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Volumn 69, Issue 3, 2014, Pages 697-705

In vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infection

Author keywords

Antimicrobial persistence; Chemostat; MICs

Indexed keywords

CADAZOLID; OXAZOLIDINONE DERIVATIVE;

EID: 84894042563     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt411     Document Type: Article
Times cited : (57)

References (33)
  • 1
    • 0019949758 scopus 로고
    • Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions
    • George WL, Rolfe RD, Finegold SM. Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions. J Clin Microbiol 1982; 15: 1049-53.
    • (1982) J Clin Microbiol , vol.15 , pp. 1049-1053
    • George, W.L.1    Rolfe, R.D.2    Finegold, S.M.3
  • 2
    • 77954581650 scopus 로고    scopus 로고
    • The changing epidemiology of Clostridium difficile infections
    • Freeman J, Bauer MP, Baines SD et al. The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev 2010; 23: 529-49.
    • (2010) Clin Microbiol Rev , vol.23 , pp. 529-549
    • Freeman, J.1    Bauer, M.P.2    Baines, S.D.3
  • 3
    • 84860348952 scopus 로고    scopus 로고
    • Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection
    • Wiegand PN, Nathwani D, Wilcox MH et al. Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection. J Hosp Infect 2012; 81: 1-14.
    • (2012) J Hosp Infect , vol.81 , pp. 1-14
    • Wiegand, P.N.1    Nathwani, D.2    Wilcox, M.H.3
  • 4
    • 77952564778 scopus 로고    scopus 로고
    • Economic healthcare costs of Clostridium difficile infection: a systematic review
    • Ghantoji SS, Sail K, Lairson DR et al. Economic healthcare costs of Clostridium difficile infection: a systematic review. J Hosp Infect 2010; 74: 309-18.
    • (2010) J Hosp Infect , vol.74 , pp. 309-318
    • Ghantoji, S.S.1    Sail, K.2    Lairson, D.R.3
  • 5
    • 34547133720 scopus 로고    scopus 로고
    • A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
    • Zar FA, Bakkanagari SR, Moorthi KM et al. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 2007; 45: 302-7.
    • (2007) Clin Infect Dis , vol.45 , pp. 302-307
    • Zar, F.A.1    Bakkanagari, S.R.2    Moorthi, K.M.3
  • 6
    • 67349239352 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile infection:areviewof risk factors, treatments, and outcomes
    • Johnson S.Recurrent Clostridium difficile infection:areviewof risk factors, treatments, and outcomes. J Infect 2009; 58: 403-10.
    • (2009) J Infect , vol.58 , pp. 403-410
    • Johnson, S.1
  • 7
    • 79551527297 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for Clostridium difficile infection
    • Louie TJ, Miller MA, Mullane KM et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. New Engl J Med 2011; 364: 422-31.
    • (2011) New Engl J Med , vol.364 , pp. 422-431
    • Louie, T.J.1    Miller, M.A.2    Mullane, K.M.3
  • 8
    • 84863676557 scopus 로고    scopus 로고
    • Treatment of first recurrence of Clostridium difficile infection: fidaxomicin versus vancomycin
    • Cornely OA, Miller MA, Louie TJ et al. Treatment of first recurrence of Clostridium difficile infection: fidaxomicin versus vancomycin. Clin Infect Dis 2012; 55 Suppl 2: S154-61.
    • (2012) Clin Infect Dis , vol.55 , Issue.SUPPL. 2
    • Cornely, O.A.1    Miller, M.A.2    Louie, T.J.3
  • 9
    • 0035182827 scopus 로고    scopus 로고
    • Reduced susceptibility of Clostridium difficile to metronidazole
    • Brazier JS, Fawley W, Freeman J et al.Reduced susceptibility of Clostridium difficile to metronidazole. J Antimicrob Chemother 2001; 48: 741-2.
    • (2001) J Antimicrob Chemother , vol.48 , pp. 741-742
    • Brazier, J.S.1    Fawley, W.2    Freeman, J.3
  • 10
    • 54549118257 scopus 로고    scopus 로고
    • Emergence of reduced susceptibility to metronidazole in Clostridium difficile
