Moderate relationships between NAA and cognitive ability in healthy adults: Implications for cognitive spectroscopy

Frontiers in Human Neuroscience

Volumn 8, Issue 1 FEB, 2014, Pages

  Patel, Tulpesh ^a   Blyth, Jacqueline C ^b   Griffiths, Gareth ^a   Kelly, Deirdre ^b   Talcott, Joel B ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

Cognition; Cognitive spectroscopy; IQ; N acetyl aspartate; Processing speed; Proton magnetic resonance spectroscopy

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN EXPERIMENT; INTELLIGENCE QUOTIENT; MALE; NEUROCHEMISTRY; NORMAL HUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSYCHOMETRY; SPECTROSCOPY;

EID: 84894106155     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2014.00039     Document Type: Article

References (70)

1. Angelie, E., Bonmartin, A., Boudraa, A., Gonnaud, P. M., Mallet, J. J., and Sappey-Marinier, D. (2001). Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study. AJNR Am. J. Neuroradiol. 22, 119-127. Available online at: http://www.ajnr.org/content/22/1/119.long
2. Aydin, K., Uysal, S., Yakut, A., Emiroglu, B., and Yilmaz, F. (2012). N-acetylaspartate concentration in corpus callosum is positively correlated with intelligence in adolescents. Neuroimage 59, 1058-1064. doi: 10.1016/j.neuroimage.2011.08.114
3. Baddeley, A. (1996). Exploring the central executive. Q. J. Exp. Psychol. 49A, 5-28. doi: 10.1080/027249896392784
4. Barker, P. B. (2001). N-acetyl aspartate-a neuronal marker? Ann. Neurol. 49, 423-424. doi: 10.1002/ana.90
5. Baslow, M. H. (2002). Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review. Neurochem. Int. 40, 295-300. doi: 10.1016/S01970186(01)00095-X
6. Bjartmar, C., Battistuta, J., Terada, N., Dupree, E., and Trapp, B. D. (2002). Nacetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve. Ann. Neurol. 51, 51-58. doi: 10.1002/ana.10052
7. Burlina, A. P., Aureli, T., Bracco, F., Conti, F., and Battistin, L. (2000). MR spectroscopy: a powerful tool for investigating brain function and neurological diseases. Neurochem. Res. 25, 1365-1372. doi: 10.1023/A:1007660632520
8. Charles, H. C., Lazeyras, F., Krishnan, K. R. R., Boyko, O. B., Patterson, L. J., Doraiswamy, P. M., et al. (1994). Proton spectroscopy of human brain: effects of age and sex. Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 995-1004. doi: 10.1016/0278-5846(94)90125-2
9. Charlton, R. A., McIntyre, D. J., Howe, F. A., Morris, R. G., and Markus, H. S. (2007). The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study. Brain Res. 1164, 108-116. doi: 10.1016/j.brainres.2007.06.027
10. Danielsen, E. R., and Ross, B. (1999). Magnetic Resonance Spectroscopy Diagnosis of Neurological Diseases. New York, NY: Marcel Dekker.
11. de Beer, R., Bachert-Baumann, P., Bovee, W. M., Cady, E., Chambron, J., Dommisse, R., et al. (1995). Quality assessment in in vivo NMR spectroscopy: VI. Multicentre quantification of MRS test signals. Magn. Reson. Imag. 13, 169-176. doi: 10.1016/0730-725X(94)00092-H
12. de Stefano, N., and Filippi, M. (2007). MR spectroscopy in multiple sclerosis. J. Neuroimag. 17(Suppl. 1), 31S-35S. doi: 10.1111/j.1552-6569.2007.00134.x
13. Duncan, J., Seitz, R. J., Kolodny, J., Bor, D., Herzog, H., Ahmed, A., et al. (2000). A neural basis for general intelligence. Science 289, 457-460. doi: 10.1126/science.289.5478.457
14. Ferguson, K. J., Maclullich, A. M., Marshall, I., Deary, I. J., Starr, J. M., Seckl, J. R., et al. (2002). Magnetic resonance spectroscopy and cognitive function in healthy elderly men. Brain 125, 2743-2749. doi: 10.1093/ brain/awf278
15. Filippi, C. G., Ulug, A. M., Deck, M. D., Zimmerman, R. D., and Heier, L. A. (2002). Developmental delay in children: assessment with proton MR spectroscopy. AJNR Am. J. Neuroradiol. 23, 882-888. Available online at: http://www.ajnr.org/content/23/5/882.long
