Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action

Journal of Vascular Surgery

Volumn 35, Issue 6, 2002, Pages 1204-1209

  Payne, D A ^a   Hayes, P D ^a   Jones, C I ^a   Belham, P ^a   Naylor, A R ^a   Goodall, A H ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; DRUG DERIVATIVE; TICLOPIDINE; ADENOSINE DIPHOSPHATE; FIBRINOGEN;

ADULT; ARTICLE; BLEEDING TIME; DRUG COMBINATION; DRUG EFFECT; DRUG INTERACTION; HUMAN; MALE; THROMBOCYTE AGGREGATION; TIME; ATHEROSCLEROSIS; BLEEDING; DOSE RESPONSE; DRUG RESPONSE; PRIORITY JOURNAL; RISK FACTOR; THROMBOCYTE FUNCTION; THROMBOEMBOLISM; VASCULAR SURGERY;

ADULT; ASPIRIN; BLEEDING TIME; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; HUMANS; MALE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE; TIME FACTORS;

EID: 0036598117     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1067/mva.2002.122027     Document Type: Article

References (30)

1. Fuster V, Badimon L, Badimon JJ, et al. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 1992;326:242-50.
2. Patrono C. Drug therapy: aspirin as an antiplatelet agent. N Engl J Med 1994;330:1287-94.
3. Antiplatelct Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy. I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Br Med J 1994;308:81-106.
4. Quinn MJ, Fitzgerald DJ. Ticlopidine and clopidogrel. Circulation 1999;100:1667-72.
5. CAPRIE Steering Committee. A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-39.
6. Bhatt DL, Hirsch AT, Ringleb PA, et al. Reduction in the need for hospitalisation for recurrent ischemic events and bleeding with clopidogrel instead of aspirin. Am Heart J 2000;140:67-73.
7. Harker LA, Boissel JP, Pilgrim AJ, et al. Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE: CAPRIE Steering Committee and Investigators: clopidogrel versus aspirin in patients at risk of ischaemic events. Drug Safety 1999;21:325-35.
8. European Carotid Surgery Trialists' Collaborative Group. MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. Lancet 1991;337:1235-43.
9. Gaunt ME, Smith JL, Ratliff DA, et al. A comparison of quality control methods applied to carotid endartercctomy. Eur J Vasc Endovasc Surg 1996;11:4-11.
10. Levi CR, Roberts AK, Fell G, et al. Transcranial Doppler microembolus detection in the identification of patients at high risk of perioperative stroke. Eur J Vasc Endovasc Surg 1997;14:170-6.
11. Taylor DW, Barnett HJ, Haynes RB, Ferguson GG, Sackett DL, Thorpe KE, et al. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endartercctomy: a randomised controlled trial. ASA and Carotid Endarterectomy (ACE) Trial Collaborators. Lancet 1999;353(9171):2179-84.
12. Hayes DP, Box H, Tull S, et al. Pre-operative platelet function predicts thromboembolic events after carotid endarterectomy [abstract]. Thromb Haemost 1999;suppl:449.
13. Herbert J-M, Dol F, Bernat A, et al. The antiaggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several animal models in the rabbit. Thromb Haemost 1998;80:512-8.
14. Makkar RR, Eigler NL, Kaul S, et al. Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis. Eur Heart J 1998;19:1538-46.
15. Harker LA, Marzec UM, Kelly AB, et al. Clopidogrel inhibition of stent, graft, and vascular thrombogenesis with antithrombotic enhancement by aspirin in nonhuman primates. Circulation 1998;98:2461-9.
16. Lablanche JM, McFadden EP, Bonnet JL, et al. Combined antiplatelet therapy with ticlopidine and aspirin. A simplified approach to intercoronary stent management. Eur Heart J 1996;17:1373-80.
17. Bertrand ME, Legrand V, Boland J, et al. Randomised multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting: the full anticoagulation versus aspirin and ticlopidine (FANTASTIC) study. Circulation 1998;98:1597-603.
18. Bertrand ME, Rupprecht H-J, Urban P, et al. Investigators for the CLASSICS. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the Clopidogrel Aspirin Stent International Cooperative Study (CLASSICS). Circulation 2000;102:624-9.
19. Hjemdahl P, Chronos NAF, Wilson DJ, et al. Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and P-selectin expression. Arterioscler Thromb 1994;14:77-84.
20. Chronos NAF, Wilson DJ, Janes SL, et al. Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of α-granules or lysosomes from, human platelets. Clin Sci 1994;87:575-80.
21. Panak E, Blanchard J, Roe RL. Evaluation of the antithrombotic efficacy of ticlopidine in man. Agents Actions Suppl 1984;15:148-66.
22. Coukell AJ, Markham A. Clopidogrel. Drugs 1997;54:745-50.
23. Klinkhardt U, Kirchmaier CM, Westrup D, et al. Ex vivo-in vitro interaction between aspirin, clopidogrel and the glycoprotein IIb/IIIa inhibitors abciximab and SR121566A. Clin Pharmacol Ther 2000;67:305-13.
24. David JL, Limet R. Antiplatelet activity of clopidogrel in coronary artery bypass graft surgery patients. Thromb Haemost 1999;82:1417-21.
25. Boneu B, Destelle G. Platelet anti-aggregating activity and tolerance of clopidogrel in atherosclerotic patients. Thromb Haemost 1996;76:939-43.
26. Savcic M, Hauert J, Bachmann F, et al. Clopidogrel loading dose regimens: kinetic profile of pharmacodynamic response in healthy subjects. Semin Thromb Haemost 1999;25(suppl 2):15-9.
27. Burns ER, Lawrence C. Bleeding time. A guide to its diagnostic and clinical utility. Arch Pathol Lab Med 1989;113:1219-24.
28. De Caterina R, Lanza M, Manca G, et al. Bleeding time and bleeding: an analysis of the relationship of the bleeding time test with parameters of surgical bleeding. Blood 1994;84:3363-70.
29. Francis J, Francis D, Larson L, et al. Can the platelet function analyser (PFA®)-100 test substitute for the template bleeding time in routine clinical practice? Platelets 1999;10:132-6.
30. CURE trial investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST elevation. N Engl J Med 2001;345:494-502.