메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages 75-83

Pharmacokinetics and pharmacodynamics of rivaroxaban - an oral, direct factor Xa inhibitor

Author keywords

Anticoagulation; Arterial thromboembolism; Pharmacodynamics; Pharmacokinetics; Rivaroxaban; Venous thromboembolism

Indexed keywords

ACENOCOUMAROL; ACETYLSALICYLIC ACID; ANTIVITAMIN K; ATORVASTATIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; CLARITHROMYCIN; CLOPIDOGREL; CYTOCHROME P450 3A4; DABIGATRAN; DIGOXIN; ENOXAPARIN; ERYTHROMYCIN; KETOCONAZOLE; MIDAZOLAM; NAPROXEN; PLACEBO; RIFAMPICIN; RITONAVIR; RIVAROXABAN; TICLOPIDINE; WARFARIN;

EID: 84894081076     PISSN: 15748847     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574884708666131111204658     Document Type: Review
Times cited : (45)

References (80)
  • 1
    • 84856797169 scopus 로고    scopus 로고
    • Prevention of VTE in orthopedic surgery patients: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • Falck-Ytter Y, Francis CW, Johanson NA, et al. Prevention of VTE in orthopedic surgery patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012; 141: e278S-e325S.
    • (2012) Chest , vol.141
    • Falck-Ytter, Y.1    Francis, C.W.2    Johanson, N.A.3
  • 2
    • 84856778149 scopus 로고    scopus 로고
    • Prevention of VTE in nonorthopedic surgical patients: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012; 141: e227S-e277S.
    • (2012) Chest , vol.141
    • Gould, M.K.1    Garcia, D.A.2    Wren, S.M.3
  • 3
    • 84856806342 scopus 로고    scopus 로고
    • Prevention of VTE in nonsurgical patients: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • Kahn SR, Lim W, Dunn AS, et al. Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012; 141: e195S-e226S.
    • (2012) Chest , vol.141
    • Kahn, S.R.1    Lim, W.2    Dunn, A.S.3
  • 4
    • 84856802635 scopus 로고    scopus 로고
    • Antithrombotic therapy for VTE disease: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012; 141: e419S-e494S.
    • (2012) Chest , vol.141
    • Kearon, C.1    Akl, E.A.2    Comerota, A.J.3
  • 5
    • 84856745317 scopus 로고    scopus 로고
    • Antithrombotic therapy for atrial fibrillation: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • You JJ, Singer DE, Howard PA, et al. Antithrombotic therapy for atrial fibrillation: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012; 141: e531S-e575S.
    • (2012) Chest , vol.141
    • You, J.J.1    Singer, D.E.2    Howard, P.A.3
  • 6
    • 84856794168 scopus 로고    scopus 로고
    • Primary and secondary prevention of cardiovascular disease: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • Vandvik PO, Lincoff AM, Gore JM, et al. Primary and secondary prevention of cardiovascular disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012; 141: e637S-e668S.
    • (2012) Chest , vol.141
    • Vandvik, P.O.1    Lincoff, A.M.2    Gore, J.M.3
  • 7
    • 84868523625 scopus 로고    scopus 로고
    • 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: An update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association
    • Camm AJ, Lip GYH, De Caterina R, et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 2012; 33: 2719-47.
    • (2012) Eur Heart J , vol.33 , pp. 2719-2747
    • Camm, A.J.1    Lip, G.Y.H.2    De Caterina, R.3
  • 8
    • 84856158305 scopus 로고    scopus 로고
    • ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the Management of Acute Coronary Syndromes (ACS) in Patients Presenting without Persistent ST-segment Elevation of the European Society of Cardiology (ESC)
    • Hamm CW, Bassand JP, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the Management of Acute Coronary Syndromes (ACS) in Patients Presenting without Persistent ST-segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 2011; 32: 2999-3054.
    • (2011) Eur Heart J , vol.32 , pp. 2999-3054
    • Hamm, C.W.1    Bassand, J.P.2    Agewall, S.3
  • 9
    • 26944436300 scopus 로고    scopus 로고
    • Treatment of venous thromboembolism: Adherence to guidelines and impact of physician knowledge, attitudes, and beliefs
    • Caprini JA, Tapson VF, Hyers TM, et al. Treatment of venous thromboembolism: adherence to guidelines and impact of physician knowledge, attitudes, and beliefs. J Vasc Surg 2005; 42: 726-33.
