Sectorial loss of retinal ganglion cells in inherited photoreceptor degeneration is due to RGC death

British Journal of Ophthalmology

Volumn 98, Issue 3, 2014, Pages 396-401

  García Ayuso, Diego ^a   Salinas Navarro, Manuel ^a   Nadal Nicolás, Francisco Manuel ^b   Ortín Martínez, Arturo ^a   Agudo Barriuso, Marta ^b   Vidal Sanz, Manuel ^a   Villegas Pérez, María P ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EXPERIMENTAL – ANIMAL MODELS; RETINA;

ANIMALS; AXONAL TRANSPORT; AXONS; CELL COUNT; FEMALE; MICROSCOPY, FLUORESCENCE; PHOTORECEPTOR CELLS, VERTEBRATE; RATS; RATS, MUTANT STRAINS; RETINAL GANGLION CELLS; RETINITIS PIGMENTOSA; TRANSCRIPTION FACTOR BRN-3A;

EID: 84894057072     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjophthalmol-2013-303958     Document Type: Article

References (25)

1. Wright AF, Chakarova CF, Abd El-Aziz MM, et al. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Nat Rev Genet 2010;11: 273-84.
2. Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet 2006;368: 1795-809.
3. Eng JG, Agrawal RN, Tozer KR, et al. Morphometric analysis of optic nerves and retina from an end-stage retinitis pigmentosa patient with an implanted active epiretinal array. Invest Ophthalmol Vis Sci 2011;52: 4610-16.
4. Chader JG. Animals models in research on retinal degenerations: past progress and future hopes. Vision Res 2002;42: 393-9.
5. Villegas-Pérez MP, Vidal-Sanz M, Lund RD. Mechanism of retinal ganglion cell loss in inherited retinal dystrophy. Neuroreport 1996;7: 1995-9.
6. Villegas-Pérez MP, Lawrence JM, Vidal-Sanz M, et al. Ganglion cell loss in RCS rat retina: a result of compression of axons by contracting intraretinal vessels linked to the pigment epithelium. J Comp Neurol 1998;392: 58-77.
7. Wang S, Villegas-Pérez MP, Holmes T, et al. Evolving neurovascular relationships in the RCS rat with age. Curr Eye Res 2003;27: 183-96.
8. García-Ayuso D, Salinas-Navarro M, Agudo M, et al. Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina. Exp Eye Res 2010;91: 800-10.
9. Wang S, Villegas-Pérez MP, Vidal-Sanz M, et al. Progressive optic axon dystrophy and vascular changes in rd mice. Invest Ophthalmol Vis Sci 2000;41: 537-45.
10. García-Ayuso D, Salinas-Navarro M, Agudo M, et al. Retinal ganglion cell axonal compression by retinal vessels in light-induced retinal degeneration. Mol Vis 2011;17: 1716-33.
11. Marco-Gomariz MA, Hurtado-Montalbán N, Vidal-Sanz M, et al. Phototoxic induced photoreceptor degeneration causes retinal ganglion cell degeneration in pigmented rats. J Comp Neurol 2006;498: 163-79.
12. Vidal-Sanz M, Salinas-Navarro M, Nadal-Nicolás FM, et al. Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas. Prog Retin Eye Res 2012;31: 1-27.
13. Sposato V, Iovieno A, Sornelli F, et al. Axonal transport deficit in the optic nerve of rats with inherited retinitis pigmentosa and experimentally induced glaucoma. Graefes Arch Clin Exp Ophthalmol 2008;246: 1553-8.
14. Pavlidis M, Fischer D, Thanos S. Photoreceptor degeneration in the RCS rat attenuates dendritic transport and axonal regeneration of ganglion cells. Invest Ophthalmol Vis Sci 2000;41: 2318-28.
15. Eisenfeld AJ, LaVail MM, LaVail JH. Assessment of possible transneuronal changes in the retina of rats with inherited retinal dystrophy: cell size, number, synapses, and axonal transport by retinal ganglion cells. J Comp Neurol 1984; 223: 22-34.
16. Bourne MC, Campbell DA, Tansley K. Hereditary degeneration of the rat retina. Br J Ophthalmol 1938;22: 613-23.
17. D'Cruz PM, Yasumura D, Weir J, et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Gen 2000;9: 645-51.
18. Gartner S, Henkind P. Pathology of retinitis pigmentosa. Ophthalmology 1982;89: 1425-32.
19. Walia S, Fishman GA. Retinal nerve fiber layer analysis in RP patients using Fourier-domain OCT. Invest Ophthalmol Vis Sci 2008;49: 3525-8.
20. Li ZY, Kljavin IJ, Milam AH. Rod photoreceptor neurite sprouting in retinitis pigmentosa. J Neurosci 1995;15: 5429-38.
21. Newman NM, Stevens RA, Heckenlively JR. Nerve fibre layer loss in diseases of the outer retinal layer. Br J Ophthalmol 1987;71: 21-6.
22. Jonas JB, Schiro D. Localized retinal nerve fiber layer defects in nonglaucomatous optic nerve atrophy. Graefes Arch Clin Exp Ophthalmol 1994;232: 759-60.
23. Tatham AJ, Weinreb RN, Zangwill LM, et al. Estimated Retinal Ganglion Cell Counts in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects. Am J Ophthalmol 2013;156: 578-87.
24. Zhang Y, Xu L, Zhang L, et al. Ophthalmoscopic Assessment of the Retinal Nerve Fiber Layer. The Beijing Eye Study. PLoS One 2013;8:e62022.
25. Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathologica 2009;118: 103-13.