    • Baines SD, O'Connor R, Freeman J et al. Emergence of reduced susceptibility to metronidazole in Clostridium difficile. J Antimicrob Chemother 2008; 62: 1046-52.
    • (2008) J Antimicrob Chemother , vol.62 , pp. 1046-1052
    • Baines, S.D.1    O'Connor, R.2    Freeman, J.3
  • 11
    • 84894056525 scopus 로고    scopus 로고
    • Clostridium difficile Ribotyping Network (CDRN) for England and Northern Ireland,Annual Report.,(18 February 2013, date last accessed).
    • Clostridium difficile Ribotyping Network (CDRN) for England and Northern Ireland. 2010/11 Annual Report. http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317133396963 (18 February 2013, date last accessed).
    • (2010)
  • 12
    • 84894047273 scopus 로고    scopus 로고
    • In vitro activity of cadazolid against 209 toxigenic isolates of Clostridium difficile
    • San Francisco, CA, USA,Abstract E-808. American Society for Microbiology,Washington, DC, U.S.A.
    • Hecht DW, Gerding DN, Osmolski JR et al. In vitro activity of cadazolid against 209 toxigenic isolates of Clostridium difficile. In: Abstracts of the Fifty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA, 2012. Abstract E-808. American Society for Microbiology,Washington, DC, U.S.A.
    • (2012) Abstracts of the Fifty-second Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Hecht, D.W.1    Gerding, D.N.2    Osmolski, J.R.3
  • 13
    • 84893480045 scopus 로고    scopus 로고
    • Cadazolid, a novel quinolonyl-oxazolidinone antibiotic with potent activity against Clostridium difficile: in vitro antibacterial activity and propensity for resistance development
    • San Francisco, CA, USA, Abstract C1-1346, Washington, DC, U.S.A.,American Society for Microbiology
    • Locher HH, Pfaff P, Schroeder S et al. Cadazolid, a novel quinolonyl-oxazolidinone antibiotic with potent activity against Clostridium difficile: in vitro antibacterial activity and propensity for resistance development. In: Abstracts of the Fifty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA, 2012. Abstract C1-1346. American Society for Microbiology, Washington, DC, U.S.A.
    • (2012) Abstracts of the Fifty-second Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Locher, H.H.1    Pfaff, P.2    Schroeder, S.3
  • 14
    • 84957399395 scopus 로고    scopus 로고
    • Multicentre, double-blind, randomised, phase 2 study evaluating the novel antibiotic, cadazolid, in subjects with Clostridium difficile-associated diarrhoea
    • Berlin, Germany,Abstract LB-2956. European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland.
    • Louie TBM, Cornely OA, Kracker H et al. Multicentre, double-blind, randomised, phase 2 study evaluating the novel antibiotic, cadazolid, in subjects with Clostridium difficile-associated diarrhoea. In: Abstracts of the Twenty-third European Congress of Clinical Microbiology and Infectious Diseases, Berlin, Germany, 2013. Abstract LB-2956. European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland.
    • (2013) Abstracts of the Twenty-third European Congress of Clinical Microbiology and Infectious Diseases
    • Louie, T.B.M.1    Cornely, O.A.2    Kracker, H.3
  • 15
    • 84875608759 scopus 로고    scopus 로고
    • In vitro activity of cadazolid against Clostridium difficile strains isolated from primary and recurrent infections in Stockholm, Sweden
    • Rashid MU, Lozano HM, Weintraub A et al. In vitro activity of cadazolid against Clostridium difficile strains isolated from primary and recurrent infections in Stockholm, Sweden. Anaerobe 2013; 20: 32-5.
    • (2013) Anaerobe , vol.20 , pp. 32-35
    • Rashid, M.U.1    Lozano, H.M.2    Weintraub, A.3
  • 16
    • 0035131693 scopus 로고    scopus 로고
    • Antibiotic activity against genotypically distinct and indistinguishable Clostridium difficile isolates
    • Freeman J, Wilcox MH. Antibiotic activity against genotypically distinct and indistinguishable Clostridium difficile isolates. J Antimicrob Chemother 2001; 47: 244-6.