    • (2005) J Vasc Surg , vol.42 , pp. 726-733
    • Caprini, J.A.1    Tapson, V.F.2    Hyers, T.M.3
  • 10
    • 84856804647 scopus 로고    scopus 로고
    • Parenteral anticoagulants: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • Garcia DA, Baglin TP, Weitz JI, Samama MM. Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012; 141: e24S-e43S.
    • (2012) Chest , vol.141
    • Garcia, D.A.1    Baglin, T.P.2    Weitz, J.I.3    Samama, M.M.4
  • 11
    • 84856784474 scopus 로고    scopus 로고
    • Oral anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines
    • Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G. Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012; 141: e44S-e88S.
    • (2012) Chest , vol.141
    • Ageno, W.1    Gallus, A.S.2    Wittkowsky, A.3    Crowther, M.4    Hylek, E.M.5    Palareti, G.6
  • 12
    • 65449163045 scopus 로고    scopus 로고
    • Meta-analysis to assess the quality of warfarin control in atrial fibrillation patients in the United States
    • Baker WL, Cios DA, Sander SD, Coleman CI. Meta-analysis to assess the quality of warfarin control in atrial fibrillation patients in the United States. J Manag Care Pharm 2009; 15: 244-52.
    • (2009) J Manag Care Pharm , vol.15 , pp. 244-252
    • Baker, W.L.1    Cios, D.A.2    Sander, S.D.3    Coleman, C.I.4
  • 13
    • 77954412934 scopus 로고    scopus 로고
    • New oral anticoagulants in development: Potential for improved safety profiles
    • Bauer KA. New oral anticoagulants in development: potential for improved safety profiles. Rev Neurol Dis 2010; 7: 1-8.
    • (2010) Rev Neurol Dis , vol.7 , pp. 1-8
    • Bauer, K.A.1
  • 17
    • 24944536065 scopus 로고    scopus 로고
    • Discovery of the novel antithrombotic agent 5-chloro-N-([(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl)thiophene-2-carboxamide (BAY 59-7939): An oral, direct Factor Xa inhibitor
    • Roehrig S, Straub A, Pohlmann J, et al. Discovery of the novel antithrombotic agent 5-chloro-N-([(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl)thiophene-2-carboxamide (BAY 59-7939): an oral, direct Factor Xa inhibitor. J Med Chem 2005; 48: 5900-8.
    • (2005) J Med Chem , vol.48 , pp. 5900-5908
    • Roehrig, S.1    Straub, A.2    Pohlmann, J.3
  • 18
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct Factor Xa inhibitor
    • Perzborn E, Strassburger J, Wilmen A, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct Factor Xa inhibitor. J Thromb Haemost 2005; 3: 514-21.
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3
  • 19
    • 33748779231 scopus 로고    scopus 로고
    • Effect of BAY 59-7939-a novel, oral, direct Factor Xa inhibitor-on clot-bound Factor Xa activity in vitro
    • Abstract P1104
    • Depasse F, Busson J, Mnich J, Le Flem L, Gerotziafas GT, Samama MM. Effect of BAY 59-7939-a novel, oral, direct Factor Xa inhibitor-on clot-bound Factor Xa activity in vitro. J Thromb Haemost 2005; 3 (Suppl 1). Abstract P1104.
    • (2005) J Thromb Haemost , vol.3 , Issue.SUPPL. 1
    • Depasse, F.1    Busson, J.2    Mnich, J.3    Le Flem, L.4    Gerotziafas, G.T.5    Samama, M.M.6
  • 21
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct Factor Xa inhibitor
    • Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct Factor Xa inhibitor. Clin Pharmacol Ther 2005; 78: 412-21.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 22
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D, Becka M, Wensing G, Voith B, Zuehlsdorf M. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 2005; 61: 873-80.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 23
    • 55549139511 scopus 로고    scopus 로고
    • Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects
    • Kubitza D, Becka M, Roth A, Mueck W. Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects. Curr Med Res Opin 2008; 24: 2757-65.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2757-2765
    • Kubitza, D.1    Becka, M.2    Roth, A.3    Mueck, W.4
  • 24
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct Factor Xa inhibitor, in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M, Mueck W. Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct Factor Xa inhibitor, in healthy subjects. J Clin Pharmacol 2006; 46: 549-58.