16. Firbank, M. J., Harrison, R. M., and O'Brien, J. T. (2002). A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease. Dement. Geriatr. Cogn. Disord. 14, 64-76. doi: 10.1159/000064927
17. Freeman, R. (2003). Magnetic Resonance in Chemistry and Medicine. Oxford: Oxford University Press.
18. Friedman, H. (1968). Magnitude of experimental effect and a table for its rapid estimation. Psychol. Bull. 70, 245-253. doi: 10.1037/h0026258
19. Friedman, S. D., Brooks, W. M., Jung, R. E., Chiulli, S. J., Sloan, J. H., Montoya, B. T., et al. (1999). Quantitative proton MRS predicts outcome after traumatic brain injury. Neurology 52, 1384-1391. doi: 10.1212/WNL.52.7.1384
20. Gimenez, M., Junque, C., Narberhaus, A., Caldu, X., Segarra, D., Vendrell, P., et al. (2004). Medial temporal MR spectroscopy is related to memory performance in normal adolescent subjects. Neuroreport 15, 703-707. doi: 10.1097/00001756200403220-00026
21. Glodzik, L., Wu, W. E., Babb, J. S., Achtnichts, L., Amann, M., Sollberger, M., Monsch, A. U., et al. (2012). The whole-brain N-acetylaspartate correlates with education in normal adults. Psychiatry Res. 204, 49-54. doi: 10.1016/j.pscychresns.2012.04.013
22. Gonzalez-Toledo, E., Kelley, R. E., and Minagar, A. (2006). Role of magnetic resonance spectroscopy in diagnosis and management of multiple sclerosis. Neurol. Res. 28, 280-283. doi: 10.1179/016164106X98161
23. Groth-Marnat, G., Gallagher, R. E., Hale, J. B., and Kaplan, E. (2000). "The wechsler intelligence scales," in Neuropsychological Assessment in Clinical Practice. A Guide to Test Interpretation and Integration, ed G. Groth-Marnat (New York, NY: John Wiley & Sons, Inc.), 129-194.
24. Haga, K. K., Khor, Y. P., Farrall, A., and Wardlaw, J. M. (2009). A systematic review of brain metabolite changes, measured with 1H. Neurobiol. Aging 30, 353-363. doi: 10.1016/j.neurobiolaging.2007.07.005
25. Haier, R. J. (2009). Neuro-intelligence, neuro-metrics and the next phase of brain imaging studies. Intelligence 37, 121-123. doi: 10.1016/j.intell.2008.12.006
26. Hollingworth, W., Medina, L. S., Lenkinski, R. E., Shibata, D. K., Bernal, B., Zurakowski, D., et al. (2006). A systematic literature review of magnetic resonance spectroscopy for the characterization of brain tumors. AJNR Am. J. Neuroradiol. 27, 1404-1411. Available online at: http://www.ajnr.org/content/27/7/1404.long
27. Hou, B. L., and Hu, J. (2009). MRI and MRS of human brain tumors. Methods Mol. Biol. 520, 297-314. doi: 10.1007/978-1-60327-811-9_21
28. Jansen, J. F., Backes, W. H., Nicolay, K., and Kooi, M. E. (2006). 1H MR spectroscopy of the brain: absolute quantification of metabolites. Radiol. 240, 318-332.
29. Jung, R. E., Brooks, W. M., Yeo, R. A., Chiulli, S. J., Weers, D. C., and Sibbitt, W. L. Jr. (1999a). Biochemical markers of intelligence: a proton MR spectroscopy study of normal human brain. Proc. Biol. Sci. U.S.A. 266, 1375-1379. doi: 10.1098/rspb.1999.0790
30. Jung, R. E., Gasparovic, C., Chavez, R. S., Caprihan, A., Barrow, R., and Yeo, R. A. (2009). Imaging intelligence with proton magnetic resonance spectroscopy. Intelligence 37, 192-198. doi: 10.1016/j.intell.2008.10.009
31. Jung, R. E., and Haier, R. J. (2007). The Parieto-Frontal Integration Theory (PFIT) of intelligence: converging neuroimaging evidence. Behav. Brain Sci. 30, 135-154. discussion: 154-187. doi: 10.1017/S0140525X07001185
32. Jung, R. E., Haier, R. J., Yeo, R. A., Rowland, L. M., Petropoulos, H., Levine, A. S., et al. (2005). Sex differences in N-acetylaspartate correlates of general intelligence: an 1H-MRS study of normal human brain. Neuroimage 26, 965-972. doi: 10.1016/j.neuroimage.2005.02.039
33. Jung, R. E., Yeo, R. A., Chiulli, S. J., Sibbitt, W. L. Jr., Weers, D. C., Hart, B. L., et al. (1999b). Biochemical markers of cognition: a proton MR spectroscopy study of normal human brain. Neuroreport. 10, 3327-3331. doi: 10.1097/00001756199911080-00014
