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Volumn 31, Issue 3, 2014, Pages 263-272

The role of the one-carbon cycle in the developmental origins of type 2 diabetes and obesity

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSITY; CARBON CYCLE; DIABETES MELLITUS, TYPE 2; ENVIRONMENTAL EXPOSURE; FEMALE; FETAL DEVELOPMENT; FOLIC ACID; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; HUMANS; INFANT, NEWBORN; INSULIN RESISTANCE; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; METHYLMALONIC ACID; OBESITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84894104599     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.12390     Document Type: Review
Times cited : (75)

References (44)
  • 1
    • 0025069749 scopus 로고
    • Does early diet program future outcome?
    • Lucas A. Does early diet program future outcome? Acta Paediatr Scand Suppl 1990; 365: 58-67.
    • (1990) Acta Paediatr Scand Suppl , vol.365 , pp. 58-67
    • Lucas, A.1
  • 4
    • 33746911576 scopus 로고    scopus 로고
    • The Dutch famine and its long-term consequences for adult health
    • Roseboom T, De Rooij S, Painter R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev 2006; 82: 485-491.
    • (2006) Early Hum Dev , vol.82 , pp. 485-491
    • Roseboom, T.1    De Rooij, S.2    Painter, R.3
  • 6
    • 77957591910 scopus 로고    scopus 로고
    • Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood
    • Li Y, He Y, Qi L, Jaddoe VW, Feskens EJM, Yang X et al. Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes 2010; 59: 2400-2406.
    • (2010) Diabetes , vol.59 , pp. 2400-2406
    • Li, Y.1    He, Y.2    Qi, L.3    Jaddoe, V.W.4    Feskens, E.J.M.5    Yang, X.6
  • 7
    • 0030704615 scopus 로고    scopus 로고
    • Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study
    • Stanner SA, Bulmer K, Andrès C, Lantseva OE, Borodina V, Poteen VV et al. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. Br Med J (Clin Res Ed) 1997; 315: 1342-1348.
    • (1997) Br Med J (Clin Res Ed) , vol.315 , pp. 1342-1348
    • Stanner, S.A.1    Bulmer, K.2    Andrès, C.3    Lantseva, O.E.4    Borodina, V.5    Poteen, V.V.6
  • 8
    • 37649011327 scopus 로고    scopus 로고
    • DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
    • Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, Bispham J et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A 2007; 104: 19351-19356.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19351-19356
    • Sinclair, K.D.1    Allegrucci, C.2    Singh, R.3    Gardner, D.S.4    Sebastian, S.5    Bispham, J.6
  • 9
    • 36649035030 scopus 로고    scopus 로고
    • Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study
    • Yajnik CS, Deshpande SS, Jackson AA, Refsum H, Rao S, Fisher DJ et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia 2008; 51: 29-38.
    • (2008) Diabetologia , vol.51 , pp. 29-38
    • Yajnik, C.S.1    Deshpande, S.S.2    Jackson, A.A.3    Refsum, H.4    Rao, S.5    Fisher, D.J.6
  • 10
    • 84891880515 scopus 로고    scopus 로고
    • Vitamin B12: one carbon metabolism, fetal growth and programming for chronic disease
    • Rush E, Katre P, Yajnik C. Vitamin B12: one carbon metabolism, fetal growth and programming for chronic disease. Eur J Clin Nutr 2013; 68: 2-7.
    • (2013) Eur J Clin Nutr , vol.68 , pp. 2-7
    • Rush, E.1    Katre, P.2    Yajnik, C.3
  • 11
    • 70449553669 scopus 로고    scopus 로고
    • Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
    • Hazra A, Kraft P, Lazarus R, Chen C, Chanock SJ, Jacques P et al. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet 2009; 18: 4677-4687.
    • (2009) Hum Mol Genet , vol.18 , pp. 4677-4687
    • Hazra, A.1    Kraft, P.2    Lazarus, R.3    Chen, C.4    Chanock, S.J.5    Jacques, P.6
  • 12
    • 64149102559 scopus 로고    scopus 로고
    • Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations
    • Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G et al. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet 2009; 84: 477-482.
    • (2009) Am J Hum Genet , vol.84 , pp. 477-482
    • Tanaka, T.1    Scheet, P.2    Giusti, B.3    Bandinelli, S.4    Piras, M.G.5    Usala, G.6
  • 13
    • 33744943760 scopus 로고    scopus 로고
    • Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians
    • Muthayya S, Kurpad A V, Duggan CP, Bosch RJ, Dwarkanath P, Mhaskar A et al. Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr 2006; 60: 791-801.