    • (2006) J Clin Pharmacol , vol.46 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 25
    • 34250166525 scopus 로고    scopus 로고
    • Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct Factor Xa inhibitor-in healthy subjects
    • Mueck W, Becka M, Kubitza D, Voith B, Zuehlsdorf M. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct Factor Xa inhibitor-in healthy subjects. Int J Clin Pharmacol Ther 2007; 45: 335-44.
    • (2007) Int J Clin Pharmacol Ther , vol.45 , pp. 335-344
    • Mueck, W.1    Becka, M.2    Kubitza, D.3    Voith, B.4    Zuehlsdorf, M.5
  • 26
    • 34147147085 scopus 로고    scopus 로고
    • In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct Factor Xa inhibitor rivaroxaban
    • Gerotziafas GT, Elalamy I, Depasse F, Perzborn E, Samama MM. In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct Factor Xa inhibitor rivaroxaban. J Thromb Haemost 2007; 5: 886-8.
    • (2007) J Thromb Haemost , vol.5 , pp. 886-888
    • Gerotziafas, G.T.1    Elalamy, I.2    Depasse, F.3    Perzborn, E.4    Samama, M.M.5
  • 27
    • 42949123582 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct Factor Xa inhibitor-in patients undergoing major orthopaedic surgery
    • Mueck W, Eriksson BI, Bauer KA, et al. Population pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct Factor Xa inhibitor-in patients undergoing major orthopaedic surgery. Clin Pharmacokinet 2008; 47: 203-16.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 203-216
    • Mueck, W.1    Eriksson, B.I.2    Bauer, K.A.3
  • 28
    • 51349095537 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of once-and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement
    • Mueck W, Borris LC, Dahl OE, et al. Population pharmacokinetics and pharmacodynamics of once-and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement. Thromb Haemost 2008; 100: 453-61.
    • (2008) Thromb Haemost , vol.100 , pp. 453-461
    • Mueck, W.1    Borris, L.C.2    Dahl, O.E.3
  • 29
    • 80052485992 scopus 로고    scopus 로고
    • Rivaroxaban: Population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention
    • Mueck W, Lensing AW, Agnelli G, Decousus H, Prandoni P, Misselwitz F. Rivaroxaban: population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention. Clin Pharmacokinet 2011; 50: 675-86.
    • (2011) Clin Pharmacokinet , vol.50 , pp. 675-686
    • Mueck, W.1    Lensing, A.W.2    Agnelli, G.3    Decousus, H.4    Prandoni, P.5    Misselwitz, F.6
  • 30
    • 66449099711 scopus 로고    scopus 로고
    • Metabolism and excretion of rivaroxaban, an oral, direct Factor Xa inhibitor, in rats, dogs and humans
    • Weinz C, Schwarz T, Kubitza D, Mueck W, Lang D. Metabolism and excretion of rivaroxaban, an oral, direct Factor Xa inhibitor, in rats, dogs and humans. Drug Metab Dispos 2009; 37: 1056-64.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1056-1064
    • Weinz, C.1    Schwarz, T.2    Kubitza, D.3    Mueck, W.4    Lang, D.5
  • 31
    • 74249121331 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban-an oral, direct Factor Xa inhibitor-in elderly Chinese subjects
    • Jiang J, Hu Y, Zhang J, et al. Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban-an oral, direct Factor Xa inhibitor-in elderly Chinese subjects. Thromb Haemost 2010; 103: 234-41.
    • (2010) Thromb Haemost , vol.103 , pp. 234-241
    • Jiang, J.1    Hu, Y.2    Zhang, J.3
  • 32
    • 55549097280 scopus 로고    scopus 로고
    • Pharmacology of the oral, direct Factor Xa inhibitor rivaroxaban-effect of extreme age and gender
    • Abstract P004
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M. Pharmacology of the oral, direct Factor Xa inhibitor rivaroxaban-effect of extreme age and gender. Hämostaseologie 2007; 27: A40. Abstract P004.