34. Kantarci, K. (2007). 1H magnetic resonance spectroscopy in dementia. Br. J. Radiol. 80, S146-S152. doi: 10.1259/bjr/60346217
35. Keevil, S. F., Barbiroll, B., Brooks, J. C. W., Cady, E. B., Canese, R., Carlier, D. J., et al. (1998). Absolute metabolite quantification by in vivo NMR spectroscopy: II. A multicentre trial of protocols for in vivo localised proton studies of human brain. Magn. Reson. Imaging. 16, 1093-1106.
36. Knight-Scott, J., Haley, A. P., Rossmiller, S. R., Farace, E., Mai, V. M., Christopher, J. M., et al. (2003). Molality as a unit of measure for expressing 1H MRS brain metabolite concentrations in vivo. Magn. Reson. Imag. 21, 787-797. doi: 10.1016/S0730-725X(03)00179-6
37. Kochunov, P., Coyle, T., Lancaster, J., Robin, D. A., Hardies, J., Kochunov, V., et al. (2010). Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging. Neuroimage 49, 1190-1199. doi: 10.1016/j.neuroimage.2009.09.052
38. Komoroski, R. A., Heimberg, C., Cardwell, D., and Karson, C. N. (1999). Effects of gender and region on proton MRS of normal human brain. Magn. Reson. Imag. 17, 427-433. doi: 10.1016/S0730-725X(98)00186-6
39. Lee, M. R., Denic, A., Hinton, D. J., Mishra, P. K., Choi, D. S., Pirko, I., et al. (2012). Preclinical (1)H-MRS neurochemical profiling in neurological and psychiatric disorders. Bioanalysis 4, 1787-1804. doi: 10.4155/bio.12.129
40. Li, B. S. Y., Wang, H., and Gonen, O. (2003). Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy. Magn. Res. Imag. 21, 923-928. doi: 10.1016/S0730-725X(03)00181-4
41. Loos, C., Achten, E., and Santens, P. (2010). Proton magnetic resonance spectroscopy in Alzheimer's disease, a review. Acta Neurol. Belg. 110, 291-298.
42. Maniega, S. M., Cvoro, V., Armitage, P. A., Marshall, I., Bastin, M. E., and Wardlaw, J. M. (2008). Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. Stroke 39, 2467-2469. doi: 10.1161/STROKEAHA.107.507020
43. Marino, S., Ciurleo, R., Bramanti, P., Federico, A., and De Stefano, N. (2011). 1HMR spectroscopy in traumatic brain injury. Neurocrit. Care 14, 127-133. doi: 10.1007/s12028-010-9406-6
44. Matalon, R., Michals, K., Sebesta, D., Deanching, M., Gashkoff, P., and Casanova, J. (1988). Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. Am. J. Med. Genet. 29, 463-471. doi: 10.1002/ajmg.1320290234
45. Maudsley, A. A., Domenig, C., Govind, V., Darkazanli, A., Studholme, C., Arheart, K., et al. (2009). Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn. Reson. Med. 61, 548-559. doi: 10.1002/mrm.21875
46. McLean, M. A., Woermann, F. G., Barker, G. J., and Duncan, J. S. (2000). Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter. Magn. Reson. Med. 44, 401-411.
47. Minati, L., Aquino, D., Bruzzone, M. G., and Erbetta, A. (2010). Quantitation of normal metabolite concentrations in six brain regions by in-vivo 1H-MR spectroscopy. J. Med. Phys. 35, 154-163. doi: 10.4103/0971-6203.62128
48. Moffett, J. R., Ross, B., Arun, P., Madhavarao, C. N., and Namboodiri, A. M. (2007). N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog. Neurobiol. 81, 89-131. doi: 10.1016/j.pneurobio.2006.12.003
49. Namboodiri, A. M., Peethambaran, A., Mathew, R., Sambhu, P. A., Hershfield, J., Moffett, J. R., et al. (2006). Canavan disease and the role of Nacetylaspartate in myelin synthesis. Mol. Cell Endocrinol. 252, 216-223. doi: 10.1016/j.mce.2006.03.016
50. Nie, K., Zhang, Y., Huang, B., Wang, L., Zhao, J., Huang, Z., et al. (2013). Marked Nacetylaspartate and choline metabolite changes in Parkinson's disease patients with mild cognitive impairment. Parkinsonism Relat. Disord. 19, 329-334. doi: 10.1016/j.parkreldis.2012.11.012
51. Ozturk, A., Degaonkar, M., Matson, M. A., Wells, C. T., Mahone, E. M., and Horska, A. (2009). Proton MR spectroscopy correlates of frontal lobe function in healthy children. AJNR Am. J. Neuroradiol. 30, 1308-1314. doi: 10.3174/ajnr.A1576