    • (2006) Eur J Clin Nutr , vol.60 , pp. 791-801
    • Muthayya, S.1    Kurpad, A.V.2    Duggan, C.P.3    Bosch, R.J.4    Dwarkanath, P.5    Mhaskar, A.6
  • 14
    • 31544483014 scopus 로고    scopus 로고
    • Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women
    • Troen AM, Mitchell B, Sorensen B, Wener MH, Johnston A, Wood B et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 2006; 136: 189-194.
    • (2006) J Nutr , vol.136 , pp. 189-194
    • Troen, A.M.1    Mitchell, B.2    Sorensen, B.3    Wener, M.H.4    Johnston, A.5    Wood, B.6
  • 15
    • 0019417331 scopus 로고
    • The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia
    • Scott JM, Weir DG. The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet 1981; 2: 337-340.
    • (1981) Lancet , vol.2 , pp. 337-340
    • Scott, J.M.1    Weir, D.G.2
  • 16
    • 84894086753 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence. Diabetes in Pregnancy: Management of Diabetes and its Complications from Pre-Conception to the Post-Natal Period. CG63 N clinical guidelines. Available at, Last accessed 25 November 2013.
    • National Institute for Health and Clinical Excellence. Diabetes in Pregnancy: Management of Diabetes and its Complications from Pre-Conception to the Post-Natal Period. CG63 N clinical guidelines. 2008. Available at http://publications.nice.org.uk/diabetes-in-pregnancy-cg63 Last accessed 25 November 2013.
    • (2008)
  • 17
    • 79953718498 scopus 로고    scopus 로고
    • Folic acid food fortification-its history, effect, concerns, and future directions
    • Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients 2011; 3: 370-384.
    • (2011) Nutrients , vol.3 , pp. 370-384
    • Crider, K.S.1    Bailey, L.B.2    Berry, R.J.3
  • 18
    • 33749579459 scopus 로고    scopus 로고
    • Risk factors of vitamin B(12) deficiency in patients receiving metformin
    • Ting RZ-W, Szeto CC, Chan MH-M, Ma KK, Chow KM. Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med 2006; 166: 1975-1979.
    • (2006) Arch Intern Med , vol.166 , pp. 1975-1979
    • Ting, R.-W.1    Szeto, C.C.2    Chan, M.-M.3    Ma, K.K.4    Chow, K.M.5
  • 19
    • 84878928396 scopus 로고    scopus 로고
    • Vitamin B12 and homocysteine status during pregnancy in the Metformin in Gestational Diabetes trial: responses to maternal metformin compared with insulin treatment
    • Gatford KL, Houda CM, Lu ZX, Coat S, Baghurst PA, Owens JA et al. Vitamin B12 and homocysteine status during pregnancy in the Metformin in Gestational Diabetes trial: responses to maternal metformin compared with insulin treatment. Diabetes Obes Metab 2013; 15: 660-667.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 660-667
    • Gatford, K.L.1    Houda, C.M.2    Lu, Z.X.3    Coat, S.4    Baghurst, P.A.5    Owens, J.A.6
  • 20
    • 84870436712 scopus 로고    scopus 로고
    • Maternal dietary folate and/or vitamin B(12) restrictions alter body composition (adiposity) and lipid metabolism in Wistar rat offspring
    • Kumar KA, Lalitha A, Pavithra D, Padmavathi IJN, Ganeshan M, Rao KR et al. Maternal dietary folate and/or vitamin B(12) restrictions alter body composition (adiposity) and lipid metabolism in Wistar rat offspring. J Nutr Biochem 2013; 24: 25-31.
    • (2013) J Nutr Biochem , vol.24 , pp. 25-31
    • Kumar, K.A.1    Lalitha, A.2    Pavithra, D.3    Padmavathi, I.J.N.4    Ganeshan, M.5    Rao, K.R.6
  • 21
    • 0015895895 scopus 로고
    • Folic acid metabolism in vitamin B12-deficient sheep. Depletion of liver folates
    • Smith RM, Osborne-White WS. Folic acid metabolism in vitamin B12-deficient sheep. Depletion of liver folates. Biochem J 1973; 136: 279-293.
    • (1973) Biochem J , vol.136 , pp. 279-293
    • Smith, R.M.1    Osborne-White, W.S.2
  • 22
    • 0036326660 scopus 로고    scopus 로고
    • Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology
    • James SJ, Melnyk S, Pogribna M, Pogribny IP, Caudill MA. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 2002; 132: 2361S-2366S.
    • (2002) J Nutr , vol.132
    • James, S.J.1    Melnyk, S.2    Pogribna, M.3    Pogribny, I.P.4    Caudill, M.A.5
  • 23
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007; 8: 253-262.