    • (2007) Hämostaseologie , vol.27
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 33
    • 34547110933 scopus 로고    scopus 로고
    • The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban-an oral, direct Factor Xa inhibitor
    • Abstract 905
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M. The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban-an oral, direct Factor Xa inhibitor. Blood (ASH Annual Meeting Abstracts) 2006; 108. Abstract 905.
    • (2006) Blood (ASH Annual Meeting Abstracts) , vol.108
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 34
    • 67650932119 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa inhibitor rivaroxaban in healthy Chinese subjects
    • Zhao X, Sun P, Zhou Y, et al. Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa inhibitor rivaroxaban in healthy Chinese subjects. Br J Clin Pharmacol 2009; 68: 77-88.
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 77-88
    • Zhao, X.1    Sun, P.2    Zhou, Y.3
  • 35
    • 33846448135 scopus 로고    scopus 로고
    • Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M, Mueck W. Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J Clin Pharmacol 2007; 47: 218-26.
    • (2007) J Clin Pharmacol , vol.47 , pp. 218-226
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 36
    • 78649289929 scopus 로고    scopus 로고
    • Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor
    • Kubitza D, Becka M, Mueck W, et al. Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor. Br J Clin Pharmacol 2010; 70: 703-12.
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 703-712
    • Kubitza, D.1    Becka, M.2    Mueck, W.3
  • 37
    • 0016916438 scopus 로고
    • Prediction of creatinine clearance from serum creatinine
    • Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41.
    • (1976) Nephron , vol.16 , pp. 31-41
    • Cockcroft, D.W.1    Gault, M.H.2
  • 38
    • 45949099359 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    • Eriksson BI, Borris LC, Friedman RJ, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 2008; 358: 2765-75.
    • (2008) N Engl J Med , vol.358 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 39
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A doubleblind, randomised controlled trial
    • Kakkar AK, Brenner B, Dahl OE, et al. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a doubleblind, randomised controlled trial. Lancet 2008; 372: 31-9.
    • (2008) Lancet , vol.372 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 40
    • 45949103416 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen MR, Ageno W, Borris LC, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008; 358: 2776-86.
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 41
    • 65549169515 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomised trial
    • Turpie AGG, Lassen MR, Davidson BL, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. Lancet 2009; 373: 1673-80.
    • (2009) Lancet , vol.373 , pp. 1673-1680
    • Turpie, A.G.G.1    Lassen, M.R.2    Davidson, B.L.3
  • 42
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • The EINSTEIN Investigators
    • The EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010; 363: 2499-510.
    • (2010) N Engl J Med , vol.363 , pp. 2499-2510
  • 43
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • The EINSTEIN-PE Investigators
    • The EINSTEIN-PE Investigators. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012; 366: 1287-97.
    • (2012) N Engl J Med , vol.366 , pp. 1287-1297
  • 44
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365: 883-91.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 45
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct Factor Xa inhibitor-are not affected by aspirin
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M. Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct Factor Xa inhibitor-are not affected by aspirin. J Clin Pharmacol 2006; 46: 981-90.
    • (2006) J Clin Pharmacol , vol.46 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 46
    • 33947205635 scopus 로고    scopus 로고
    • Rivaroxaban (BAY 59-7939)-an oral, direct Factor Xa inhibitor-has no clinically relevant interaction with naproxen
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M. Rivaroxaban (BAY 59-7939)-an oral, direct Factor Xa inhibitor-has no clinically relevant interaction with naproxen. Br J Clin Pharmacol 2007; 63: 469-76.
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 469-476
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 47
    • 64549143503 scopus 로고    scopus 로고
    • Co-administration of rivaroxaban-a novel, oral, direct Factor Xa inhibitor-and clopidogrel in healthy subjects
    • Abstract P1272
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M. Co-administration of rivaroxaban-a novel, oral, direct Factor Xa inhibitor-and clopidogrel in healthy subjects. Eur Heart J 2007; 28 (Suppl 1): 189. Abstract P1272.