52. Pfleiderer, B., Ohrmann, P., Suslow, T., Wolgast, M., Gerlach, A. L., Heindel, W., et al. (2004). N-acetylaspartate levels of left frontal cortex are associated with verbal intelligence in women but not in men: a proton magnetic resonance spectroscopy study. Neuroscience 123, 1053-1058. doi: 10.1016/j.neuroscience.2003.11.008
53. Pouwels, P. J., Brockmann, K., Kruse, B., Wilken, B., Wick, M., Hanefeld, F., et al. (1999). Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr. Res. 46, 474-485. doi: 10.1203/00006450-199910000-00019
54. Pouwels, P. J., and Frahm, J. (1998). Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn. Reson. Med. 39, 53-60. doi: 10.1002/mrm.1910390110
55. Provencher, S. W. (2001). Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed. 14, 260-264. doi: 10.1002/nbm.698
56. Provencher, S. W. (2008). LCModel & LCMgui User's Manual: LCModel 6.2-1. Available online at: http://s-provencher.com/pages/lcm-manual.shtml
57. Rango, M., Arighi, A., Biondetti, P., Barberis, B., Bonifati, C., Blandini, F., et al. (2007). Magnetic resonance spectroscopy in Parkinson's disease and parkinsonian syndromes. Funct. Neurol. 22, 75-79. Available online at: http://www.functionalneurology.com/index.php?PAGE=articolo_dett&id_article=2284&ID_ISSUE=244
58. Ross, A. J., and Sachdev, P. S. (2004). Magnetic resonance spectroscopy in cognitive research. Brain Res. Brain Res. Rev. 44, 83-102. doi: 10.1016/j.brainresrev.2003.11.001
59. Ross, A. J., Sachdev, P. S., Wen, W., Valenzuela, M. J., and Brodaty, H. (2005). Cognitive correlates of 1H MRS measures in the healthy elderly brain. Brain Res. Bull. 66, 9-16. doi: 10.1016/j.brainresbull.2005.01.015
60. Safriel, Y., Pol-Rodriguez, M., Novotny, E. J., Rothman, D. L., and Fulbright, R. K. (2005). Reference values for long echo time MR spectroscopy in healthy adults. Am. J. Neuroradiol. 26, 1439-1445. Available online at: http://www.ajnr.org/content/26/6/1439.long
61. Shim, T. S., Lee, J. H., Kim, S. Y., Lim, T. H., Kim, S. J., Kim, D. S., et al. (2001). Cerebral metabolic abnormalities in COPD patients detected by localized proton magnetic resonance spectroscopy. Chest 120, 1506-1513. doi: 10.1378/chest.120.5.1506
62. Tabachnik, B. G., and Fidell, L. S. (2001). Using Multivariate Statistics. London: Pearson Education.
63. Targosz-Gajniak, M. G., Siuda, J. S., Wicher, M. M., Banasik, T. J., Bujak, M. A., Augusciak-Duma, A. M., et al. (2013). Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia. J. Neurol. Sci. 335, 58-63. doi: 10.1016/j.jns.2013.08.023
64. Tran, T., Ross, B., and Lin, A. (2009). Magnetic resonance spectroscopy in neurological diagnosis. Neurol. Clin. 27, 21-60, xiii. doi: 10.1016/j.ncl.2008.09.007
65. Valenzuela, M. J., Sachdev, P. S., Wen, W., Shnier, R., Brodaty, H., and Gillies, D. (2000). Dual voxel proton magnetic resonance spectroscopy in the healthy elderly: subcortical-frontal axonal N-acetylaspartate levels are correlated with fluid cognitive abilities independent of structural brain changes. Neuroimage 12, 747-756. doi: 10.1006/nimg.2000.0629
66. Wang, Y., and Li, S. J. (1998). Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy. Magn. Reson. Med. 39, 28-33. doi: 10.1002/mrm.1910390107
67. Wechsler, D. (1997a). Wechsler Abbreviated Scale of Intelligence. San Antonio, TX: The Psychological Corporation.
68. Wechsler, D. (1997b). Wechsler Adult Intelligence Scale-III. San Antonio, TX: The Psychological Corporation.
69. Wiedermann, D., Schuff, N., Matson, G. B., Soher, B. J., Du, A. T., Maudsley, A. A., et al. (2001). Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability. Magn. Reson. Imag. 19, 1073-1080. doi: 10.1016/S0730-725X(01)00441-6
70. Yeo, R. A., Hill, D., Campbell, R., Vigil, J., and Brooks, W. M. (2000). Developmental instability and working memory ability in children: a magnetic resonance spectroscopy investigation. Dev. Neuropsychol. 17, 143-159. doi: 10.1207/S15326942DN1702_01