Structure of Bacillus subtilis γ-glutamyl-transpeptidase in complex with acivicin: Diversity of the binding mode of a classical and electrophilic active-site-directed glutamate analogue

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 2, 2014, Pages 607-614

  Ida, Tomoyo ^a   Suzuki, Hideyuki ^b   Fukuyama, Keiichi ^a   Hiratake, Jun ^c   Wada, Kei ^d  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

glutamyltranspeptidase; acivicin; glutamine amidotransferase; glutamine antagonist; glutathione; inhibitors; Ntn hydrolase family

Indexed keywords

ACIVICIN; BACTERIAL PROTEIN; ENZYME INHIBITOR; GAMMA GLUTAMYLTRANSFERASE; GLUTAMIC ACID; GLUTAMINE AMIDOTRANSFERASE; GLUTAMINE ANTAGONIST; GLUTATHIONE; ISOXAZOLE DERIVATIVE; LIGAND; RECOMBINANT PROTEIN;

ARTICLE; BACILLUS SUBTILIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; HELICOBACTER PYLORI; INHIBITORS; METABOLISM; NTN-HYDROLASE FAMILY; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY; Γ-GLUTAMYLTRANSPEPTIDASE;

ACIVICIN; GLUTAMINE AMIDOTRANSFERASE; GLUTAMINE ANTAGONIST; GLUTATHIONE; INHIBITORS; NTN-HYDROLASE FAMILY; Γ-GLUTAMYLTRANSPEPTIDASE;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; GAMMA-GLUTAMYLTRANSFERASE; GLUTAMIC ACID; HELICOBACTER PYLORI; ISOXAZOLES; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84894162225     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004713031222     Document Type: Article

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