    • (2001) J Antimicrob Chemother , vol.47 , pp. 244-246
    • Freeman, J.1    Wilcox, M.H.2
  • 17
    • 84872412204 scopus 로고    scopus 로고
    • Analysis of metronidazole susceptibility in different Clostridium difficile PCR ribotypes
    • Moura I, Spigaglia P, Barbanti F et al. Analysis of metronidazole susceptibility in different Clostridium difficile PCR ribotypes. J Antimicrob Chemother 2013; 68: 362-5.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 362-365
    • Moura, I.1    Spigaglia, P.2    Barbanti, F.3
  • 18
    • 0038601431 scopus 로고    scopus 로고
    • Effects of cefotaxime and desacetylcefotaxime upon Clostridium difficile proliferation and toxin production in a triple-stage chemostat model of the human gut
    • Freeman J, O'Neill FJ, Wilcox MH. Effects of cefotaxime and desacetylcefotaxime upon Clostridium difficile proliferation and toxin production in a triple-stage chemostat model of the human gut. J Antimicrob Chemother 2003; 52: 96-102.
    • (2003) J Antimicrob Chemother , vol.52 , pp. 96-102
    • Freeman, J.1    O'Neill, F.J.2    Wilcox, M.H.3
  • 19
    • 21244433196 scopus 로고    scopus 로고
    • Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model
    • Baines SD, Freeman J,Wilcox MH. Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model. J Antimicrob Chemother 2005; 55: 974-82.
    • (2005) J Antimicrob Chemother , vol.55 , pp. 974-982
    • Baines, S.D.1    Freeman, J.2    Wilcox, M.H.3
  • 20
    • 27144453578 scopus 로고    scopus 로고
    • Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection
    • Freeman J, Baines SD, Jabes D et al. Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection. J Antimicrob Chemother 2005; 56: 717-25.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 717-725
    • Freeman, J.1    Baines, S.D.2    Jabes, D.3
  • 21
    • 34447572800 scopus 로고    scopus 로고
    • Effect of metronidazole on growth and toxin production byepidemic Clostridium difficile PCR ribotypes001 and 027 in a human gut model
    • Freeman J, Baines SD, Saxton K et al. Effect of metronidazole on growth and toxin production byepidemic Clostridium difficile PCR ribotypes001 and 027 in a human gut model. J Antimicrob Chemother 2007; 60: 83-91.
    • (2007) J Antimicrob Chemother , vol.60 , pp. 83-91
    • Freeman, J.1    Baines, S.D.2    Saxton, K.3
  • 22
    • 54549090087 scopus 로고    scopus 로고
    • Comparison of oritavancin versus vancomycin as treatments forclindamycin-induced Clostridium difficile PCR ribotype027infection inahumangut model
    • Baines SD, O'Connor R, Saxton K et al. Comparison of oritavancin versus vancomycin as treatments forclindamycin-induced Clostridium difficile PCR ribotype027infection inahumangut model. J AntimicrobChemother2008; 62: 1078-85.
    • (2008) J Antimi crob Chemother , vol.62 , pp. 1078-1085
    • Baines, S.D.1    O'Connor, R.2    Saxton, K.3
  • 23
    • 79958807215 scopus 로고    scopus 로고
    • Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model
    • Baines SD, Noel AR, Huscroft GS et al. Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model. J Antimicrob Chemother 2011; 66: 1537-46.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 1537-1546
    • Baines, S.D.1    Noel, A.R.2    Huscroft, G.S.3
  • 24
    • 0031944894 scopus 로고    scopus 로고
    • Validation of a three-stage compound continuous culture system for investigating the effect of retention time on the ecology and metabolism of bacteria in the human colon
    • MacFarlane GT, Macfarlane S, Gibson GR. Validation of a three-stage compound continuous culture system for investigating the effect of retention time on the ecology and metabolism of bacteria in the human colon. Microb Ecol 1998; 35: 180-7.
    • (1998) Microb Ecol , vol.35 , pp. 180-187