    • (2007) Eur Heart J , vol.28 , Issue.SUPPL. 1 , pp. 189
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 48
    • 0036598117 scopus 로고    scopus 로고
    • Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action
    • Payne DA, Hayes PD, Jones CI, Belham P, Naylor AR, Goodall AH. Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action. J Vasc Surg 2002; 35: 1204-9.
    • (2002) J Vasc Surg , vol.35 , pp. 1204-1209
    • Payne, D.A.1    Hayes, P.D.2    Jones, C.I.3    Belham, P.4    Naylor, A.R.5    Goodall, A.H.6
  • 49
    • 33746790467 scopus 로고    scopus 로고
    • Effect of enoxaparin on the safety, tolerability, pharmacodynamics and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor
    • Abstract P1704
    • Kubitza D, Becka M, Voith B, Zuehlsdorf M. Effect of enoxaparin on the safety, tolerability, pharmacodynamics and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor. J Thromb Haemost 2005; 3 (Suppl 1). Abstract P1704.
    • (2005) J Thromb Haemost , vol.3 , Issue.SUPPL. 1
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4
  • 50
    • 57449103733 scopus 로고    scopus 로고
    • No interaction between rivaroxaban-a novel, oral, direct Factor Xa inhibitor-and atorvastatin
    • Abstract P062
    • Kubitza D, Mueck W, Becka M. No interaction between rivaroxaban-a novel, oral, direct Factor Xa inhibitor-and atorvastatin. Pathophysiol Haemost Thromb 2008; 36: A40. Abstract P062.
    • (2008) Pathophysiol Haemost Thromb , vol.36
    • Kubitza, D.1    Mueck, W.2    Becka, M.3
  • 51
    • 38649115655 scopus 로고    scopus 로고
    • Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): A multinational cross-sectional study
    • Cohen AT, Tapson VF, Bergmann JF, et al. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet 2008; 371: 387-94.
    • (2008) Lancet , vol.371 , pp. 387-394
    • Cohen, A.T.1    Tapson, V.F.2    Bergmann, J.F.3
  • 52
    • 46049090201 scopus 로고    scopus 로고
    • Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition)
    • Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition). Chest 2008; 133: 381S-453S.
    • (2008) Chest , vol.133
    • Geerts, W.H.1    Bergqvist, D.2    Pineo, G.F.3
  • 53
    • 4644288189 scopus 로고    scopus 로고
    • Prevention of venous thromboembolism: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126: 338S-400S.
    • (2004) Chest , vol.126
    • Geerts, W.H.1    Pineo, G.F.2    Heit, J.A.3
  • 54
    • 0033539025 scopus 로고    scopus 로고
    • A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in Medical Patients with Enoxaparin Study Group
    • Samama MM, Cohen AT, Darmon JY, et al. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in Medical Patients with Enoxaparin Study Group. N Engl J Med 1999; 341: 793-800.
    • (1999) N Engl J Med , vol.341 , pp. 793-800
    • Samama, M.M.1    Cohen, A.T.2    Darmon, J.Y.3
  • 55
    • 80052341686 scopus 로고    scopus 로고
    • Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol
    • Cohen AT, Spiro TE, Büller HR, et al. Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol. J Thromb Thrombolysis 2011; 31: 407-16.
    • (2011) J Thromb Thrombolysis , vol.31 , pp. 407-416
    • Cohen, A.T.1    Spiro, T.E.2    Büller, H.R.3
  • 56
    • 84859965096 scopus 로고    scopus 로고
    • Rivaroxaban compared with enoxaparin for the prevention of venous thromboembolism in acutely ill medical patients
    • New Orleans, USA, 2-5 April; Oral presentation (Accessed July 11, 2013)
    • Cohen AT, Spiro TE, Büller HR, et al. Rivaroxaban compared with enoxaparin for the prevention of venous thromboembolism in acutely ill medical patients. American College of Cardiology Congress 60th Annual Scientific Session. New Orleans, USA, 2-5 April 2011; Oral presentation. http://my.americanheart.org/idc/groups/ ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_ 425442.pdf (Accessed July 11, 2013).
