Effect of temperature on dopamine transporter function and intracellular accumulation of methamphetamine: Implications for methamphetamine-induced dopaminergic neurotoxicity

Journal of Neuroscience

Volumn 20, Issue 20, 2000, Pages 7838-7845

  Xie, T ^a   McCann, U D ^a   Kim, S ^a   Yuan, J ^a   Ricaurte, G A ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Dopamine; Dopamine transporter; Methamphetamine; MPP+; Neurotoxicity; Temperature

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; DOPAMINE TRANSPORTER; METHAMPHETAMINE;

ANIMAL EXPERIMENT; ARTICLE; ENVIRONMENTAL TEMPERATURE; HYPERTHERMIA; HYPOTHERMIA; HYPOTHESIS; MALE; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE;

EID: 0034667644     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-20-07838.2000     Document Type: Article

References (70)

1. Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: Pharmacological profile of protective and nonprotective agents
2. Damage to dopaminergic nerve terminals in mice by combined treatment of intrastriatal malonate with systemic methamphetamine or MPTP
3. Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
4. Differing neurotoxic potencies of methamphetamine, mazindol, and cocaine in mesencephalic cultures
5. Methamphetamine-induced alterations in dopamine transporter function
6. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter
7. The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in striatum
8. Further studies of the role of hyperthermia in methamphetamine neurotoxicity
9. Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum
10. Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response
11. Methamphetamine selectively damages dopaminergic innervation to the nucleus accumbens core while sparing the shell
12. Central administration of methamphetamine synergizes with metabolic inhibition to deplete striatal monoamines
13. Effect of 7-nitroindazole on body temperature and methamphetamine-induced dopamine toxicity
14. Effect of dopamine uptake blockers on methamphetamine toxicity in primary mesencephalic cultures
15. Ontogeny of methamphetamine-induced neurotoxicity and associated hyperthermic response
16. Rapid ATP loss caused by methamphetamine in the mouse striatum: Relationship between energy impairment and dopaminergic neurotoxicity
17. +, a metabolite of MPP+, by brain synaptosomes
18. Time course of brain temperature and caudate/putamen microdialysate levels of amphetamine and dopamine in rats after multiple doses of D-amphetamine
19. Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress
20. Cocaine reward and MPTP toxicity: Alteration by regional variant dopamine transporter overexpression
21. Long-term changes in dopaminergic innervation of caudate nucleus after continuous amphetamine administration
22. Reduced striatal vesicular monoamine transporters after neurotoxic but not after behaviorally-sensitizing doses of methamphetamine
23. +-induced effects on body temperature exhibit age- and strain-dependence in mice
24. A single dose model of methamphetamine-induced neurotoxicity in rats: Effects on neostriatal monoamines and glial fibrillary acidic protein
25. Role of dopamine transporter in methamphetamine-induced neurotoxicity: Evidence from mice lacking the transporter
26. Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice
27. Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter
28. Neurochemical mechanisms of toxicity
29. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors
30. p53-Knockout mice are protected against the long-term effccts of methamphetamine on dopaminergic terminals and cell bodies
31. Autoradiographic evidence for methamphetamine-induced striatal dopaminergic loss in mouse brain: Attenuation in CuZn-superoxide dismutase transgenic mice
32. Nicotinamide attenuates methamphetamine-induced striatal dopamine depletion in rats
33. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
34. Toward development of an in vitro model of methamphetamine-induced dopamine nerve terminal toxicity
35. Cellular and molecular mechanisms of drug dependence
36. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
37. Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey
38. Evidence for mechanism of action of neurotoxicity of amphetamine related compounds
39. Comparison of the release of [3H]dopamine from isolated corpus striatum by amphetamine, fenfluramine and unlabelled dopamine
40. Fluorescence histochemistry indicates damage of striatal dopamine nerve terminals in rats after multiple doses of methamphetamine
41. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat
42. Dopamine uptake inhibitors block long-term neurotoxic effects of methamphetamine upon dopaminergic neurons
43. 11C]WIN-35,428
44. Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP
45. Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse
46. Dopamine transporters and neuronal injury
47. + levels and enhances toxicity to dopamine neurons in MPTP-treated mice
48. Dopamine transporter expression confers cytotoxicity to low doses of the Parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium
49. The effects of amfonelic acid, a dopamine uptake inhibitor, on methamphetamine-induced dopaminergic terminal degeneration and astrocytic response in rat striatum
50. Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain
51. Fluoxetine increases long-lasting neostriatal dopamine depletion after administration of D-methamphetamine and D-amphetamine
52. Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers
53. Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum
54. Lasting effects of (+-)-3.,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: Neurochemical observations
55. Cocaine receptors on dopamine transporters are related to self-administration of cocaine
56. The molecular mechanism of 'ecstasy' [3,4-methylenedioxy-methamphetamine (MDMA)]: Serotonin transporters are targets for MDMA-induced serotonin release
57. Neurotoxicity of methamphetamine and related drugs
58. Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine
59. Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA
60. A high percentage yield of tyrosine hydroxylase-positive cells from rat E14 mesencephalic cell culture
61. Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity
62. Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice
63. Treatment of mice with methamphetamine produces cell loss in the substantia nigra
64. Methamphetamine-induced neurotoxicity: Roles for glutamate and dopamine efflux
65. Substrates of energy metabolism attenuate methamphetamine-induced neurotoxicity in striatum
66. Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: Evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations
67. In vivo evidence that methamphetamine abuse produces long-lasting changes in dopamine transporters in human brain
68. Long-term effects of chronic methamphetamine administration in rhesus monkeys
69. Interactions of [3H]amphetamine with rat brain synaptosomes. II. Active transport
70. 3H]amphetamine with rat brain synaptosomes. I. Saturable sequestration