    • MacFarlane, G.T.1    Macfarlane, S.2    Gibson, G.R.3
  • 25
    • 0017273427 scopus 로고
    • Penetration of clindamycin phosphate into the abnormal human biliary tract
    • Brown RB, Martyak SN, Barza M et al. Penetration of clindamycin phosphate into the abnormal human biliary tract. Ann Intern Med 1976; 84: 168-70.
    • (1976) Ann Intern Med , vol.84 , pp. 168-170
    • Brown, R.B.1    Martyak, S.N.2    Barza, M.3
  • 26
    • 59749088788 scopus 로고    scopus 로고
    • Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model
    • Saxton K, Baines SD, Freeman J et al. Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model. Antimicrob Agents Chemother 2009; 53: 412-20.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 412-420
    • Saxton, K.1    Baines, S.D.2    Freeman, J.3
  • 27
    • 60649089055 scopus 로고    scopus 로고
    • Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model
    • Baines SD, O'Connor R, Saxton K et al. Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model. J Antimicrob Chemother 2009; 63: 520-5.
    • (2009) J Antimicrob Chemother , vol.63 , pp. 520-525
    • Baines, S.D.1    O'Connor, R.2    Saxton, K.3
  • 28
    • 84871182628 scopus 로고    scopus 로고
    • Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection
    • Crowther GS, Baines SD, Todhunter SL et al. Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection. J Antimicrob Chemother 2013; 68: 168-76.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 168-176
    • Crowther, G.S.1    Baines, S.D.2    Todhunter, S.L.3
  • 29
    • 84882685517 scopus 로고    scopus 로고
    • Effectiveness of a short (4 day) course of oritavancin in the treatment of simulated Clostridium difficile infection using a human gut model
    • Chilton CH, FreemanJ, Crowther GS et al. Effectiveness of a short (4 day) course of oritavancin in the treatment of simulated Clostridium difficile infection using a human gut model. J Antimicrob Chemother 2013; 68: 2078-82.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 2078-2082
    • Chilton, C.H.1    Freeman, J.2    Crowther, G.S.3
  • 30
    • 59749103290 scopus 로고    scopus 로고
    • OPT-80 eliminates Clostridium difficile and is sparing of Bacteroides species during treatment of C
    • Louie TJ, Emery J, Krulicki W et al. OPT-80 eliminates Clostridium difficile and is sparing of Bacteroides species during treatment of C. difficile infection. Antimicrob Agents Chemother 2009; 53: 261-3.
    • (2009) difficile infection. Antimicrob Agents Chemother , vol.53 , pp. 261-263
    • Louie, T.J.1    Emery, J.2    Krulicki, W.3
  • 31
    • 34250335092 scopus 로고    scopus 로고
    • Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model
    • Baines SD, Saxton K, Freeman J et al. Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model. J Antimicrob Chemother 2006; 58: 1062-5.
    • (2006) J Antimicrob Chemother , vol.58 , pp. 1062-1065
    • Baines, S.D.1    Saxton, K.2    Freeman, J.3
  • 32
    • 84858691905 scopus 로고    scopus 로고
    • Co-amoxiclav induces proliferation and cytotoxin production of Clostridium difficile ribotype 027 in a human gut model
    • Chilton CH, Freeman J, Crowther GS et al. Co-amoxiclav induces proliferation and cytotoxin production of Clostridium difficile ribotype 027 in a human gut model. J Antimicrob Chemother 2012; 67: 951-4.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 951-954
    • Chilton, C.H.1    Freeman, J.2    Crowther, G.S.3
  • 33
    • 66149098843 scopus 로고    scopus 로고
    • Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection
    • Baines SD, Freeman J, Wilcox MH. Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection. Antimicrob Agents Chemother 2009; 53: 2202-4.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2202-2204
    • Baines, S.D.1    Freeman, J.2    Wilcox, M.H.3


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