    • (2007) Nat Rev Genet , vol.8 , pp. 253-262
    • Jirtle, R.L.1    Skinner, M.K.2
  • 24
    • 84859150673 scopus 로고    scopus 로고
    • Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12
    • McKay JA, Groom A, Potter C, Coneyworth LJ, Ford D, Mathers JC et al. Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. PloS One 2012; 7: e33290.
    • (2012) PloS One , vol.7
    • McKay, J.A.1    Groom, A.2    Potter, C.3    Coneyworth, L.J.4    Ford, D.5    Mathers, J.C.6
  • 25
    • 79960150663 scopus 로고    scopus 로고
    • Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy
    • Hoyo C, Murtha AP, Schildkraut JM, Jirtle RL, Demark-Wahnefried W, Forman MR et al. Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy. Epigenetics 2011; 6: 928-936.
    • (2011) Epigenetics , vol.6 , pp. 928-936
    • Hoyo, C.1    Murtha, A.P.2    Schildkraut, J.M.3    Jirtle, R.L.4    Demark-Wahnefried, W.5    Forman, M.R.6
  • 26
    • 84882974351 scopus 로고    scopus 로고
    • PPAR signaling pathway is a key modulator of liver proteome in pups born to vitamin B12 deficient rats
    • Ahmad S, Kumar KA, Basak T, Bhardwaj G, Yadav DK, Lalitha A et al. PPAR signaling pathway is a key modulator of liver proteome in pups born to vitamin B12 deficient rats. J Proteomics 2013; 91: 297-308.
    • (2013) J Proteomics , vol.91 , pp. 297-308
    • Ahmad, S.1    Kumar, K.A.2    Basak, T.3    Bhardwaj, G.4    Yadav, D.K.5    Lalitha, A.6
  • 27
    • 84894093720 scopus 로고    scopus 로고
    • Committee on Medical Aspects of Food and Nutrition Policy and Scientific Advisory Committee on Nutrition. London: British Nutrition Foundation, Available at, Last accessed 6 January 2014.
    • Committee on Medical Aspects of Food and Nutrition Policy and Scientific Advisory Committee on Nutrition. London: British Nutrition Foundation, 2012. Available at http://www.nutrition.org.uk/nutritionscience/nutrients/nutrient-requirements Last accessed 6 January 2014.
    • (2012)
  • 28
    • 53849124004 scopus 로고    scopus 로고
    • Assessment and interpretation of micronutrient status during pregnancy
    • Wheeler S. Assessment and interpretation of micronutrient status during pregnancy. Proc Nutr Soc 2008; 67: 437-450.
    • (2008) Proc Nutr Soc , vol.67 , pp. 437-450
    • Wheeler, S.1
  • 29
    • 84864193306 scopus 로고    scopus 로고
    • Failures of cobalamin assays in pernicious anemia
    • Carmel R, Agrawal YP. Failures of cobalamin assays in pernicious anemia. N Engl J Med 2012; 367: 385-386.
    • (2012) N Engl J Med , vol.367 , pp. 385-386
    • Carmel, R.1    Agrawal, Y.P.2
  • 30
    • 71749120426 scopus 로고    scopus 로고
    • Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status
    • Vogiatzoglou A, Oulhaj A, Smith AD, Nurk E, Drevon CA, Ueland PM et al. Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clin Chem 2009; 55: 2198-2206.
    • (2009) Clin Chem , vol.55 , pp. 2198-2206
    • Vogiatzoglou, A.1    Oulhaj, A.2    Smith, A.D.3    Nurk, E.4    Drevon, C.A.5    Ueland, P.M.6
  • 31
    • 79957754169 scopus 로고    scopus 로고
    • Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B status in the elderly
    • Valente E, Scott JM, Ueland P-M, Cunningham C, Casey M, Molloy AM. Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B status in the elderly. Clin Chem 2011; 57: 856-863.
    • Clin Chem 2011 , vol.57 , pp. 856-863
    • Valente, E.1    Scott, J.M.2    Ueland, P.-M.3    Cunningham, C.4    Casey, M.5    Molloy, A.M.6
  • 32
    • 84875838310 scopus 로고    scopus 로고
    • Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes
    • Obeid R, Jung J, Falk J, Herrmann W, Geisel J, Friesenhahn-Ochs B et al. Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimie 2013; 95: 1056-1061.
