Hurt CS, Banerjee S, Tunnard C, Whitehead DL, Tsolaki M, Mecocci P, Kloszewska I, Soininen H, Vellas B, Lovestone S (2010) Insight, cognition and quality of life in Alzheimer's disease. J Neurol Neurosurg Psychiatry 81, 331-336.
31. Conde-Sala JL, Reñé-Raḿirez R, Turró-Garriga O, Gascón-Bayarri J, Campdelacreu-Fumadó J, Juncadella-Puig M, Rico-Pons I, Garre-Olmo J (2013) Severity of dementia, anosognosia and depression in relation to the quality of life of patients with Alzheimer's disease: Discrepancies between patients and caregivers. Am J Geriatr Psychiatry, doi: 10.1016/j.jagp.2012.07.001.
32. Ettema TP, Dröes RM, de Lange J, Ooms ME, Mellenbergh GJ, Ribbe MW (2005) The conceptofqualityoflifein dementia in the different stages of the disease. Int Psychogeriatr 17, 353-370.
33. Clare L (2003) Managing threats to self: Awareness in early stage Alzheimer's disease. Soc Sci Med 57, 1017-1029.
34. Conde-Sala JL, Reñé-Ramirez R, Turró-Garriga O, Gascón-Bayarri J, Juncadella-Puig M, Moreno-Cordón L, Viñas-D́iez V, Vilalta-Franch J, Garre-Olmo J (2013) Factors associated with the variability in caregiver assessments of the capacities of patients with Alzheimer disease. J Geriatr Psychiatry Neurol 26, 86-94.
35. Karttunen K, Karppi P, Hiltunen A, Vanhanen M, Välimäki T, Martikainen J, Valtonen H, Sivenius J, Soininen H, Har-tikainen S, Suhonen J, Pirttilä T, study ALSOVA, group (2011) Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease. Int J Geriatr Psychiatry 26, 473-482.
36. Hoe J, Katona C, Orrell M, Livingston G (2007) Qualityoflife in dementia: Care recipient and caregiver perceptions of quality of life in dementia: The LASER-AD study. Int J Geriatr Psychiatry 22, 1031-1036.
37. Gómez-Gallego M, Gómez-Amor J, Gómez-Garcia J (2012) Determinants of quality of life in Alzheimer's disease: Perspective of patients, informal caregivers, and professional caregivers. Int Psychogeriatr 24, 1805-1815.
38. Hoe J, Hancock G, Livingston G, Woods B, Challis D, Orrell M (2009) Changes in the quality of life of people with dementia living in care homes. Alzheimer Dis Assoc Disord 23, 285-290.
39. Conde-Sala JL, Reñé-Raḿirez R, Turró-Garriga O, Gascón-Bayarri J, Juncadella-Puig M, Moreno-Cordón L, Viñas-D́iez L, Garre-Olmo J (2013) Clinical differences in patients with Alzheimer's disease according to the presence or absence of anosognosia: Implications for perceived quality of life. J Alzheimers Dis 33, 1105-1116.
40. Agnew SK, Morris RG (1998) The heterogeneity of anosog-nosia for memory impairment in Alzheimer's disease: A review of the literature and a proposed model. Aging Ment Health 2, 7-19.
41. Karlawish JH, Zbrozek A, Kinosian B, Gregory A, Ferguson A, Glick HA (2008) Preference-based quality of life in patients with Alzheimer's disease. Alzheimers Dement 4, 193-202.
42. Mohamed S, Rosenheck R, Lyketsos CG, Schneider LS (2010) Caregiver burden in Alzheimer disease: Cross-sectional and longitudinal patient correlates. Am J Geriatr Psychiatry 18, 917-927.
43. Turró-Garriga O, Garre-Olmo J, Vilalta-Franch J, Conde-Sala J, de Gracia-Blanco M, López-Pousa S (2013) Burden associated with the presence of anosognosia in Alzheimer's disease. Int J Geriatr Psychiatry 28, 291-297.
44. Karlawish JH, Casarett D, Klocinski J, Clark CM (2001) The relationship between caregivers' global ratings of Alzheimer's disease patients' quality of life, disease severity, and the caregiving experience. J Am Geriatr Soc 49, 1066-1070.
45. Schulz R, Cook TB, Beach SR, Lingler JH, Martire LM, Monin JK, Czaja SJ (2013) Magnitude and causes of bias among family caregivers rating Alzheimer disease patients. Am J Geriatr Psychiatry 21, 14-25.
46. Pinquart M, Sörensen S (2006) Helping caregivers of persons with dementia: Which interventions work and how large are their effects? Int Psychogeriatr 18, 577-595.
47. Gallagher-Thompson D, Coon DW, Solano N, Ambler C, Rabinowitz Y, Thompson LW (2003) Change in indices of distress among Latino and Anglo female caregivers of elderly relatives with dementia: Site-specific results from the REACH national collaborative study. Gerontologist 43, 580-591.
48. Gitlin LN, Hauck WW, Dennis MP, Winter L (2005) Maintenance of effects of the home environmental skill-building program for family caregivers and individuals with Alzheimer's disease and related disorders. J Gerontol A Biol Sci Med Sci 60, 368-374.
49. Belle SH, Burgio L, Burns R, Coon D, Czaja SJ, Gallagher-Thompson D, Gitlin LN, Klinger J, Koepke KM, Lee CC, Martindale-Adams J, Nichols L, Schulz R, Stahl S, Stevens A, Winter L, Zhang S, Resources for Enhancing Alzheimer's Caregiver Health (REACH) II, Investigators (2006) Enhancing the quality of life of dementia caregivers from different ethnic or racial groups: A randomized, controlled trial. Ann Intern Med 145, 727-738.