Computational modelling of LQT1 in human induced pluripotent stem cell derived cardiomyocytes

Computing in Cardiology

Volumn 40, Issue , 2013, Pages 1239-1242

  Paci, Michelangelo ^a,b   Hyttinen, Jari ^a,b   Severi, Stefano ^c  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84894194980     PISSN: 23258861     EISSN: 2325887X     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (5)

1. Moretti A, Bellin M, Welling A, Jung CB, Lam IT, Bott-Fllgel L, et al. Patient-specific induced pluripotent stemcell models for long-QT syndrome. N Engl J Med. 2010;363(15):1397-409.
2. Lahti AL, Kujala VJ, Chapman H, Koivisto A-P, Pekkanen-Mattila M, Kerkela E, et al. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech. 2001;5(2):220-30.
3. Paci M, Hyttinen J, Aalto-Setälä K, Severi S. Computational models of ventricular- and atrial-like human induced pluripotent stem cell derived cardiomyocytes. Ann Biomed Eng. 2013;41(11):2334-48.
4. Ma J, Guo L, Fiene S, Anson B, Thomson J, Kamp T, et al. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol 2001;301(5):H2006-17.
5. Severi S, Corsi C, Rocchetti M, Zaza A. Mechanisms of beta-adrenergic modulation of I (Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophys J 2009;96(9):3862-72.