    • (2011) American College of Cardiology Congress 60th Annual Scientific Session
    • Cohen, A.T.1    Spiro, T.E.2    Büller, H.R.3
  • 57
    • 35048860791 scopus 로고    scopus 로고
    • Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality
    • Cohen AT, Agnelli G, Anderson FA, et al. Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost 2007; 98: 756-64.
    • (2007) Thromb Haemost , vol.98 , pp. 756-764
    • Cohen, A.T.1    Agnelli, G.2    Anderson, F.A.3
  • 58
    • 33748796017 scopus 로고    scopus 로고
    • Estimated annual number of incident and recurrent, non-fatal and fatal venous thromboembolism (VTE) events in the US
    • on behalf of the VTE Impact Assessment Group, Abstract 910
    • Heit JA, Cohen AT, Anderson FA, on behalf of the VTE Impact Assessment Group. Estimated annual number of incident and recurrent, non-fatal and fatal venous thromboembolism (VTE) events in the US. Blood (ASH Annual Meeting Abstracts) 2005; 106. Abstract 910.
    • (2005) Blood (ASH Annual Meeting Abstracts) , pp. 106
    • Heit, J.A.1    Cohen, A.T.2    Anderson, F.A.3
  • 59
    • 0035832261 scopus 로고    scopus 로고
    • Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
    • Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 2001; 285: 2370-5.
    • (2001) JAMA , vol.285 , pp. 2370-2375
    • Go, A.S.1    Hylek, E.M.2    Phillips, K.A.3
  • 60
    • 0023625745 scopus 로고
    • Atrial fibrillation: A major contributor to stroke in the elderly. The Framingham Study
    • Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med 1987; 147: 1561-4.
    • (1987) Arch Intern Med , vol.147 , pp. 1561-1564
    • Wolf, P.A.1    Abbott, R.D.2    Kannel, W.B.3
  • 61
    • 23644443663 scopus 로고    scopus 로고
    • Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: Meta-analysis with estimates of risk and benefit
    • Rothberg MB, Celestin C, Fiore LD, Lawler E, Cook JR. Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: meta-analysis with estimates of risk and benefit. Ann Intern Med 2005; 143: 241-50.
    • (2005) Ann Intern Med , vol.143 , pp. 241-250
    • Rothberg, M.B.1    Celestin, C.2    Fiore, L.D.3    Lawler, E.4    Cook, J.R.5
  • 62
    • 33645229796 scopus 로고    scopus 로고
    • Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: An updated and comprehensive meta-analysis of 25,307 patients
    • Andreotti F, Testa L, Biondi-Zoccai GG, Crea F. Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: an updated and comprehensive meta-analysis of 25,307 patients. Eur Heart J 2006; 27: 519-26.
    • (2006) Eur Heart J , vol.27 , pp. 519-526
    • Andreotti, F.1    Testa, L.2    Biondi-Zoccai, G.G.3    Crea, F.4
  • 63
    • 79551592248 scopus 로고    scopus 로고
    • "Triple therapy" rather than "triple threat": A meta-analysis of the two antithrombotic regimens after stent implantation in patients receiving long-term oral anticoagulant treatment
    • Zhao HJ, Zheng ZT, Wang ZH, et al. "Triple therapy" rather than "triple threat": a meta-analysis of the two antithrombotic regimens after stent implantation in patients receiving long-term oral anticoagulant treatment. Chest 2011; 139: 260-70.
    • (2011) Chest , vol.139 , pp. 260-270
    • Zhao, H.J.1    Zheng, Z.T.2    Wang, Z.H.3
  • 64
    • 67649562905 scopus 로고    scopus 로고
    • Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACSTIMI 46): A randomised, double-blind, phase II trial
    • Mega JL, Braunwald E, Mohanavelu S, et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACSTIMI 46): a randomised, double-blind, phase II trial. Lancet 2009; 374: 29-38.
