Crystal structure of acivicin-inhibited γ-glutamyltranspeptidase reveals critical roles for Its C-Terminus in autoprocessing and catalysis

Biochemistry

Volumn 48, Issue 11, 2009, Pages 2459-2467

  Williams, Kristin ^a   Cullati, Sierra ^a   Sand, Aaron ^a   Biterova, Ekaterina I ^a   Barycki, Joseph J ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES; AUTOPROCESSING; BINDING POCKETS; C TERMINUS; C-TERMINAL REGIONS; CATALYTIC NUCLEOPHILES; ELECTROSTATIC INTERACTIONS; ENZYMATIC ACTIVITIES; ENZYMATIC REACTIONS; ESSENTIAL AMINO ACIDS; EXTRACELLULAR; GLUTATHIONE; HELICOBACTER PYLORUS; HYDROLASE; HYDROXYL GROUPS; MECHANISM OF ACTIONS; MUTATIONAL ANALYSIS; N TERMINALS; OXYANION HOLES; R FACTORS; SALT BRIDGES; STRUCTURE DETERMINATIONS; TIME DEPENDENTS; VIRULENCE FACTORS;

AMINES; AMINO ACIDS; BIOCHEMISTRY; CATALYSIS; CHLORINE COMPOUNDS; ENZYMES; NUCLEOPHILES; ORGANIC ACIDS;

CRYSTAL STRUCTURE;

ACIVICIN; ARGININE; GAMMA GLUTAMYLTRANSFERASE; GLUTAMINE; PHENYLALANINE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MODIFICATION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GAMMA-GLUTAMYLTRANSFERASE; HELICOBACTER PYLORI; ISOXAZOLES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

EID: 64849086541     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8014955     Document Type: Article

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