    • (2013) Biochimie , vol.95 , pp. 1056-1061
    • Obeid, R.1    Jung, J.2    Falk, J.3    Herrmann, W.4    Geisel, J.5    Friesenhahn-Ochs, B.6
  • 33
    • 34548094288 scopus 로고    scopus 로고
    • Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring
    • Murphy MM, Molloy AM, Ueland PM, Fernandez-Ballart JD, Schneede J, Arija V et al. Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring. J Nutr 2007; 137: 1863-1867.
    • (2007) J Nutr , vol.137 , pp. 1863-1867
    • Murphy, M.M.1    Molloy, A.M.2    Ueland, P.M.3    Fernandez-Ballart, J.D.4    Schneede, J.5    Arija, V.6
  • 35
    • 43549097337 scopus 로고    scopus 로고
    • Current protein intake in America: analysis of the National Health and Nutrition Examination Survey, 2003-2004
    • Fulgoni VL. Current protein intake in America: analysis of the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr 2008; 87: 1554S-1557S.
    • (2008) Am J Clin Nutr , vol.87
    • Fulgoni, V.L.1
  • 36
    • 33646710996 scopus 로고    scopus 로고
    • Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study
    • Cho E, Zeisel SH, Jacques P, Selhub J, Dougherty L, Colditz GA et al. Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr 2006; 83: 905-911.
    • (2006) Am J Clin Nutr , vol.83 , pp. 905-911
    • Cho, E.1    Zeisel, S.H.2    Jacques, P.3    Selhub, J.4    Dougherty, L.5    Colditz, G.A.6
  • 37
    • 84878409215 scopus 로고    scopus 로고
    • DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women
    • Dominguez-Salas P, Moore SE, Cole D, Da Costa K-A, Cox SE, Dyer RA et al. DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr 2013; 97: 1217-1227.
    • (2013) Am J Clin Nutr , vol.97 , pp. 1217-1227
    • Dominguez-Salas, P.1    Moore, S.E.2    Cole, D.3    Da, C.K.-A.4    Cox, S.E.5    Dyer, R.A.6
  • 39
    • 84882322649 scopus 로고    scopus 로고
    • Plasma choline and betaine correlate with serum folate, plasma S-adenosyl-methionine and S-adenosyl-homocysteine in healthy volunteers
    • Imbard A, Smulders YM, Barto R, Smith DEC, Kok RM, Jakobs C et al. Plasma choline and betaine correlate with serum folate, plasma S-adenosyl-methionine and S-adenosyl-homocysteine in healthy volunteers. Clin Chem Lab Med 2013; 51: 683-692.
    • (2013) Clin Chem Lab Med , vol.51 , pp. 683-692
    • Imbard, A.1    Smulders, Y.M.2    Barto, R.3    Smith, D.E.C.4    Kok, R.M.5    Jakobs, C.6
  • 40
    • 70349999407 scopus 로고    scopus 로고
    • DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    • Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 2009; 18: 4046-4053.
    • (2009) Hum Mol Genet , vol.18 , pp. 4046-4053
    • Tobi, E.W.1    Lumey, L.H.2    Talens, R.P.3    Kremer, D.4    Putter, H.5    Stein, A.D.6
  • 41
    • 0035070666 scopus 로고    scopus 로고
    • Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune Maternal Nutrition Study
    • Rao S, Yajnik CS, Kanade A, Fall CH, Margetts BM, Jackson AA et al. Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune Maternal Nutrition Study. J Nutr 2001; 131: 1217-1224.
    • (2001) J Nutr , vol.131 , pp. 1217-1224
    • Rao, S.1    Yajnik, C.S.2    Kanade, A.3    Fall, C.H.4    Margetts, B.M.5    Jackson, A.A.6
  • 42
    • 0031752017 scopus 로고    scopus 로고
    • Association between poor glucose tolerance and rapid post-natal weight gain in seven-year-old children
    • Crowther NJ, Cameron N, Trusler J, Gray IP. Association between poor glucose tolerance and rapid post-natal weight gain in seven-year-old children. Diabetologia 1998; 41: 1163-1167.
    • (1998) Diabetologia , vol.41 , pp. 1163-1167
    • Crowther, N.J.1    Cameron, N.2    Trusler, J.3    Gray, I.P.4
  • 44
    • 84894041764 scopus 로고    scopus 로고
    • B12 deficiency is more common than folate deficiency in early pregnancy: Do we need to consider B12 fortification?
    • Suppl 1
    • Saravanan P, Wood C, Anderson N. B12 deficiency is more common than folate deficiency in early pregnancy: Do we need to consider B12 fortification? Diabetologia 2010; 53(Suppl 1): S151-S2.
    • (2010) Diabetologia , vol.53
    • Saravanan, P.1    Wood, C.2    Anderson, N.3


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