    • (2009) Lancet , vol.374 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3
  • 65
    • 79955887785 scopus 로고    scopus 로고
    • Rationale and design of the Anti-Xa Therapy to Lower cardiovascular events in Addition to standard therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 51 (ATLAS-ACS 2 TIMI 51) trial: A randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rivaroxaban in subjects with acute coronary syndrome
    • Gibson CM, Mega JL, Burton P, et al. Rationale and design of the Anti-Xa Therapy to Lower cardiovascular events in Addition to standard therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 51 (ATLAS-ACS 2 TIMI 51) trial: A randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rivaroxaban in subjects with acute coronary syndrome. Am Heart J 2011; 161: 815-21.
    • (2011) Am Heart J , vol.161 , pp. 815-821
    • Gibson, C.M.1    Mega, J.L.2    Burton, P.3
  • 66
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • Mega JL, Braunwald E, Wiviott SD, et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med 2012; 366: 9-19.
    • (2012) N Engl J Med , vol.366 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 67
    • 80053463472 scopus 로고    scopus 로고
    • Cost-effectiveness of rivaroxaban versus heparins for prevention of venous thromboembolism after total hip or knee surgery in Sweden
    • Ryttberg L, Diamantopoulos A, Forster F, Lees M, Fraschke A, Bjorholt I. Cost-effectiveness of rivaroxaban versus heparins for prevention of venous thromboembolism after total hip or knee surgery in Sweden. Expert Rev Pharmacoecon Outcomes Res 2011; 11: 601-15.
    • (2011) Expert Rev Pharmacoecon Outcomes Res , vol.11 , pp. 601-615
    • Ryttberg, L.1    Diamantopoulos, A.2    Forster, F.3    Lees, M.4    Fraschke, A.5    Bjorholt, I.6
  • 68
    • 84855886240 scopus 로고    scopus 로고
    • Cost effectiveness of rivaroxaban versus enoxaparin for prevention of post-surgical venous thromboembolism from a US payer's perspective
    • Duran A, Sengupta N, Diamantopoulos A, Forster F, Kwong L, Lees M. Cost effectiveness of rivaroxaban versus enoxaparin for prevention of post-surgical venous thromboembolism from a US payer's perspective. Pharmacoeconomics 2012; 30: 87-101.
    • (2012) Pharmacoeconomics , vol.30 , pp. 87-101
    • Duran, A.1    Sengupta, N.2    Diamantopoulos, A.3    Forster, F.4    Kwong, L.5    Lees, M.6
  • 69
    • 84864503151 scopus 로고    scopus 로고
    • Cost-effectiveness of rivaroxaban in the prevention of venous thromboembolism: A Canadian analysis using the Ontario Ministry of Health Perspective
    • McDonald H, Diamantopoulos A, Wells P, et al. Cost-effectiveness of rivaroxaban in the prevention of venous thromboembolism: A Canadian analysis using the Ontario Ministry of Health Perspective. J Med Econ 2012; 15: 817-28.
    • (2012) J Med Econ , vol.15 , pp. 817-828
    • McDonald, H.1    Diamantopoulos, A.2    Wells, P.3
  • 70
    • 84891814768 scopus 로고    scopus 로고
    • The cost-effectiveness of oral direct Factor Xa inhibitors compared with low-molecular-weight heparin for the prevention of venous thromboembolism prophylaxis in total hip or knee replacement surgery
    • doi: 10.1002/phar.1269
    • Mahmoudi M, Sobieraj DM. The cost-effectiveness of oral direct Factor Xa inhibitors compared with low-molecular-weight heparin for the prevention of venous thromboembolism prophylaxis in total hip or knee replacement surgery. Pharmacotherapy 2013: doi: 10.1002/phar.1269.
    • (2013) Pharmacotherapy
    • Mahmoudi, M.1    Sobieraj, D.M.2
  • 71
    • 84865456696 scopus 로고    scopus 로고
    • Cost-effectiveness of rivaroxaban compared to warfarin for stroke prevention in atrial fibrillation
    • Lee S, Anglade MW, Pham D, Pisacane R, Kluger J, Coleman CI. Cost-effectiveness of rivaroxaban compared to warfarin for stroke prevention in atrial fibrillation. Am J Cardiol 2012; 110: 845-51.
    • (2012) Am J Cardiol , vol.110 , pp. 845-851
    • Lee, S.1    Anglade, M.W.2    Pham, D.3    Pisacane, R.4    Kluger, J.5    Coleman, C.I.6
  • 72
    • 85039617000 scopus 로고    scopus 로고
    • Cost-effectiveness of rivaroxaban for the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation with one or more risk factors-a UK perspective
    • Berlin, Germany, November 3-7, Abstract PCV51
    • Asukai Y, Duran A, Lloyd A, McLeod E, Evers T, Broughton J. Cost-effectiveness of rivaroxaban for the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation with one or more risk factors-a UK perspective. The International Society for Pharmacoeconomics and Outcomes Research 15th Annual European Congress. Berlin, Germany, November 3-7, 2012; Abstract PCV51.
    • (2012) The International Society for Pharmacoeconomics and Outcomes Research 15th Annual European Congress
    • Asukai, Y.1    Duran, A.2    Lloyd, A.3    McLeod, E.4    Evers, T.5    Broughton, J.6
  • 73
    • 84879409410 scopus 로고    scopus 로고
    • Cost-effectiveness of new oral anticoagulants compared with warfarin in preventing stroke and other cardiovascular events in patients with atrial fibrillation
    • Coyle D, Coyle K, Cameron C, et al. Cost-effectiveness of new oral anticoagulants compared with warfarin in preventing stroke and other cardiovascular events in patients with atrial fibrillation. Value Health 2013; 16: 498-506.
    • (2013) Value Health , vol.16 , pp. 498-506
    • Coyle, D.1    Coyle, K.2    Cameron, C.3
  • 74
    • 84867259621 scopus 로고    scopus 로고
    • Dabigatran versus rivaroxaban for the prevention of stroke and systemic embolism in atrial fibrillation in Canada. Comparative efficacy and cost-effectiveness
    • Kansal AR, Sharma M, Bradley-Kennedy C, et al. Dabigatran versus rivaroxaban for the prevention of stroke and systemic embolism in atrial fibrillation in Canada. Comparative efficacy and cost-effectiveness. Thromb Haemost 2012; 108: 672-82.
    • (2012) Thromb Haemost , vol.108 , pp. 672-682
    • Kansal, A.R.1    Sharma, M.2    Bradley-Kennedy, C.3
  • 75
    • 84870032549 scopus 로고    scopus 로고
    • Management consensus guidance for the use of rivaroxaban-an oral, direct Factor Xa inhibitor
    • Turpie AGG, Kreutz R, Llau J, Norrving B, Haas S. Management consensus guidance for the use of rivaroxaban-an oral, direct Factor Xa inhibitor. Thromb Haemost 2012; 108: 876-86.
    • (2012) Thromb Haemost , vol.108 , pp. 876-886
    • Turpie, A.G.G.1    Kreutz, R.2    Llau, J.3    Norrving, B.4    Haas, S.5
  • 76
    • 8844227509 scopus 로고    scopus 로고
    • Warfarin reversal: Consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis
    • Baker RI, Coughlin PB, Gallus AS, et al. Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis. Med J Aust 2004; 181: 492-7.
    • (2004) Med J Aust , vol.181 , pp. 492-497
    • Baker, R.I.1    Coughlin, P.B.2    Gallus, A.S.3
  • 77
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011; 124: 1573-9.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 78
    • 79954534386 scopus 로고    scopus 로고
    • Laboratory assessment of new anticoagulants
    • Samama MM, Guinet C. Laboratory assessment of new anticoagulants. Clin Chem Lab Med 2011; 49: 761-72.
    • (2011) Clin Chem Lab Med , vol.49 , pp. 761-772
    • Samama, M.M.1    Guinet, C.2
  • 80
    • 84867573339 scopus 로고    scopus 로고
    • Evaluation of the anti-Factor Xa chromogenic assay for measuring rivaroxaban plasma concentrations using calibrators and controls
    • Abstract 3330
    • Samama MM, Contant G, Spiro TE, et al. Evaluation of the anti-Factor Xa chromogenic assay for measuring rivaroxaban plasma concentrations using calibrators and controls. Blood (ASH Annual Meeting Abstracts) 2010; 116: 1363-4. Abstract 3330.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 1363-1364
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.